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Protein

FAD-dependent oxidoreductase domain-containing protein 2

Gene

FOXRED2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.1 Publication

Cofactori

FAD1 Publication

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: UniProtKB
  • glycoprotein binding Source: UniProtKB
  • monooxygenase activity Source: GO_Central

GO - Biological processi

  • ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • oxidation-reduction process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
FAD-dependent oxidoreductase domain-containing protein 2
Alternative name(s):
Endoplasmic reticulum flavoprotein associated with degradation
Gene namesi
Name:FOXRED2Imported
Synonyms:ERFAD1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:26264. FOXRED2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100350.
PharmGKBiPA145148808.

Polymorphism and mutation databases

BioMutaiFOXRED2.
DMDMi74759632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000033769227 – 684FAD-dependent oxidoreductase domain-containing protein 2Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi143N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IWF2.
MaxQBiQ8IWF2.
PaxDbiQ8IWF2.
PeptideAtlasiQ8IWF2.
PRIDEiQ8IWF2.

PTM databases

iPTMnetiQ8IWF2.
PhosphoSitePlusiQ8IWF2.

Expressioni

Gene expression databases

BgeeiENSG00000100350.
CleanExiHS_FOXRED2.
ExpressionAtlasiQ8IWF2. baseline and differential.
GenevisibleiQ8IWF2. HS.

Organism-specific databases

HPAiHPA031611.
HPA031612.

Interactioni

Subunit structurei

Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16 (PubMed:21359175).2 Publications

Protein-protein interaction databases

BioGridi123074. 36 interactors.
DIPiDIP-48946N.
IntActiQ8IWF2. 5 interactors.
STRINGi9606.ENSP00000216187.

Structurei

3D structure databases

ProteinModelPortaliQ8IWF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi681 – 684Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the FOXRED2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00640000091519.
HOGENOMiHOG000031485.
HOVERGENiHBG100868.
InParanoidiQ8IWF2.
OMAiQAWNGHY.
OrthoDBiEOG091G08UJ.
PhylomeDBiQ8IWF2.
TreeFamiTF324712.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLSAAAPLW GPPGLLLAIA LHPALSVPPR RDYCVLGAGP AGLQMAYFLQ
60 70 80 90 100
RAGRDYAVFE RAPRPGSFFT RYPRHRKLIS INKRYTGKAN AEFNLRHDWN
110 120 130 140 150
SLLSHDPRLL FRHYSRAYFP DARDMVRYLG DFADTLGLRV QYNTTIAHVT
160 170 180 190 200
LDKDRQAWNG HYFILTDQKG QVHQCSVLFV ATGLSVPNQV DFPGSEYAEG
210 220 230 240 250
YESVSVDPED FVGQNVLILG RGNSAFETAE NILGVTNFIH MLSRSRVRLS
260 270 280 290 300
WATHYVGDLR AINNGLLDTY QLKSLDGLLE SDLTDLAILK DSKGKFHVTP
310 320 330 340 350
KFFLEEANTN QSADSITLPQ DDNDNFAMRV PYDRVIRCLG WNFDFSIFNK
360 370 380 390 400
SLRLNSGNAF GKKYPLIRAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH
410 420 430 440 450
GFRYTVRAVH RLLEHRHHSV TWPATELPIT QLTSSIVRRV NEASGLYQMF
460 470 480 490 500
GVLADVILLK ENSTAFEYLE EFPIQMLAQL ETLTGRKAKH GLFVINMEYG
510 520 530 540 550
RNFSGPDKDV FFDDRSVGHT EDAWQSNFLH PVIYYYRYLP TEQEVRFRPA
560 570 580 590 600
HWPLPRPTAI HHIVEDFLTD WTAPIGHILP LRRFLENCLD TDLRSFYAES
610 620 630 640 650
CFLFALTRQK LPPFCQQGYL RMQGLVSTES LWQHRVESRL LRDYAPTGRR
660 670 680
LEDSSQQLGD QEPLGSPLAP GPLAQSVDSN KEEL
Length:684
Mass (Da):77,791
Last modified:March 1, 2003 - v1
Checksum:i8209FFAF6289DDAF
GO
Isoform 2 (identifier: Q8IWF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-327: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):41,157
Checksum:i14C82B1E14D54A0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345F → S in BAB15610 (PubMed:14702039).Curated1
Sequence conflicti607T → A in BAB15227 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06224771R → C.Corresponds to variant rs56767103dbSNPEnsembl.1
Natural variantiVAR_043704179F → L.2 PublicationsCorresponds to variant rs760718dbSNPEnsembl.1
Natural variantiVAR_043705308N → S.3 PublicationsCorresponds to variant rs2277841dbSNPEnsembl.1
Natural variantiVAR_043706374K → R.Corresponds to variant rs35813894dbSNPEnsembl.1
Natural variantiVAR_043707637E → D.Corresponds to variant rs35748020dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339971 – 327Missing in isoform 2. 1 PublicationAdd BLAST327

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456444 mRNA. Translation: CAG30330.1.
AK025714 mRNA. Translation: BAB15227.1.
AK026975 mRNA. Translation: BAB15610.1.
AK315555 mRNA. Translation: BAG37931.1.
AL022313 Genomic DNA. Translation: CAI19228.1.
CH471095 Genomic DNA. Translation: EAW60106.1.
BC015726 mRNA. Translation: AAH15726.1.
BC027716 mRNA. Translation: AAH27716.1.
BC040351 mRNA. Translation: AAH40351.1.
CCDSiCCDS13929.1. [Q8IWF2-1]
RefSeqiNP_001095841.1. NM_001102371.1. [Q8IWF2-1]
NP_079231.4. NM_024955.5. [Q8IWF2-1]
UniGeneiHs.387601.

Genome annotation databases

EnsembliENST00000216187; ENSP00000216187; ENSG00000100350. [Q8IWF2-1]
ENST00000397223; ENSP00000380400; ENSG00000100350. [Q8IWF2-1]
ENST00000397224; ENSP00000380401; ENSG00000100350. [Q8IWF2-1]
GeneIDi80020.
KEGGihsa:80020.
UCSCiuc003apn.5. human. [Q8IWF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456444 mRNA. Translation: CAG30330.1.
AK025714 mRNA. Translation: BAB15227.1.
AK026975 mRNA. Translation: BAB15610.1.
AK315555 mRNA. Translation: BAG37931.1.
AL022313 Genomic DNA. Translation: CAI19228.1.
CH471095 Genomic DNA. Translation: EAW60106.1.
BC015726 mRNA. Translation: AAH15726.1.
BC027716 mRNA. Translation: AAH27716.1.
BC040351 mRNA. Translation: AAH40351.1.
CCDSiCCDS13929.1. [Q8IWF2-1]
RefSeqiNP_001095841.1. NM_001102371.1. [Q8IWF2-1]
NP_079231.4. NM_024955.5. [Q8IWF2-1]
UniGeneiHs.387601.

3D structure databases

ProteinModelPortaliQ8IWF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123074. 36 interactors.
DIPiDIP-48946N.
IntActiQ8IWF2. 5 interactors.
STRINGi9606.ENSP00000216187.

PTM databases

iPTMnetiQ8IWF2.
PhosphoSitePlusiQ8IWF2.

Polymorphism and mutation databases

BioMutaiFOXRED2.
DMDMi74759632.

Proteomic databases

EPDiQ8IWF2.
MaxQBiQ8IWF2.
PaxDbiQ8IWF2.
PeptideAtlasiQ8IWF2.
PRIDEiQ8IWF2.

Protocols and materials databases

DNASUi80020.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216187; ENSP00000216187; ENSG00000100350. [Q8IWF2-1]
ENST00000397223; ENSP00000380400; ENSG00000100350. [Q8IWF2-1]
ENST00000397224; ENSP00000380401; ENSG00000100350. [Q8IWF2-1]
GeneIDi80020.
KEGGihsa:80020.
UCSCiuc003apn.5. human. [Q8IWF2-1]

Organism-specific databases

CTDi80020.
GeneCardsiFOXRED2.
H-InvDBHIX0203159.
HGNCiHGNC:26264. FOXRED2.
HPAiHPA031611.
HPA031612.
MIMi613777. gene.
neXtProtiNX_Q8IWF2.
OpenTargetsiENSG00000100350.
PharmGKBiPA145148808.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00640000091519.
HOGENOMiHOG000031485.
HOVERGENiHBG100868.
InParanoidiQ8IWF2.
OMAiQAWNGHY.
OrthoDBiEOG091G08UJ.
PhylomeDBiQ8IWF2.
TreeFamiTF324712.

Miscellaneous databases

ChiTaRSiFOXRED2. human.
GenomeRNAii80020.
PROiQ8IWF2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100350.
CleanExiHS_FOXRED2.
ExpressionAtlasiQ8IWF2. baseline and differential.
GenevisibleiQ8IWF2. HS.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXRD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWF2
Secondary accession number(s): B2RDI4
, Q8N378, Q96BD1, Q9H5L5, Q9H6M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.