Q8IWG1 (WDR63_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 63

Alternative name(s):
Testis development protein NYD-SP29

Gene names

Name:

WDR63

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	891 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 5 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWG1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWG1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-286: WTYPKNATTQYYPREFSEEEKETLKQSKPLVDFLNNASIS → C

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 891	891	WD repeat-containing protein 63		PRO_0000233162
Regions
	Repeat	395 – 435	41	WD 1
	Repeat	477 – 533	57	WD 2
	Repeat	670 – 709	40	WD 3
	Repeat	713 – 753	41	WD 4
	Repeat	761 – 800	40	WD 5
	Coiled coil	818 – 861	44	Potential
Natural variations
	Alternative sequence	247 – 286	40	WTYPK…NASIS → C in isoform 2.		VSP_018080
	Natural variant	674	1	T → A. Corresponds to variant rs17121745 [ dbSNP | Ensembl ].		VAR_057630
	Natural variant	798	1	R → H. Corresponds to variant rs709783 [ dbSNP | Ensembl ].		VAR_057631
Experimental info
	Sequence conflict	108	1	K → E in AAL06239. Ref.1
	Sequence conflict	441	1	G → D in AAL06239. Ref.1
	Sequence conflict	496	1	R → G in AAL06239. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 982EA7B814BCC1F1	FASTA	891	102,935
	10 20 30 40 50 60 MAPKQKKKTS RGKKRLKPVL AASEDMEPVN MESMGHPEIY PLVLTTKTQE IFNCRIDEDV 70 80 90 100 110 120 TDEQPYKLIN KEDIFEDLRN RAAVSDFHPV KKIVQEYPGN ELLLVYDKDF KYGLNFYLIA 130 140 150 160 170 180 TEEGKENYLN PPEVPEEQEE YKEHIPEDVY IYKPPVSKPW VSLGSEKEIE EESVTESTKQ 190 200 210 220 230 240 ITYMISRKRS EFGAPIKFSD QNASSVKDAY IECTAYPDKN FTLKQLEKDV GMQVIPQIKD 250 260 270 280 290 300 ISTQTKWTYP KNATTQYYPR EFSEEEKETL KQSKPLVDFL NNASISVEIA LQQNEIMNTF 310 320 330 340 350 360 IDDWKYLAEE EGTFGDKTDT HLKEYQSFTD LHSPTEKMIT CVSWHPTIYG LIAVSVAVRL 370 380 390 400 410 420 SFEDRVHFSG KLLLQPSLIL FWSFSDPIHP QLMLESPDDI FCFKFCPSDP NIIAGGCING 430 440 450 460 470 480 QIVMWDITAH ADRIENIKAG GSRSKRATLK PMFLLEPESN KEAMYIRHCA VSSIENGHKK 490 500 510 520 530 540 VITDIHWLSD TFEINRMGSV FENRSGICCQ LVTCSADCTI CFWDIRPQKP LTPQTTEKKK 550 560 570 580 590 600 EESIEIPFDV PSTFLHLDLS WKPLTKVRLS KGETSLDHCP TKISLNEDHL LCKTQDKMLA 610 620 630 640 650 660 QSKTEKAEEM NPYHNLESGM ANLLKPIDDF CTKFFVGTEE GEVIYTDWKM EKDPETGRLM 670 680 690 700 710 720 SKKPVSHHTI HDGTVHTIQR SPFYNDIILT VGGWNVAIWK EGVMTGPLLQ SCCAPKRYTS 730 740 750 760 770 780 GHWSLTRPGV FYIGREDGYI DIWDLLEKTH EPAQSQNICI TMITYIKPWI FSSKQQFIAT 790 800 810 820 830 840 ADYYGTLHIL EIPWTLSRPS TNEMASVNHY FEREVKHLEY VEQRKKIREQ EKKEMELEMA 850 860 870 880 890 KKKVKTYQKS KEQMQAELKM DYESYLELEK TVLINLGLIK VTEKGSYMEV M
	Isoform 2 [UniParc]. Checksum: AC62D7D6F05AE2E0	FASTA	852	98,301
	10 20 30 40 50 60 MAPKQKKKTS RGKKRLKPVL AASEDMEPVN MESMGHPEIY PLVLTTKTQE IFNCRIDEDV 70 80 90 100 110 120 TDEQPYKLIN KEDIFEDLRN RAAVSDFHPV KKIVQEYPGN ELLLVYDKDF KYGLNFYLIA 130 140 150 160 170 180 TEEGKENYLN PPEVPEEQEE YKEHIPEDVY IYKPPVSKPW VSLGSEKEIE EESVTESTKQ 190 200 210 220 230 240 ITYMISRKRS EFGAPIKFSD QNASSVKDAY IECTAYPDKN FTLKQLEKDV GMQVIPQIKD 250 260 270 280 290 300 ISTQTKCVEI ALQQNEIMNT FIDDWKYLAE EEGTFGDKTD THLKEYQSFT DLHSPTEKMI 310 320 330 340 350 360 TCVSWHPTIY GLIAVSVAVR LSFEDRVHFS GKLLLQPSLI LFWSFSDPIH PQLMLESPDD 370 380 390 400 410 420 IFCFKFCPSD PNIIAGGCIN GQIVMWDITA HADRIENIKA GGSRSKRATL KPMFLLEPES 430 440 450 460 470 480 NKEAMYIRHC AVSSIENGHK KVITDIHWLS DTFEINRMGS VFENRSGICC QLVTCSADCT 490 500 510 520 530 540 ICFWDIRPQK PLTPQTTEKK KEESIEIPFD VPSTFLHLDL SWKPLTKVRL SKGETSLDHC 550 560 570 580 590 600 PTKISLNEDH LLCKTQDKML AQSKTEKAEE MNPYHNLESG MANLLKPIDD FCTKFFVGTE 610 620 630 640 650 660 EGEVIYTDWK MEKDPETGRL MSKKPVSHHT IHDGTVHTIQ RSPFYNDIIL TVGGWNVAIW 670 680 690 700 710 720 KEGVMTGPLL QSCCAPKRYT SGHWSLTRPG VFYIGREDGY IDIWDLLEKT HEPAQSQNIC 730 740 750 760 770 780 ITMITYIKPW IFSSKQQFIA TADYYGTLHI LEIPWTLSRP STNEMASVNH YFEREVKHLE 790 800 810 820 830 840 YVEQRKKIRE QEKKEMELEM AKKKVKTYQK SKEQMQAELK MDYESYLELE KTVLINLGLI 850 KVTEKGSYME VM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NYD-SP29: a new gene related to testis development." Sha J.H. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Astrocyte and Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY049724 mRNA. Translation: AAL06239.1. AK054629 mRNA. Translation: BAB70778.1. AK292603 mRNA. Translation: BAF85292.1. AL358789 Genomic DNA. Translation: CAI14916.1. AL358789 Genomic DNA. Translation: CAI14917.1. CH471097 Genomic DNA. Translation: EAW73212.1. BC040265 mRNA. Translation: AAH40265.1.
IPI	IPI00293098. IPI00332144.
RefSeq	NP_660155.2. NM_145172.3.
UniGene	Hs.97933.
3D structure databases
ProteinModelPortal	Q8IWG1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000294664.
PTM databases
PhosphoSite	Q8IWG1.
Polymorphism databases
DMDM	74759634.
Proteomic databases
PaxDb	Q8IWG1.
PRIDE	Q8IWG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294664; ENSP00000294664; ENSG00000162643. ENST00000326813; ENSP00000317463; ENSG00000162643. ENST00000370596; ENSP00000359628; ENSG00000162643.
GeneID	126820.
KEGG	hsa:126820.
UCSC	uc001dkt.3. human. uc009wcl.3. human.
Organism-specific databases
CTD	126820.
GeneCards	GC01P085464.
HGNC	HGNC:30711. WDR63.
HPA	HPA038066.
neXtProt	NX_Q8IWG1.
PharmGKB	PA142670596.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG261484.
HOGENOM	HOG000013188.
HOVERGEN	HBG069410.
InParanoid	Q8IWG1.
OMA	VAIWKEG.
PhylomeDB	Q8IWG1.
Gene expression databases
ArrayExpress	Q8IWG1.
Bgee	Q8IWG1.
CleanEx	HS_WDR63.
Genevestigator	Q8IWG1.
GermOnline	ENSG00000162643. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 3 hits.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	126820.
NextBio	81927.

Entry information

Entry name

WDR63_HUMAN

Accession

Primary (citable) accession number: Q8IWG1
Secondary accession number(s): A8K988, Q96L72, Q96NU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.