MAP7D3

Functionⁱ

Promotes the assembly and stability of microtubules.2 Publications

GO - Molecular functionⁱ

microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22142902
structural molecule activity Source: GO_Central
tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22142902

Complete GO annotation...

GO - Biological processⁱ

microtubule cytoskeleton organization
Source: UniProtKB
Inferred from direct assayⁱ
- 22142902
microtubule polymerization
Source: UniProtKB
Inferred from direct assayⁱ
- 24927501

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MAP7 domain-containing protein 3
Gene namesⁱ	Name:MAP7D3 Synonyms:MDP31 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25742. MAP7D3.

HGNCⁱ

HGNC:25742. MAP7D3.

Subcellular locationⁱ

Cytoplasm › cytoskeleton › spindle
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Proteome analysis of the human mitotic spindle."
  Sauer G., Koerner R., Hanisch A., Ries A., Nigg E.A., Sillje H.H.W.
  Mol. Cell. Proteomics 4:35-43(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.

Note:

Localizes to the microtubules throughout mitosis.1 Publication

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-KW
membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 19946888
microtubule cytoskeleton Source: GO_Central
spindle Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000129680.
PharmGKBⁱ	PA162394972.

Polymorphism and mutation databases

BioMutaⁱ	MAP7D3.
DMDMⁱ	158705880.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000306812	1 – 876	MAP7 domain-containing protein 3Add BLAST		876

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	185	PhosphoserineCombined sources	1
Modified residueⁱ	322	PhosphoserineCombined sources	1
Modified residueⁱ	441	PhosphoserineCombined sources	1
Modified residueⁱ	457	PhosphoserineCombined sources	1
Modified residueⁱ	461	PhosphoserineCombined sources	1
Modified residueⁱ	490	PhosphoserineCombined sources	1
Modified residueⁱ	524	PhosphoserineCombined sources	1
Modified residueⁱ	770	PhosphoserineCombined sources	1
Modified residueⁱ	817	PhosphoserineCombined sources	1
Modified residueⁱ	832	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8IWC1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IWC1.
PaxDbⁱ	Q8IWC1.
PeptideAtlas More...PeptideAtlasⁱ	Q8IWC1.
PRIDEⁱ	Q8IWC1.

PTM databases

iPTMnetⁱ	Q8IWC1.
PhosphoSitePlusⁱ	Q8IWC1.

Expressionⁱ

Inductionⁱ

Expression is cell cycle dependent with the highest levels during G1, S, and M phases, and low level in G2 phase.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000129680.
CleanExⁱ	HS_MAP7D3.
ExpressionAtlasⁱ	Q8IWC1. baseline and differential.
Genevisibleⁱ	Q8IWC1. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035598. HPA058101.

HPAⁱ

HPA035598.
HPA058101.

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminus coiled coil domains) with tubulin and microtubules.2 Publications

GO - Molecular functionⁱ

microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22142902
tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22142902

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	122777. 37 interactors.
IntActⁱ	Q8IWC1. 30 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4990235.
STRINGⁱ	9606.ENSP00000318086.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IWC1.
SMRⁱ	Q8IWC1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	65 – 144	Sequence analysisAdd BLAST	80
Coiled coilⁱ	558 – 640	Sequence analysisAdd BLAST	83
Coiled coilⁱ	689 – 724	Sequence analysisAdd BLAST	36

Sequence similaritiesⁱ

Belongs to the MAP7 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IIZ9. Eukaryota. ENOG410YMWJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00660000095160.
HOVERGENⁱ	HBG103577.
InParanoidⁱ	Q8IWC1.
KEGG Orthology (KO) More...KOⁱ	K16807.
OMAⁱ	SAMANSE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05LZ.
PhylomeDBⁱ	Q8IWC1.
TreeFamⁱ	TF332273.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008604. MAP7_fam.
PANTHERⁱ	PTHR15073. PTHR15073. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05672. MAP7. 1 hit.

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8IWC1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI 
        60         70         80         90        100
RSTFKPVIDG SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL 
       110        120        130        140        150
QYEKQMEERQ RKLKERKEKE EQRRIAAEEK RHQKDEAQKE KFTAILYRTL 
       160        170        180        190        200
ERRRLADDYQ QKRWSWGGSA MANSESKTAN KRSASTEKLE QGTSALIRQM 
       210        220        230        240        250
PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA ERKPRVTGVT 
       260        270        280        290        300
NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK 
       310        320        330        340        350
ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS 
       360        370        380        390        400
TYDSEMSMDA SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA 
       410        420        430        440        450
LPEVSVEAAP EGSLEAPPKG SAEVAPKESV KGSPKESMEA SPEAMVKASP 
       460        470        480        490        500
KTSLEASMEA SPKAKARDAP KKSEMDKQAL IPIAKKRLSS YTECYKWSSS 
       510        520        530        540        550
PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY KIMPIQHTLS 
       560        570        580        590        600
VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT 
       610        620        630        640        650
KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL 
       660        670        680        690        700
KLKDGQQQNE TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI 
       710        720        730        740        750
MLQNLQERLE RKKRIEEIMK RTRKTDVNAS KVTETSSHDI YEEAEADNEE 
       760        770        780        790        800
SDKDSLNEMF PSAILNGTGS PTKFKMPFNN AKKMTHKLVF LEDGTSQVRK 
       810        820        830        840        850
EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT KTRKADETNT 
       860        870 
TSRSSAQTKS EGFHDILPKS SDTFRQ

Length:876

Mass (Da):98,429

Last modified:October 2, 2007 - v2

Checksum:ⁱC149899FB0002B39

GO

Isoform 2 (identifier: Q8IWC1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
246-286: Missing.

« Hide

        10         20         30         40         50
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI 
        60         70         80         90        100
RSTFKPVIDG SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL 
       110        120        130        140        150
QYEKQMEERQ RKLKERKEKE EQRRIAAEEK RHQKDEAQKE KFTAILYRTL 
       160        170        180        190        200
ERRRLADDYQ QKRWSWGGSA MANSESKTAN KRSASTEKLE QGTSALIRQM 
       210        220        230        240        250
PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA ERKPRVEESP 
       260        270        280        290        300
LEKVETPPKA SVDAPPQVNV EVFCNTSMEA SPKAGVGMAP EVSTDSFPVV 
       310        320        330        340        350
SVDVSPVVST YDSEMSMDAS PELSIEALPK VDLETVPKVS IVASPEASLE 
       360        370        380        390        400
APPEVSLEAL PEVSVEAAPE GSLEAPPKGS AEVAPKESVK GSPKESMEAS 
       410        420        430        440        450
PEAMVKASPK TSLEASMEAS PKAKARDAPK KSEMDKQALI PIAKKRLSSY 
       460        470        480        490        500
TECYKWSSSP ENACGLPSPI STNRQIQKNC PPSPLPLISK QSPQTSFPYK 
       510        520        530        540        550
IMPIQHTLSV QSASSTVKKK KETVSKTTNR CEALSQRHMI YEESGNKSTA 
       560        570        580        590        600
GIMNAEAATK ILTELRRLAR EQREKEEEER QREEMQQRVI KKSKDMAKEA 
       610        620        630        640        650
VGGQAEDHLK LKDGQQQNET KKKKGWLDQE DQEAPLQKGD AKIKAQEEAD 
       660        670        680        690        700
KRKKEHERIM LQNLQERLER KKRIEEIMKR TRKTDVNASK VTETSSHDIY 
       710        720        730        740        750
EEAEADNEES DKDSLNEMFP SAILNGTGSP TKFKMPFNNA KKMTHKLVFL 
       760        770        780        790        800
EDGTSQVRKE PKTYFNGDLK NFRQKSMKDT SIQEVVSRPS SKRMTSHTTK 
       810        820        830 
TRKADETNTT SRSSAQTKSE GFHDILPKSS DTFRQ

Note: No experimental confirmation available.

Show »

Length:835

Mass (Da):93,785

Checksum:ⁱ636105ADE4362780

GO

Isoform 3 (identifier: Q8IWC1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
179-214: ANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKR → G

« Hide

        10         20         30         40         50
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI 
        60         70         80         90        100
RSTFKPVIDG SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL 
       110        120        130        140        150
QYEKQMEERQ RKLKERKEKE EQRRIAAEEK RHQKDEAQKE KFTAILYRTL 
       160        170        180        190        200
ERRRLADDYQ QKRWSWGGSA MANSESKTGK TDKERSSSLN RRDSNLHSST 
       210        220        230        240        250
DKEQAERKPR VTGVTNYVMQ YVTVPLRKCT SDELRAVMFP MSTMKIPPQT 
       260        270        280        290        300
KVEESPLEKV ETPPKASVDA PPQVNVEVFC NTSMEASPKA GVGMAPEVST 
       310        320        330        340        350
DSFPVVSVDV SPVVSTYDSE MSMDASPELS IEALPKVDLE TVPKVSIVAS 
       360        370        380        390        400
PEASLEAPPE VSLEALPEVS VEAAPEGSLE APPKGSAEVA PKESVKGSPK 
       410        420        430        440        450
ESMEASPEAM VKASPKTSLE ASMEASPKAK ARDAPKKSEM DKQALIPIAK 
       460        470        480        490        500
KRLSSYTECY KWSSSPENAC GLPSPISTNR QIQKNCPPSP LPLISKQSPQ 
       510        520        530        540        550
TSFPYKIMPI QHTLSVQSAS STVKKKKETV SKTTNRCEAL SQRHMIYEES 
       560        570        580        590        600
GNKSTAGIMN AEAATKILTE LRRLAREQRE KEEEERQREE MQQRVIKKSK 
       610        620        630        640        650
DMAKEAVGGQ AEDHLKLKDG QQQNETKKKK GWLDQEDQEA PLQKGDAKIK 
       660        670        680        690        700
AQEEADKRKK EHERIMLQNL QERLERKKRI EEIMKRTRKT DVNASKVTET 
       710        720        730        740        750
SSHDIYEEAE ADNEESDKDS LNEMFPSAIL NGTGSPTKFK MPFNNAKKMT 
       760        770        780        790        800
HKLVFLEDGT SQVRKEPKTY FNGDLKNFRQ KSMKDTSIQE VVSRPSSKRM 
       810        820        830        840 
TSHTTKTRKA DETNTTSRSS AQTKSEGFHD ILPKSSDTFR Q

Note: No experimental confirmation available.

Show »

Length:841

Mass (Da):94,675

Checksum:ⁱ991CB99A9EA667C2

GO

Isoform 4 (identifier: Q8IWC1-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-23: MMADGAAAGAGGSPSLRELRARM → MTSPR

« Hide

        10         20         30         40         50
MTSPRVAAAN EIAKERRKQD VVNRVATHSS NIRSTFKPVI DGSMLKNDIK 
        60         70         80         90        100
QRLARERREE KRRQQDANKE TQLLEKERKT KLQYEKQMEE RQRKLKERKE 
       110        120        130        140        150
KEEQRRIAAE EKRHQKDEAQ KEKFTAILYR TLERRRLADD YQQKRWSWGG 
       160        170        180        190        200
SAMANSESKT ANKRSASTEK LEQGTSALIR QMPLSSAGLQ NSVAKRKTDK 
       210        220        230        240        250
ERSSSLNRRD SNLHSSTDKE QAERKPRVTG VTNYVMQYVT VPLRKCTSDE 
       260        270        280        290        300
LRAVMFPMST MKIPPQTKVE ESPLEKVETP PKASVDAPPQ VNVEVFCNTS 
       310        320        330        340        350
MEASPKAGVG MAPEVSTDSF PVVSVDVSPV VSTYDSEMSM DASPELSIEA 
       360        370        380        390        400
LPKVDLETVP KVSIVASPEA SLEAPPEVSL EALPEVSVEA APEGSLEAPP 
       410        420        430        440        450
KGSAEVAPKE SVKGSPKESM EASPEAMVKA SPKTSLEASM EASPKAKARD 
       460        470        480        490        500
APKKSEMDKQ ALIPIAKKRL SSYTECYKWS SSPENACGLP SPISTNRQIQ 
       510        520        530        540        550
KNCPPSPLPL ISKQSPQTSF PYKIMPIQHT LSVQSASSTV KKKKETVSKT 
       560        570        580        590        600
TNRCEALSQR HMIYEESGNK STAGIMNAEA ATKILTELRR LAREQREKEE 
       610        620        630        640        650
EERQREEMQQ RVIKKSKDMA KEAVGGQAED HLKLKDGQQQ NETKKKKGWL 
       660        670        680        690        700
DQEDQEAPLQ KGDAKIKAQE EADKRKKEHE RIMLQNLQER LERKKRIEEI 
       710        720        730        740        750
MKRTRKTDVN ASKVTETSSH DIYEEAEADN EESDKDSLNE MFPSAILNGT 
       760        770        780        790        800
GSPTKFKMPF NNAKKMTHKL VFLEDGTSQV RKEPKTYFNG DLKNFRQKSM 
       810        820        830        840        850
KDTSIQEVVS RPSSKRMTSH TTKTRKADET NTTSRSSAQT KSEGFHDILP 

KSSDTFRQ

Note: No experimental confirmation available.

Show »

Length:858

Mass (Da):96,743

Checksum:ⁱ46B3C99CFE457147

GO

Sequence cautionⁱ

The sequence AAH64350 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence CAM21578 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	71	L → S in BAG62994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	447	K → R in BAG62994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	448	A → T in AAH40518 (PubMed:15489334).Curated	1
Sequence conflictⁱ	623	R → Q in AL832120 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_035314	502	E → A1 PublicationCorresponds to variant dbSNP:rs1055497Ensembl.	1
Natural variantⁱVAR_077003	561	K → R1 PublicationCorresponds to variant dbSNP:rs748582851Ensembl.	1
Natural variantⁱVAR_035315	628	Q → R1 PublicationCorresponds to variant dbSNP:rs2273221Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045008	1 – 23	MMADG…LRARM → MTSPR in isoform 4. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_028498	179 – 214	ANKRS…SVAKR → G in isoform 3. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_028499	246 – 286	Missing in isoform 2. 1 PublicationAdd BLAST	41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022711 mRNA. Translation: BAB14195.1. AK301478 mRNA. Translation: BAG62994.1. AL832120 mRNA. No translation available. AL078638 Genomic DNA. Translation: CAI41063.2. AL078638 Genomic DNA. Translation: CAI41064.2. AL078638 Genomic DNA. Translation: CAM21578.1. Sequence problems. CH471150 Genomic DNA. Translation: EAW88475.1. BC040518 mRNA. Translation: AAH40518.1. BC064350 mRNA. Translation: AAH64350.1. Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44004.1. [Q8IWC1-1] CCDS55508.1. [Q8IWC1-3] CCDS55509.1. [Q8IWC1-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001166987.1. NM_001173516.1. [Q8IWC1-4] NP_001166988.1. NM_001173517.1. [Q8IWC1-3] NP_078873.2. NM_024597.3. [Q8IWC1-1]
UniGeneⁱ	Hs.446275.

Genome annotation databases

Ensemblⁱ	ENST00000316077; ENSP00000318086; ENSG00000129680. [Q8IWC1-1] ENST00000370661; ENSP00000359695; ENSG00000129680. [Q8IWC1-3] ENST00000370663; ENSP00000359697; ENSG00000129680. [Q8IWC1-4]
GeneIDⁱ	79649.
KEGGⁱ	hsa:79649.
UCSC genome browser More...UCSCⁱ	uc004ezs.4. human. [Q8IWC1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022711 mRNA. Translation: BAB14195.1. AK301478 mRNA. Translation: BAG62994.1. AL832120 mRNA. No translation available. AL078638 Genomic DNA. Translation: CAI41063.2. AL078638 Genomic DNA. Translation: CAI41064.2. AL078638 Genomic DNA. Translation: CAM21578.1. Sequence problems. CH471150 Genomic DNA. Translation: EAW88475.1. BC040518 mRNA. Translation: AAH40518.1. BC064350 mRNA. Translation: AAH64350.1. Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44004.1. [Q8IWC1-1] CCDS55508.1. [Q8IWC1-3] CCDS55509.1. [Q8IWC1-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001166987.1. NM_001173516.1. [Q8IWC1-4] NP_001166988.1. NM_001173517.1. [Q8IWC1-3] NP_078873.2. NM_024597.3. [Q8IWC1-1]
UniGeneⁱ	Hs.446275.

3D structure databases

ProteinModelPortalⁱ	Q8IWC1.
SMRⁱ	Q8IWC1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122777. 37 interactors.
IntActⁱ	Q8IWC1. 30 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4990235.
STRINGⁱ	9606.ENSP00000318086.

PTM databases

iPTMnetⁱ	Q8IWC1.
PhosphoSitePlusⁱ	Q8IWC1.

Polymorphism and mutation databases

BioMutaⁱ	MAP7D3.
DMDMⁱ	158705880.

Proteomic databases

EPDⁱ	Q8IWC1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IWC1.
PaxDbⁱ	Q8IWC1.
PeptideAtlas More...PeptideAtlasⁱ	Q8IWC1.
PRIDEⁱ	Q8IWC1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000316077; ENSP00000318086; ENSG00000129680. [Q8IWC1-1] ENST00000370661; ENSP00000359695; ENSG00000129680. [Q8IWC1-3] ENST00000370663; ENSP00000359697; ENSG00000129680. [Q8IWC1-4]
GeneIDⁱ	79649.
KEGGⁱ	hsa:79649.
UCSC genome browser More...UCSCⁱ	uc004ezs.4. human. [Q8IWC1-1]

Organism-specific databases

CTDⁱ	79649.
GeneCardsⁱ	MAP7D3.
H-InvDBⁱ	HIX0017079.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25742. MAP7D3.
Human Protein Atlas More...HPAⁱ	HPA035598. HPA058101.
MIMⁱ	300930. gene.
neXtProtⁱ	NX_Q8IWC1.
Open Targets More...OpenTargetsⁱ	ENSG00000129680.
PharmGKBⁱ	PA162394972.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIZ9. Eukaryota. ENOG410YMWJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00660000095160.
HOVERGENⁱ	HBG103577.
InParanoidⁱ	Q8IWC1.
KEGG Orthology (KO) More...KOⁱ	K16807.
OMAⁱ	SAMANSE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05LZ.
PhylomeDBⁱ	Q8IWC1.
TreeFamⁱ	TF332273.

Miscellaneous databases

ChiTaRSⁱ	MAP7D3. human.
GenomeRNAiⁱ	79649.
Protein Ontology More...PROⁱ	PR:Q8IWC1.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129680.
CleanExⁱ	HS_MAP7D3.
ExpressionAtlasⁱ	Q8IWC1. baseline and differential.
Genevisibleⁱ	Q8IWC1. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008604. MAP7_fam.
PANTHERⁱ	PTHR15073. PTHR15073. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05672. MAP7. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MA7D3_HUMAN
Accessionⁱ	Q8IWC1Primary (citable) accession number: Q8IWC1 Secondary accession number(s): A2A2J0 Q9H9M8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	June 7, 2017
	This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IWC1 (MA7D3_HUMAN)

Your basket is currently empty.

MAP7 domain-containing protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (4)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ