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Q8IWD5

- MFS6L_HUMAN

UniProt

Q8IWD5 - MFS6L_HUMAN

Protein

Major facilitator superfamily domain-containing protein 6-like

Gene

MFSD6L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    TCDBi2.A.1.65.10. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major facilitator superfamily domain-containing protein 6-like
    Gene namesi
    Name:MFSD6L
    ORF Names:FP7072
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26656. MFSD6L.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164722299.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Major facilitator superfamily domain-containing protein 6-likePRO_0000321944Add
    BLAST

    Proteomic databases

    PaxDbiQ8IWD5.
    PRIDEiQ8IWD5.

    PTM databases

    PhosphoSiteiQ8IWD5.

    Expressioni

    Gene expression databases

    BgeeiQ8IWD5.
    CleanExiHS_MFSD6L.
    GenevestigatoriQ8IWD5.

    Organism-specific databases

    HPAiHPA023164.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4723110.
    STRINGi9606.ENSP00000330051.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei400 – 42021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei433 – 45523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei499 – 51921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265282.
    HOGENOMiHOG000049138.
    HOVERGENiHBG097504.
    InParanoidiQ8IWD5.
    OMAiCAFLAKS.
    OrthoDBiEOG78SQK5.
    PhylomeDBiQ8IWD5.
    TreeFamiTF314366.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8IWD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT    50
    LMGTKHLIAA FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV 100
    DKNRVHFPCN GSSGLTSTDA LPGVTLPVNI TSAQESASSH PAKRTAEVEM 150
    PGFRNPPGES DRETFRDLHV YLAPSVEGAR TTSQALLHPV TSGLKDHPWE 200
    VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE ALRRTFILSL 250
    GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC 300
    GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE 350
    PSYKRVKALS IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE 400
    LVMGFSVALS LLGEILLHPF KATLLRKLSR TGLVGLGLSC LAGQLLYYSF 450
    LWSWWSVLPI QILSAISNRA LWWAVGASVE DLATPRMERA LSALFRGHFY 500
    GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS IQRRLPRERK 550
    IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD 586
    Length:586
    Mass (Da):64,005
    Last modified:February 26, 2008 - v2
    Checksum:iAF1607041015758D
    GO

    Sequence cautioni

    The sequence AAM98769.1 differs from that shown. Reason: Frameshift at position 365.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti214 – 2141P → T in AAH40487. (PubMed:15489334)Curated
    Sequence conflicti277 – 2771F → S in BAC04050. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti486 – 4861R → H.
    Corresponds to variant rs2242373 [ dbSNP | Ensembl ].
    VAR_039389

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY129026 mRNA. Translation: AAM98769.1. Frameshift.
    AK093092 mRNA. Translation: BAC04050.1.
    BC040487 mRNA. Translation: AAH40487.1.
    CCDSiCCDS11146.1.
    RefSeqiNP_689812.3. NM_152599.3.
    UniGeneiHs.213603.

    Genome annotation databases

    EnsembliENST00000329805; ENSP00000330051; ENSG00000185156.
    GeneIDi162387.
    KEGGihsa:162387.
    UCSCiuc002glp.2. human.

    Polymorphism databases

    DMDMi190360169.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY129026 mRNA. Translation: AAM98769.1 . Frameshift.
    AK093092 mRNA. Translation: BAC04050.1 .
    BC040487 mRNA. Translation: AAH40487.1 .
    CCDSi CCDS11146.1.
    RefSeqi NP_689812.3. NM_152599.3.
    UniGenei Hs.213603.

    3D structure databases

    ProteinModelPortali Q8IWD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4723110.
    STRINGi 9606.ENSP00000330051.

    Protein family/group databases

    TCDBi 2.A.1.65.10. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q8IWD5.

    Polymorphism databases

    DMDMi 190360169.

    Proteomic databases

    PaxDbi Q8IWD5.
    PRIDEi Q8IWD5.

    Protocols and materials databases

    DNASUi 162387.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329805 ; ENSP00000330051 ; ENSG00000185156 .
    GeneIDi 162387.
    KEGGi hsa:162387.
    UCSCi uc002glp.2. human.

    Organism-specific databases

    CTDi 162387.
    GeneCardsi GC17M008700.
    H-InvDB HIX0013527.
    HGNCi HGNC:26656. MFSD6L.
    HPAi HPA023164.
    neXtProti NX_Q8IWD5.
    PharmGKBi PA164722299.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265282.
    HOGENOMi HOG000049138.
    HOVERGENi HBG097504.
    InParanoidi Q8IWD5.
    OMAi CAFLAKS.
    OrthoDBi EOG78SQK5.
    PhylomeDBi Q8IWD5.
    TreeFami TF314366.

    Miscellaneous databases

    GenomeRNAii 162387.
    NextBioi 88158.
    PROi Q8IWD5.

    Gene expression databases

    Bgeei Q8IWD5.
    CleanExi HS_MFSD6L.
    Genevestigatori Q8IWD5.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiMFS6L_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWD5
    Secondary accession number(s): Q6YL34, Q8NA76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3