Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein NOXP20

Gene

FAM114A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neuronal cell development.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOXP20
Alternative name(s):
Nervous system overexpressed protein 20
Protein FAM114A1
Gene namesi
Name:FAM114A1
Synonyms:NOXP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25087. FAM114A1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385681.

Polymorphism and mutation databases

BioMutaiFAM114A1.
DMDMi229462912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Protein NOXP20PRO_0000274561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201Phosphoserine; in variant Pro-116Combined sources
Modified residuei185 – 1851PhosphothreonineCombined sources
Modified residuei189 – 1891PhosphothreonineCombined sources
Modified residuei196 – 1961PhosphoserineCombined sources
Modified residuei199 – 1991PhosphothreonineBy similarity
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei261 – 2611PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IWE2.
MaxQBiQ8IWE2.
PaxDbiQ8IWE2.
PeptideAtlasiQ8IWE2.
PRIDEiQ8IWE2.

PTM databases

iPTMnetiQ8IWE2.
PhosphoSiteiQ8IWE2.
SwissPalmiQ8IWE2.

Expressioni

Gene expression databases

BgeeiQ8IWE2.
CleanExiHS_FAM114A1.
ExpressionAtlasiQ8IWE2. baseline and differential.
GenevisibleiQ8IWE2. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-2686288,EBI-741181
CMTM5Q96DZ93EBI-2686288,EBI-2548702
RAB2AP610193EBI-2686288,EBI-752037
RAB2BQ8WUD13EBI-2686288,EBI-5542466
SPG21Q9NZD83EBI-2686288,EBI-742688

Protein-protein interaction databases

BioGridi124967. 17 interactions.
IntActiQ8IWE2. 8 interactions.
STRINGi9606.ENSP00000351740.

Structurei

3D structure databases

ProteinModelPortaliQ8IWE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili343 – 36725Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the FAM114 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHQB. Eukaryota.
ENOG411029H. LUCA.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ8IWE2.
OMAiVEEVYML.
OrthoDBiEOG7P5T0T.
PhylomeDBiQ8IWE2.
TreeFamiTF324360.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDDAGDTLA TGDKAEVTEM PNSDSLPEDA EVHCDSAAVS HEPTPADPRG
60 70 80 90 100
EGHENAAVQG AGAAAIGPPV QPQDANALEP PLNGDVTEDT LAECIDSVSL
110 120 130 140 150
EAEPRSEIPL QEQNYLAVDS PPSGGGWAGW GSWGKSLLSS ASATVGHGLT
160 170 180 190 200
AVKEKAGATL RIHGVNSGSS EGAQPNTENG VPEITDAATD QGPAESPPTS
210 220 230 240 250
PSSASRGMLS AITNVVQNTG KSVLTGGLDA LEFIGKKTMN VLAESDPGFK
260 270 280 290 300
RTKTLMERTV SLSQMLREAK EKEKQRLAQQ LTMERTAHYG MLFDEYQGLS
310 320 330 340 350
HLEALEILSN ESESKVQSFL ASLDGEKLEL LKNDLISIKD IFAAKELENE
360 370 380 390 400
ENQEEQGLEE KGEEFARMLT ELLFELHVAA TPDKLNKAMK RAHDWVEEDQ
410 420 430 440 450
TVVSVDVAKV SEEETKKEEK EEKSQDPQED KKEEKKTKTI EEVYMSSIES
460 470 480 490 500
LAEVTARCIE QLHKVAELIL HGQEEEKPAQ DQAKVLIKLT TAMCNEVASL
510 520 530 540 550
SKKFTNSLTT VGSNKKAEVL NPMISSVLLE GCNSTTYIQD AFQLLLPVLQ
560
VSHIQTSCLK AQP
Length:563
Mass (Da):60,742
Last modified:May 5, 2009 - v2
Checksum:i318AC32240D3786F
GO
Isoform 2 (identifier: Q8IWE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.

Note: No experimental confirmation available.
Show »
Length:356
Mass (Da):39,993
Checksum:i6C57787792550616
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401S → L.
Corresponds to variant rs34137542 [ dbSNP | Ensembl ].
VAR_053823
Natural varianti84 – 841G → R.1 Publication
Corresponds to variant rs11096964 [ dbSNP | Ensembl ].
VAR_030320
Natural varianti116 – 1161L → P.Combined sources1 Publication
Corresponds to variant rs11944159 [ dbSNP | Ensembl ].
VAR_030321
Natural varianti201 – 2011P → L.
Corresponds to variant rs430296 [ dbSNP | Ensembl ].
VAR_030322
Natural varianti367 – 3671R → H.
Corresponds to variant rs2306923 [ dbSNP | Ensembl ].
VAR_030323
Natural varianti443 – 4431V → I.
Corresponds to variant rs17429619 [ dbSNP | Ensembl ].
VAR_030324
Natural varianti446 – 4461S → L.
Corresponds to variant rs36058104 [ dbSNP | Ensembl ].
VAR_053824

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 207207Missing in isoform 2. 1 PublicationVSP_056466Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292831 mRNA. Translation: BAF85520.1.
BX640862 mRNA. Translation: CAE45923.1.
AC108044 Genomic DNA. No translation available.
BC001096 mRNA. Translation: AAH01096.2.
BC040452 mRNA. Translation: AAH40452.1.
CCDSiCCDS3447.1. [Q8IWE2-1]
RefSeqiNP_612398.2. NM_138389.2. [Q8IWE2-1]
XP_005262729.1. XM_005262672.1. [Q8IWE2-1]
XP_006714096.1. XM_006714033.1. [Q8IWE2-2]
UniGeneiHs.476517.

Genome annotation databases

EnsembliENST00000358869; ENSP00000351740; ENSG00000197712. [Q8IWE2-1]
ENST00000515037; ENSP00000424115; ENSG00000197712. [Q8IWE2-2]
GeneIDi92689.
KEGGihsa:92689.
UCSCiuc003gtn.4. human. [Q8IWE2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292831 mRNA. Translation: BAF85520.1.
BX640862 mRNA. Translation: CAE45923.1.
AC108044 Genomic DNA. No translation available.
BC001096 mRNA. Translation: AAH01096.2.
BC040452 mRNA. Translation: AAH40452.1.
CCDSiCCDS3447.1. [Q8IWE2-1]
RefSeqiNP_612398.2. NM_138389.2. [Q8IWE2-1]
XP_005262729.1. XM_005262672.1. [Q8IWE2-1]
XP_006714096.1. XM_006714033.1. [Q8IWE2-2]
UniGeneiHs.476517.

3D structure databases

ProteinModelPortaliQ8IWE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124967. 17 interactions.
IntActiQ8IWE2. 8 interactions.
STRINGi9606.ENSP00000351740.

PTM databases

iPTMnetiQ8IWE2.
PhosphoSiteiQ8IWE2.
SwissPalmiQ8IWE2.

Polymorphism and mutation databases

BioMutaiFAM114A1.
DMDMi229462912.

Proteomic databases

EPDiQ8IWE2.
MaxQBiQ8IWE2.
PaxDbiQ8IWE2.
PeptideAtlasiQ8IWE2.
PRIDEiQ8IWE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358869; ENSP00000351740; ENSG00000197712. [Q8IWE2-1]
ENST00000515037; ENSP00000424115; ENSG00000197712. [Q8IWE2-2]
GeneIDi92689.
KEGGihsa:92689.
UCSCiuc003gtn.4. human. [Q8IWE2-1]

Organism-specific databases

CTDi92689.
GeneCardsiFAM114A1.
H-InvDBHIX0018116.
HGNCiHGNC:25087. FAM114A1.
neXtProtiNX_Q8IWE2.
PharmGKBiPA162385681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHQB. Eukaryota.
ENOG411029H. LUCA.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ8IWE2.
OMAiVEEVYML.
OrthoDBiEOG7P5T0T.
PhylomeDBiQ8IWE2.
TreeFamiTF324360.

Miscellaneous databases

ChiTaRSiFAM114A1. human.
GeneWikiiFAM114A1.
GenomeRNAii92689.
PROiQ8IWE2.

Gene expression databases

BgeeiQ8IWE2.
CleanExiHS_FAM114A1.
ExpressionAtlasiQ8IWE2. baseline and differential.
GenevisibleiQ8IWE2. HS.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Salivary gland.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-84 AND PRO-116.
    Tissue: Colon and Kidney.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-185; THR-189; SER-196; SER-202 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 (VARIANT PRO-116), VARIANT [LARGE SCALE ANALYSIS] PRO-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNXP20_HUMAN
AccessioniPrimary (citable) accession number: Q8IWE2
Secondary accession number(s): A8K9W6, Q6MZV4, Q9BVL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 5, 2009
Last modified: July 6, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.