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Q8IWD5 (MFS6L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major facilitator superfamily domain-containing protein 6-like
Gene names
Name:MFSD6L
ORF Names:FP7072
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator superfamily. MFSD6 family.

Sequence caution

The sequence AAM98769.1 differs from that shown. Reason: Frameshift at position 365.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Major facilitator superfamily domain-containing protein 6-like
PRO_0000321944

Regions

Transmembrane50 – 7021Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane287 – 30721Helical; Potential
Transmembrane326 – 34621Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane400 – 42021Helical; Potential
Transmembrane433 – 45523Helical; Potential
Transmembrane456 – 47621Helical; Potential
Transmembrane499 – 51921Helical; Potential
Transmembrane521 – 54121Helical; Potential

Natural variations

Natural variant4861R → H.
Corresponds to variant rs2242373 [ dbSNP | Ensembl ].
VAR_039389

Experimental info

Sequence conflict2141P → T in AAH40487. Ref.3
Sequence conflict2771F → S in BAC04050. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8IWD5 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: AF1607041015758D

FASTA58664,005
        10         20         30         40         50         60 
MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT LMGTKHLIAA 

        70         80         90        100        110        120 
FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV DKNRVHFPCN GSSGLTSTDA 

       130        140        150        160        170        180 
LPGVTLPVNI TSAQESASSH PAKRTAEVEM PGFRNPPGES DRETFRDLHV YLAPSVEGAR 

       190        200        210        220        230        240 
TTSQALLHPV TSGLKDHPWE VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE 

       250        260        270        280        290        300 
ALRRTFILSL GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC 

       310        320        330        340        350        360 
GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE PSYKRVKALS 

       370        380        390        400        410        420 
IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE LVMGFSVALS LLGEILLHPF 

       430        440        450        460        470        480 
KATLLRKLSR TGLVGLGLSC LAGQLLYYSF LWSWWSVLPI QILSAISNRA LWWAVGASVE 

       490        500        510        520        530        540 
DLATPRMERA LSALFRGHFY GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS 

       550        560        570        580 
IQRRLPRERK IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD

« Hide

References

[1]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY129026 mRNA. Translation: AAM98769.1. Frameshift.
AK093092 mRNA. Translation: BAC04050.1.
BC040487 mRNA. Translation: AAH40487.1.
IPIIPI00293085.
RefSeqNP_689812.3. NM_152599.3.
UniGeneHs.213603.

3D structure databases

ProteinModelPortalQ8IWD5.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4723110.
STRING9606.ENSP00000330051.

PTM databases

PhosphoSiteQ8IWD5.

Polymorphism databases

DMDM190360169.

Proteomic databases

PaxDbQ8IWD5.
PRIDEQ8IWD5.

Protocols and materials databases

DNASU162387.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329805; ENSP00000330051; ENSG00000185156.
GeneID162387.
KEGGhsa:162387.
UCSCuc002glp.2. human.

Organism-specific databases

CTD162387.
GeneCardsGC17M008700.
H-InvDBHIX0013527.
HGNCHGNC:26656. MFSD6L.
HPAHPA023164.
neXtProtNX_Q8IWD5.
PharmGKBPA164722299.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG265282.
HOGENOMHOG000049138.
HOVERGENHBG097504.
InParanoidQ8IWD5.
OMAILLHPFK.
OrthoDBEOG4TQM8Q.
PhylomeDBQ8IWD5.

Gene expression databases

BgeeQ8IWD5.
CleanExHS_MFSD6L.
GenevestigatorQ8IWD5.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 2 hits.
PROSITEPS50850. MFS. False negative.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi162387.
NextBio88158.

Entry information

Entry nameMFS6L_HUMAN
AccessionPrimary (citable) accession number: Q8IWD5
Secondary accession number(s): Q6YL34, Q8NA76
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 29, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents