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Q8IWD5

- MFS6L_HUMAN

UniProt

Q8IWD5 - MFS6L_HUMAN

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Protein

Major facilitator superfamily domain-containing protein 6-like

Gene

MFSD6L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi2.A.1.65.10. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 6-like
Gene namesi
Name:MFSD6L
ORF Names:FP7072
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26656. MFSD6L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence AnalysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence AnalysisAdd
BLAST
Transmembranei433 – 45523HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Major facilitator superfamily domain-containing protein 6-likePRO_0000321944Add
BLAST

Proteomic databases

PaxDbiQ8IWD5.
PRIDEiQ8IWD5.

PTM databases

PhosphoSiteiQ8IWD5.

Expressioni

Gene expression databases

BgeeiQ8IWD5.
CleanExiHS_MFSD6L.
GenevestigatoriQ8IWD5.

Organism-specific databases

HPAiHPA023164.

Interactioni

Protein-protein interaction databases

MINTiMINT-4723110.
STRINGi9606.ENSP00000330051.

Structurei

3D structure databases

ProteinModelPortaliQ8IWD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265282.
GeneTreeiENSGT00530000063599.
HOGENOMiHOG000049138.
HOVERGENiHBG097504.
InParanoidiQ8IWD5.
OMAiCAFLAKS.
OrthoDBiEOG78SQK5.
PhylomeDBiQ8IWD5.
TreeFamiTF314366.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8IWD5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT
60 70 80 90 100
LMGTKHLIAA FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV
110 120 130 140 150
DKNRVHFPCN GSSGLTSTDA LPGVTLPVNI TSAQESASSH PAKRTAEVEM
160 170 180 190 200
PGFRNPPGES DRETFRDLHV YLAPSVEGAR TTSQALLHPV TSGLKDHPWE
210 220 230 240 250
VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE ALRRTFILSL
260 270 280 290 300
GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC
310 320 330 340 350
GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE
360 370 380 390 400
PSYKRVKALS IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE
410 420 430 440 450
LVMGFSVALS LLGEILLHPF KATLLRKLSR TGLVGLGLSC LAGQLLYYSF
460 470 480 490 500
LWSWWSVLPI QILSAISNRA LWWAVGASVE DLATPRMERA LSALFRGHFY
510 520 530 540 550
GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS IQRRLPRERK
560 570 580
IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD
Length:586
Mass (Da):64,005
Last modified:February 26, 2008 - v2
Checksum:iAF1607041015758D
GO

Sequence cautioni

The sequence AAM98769.1 differs from that shown. Reason: Frameshift at position 365. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141P → T in AAH40487. (PubMed:15489334)Curated
Sequence conflicti277 – 2771F → S in BAC04050. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti486 – 4861R → H.
Corresponds to variant rs2242373 [ dbSNP | Ensembl ].
VAR_039389

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129026 mRNA. Translation: AAM98769.1. Frameshift.
AK093092 mRNA. Translation: BAC04050.1.
BC040487 mRNA. Translation: AAH40487.1.
CCDSiCCDS11146.1.
RefSeqiNP_689812.3. NM_152599.3.
UniGeneiHs.213603.

Genome annotation databases

EnsembliENST00000329805; ENSP00000330051; ENSG00000185156.
GeneIDi162387.
KEGGihsa:162387.
UCSCiuc002glp.2. human.

Polymorphism databases

DMDMi190360169.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129026 mRNA. Translation: AAM98769.1 . Frameshift.
AK093092 mRNA. Translation: BAC04050.1 .
BC040487 mRNA. Translation: AAH40487.1 .
CCDSi CCDS11146.1.
RefSeqi NP_689812.3. NM_152599.3.
UniGenei Hs.213603.

3D structure databases

ProteinModelPortali Q8IWD5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4723110.
STRINGi 9606.ENSP00000330051.

Protein family/group databases

TCDBi 2.A.1.65.10. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q8IWD5.

Polymorphism databases

DMDMi 190360169.

Proteomic databases

PaxDbi Q8IWD5.
PRIDEi Q8IWD5.

Protocols and materials databases

DNASUi 162387.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329805 ; ENSP00000330051 ; ENSG00000185156 .
GeneIDi 162387.
KEGGi hsa:162387.
UCSCi uc002glp.2. human.

Organism-specific databases

CTDi 162387.
GeneCardsi GC17M008700.
H-InvDB HIX0013527.
HGNCi HGNC:26656. MFSD6L.
HPAi HPA023164.
neXtProti NX_Q8IWD5.
PharmGKBi PA164722299.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265282.
GeneTreei ENSGT00530000063599.
HOGENOMi HOG000049138.
HOVERGENi HBG097504.
InParanoidi Q8IWD5.
OMAi CAFLAKS.
OrthoDBi EOG78SQK5.
PhylomeDBi Q8IWD5.
TreeFami TF314366.

Miscellaneous databases

GenomeRNAii 162387.
NextBioi 88158.
PROi Q8IWD5.

Gene expression databases

Bgeei Q8IWD5.
CleanExi HS_MFSD6L.
Genevestigatori Q8IWD5.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiMFS6L_HUMAN
AccessioniPrimary (citable) accession number: Q8IWD5
Secondary accession number(s): Q6YL34, Q8NA76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3