Reviewed, UniProtKB/Swiss-Prot Q8IWJ2 (GCC2_HUMAN)

Names and origin

Protein names

Recommended name:
    GRIP and coiled-coil domain-containing protein 2
Alternative name(s):
    Golgi coiled-coil protein GCC185
    Ran-binding protein 2-like 4
      Short name=RanBP2L4
    CTCL tumor antigen se1-1
    CLL-associated antigen KW-11
    Renal carcinoma antigen NY-REN-53

Gene names

Name:	GCC2
Synonyms:	KIAA0336, RANBP2L4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1583 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probably involved in maintaining Golgi structure By similarity.
Subunit structure	Homodimer. Interacts (via its GRIP domain) to RAP6A and RAP9. Ref.12
Subcellular location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein Ref.12 Ref.8.
Tissue specificity	Ubiquitous. Ref.6
Domain	Extended rod-like protein with coiled-coil domains.
Sequence similarities	Contains 1 GRIP domain.
Sequence caution	The sequence AAH37774.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cytoplasm Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Ref.12 Inferred from direct assay. Source: UniProtKB extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	identical protein binding Ref.12 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-1645335,EBI-1645335
RAB6A	P20340	1	EBI-1645335,EBI-1052826

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWJ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWJ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEDLVQDGVA...LSLKKENIKM

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1583

1583

GRIP and coiled-coil domain-containing protein 2

PRO_0000190074

Regions

Domain

1508 – 1558

51

GRIP

Coiled coil

9 – 1517

1509

Potential

Compositional bias

138 – 947

810

Glu-rich

Amino acid modifications

Modified residue

186

1

Phosphoserine Ref.10

Modified residue

1382

1

Phosphoserine Ref.9 Ref.11

Modified residue

1441

1

Phosphoserine Ref.11

Modified residue

1548

1

Phosphoserine Ref.10 Ref.11

Natural variations

Alternative sequence

1

1

M → MEDLVQDGVASPATPGTGKS KLETLPKEDLIKFAKKQMML IQKAKSRCTELEKEIEELRS KPVTEGTGDIIKALTERLDA LLLEKAETEQQCLSLKKENI KM in isoform 2.

VSP_007733

Natural variant

1033

1

Q → E: dbSNP rs2718698. Ref.1 Ref.3 Ref.4

VAR_046635

Natural variant

1197

1

R → G: dbSNP rs1061202.

VAR_016101

Experimental info

Mutagenesis

1487

1

I → A: Slightly decreases RAB6 binding affinity. Decreases RAB9 binding affinity by 2-fold. Strongly decreases RAB6 or RAB9 binding affinity and abolishes Golgi localization; when associated with Ala-1494. Ref.12

Mutagenesis

1494

1

L → A: Decreases RAB6 binding affinity by 2-fold. Strongly decreases RAB9 binding affinity. Strongly decreases RAB6 or RAB9 binding affinity and abolishes Golgi localization; when associated with Ala-1487. Ref.12

Mutagenesis

1517

1

Y → A: No effect on RAB6A or RAB9 binding affinity. Ref.12

Sequence conflict

593 – 599

7

NNKLSSE → TINSVQK in AAG34902. Ref.6

Sequence conflict

836 – 839

4

SVKN → YCKK in AAG34902. Ref.6

Secondary structure

1

.

.

.

1583

Helix Strand Turn

Details...

Helix

1473 – 1504

32

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 3. Checksum: 65D503FAE5969494	FASTA	1,583	184,657
	10 20 30 40 50 60 MKQEVEDSVT KMGDAHKELE QSHINYVKEI ENLKNELMAV RSKYSEDKAN LQKQLEEAMN 70 80 90 100 110 120 TQLELSEQLK FQNNSEDNVK KLQEEIEKIR PGFEEQILYL QKQLDATTDE KKETVTQLQN 130 140 150 160 170 180 IIEANSQHYQ KNINSLQEEL LQLKAIHQEE VKELMCQIEA SAKEHEAEIN KLNELKENLV 190 200 210 220 230 240 KQCEASEKNI QKKYECELEN LRKATSNANQ DNQICSILLQ ENTFVEQVVN EKVKHLEDTL 250 260 270 280 290 300 KELESQHSIL KDEVTYMNNL KLKLEMDAQH IKDEFFHERE DLEFKINELL LAKEEQGCVI 310 320 330 340 350 360 EKLKSELAGL NKQFCYTVEQ HNREVQSLKE QHQKEISELN ETFLSDSEKE KLTLMFEIQG 370 380 390 400 410 420 LKEQCENLQQ EKQEAILNYE SLREIMEILQ TELGESAGKI SQEFESMKQQ QASDVHELQQ 430 440 450 460 470 480 KLRTAFTEKD ALLETVNRLQ GENEKLLSQQ ELVPELENTI KNLQEKNGVY LLSLSQRDTM 490 500 510 520 530 540 LKELEGKINS LTEEKDDFIN KLKNSHEEMD NFHKKCEREE RLILELGKKV EQTIQYNSEL 550 560 570 580 590 600 EQKVNELTGG LEETLKEKDQ NDQKLEKLMV QMKVLSEDKE VLSAEVKSLY EENNKLSSEK 610 620 630 640 650 660 KQLSRDLEVF LSQKEDVILK EHITQLEKKL QLMVEEQDNL NKLLENEQVQ KLFVKTQLYG 670 680 690 700 710 720 FLKEMGSEVS EDSEEKDVVN VLQAVGESLA KINEEKCNLA FQRDEKVLEL EKEIKCLQEE 730 740 750 760 770 780 SVVQCEELKS LLRDYEQEKV LLRKELEEIQ SEKEALQSDL LEMKNANEKT RLENQNLLIQ 790 800 810 820 830 840 VEEVSQTCSK SEIHNEKEKC FIKEHENLKP LLEQKELRDR RAELILLKDS LAKSPSVKND 850 860 870 880 890 900 PLSSVKELEE KIENLEKECK EKEEKINKIK LVAVKAKKEL DSSRKETQTV KEELESLRSE 910 920 930 940 950 960 KDQLSASMRD LIQGAESYKN LLLEYEKQSE QLDVEKERAN NFEHRIEDLT RQLRNSTLQC 970 980 990 1000 1010 1020 ETINSDNEDL LARIETLQSN AKLLEVQILE VQRAKAMVDK ELEAEKLQKE QKIKEHATTV 1030 1040 1050 1060 1070 1080 NELEELQVQL QKQKKQLQKT MQELELVKKD AQQTTLMNME IADYERLMKE LNQKLTNKNN 1090 1100 1110 1120 1130 1140 KIEDLEQEIK IQKQKQETLQ EEITSLQSSV QQYEEKNTKI KQLLVKTKKE LADSKQAETD 1150 1160 1170 1180 1190 1200 HLILQASLKG ELEASQQQVE VYKIQLAEIT SEKHKIHEHL KTSAEQHQRT LSAYQQRVTA 1210 1220 1230 1240 1250 1260 LQEECRAAKA EQATVTSEFE SYKVRVHNVL KQQKNKSMSQ AETEGAKQER EHLEMLIDQL 1270 1280 1290 1300 1310 1320 KIKLQDSQNN LQINVSELQT LQSEHDTLLE RHNKMLQETV SKEAELREKL CSIQSENMMM 1330 1340 1350 1360 1370 1380 KSEHTQTVSQ LTSQNEVLRN SFRDQVRHLQ EEHRKTVETL QQQLSKMEAQ LFQLKNEPTT 1390 1400 1410 1420 1430 1440 RSPVSSQQSL KNLRERRNTD LPLLDMHTVT REEGEGMETT DTESVSSAST YTQSLEQLLN 1450 1460 1470 1480 1490 1500 SPETKLEPPL WHAEFTKEEL VQKLSSTTKS ADHLNGLLRE TEATNAILME QIKLLKSEIR 1510 1520 1530 1540 1550 1560 RLERNQEREK SAANLEYLKN VLLQFIFLKP GSERERLLPV INTMLQLSPE EKGKLAAVAQ 1570 1580 GEEENASRSS GWASYLHSWS GLR
	Isoform 2. Checksum: 83B6135D9EB9440D	FASTA	1,684	195,910
	10 20 30 40 50 60 MEDLVQDGVA SPATPGTGKS KLETLPKEDL IKFAKKQMML IQKAKSRCTE LEKEIEELRS 70 80 90 100 110 120 KPVTEGTGDI IKALTERLDA LLLEKAETEQ QCLSLKKENI KMKQEVEDSV TKMGDAHKEL 130 140 150 160 170 180 EQSHINYVKE IENLKNELMA VRSKYSEDKA NLQKQLEEAM NTQLELSEQL KFQNNSEDNV 190 200 210 220 230 240 KKLQEEIEKI RPGFEEQILY LQKQLDATTD EKKETVTQLQ NIIEANSQHY QKNINSLQEE 250 260 270 280 290 300 LLQLKAIHQE EVKELMCQIE ASAKEHEAEI NKLNELKENL VKQCEASEKN IQKKYECELE 310 320 330 340 350 360 NLRKATSNAN QDNQICSILL QENTFVEQVV NEKVKHLEDT LKELESQHSI LKDEVTYMNN 370 380 390 400 410 420 LKLKLEMDAQ HIKDEFFHER EDLEFKINEL LLAKEEQGCV IEKLKSELAG LNKQFCYTVE 430 440 450 460 470 480 QHNREVQSLK EQHQKEISEL NETFLSDSEK EKLTLMFEIQ GLKEQCENLQ QEKQEAILNY 490 500 510 520 530 540 ESLREIMEIL QTELGESAGK ISQEFESMKQ QQASDVHELQ QKLRTAFTEK DALLETVNRL 550 560 570 580 590 600 QGENEKLLSQ QELVPELENT IKNLQEKNGV YLLSLSQRDT MLKELEGKIN SLTEEKDDFI 610 620 630 640 650 660 NKLKNSHEEM DNFHKKCERE ERLILELGKK VEQTIQYNSE LEQKVNELTG GLEETLKEKD 670 680 690 700 710 720 QNDQKLEKLM VQMKVLSEDK EVLSAEVKSL YEENNKLSSE KKQLSRDLEV FLSQKEDVIL 730 740 750 760 770 780 KEHITQLEKK LQLMVEEQDN LNKLLENEQV QKLFVKTQLY GFLKEMGSEV SEDSEEKDVV 790 800 810 820 830 840 NVLQAVGESL AKINEEKCNL AFQRDEKVLE LEKEIKCLQE ESVVQCEELK SLLRDYEQEK 850 860 870 880 890 900 VLLRKELEEI QSEKEALQSD LLEMKNANEK TRLENQNLLI QVEEVSQTCS KSEIHNEKEK 910 920 930 940 950 960 CFIKEHENLK PLLEQKELRD RRAELILLKD SLAKSPSVKN DPLSSVKELE EKIENLEKEC 970 980 990 1000 1010 1020 KEKEEKINKI KLVAVKAKKE LDSSRKETQT VKEELESLRS EKDQLSASMR DLIQGAESYK 1030 1040 1050 1060 1070 1080 NLLLEYEKQS EQLDVEKERA NNFEHRIEDL TRQLRNSTLQ CETINSDNED LLARIETLQS 1090 1100 1110 1120 1130 1140 NAKLLEVQIL EVQRAKAMVD KELEAEKLQK EQKIKEHATT VNELEELQVQ LQKQKKQLQK 1150 1160 1170 1180 1190 1200 TMQELELVKK DAQQTTLMNM EIADYERLMK ELNQKLTNKN NKIEDLEQEI KIQKQKQETL 1210 1220 1230 1240 1250 1260 QEEITSLQSS VQQYEEKNTK IKQLLVKTKK ELADSKQAET DHLILQASLK GELEASQQQV 1270 1280 1290 1300 1310 1320 EVYKIQLAEI TSEKHKIHEH LKTSAEQHQR TLSAYQQRVT ALQEECRAAK AEQATVTSEF 1330 1340 1350 1360 1370 1380 ESYKVRVHNV LKQQKNKSMS QAETEGAKQE REHLEMLIDQ LKIKLQDSQN NLQINVSELQ 1390 1400 1410 1420 1430 1440 TLQSEHDTLL ERHNKMLQET VSKEAELREK LCSIQSENMM MKSEHTQTVS QLTSQNEVLR 1450 1460 1470 1480 1490 1500 NSFRDQVRHL QEEHRKTVET LQQQLSKMEA QLFQLKNEPT TRSPVSSQQS LKNLRERRNT 1510 1520 1530 1540 1550 1560 DLPLLDMHTV TREEGEGMET TDTESVSSAS TYTQSLEQLL NSPETKLEPP LWHAEFTKEE 1570 1580 1590 1600 1610 1620 LVQKLSSTTK SADHLNGLLR ETEATNAILM EQIKLLKSEI RRLERNQERE KSAANLEYLK 1630 1640 1650 1660 1670 1680 NVLLQFIFLK PGSERERLLP VINTMLQLSP EEKGKLAAVA QGEEENASRS SGWASYLHSW SGLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-1033. Tissue: Brain.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-1033.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-1033. Tissue: Brain.
[5]	"Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX." Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G. Blood 100:2123-2131(2002) [PubMed: 12200376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-347 (ISOFORM 2).
[6]	"Serological detection of cutaneous T-cell lymphoma-associated antigens." Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D. Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed: 11149944] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-839, TISSUE SPECIFICITY. Tissue: Testis.
[7]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed: 10508479] [Abstract] Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN. Tissue: Renal cell carcinoma.
[8]	"GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network." Luke M.R., Kjer-Nielsen L., Brown D.L., Stow J.L., Gleeson P.A. J. Biol. Chem. 278:4216-4226(2003) [PubMed: 12446665] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1382, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186 AND SER-1548, MASS SPECTROMETRY.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1382; SER-1441 AND SER-1548, MASS SPECTROMETRY.
[12]	"Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185." Burguete A.S., Fenn T.D., Brunger A.T., Pfeffer S.R. Cell 132:286-298(2008) [PubMed: 18243103] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 1446-1511, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH RAB6A, MUTAGENESIS OF ILE-1487; LEU-1494 AND TYR-1517.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB002334 mRNA. Translation: BAA20794.2. Different initiation.
AC012487 Genomic DNA. Translation: AAX88838.1.
AC068941 Genomic DNA. No translation available.
CH471182 Genomic DNA. Translation: EAW53882.1.
BC037774 mRNA. Translation: AAH37774.1. Sequence problems.
BC146789 mRNA. Translation: AAI46790.1.
AF432211 mRNA. Translation: AAL99918.1. Different initiation.
AF273042 mRNA. Translation: AAG34902.1. Different initiation.

IPI

IPI00005631.
IPI00333197.

RefSeq

NP_852118.1.

UniGene

Hs.436505
Hs.469630

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BBP	X-ray	3.00	D/E/F	1446-1511	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IWJ2. 6 interactions.

STRING

Q8IWJ2.

PTM databases

PhosphoSite

Q8IWJ2.

Proteomic databases

PRIDE

Q8IWJ2.

Genome annotation databases

Ensembl

ENST00000309863; ENSP00000307939; ENSG00000135968; Homo sapiens. [Genome view]
ENST00000409325; ENSP00000386860; ENSG00000135968; Homo sapiens. [Genome view]

GeneID

9648.

KEGG

hsa:9648.

UCSC

uc002tec.1. human.

Organism-specific databases

CTD

9648.

GeneCards

GC02P108524.

H-InvDB

HIX0022004.
HIX0023314.

HGNC

HGNC:23218. GCC2.

PharmGKB

PA134876902.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG278534.

HOVERGEN

Q8IWJ2.

InParanoid

Q8IWJ2.

OMA

CQIEASA.

OrthoDB

EOG9T7BPP.

PhylomeDB

Q8IWJ2.

Gene expression databases

ArrayExpress

Q8IWJ2.

Bgee

Q8IWJ2.

CleanEx

HS_GCC2.

Genevestigator

Q8IWJ2.

GermOnline

ENSG00000135968. Homo sapiens.

Family and domain databases

InterPro

IPR000237. GRIP.
[Graphical view]

Pfam

PF01465. GRIP. 1 hit.
[Graphical view]

SMART

SM00755. Grip. 1 hit.
[Graphical view]

PROSITE

PS50913. GRIP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

36215.

Entry information

Entry name

GCC2_HUMAN

Accession

Primary (citable) accession number: Q8IWJ2
Secondary accession number(s): A6H8X8 , O15045, Q4ZG46, Q8TDH3, Q9H2G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	October 2, 2007
Last modified:	January 19, 2010
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.