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Q8IWF2

- FXRD2_HUMAN

UniProt

Q8IWF2 - FXRD2_HUMAN

Protein

FAD-dependent oxidoreductase domain-containing protein 2

Gene

FOXRED2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.1 Publication

    Cofactori

    FAD.1 Publication

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: UniProtKB
    2. glycoprotein binding Source: UniProt
    3. oxidoreductase activity Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD-dependent oxidoreductase domain-containing protein 2
    Alternative name(s):
    Endoplasmic reticulum flavoprotein associated with degradation
    Gene namesi
    Name:FOXRED2
    Synonyms:ERFAD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:26264. FOXRED2.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148808.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 684658FAD-dependent oxidoreductase domain-containing protein 2PRO_0000337692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi143 – 1431N-linked (GlcNAc...)2 Publications

    Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8IWF2.
    PaxDbiQ8IWF2.
    PRIDEiQ8IWF2.

    PTM databases

    PhosphoSiteiQ8IWF2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IWF2.
    BgeeiQ8IWF2.
    CleanExiHS_FOXRED2.
    GenevestigatoriQ8IWF2.

    Organism-specific databases

    HPAiHPA031611.
    HPA031612.

    Interactioni

    Subunit structurei

    Interacts with SEL1L. May interact with OS9 and DNAJC10.1 Publication

    Protein-protein interaction databases

    BioGridi123074. 7 interactions.
    DIPiDIP-48946N.
    STRINGi9606.ENSP00000216187.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWF2.
    SMRiQ8IWF2. Positions 28-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi681 – 6844Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the FOXRED2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG303889.
    HOGENOMiHOG000031485.
    HOVERGENiHBG100868.
    InParanoidiQ8IWF2.
    OMAiQAWNGHY.
    OrthoDBiEOG7M6D70.
    PhylomeDBiQ8IWF2.
    TreeFamiTF324712.

    Family and domain databases

    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWF2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLSAAAPLW GPPGLLLAIA LHPALSVPPR RDYCVLGAGP AGLQMAYFLQ    50
    RAGRDYAVFE RAPRPGSFFT RYPRHRKLIS INKRYTGKAN AEFNLRHDWN 100
    SLLSHDPRLL FRHYSRAYFP DARDMVRYLG DFADTLGLRV QYNTTIAHVT 150
    LDKDRQAWNG HYFILTDQKG QVHQCSVLFV ATGLSVPNQV DFPGSEYAEG 200
    YESVSVDPED FVGQNVLILG RGNSAFETAE NILGVTNFIH MLSRSRVRLS 250
    WATHYVGDLR AINNGLLDTY QLKSLDGLLE SDLTDLAILK DSKGKFHVTP 300
    KFFLEEANTN QSADSITLPQ DDNDNFAMRV PYDRVIRCLG WNFDFSIFNK 350
    SLRLNSGNAF GKKYPLIRAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH 400
    GFRYTVRAVH RLLEHRHHSV TWPATELPIT QLTSSIVRRV NEASGLYQMF 450
    GVLADVILLK ENSTAFEYLE EFPIQMLAQL ETLTGRKAKH GLFVINMEYG 500
    RNFSGPDKDV FFDDRSVGHT EDAWQSNFLH PVIYYYRYLP TEQEVRFRPA 550
    HWPLPRPTAI HHIVEDFLTD WTAPIGHILP LRRFLENCLD TDLRSFYAES 600
    CFLFALTRQK LPPFCQQGYL RMQGLVSTES LWQHRVESRL LRDYAPTGRR 650
    LEDSSQQLGD QEPLGSPLAP GPLAQSVDSN KEEL 684
    Length:684
    Mass (Da):77,791
    Last modified:March 1, 2003 - v1
    Checksum:i8209FFAF6289DDAF
    GO
    Isoform 2 (identifier: Q8IWF2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-327: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:357
    Mass (Da):41,157
    Checksum:i14C82B1E14D54A0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti345 – 3451F → S in BAB15610. (PubMed:14702039)Curated
    Sequence conflicti607 – 6071T → A in BAB15227. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711R → C.
    Corresponds to variant rs56767103 [ dbSNP | Ensembl ].
    VAR_062247
    Natural varianti179 – 1791F → L.2 Publications
    Corresponds to variant rs760718 [ dbSNP | Ensembl ].
    VAR_043704
    Natural varianti308 – 3081N → S.3 Publications
    Corresponds to variant rs2277841 [ dbSNP | Ensembl ].
    VAR_043705
    Natural varianti374 – 3741K → R.
    Corresponds to variant rs35813894 [ dbSNP | Ensembl ].
    VAR_043706
    Natural varianti637 – 6371E → D.
    Corresponds to variant rs35748020 [ dbSNP | Ensembl ].
    VAR_043707

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 327327Missing in isoform 2. 1 PublicationVSP_033997Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456444 mRNA. Translation: CAG30330.1.
    AK025714 mRNA. Translation: BAB15227.1.
    AK026975 mRNA. Translation: BAB15610.1.
    AK315555 mRNA. Translation: BAG37931.1.
    AL022313 Genomic DNA. Translation: CAI19228.1.
    CH471095 Genomic DNA. Translation: EAW60106.1.
    BC015726 mRNA. Translation: AAH15726.1.
    BC027716 mRNA. Translation: AAH27716.1.
    BC040351 mRNA. Translation: AAH40351.1.
    CCDSiCCDS13929.1. [Q8IWF2-1]
    RefSeqiNP_001095841.1. NM_001102371.1. [Q8IWF2-1]
    NP_079231.4. NM_024955.5. [Q8IWF2-1]
    UniGeneiHs.387601.

    Genome annotation databases

    EnsembliENST00000216187; ENSP00000216187; ENSG00000100350. [Q8IWF2-1]
    ENST00000397223; ENSP00000380400; ENSG00000100350. [Q8IWF2-1]
    ENST00000397224; ENSP00000380401; ENSG00000100350. [Q8IWF2-1]
    GeneIDi80020.
    KEGGihsa:80020.
    UCSCiuc003apn.4. human. [Q8IWF2-1]

    Polymorphism databases

    DMDMi74759632.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456444 mRNA. Translation: CAG30330.1 .
    AK025714 mRNA. Translation: BAB15227.1 .
    AK026975 mRNA. Translation: BAB15610.1 .
    AK315555 mRNA. Translation: BAG37931.1 .
    AL022313 Genomic DNA. Translation: CAI19228.1 .
    CH471095 Genomic DNA. Translation: EAW60106.1 .
    BC015726 mRNA. Translation: AAH15726.1 .
    BC027716 mRNA. Translation: AAH27716.1 .
    BC040351 mRNA. Translation: AAH40351.1 .
    CCDSi CCDS13929.1. [Q8IWF2-1 ]
    RefSeqi NP_001095841.1. NM_001102371.1. [Q8IWF2-1 ]
    NP_079231.4. NM_024955.5. [Q8IWF2-1 ]
    UniGenei Hs.387601.

    3D structure databases

    ProteinModelPortali Q8IWF2.
    SMRi Q8IWF2. Positions 28-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123074. 7 interactions.
    DIPi DIP-48946N.
    STRINGi 9606.ENSP00000216187.

    PTM databases

    PhosphoSitei Q8IWF2.

    Polymorphism databases

    DMDMi 74759632.

    Proteomic databases

    MaxQBi Q8IWF2.
    PaxDbi Q8IWF2.
    PRIDEi Q8IWF2.

    Protocols and materials databases

    DNASUi 80020.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216187 ; ENSP00000216187 ; ENSG00000100350 . [Q8IWF2-1 ]
    ENST00000397223 ; ENSP00000380400 ; ENSG00000100350 . [Q8IWF2-1 ]
    ENST00000397224 ; ENSP00000380401 ; ENSG00000100350 . [Q8IWF2-1 ]
    GeneIDi 80020.
    KEGGi hsa:80020.
    UCSCi uc003apn.4. human. [Q8IWF2-1 ]

    Organism-specific databases

    CTDi 80020.
    GeneCardsi GC22M036883.
    H-InvDB HIX0203159.
    HGNCi HGNC:26264. FOXRED2.
    HPAi HPA031611.
    HPA031612.
    MIMi 613777. gene.
    neXtProti NX_Q8IWF2.
    PharmGKBi PA145148808.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303889.
    HOGENOMi HOG000031485.
    HOVERGENi HBG100868.
    InParanoidi Q8IWF2.
    OMAi QAWNGHY.
    OrthoDBi EOG7M6D70.
    PhylomeDBi Q8IWF2.
    TreeFami TF324712.

    Miscellaneous databases

    GenomeRNAii 80020.
    NextBioi 70142.
    PROi Q8IWF2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IWF2.
    Bgeei Q8IWF2.
    CleanExi HS_FOXRED2.
    Genevestigatori Q8IWF2.

    Family and domain databases

    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-179 AND SER-308.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-308.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-179 AND SER-308.
      Tissue: Brain, Colon and Eye.
    6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-143.
      Tissue: Liver.
    7. Cited for: FUNCTION, FAD-BINDING, GLYCOSYLATION, SUBCELLULAR LOCATION, INTERACTION WITH DNAJC10; OS9 AND SEL1L.

    Entry informationi

    Entry nameiFXRD2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWF2
    Secondary accession number(s): B2RDI4
    , Q8N378, Q96BD1, Q9H5L5, Q9H6M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3