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Protein

Major facilitator superfamily domain-containing protein 6-like

Gene

MFSD6L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32812-MONOMER.

Protein family/group databases

TCDBi2.A.1.65.10. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 6-like
Gene namesi
Name:MFSD6L
ORF Names:FP7072
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26656. MFSD6L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei433 – 455HelicalSequence analysisAdd BLAST23
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi162387.
OpenTargetsiENSG00000185156.
PharmGKBiPA164722299.

Polymorphism and mutation databases

BioMutaiMFSD6L.
DMDMi190360169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219441 – 586Major facilitator superfamily domain-containing protein 6-likeAdd BLAST586

Proteomic databases

PaxDbiQ8IWD5.
PeptideAtlasiQ8IWD5.
PRIDEiQ8IWD5.
TopDownProteomicsiQ8IWD5.

PTM databases

iPTMnetiQ8IWD5.
PhosphoSitePlusiQ8IWD5.

Expressioni

Gene expression databases

BgeeiENSG00000185156.
CleanExiHS_MFSD6L.
GenevisibleiQ8IWD5. HS.

Organism-specific databases

HPAiHPA023164.

Interactioni

Protein-protein interaction databases

MINTiMINT-4723110.
STRINGi9606.ENSP00000330051.

Structurei

3D structure databases

ProteinModelPortaliQ8IWD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3762. Eukaryota.
ENOG410YMHR. LUCA.
GeneTreeiENSGT00530000063599.
HOGENOMiHOG000049138.
HOVERGENiHBG097504.
InParanoidiQ8IWD5.
OMAiCAFLAKS.
OrthoDBiEOG091G0507.
PhylomeDBiQ8IWD5.
TreeFamiTF314366.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR024989. MFS_assoc_dom.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF12832. MFS_1_like. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8IWD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT
60 70 80 90 100
LMGTKHLIAA FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV
110 120 130 140 150
DKNRVHFPCN GSSGLTSTDA LPGVTLPVNI TSAQESASSH PAKRTAEVEM
160 170 180 190 200
PGFRNPPGES DRETFRDLHV YLAPSVEGAR TTSQALLHPV TSGLKDHPWE
210 220 230 240 250
VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE ALRRTFILSL
260 270 280 290 300
GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC
310 320 330 340 350
GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE
360 370 380 390 400
PSYKRVKALS IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE
410 420 430 440 450
LVMGFSVALS LLGEILLHPF KATLLRKLSR TGLVGLGLSC LAGQLLYYSF
460 470 480 490 500
LWSWWSVLPI QILSAISNRA LWWAVGASVE DLATPRMERA LSALFRGHFY
510 520 530 540 550
GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS IQRRLPRERK
560 570 580
IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD
Length:586
Mass (Da):64,005
Last modified:February 26, 2008 - v2
Checksum:iAF1607041015758D
GO

Sequence cautioni

The sequence AAM98769 differs from that shown. Reason: Frameshift at position 365.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214P → T in AAH40487 (PubMed:15489334).Curated1
Sequence conflicti277F → S in BAC04050 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039389486R → H.Corresponds to variant rs2242373dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129026 mRNA. Translation: AAM98769.1. Frameshift.
AK093092 mRNA. Translation: BAC04050.1.
BC040487 mRNA. Translation: AAH40487.1.
CCDSiCCDS11146.1.
RefSeqiNP_689812.3. NM_152599.3.
UniGeneiHs.213603.

Genome annotation databases

EnsembliENST00000329805; ENSP00000330051; ENSG00000185156.
GeneIDi162387.
KEGGihsa:162387.
UCSCiuc002glp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129026 mRNA. Translation: AAM98769.1. Frameshift.
AK093092 mRNA. Translation: BAC04050.1.
BC040487 mRNA. Translation: AAH40487.1.
CCDSiCCDS11146.1.
RefSeqiNP_689812.3. NM_152599.3.
UniGeneiHs.213603.

3D structure databases

ProteinModelPortaliQ8IWD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4723110.
STRINGi9606.ENSP00000330051.

Protein family/group databases

TCDBi2.A.1.65.10. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8IWD5.
PhosphoSitePlusiQ8IWD5.

Polymorphism and mutation databases

BioMutaiMFSD6L.
DMDMi190360169.

Proteomic databases

PaxDbiQ8IWD5.
PeptideAtlasiQ8IWD5.
PRIDEiQ8IWD5.
TopDownProteomicsiQ8IWD5.

Protocols and materials databases

DNASUi162387.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329805; ENSP00000330051; ENSG00000185156.
GeneIDi162387.
KEGGihsa:162387.
UCSCiuc002glp.3. human.

Organism-specific databases

CTDi162387.
DisGeNETi162387.
GeneCardsiMFSD6L.
H-InvDBHIX0013527.
HGNCiHGNC:26656. MFSD6L.
HPAiHPA023164.
neXtProtiNX_Q8IWD5.
OpenTargetsiENSG00000185156.
PharmGKBiPA164722299.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3762. Eukaryota.
ENOG410YMHR. LUCA.
GeneTreeiENSGT00530000063599.
HOGENOMiHOG000049138.
HOVERGENiHBG097504.
InParanoidiQ8IWD5.
OMAiCAFLAKS.
OrthoDBiEOG091G0507.
PhylomeDBiQ8IWD5.
TreeFamiTF314366.

Enzyme and pathway databases

BioCyciZFISH:G66-32812-MONOMER.

Miscellaneous databases

GenomeRNAii162387.
PROiQ8IWD5.

Gene expression databases

BgeeiENSG00000185156.
CleanExiHS_MFSD6L.
GenevisibleiQ8IWD5. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR024989. MFS_assoc_dom.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF12832. MFS_1_like. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMFS6L_HUMAN
AccessioniPrimary (citable) accession number: Q8IWD5
Secondary accession number(s): Q6YL34, Q8NA76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.