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UniProtKB - Q8IWC1 (MA7D3_HUMAN)

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Protein

MAP7 domain-containing protein 3

Gene

MAP7D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the assembly and stability of microtubules.2 Publications

Caution

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • structural molecule activity Source: GO_Central
  • tubulin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • microtubule cytoskeleton organization Source: UniProtKB
  • microtubule polymerization Source: UniProtKB
View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
MAP7 domain-containing protein 3
Gene namesi
Name:MAP7D3
Synonyms:MDP31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000129680.15
HGNCiHGNC:25742 MAP7D3
MIMi300930 gene
neXtProtiNX_Q8IWC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129680
PharmGKBiPA162394972

Polymorphism and mutation databases

BioMutaiMAP7D3
DMDMi158705880

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068121 – 876MAP7 domain-containing protein 3Add BLAST876

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei832PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IWC1
MaxQBiQ8IWC1
PaxDbiQ8IWC1
PeptideAtlasiQ8IWC1
PRIDEiQ8IWC1

PTM databases

iPTMnetiQ8IWC1
PhosphoSitePlusiQ8IWC1

Expressioni

Inductioni

Expression is cell cycle dependent with the highest levels during G1, S, and M phases, and low level in G2 phase.1 Publication

Gene expression databases

BgeeiENSG00000129680
CleanExiHS_MAP7D3
ExpressionAtlasiQ8IWC1 baseline and differential
GenevisibleiQ8IWC1 HS

Organism-specific databases

HPAiHPA035598
HPA058101

Interactioni

Subunit structurei

Interacts (via N-terminus coiled coil domains) with tubulin and microtubules.2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • tubulin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi12277739 interactors.
IntActiQ8IWC1 31 interactors.
MINTiQ8IWC1
STRINGi9606.ENSP00000318086

Structurei

3D structure databases

ProteinModelPortaliQ8IWC1
SMRiQ8IWC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 144Sequence analysisAdd BLAST80
Coiled coili558 – 640Sequence analysisAdd BLAST83
Coiled coili689 – 724Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the MAP7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIZ9 Eukaryota
ENOG410YMWJ LUCA
GeneTreeiENSGT00660000095160
HOVERGENiHBG103577
InParanoidiQ8IWC1
KOiK16807
OMAiSAMANSE
OrthoDBiEOG091G05LZ
PhylomeDBiQ8IWC1
TreeFamiTF332273

Family and domain databases

InterProiView protein in InterPro
IPR008604 MAP7_fam
PANTHERiPTHR15073 PTHR15073, 1 hit
PfamiView protein in Pfam
PF05672 MAP7, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI 
        60         70         80         90        100
RSTFKPVIDG SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL 
       110        120        130        140        150
QYEKQMEERQ RKLKERKEKE EQRRIAAEEK RHQKDEAQKE KFTAILYRTL 
       160        170        180        190        200
ERRRLADDYQ QKRWSWGGSA MANSESKTAN KRSASTEKLE QGTSALIRQM 
       210        220        230        240        250
PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA ERKPRVTGVT 
       260        270        280        290        300
NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK 
       310        320        330        340        350
ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS 
       360        370        380        390        400
TYDSEMSMDA SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA 
       410        420        430        440        450
LPEVSVEAAP EGSLEAPPKG SAEVAPKESV KGSPKESMEA SPEAMVKASP 
       460        470        480        490        500
KTSLEASMEA SPKAKARDAP KKSEMDKQAL IPIAKKRLSS YTECYKWSSS 
       510        520        530        540        550
PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY KIMPIQHTLS 
       560        570        580        590        600
VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT 
       610        620        630        640        650
KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL 
       660        670        680        690        700
KLKDGQQQNE TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI 
       710        720        730        740        750
MLQNLQERLE RKKRIEEIMK RTRKTDVNAS KVTETSSHDI YEEAEADNEE 
       760        770        780        790        800
SDKDSLNEMF PSAILNGTGS PTKFKMPFNN AKKMTHKLVF LEDGTSQVRK 
       810        820        830        840        850
EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT KTRKADETNT 
       860        870 
TSRSSAQTKS EGFHDILPKS SDTFRQ
Length:876
Mass (Da):98,429
Last modified:October 2, 2007 - v2
Checksum:iC149899FB0002B39
GO
Isoform 2 (identifier: Q8IWC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-286: Missing.

Note: No experimental confirmation available.
Show »
Length:835
Mass (Da):93,785
Checksum:i636105ADE4362780
GO
Isoform 3 (identifier: Q8IWC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-214: ANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKR → G

Note: No experimental confirmation available.
Show »
Length:841
Mass (Da):94,675
Checksum:i991CB99A9EA667C2
GO
Isoform 4 (identifier: Q8IWC1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MMADGAAAGAGGSPSLRELRARM → MTSPR

Note: No experimental confirmation available.
Show »
Length:858
Mass (Da):96,743
Checksum:i46B3C99CFE457147
GO

Sequence cautioni

The sequence AAH64350 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAM21578 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71L → S in BAG62994 (PubMed:14702039).Curated1
Sequence conflicti447K → R in BAG62994 (PubMed:14702039).Curated1
Sequence conflicti448A → T in AAH40518 (PubMed:15489334).Curated1
Sequence conflicti623R → Q in AL832120 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035314502E → A1 PublicationCorresponds to variant dbSNP:rs1055497Ensembl.1
Natural variantiVAR_077003561K → R1 PublicationCorresponds to variant dbSNP:rs748582851Ensembl.1
Natural variantiVAR_035315628Q → R1 PublicationCorresponds to variant dbSNP:rs2273221Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450081 – 23MMADG…LRARM → MTSPR in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_028498179 – 214ANKRS…SVAKR → G in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_028499246 – 286Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022711 mRNA Translation: BAB14195.1
AK301478 mRNA Translation: BAG62994.1
AL832120 mRNA No translation available.
AL078638 Genomic DNA Translation: CAI41063.2
AL078638 Genomic DNA Translation: CAI41064.2
AL078638 Genomic DNA Translation: CAM21578.1 Sequence problems.
CH471150 Genomic DNA Translation: EAW88475.1
BC040518 mRNA Translation: AAH40518.1
BC064350 mRNA Translation: AAH64350.1 Sequence problems.
CCDSiCCDS44004.1 [Q8IWC1-1]
CCDS55508.1 [Q8IWC1-3]
CCDS55509.1 [Q8IWC1-4]
RefSeqiNP_001166987.1, NM_001173516.1 [Q8IWC1-4]
NP_001166988.1, NM_001173517.1 [Q8IWC1-3]
NP_078873.2, NM_024597.3 [Q8IWC1-1]
UniGeneiHs.446275

Genome annotation databases

EnsembliENST00000316077; ENSP00000318086; ENSG00000129680 [Q8IWC1-1]
ENST00000370661; ENSP00000359695; ENSG00000129680 [Q8IWC1-3]
ENST00000370663; ENSP00000359697; ENSG00000129680 [Q8IWC1-4]
GeneIDi79649
KEGGihsa:79649
UCSCiuc004ezs.4 human [Q8IWC1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMA7D3_HUMAN
AccessioniPrimary (citable) accession number: Q8IWC1
Secondary accession number(s): A2A2J0
, A6NCZ7, A6NHR4, B4DWD2, H7BY77, Q5JXI5, Q5JXI6, Q6P2S1, Q9H9M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome