UniProtKB - Q8IWC1 (MA7D3_HUMAN)
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Protein
MAP7 domain-containing protein 3
Gene
MAP7D3
Organism
Homo sapiens (Human)
Status
Functioni
Promotes the assembly and stability of microtubules.2 Publications
Caution
GO - Molecular functioni
- microtubule binding Source: UniProtKB
- structural molecule activity Source: GO_Central
- tubulin binding Source: UniProtKB
GO - Biological processi
- microtubule cytoskeleton organization Source: UniProtKB
- microtubule polymerization Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: MAP7 domain-containing protein 3 |
Gene namesi | Name:MAP7D3 Synonyms:MDP31 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000129680.15 |
HGNCi | HGNC:25742 MAP7D3 |
MIMi | 300930 gene |
neXtProti | NX_Q8IWC1 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000129680 |
PharmGKBi | PA162394972 |
Polymorphism and mutation databases
BioMutai | MAP7D3 |
DMDMi | 158705880 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306812 | 1 – 876 | MAP7 domain-containing protein 3Add BLAST | 876 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 185 | PhosphoserineCombined sources | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources | 1 | |
Modified residuei | 441 | PhosphoserineCombined sources | 1 | |
Modified residuei | 457 | PhosphoserineCombined sources | 1 | |
Modified residuei | 461 | PhosphoserineCombined sources | 1 | |
Modified residuei | 490 | PhosphoserineCombined sources | 1 | |
Modified residuei | 524 | PhosphoserineCombined sources | 1 | |
Modified residuei | 770 | PhosphoserineCombined sources | 1 | |
Modified residuei | 817 | PhosphoserineCombined sources | 1 | |
Modified residuei | 832 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8IWC1 |
MaxQBi | Q8IWC1 |
PaxDbi | Q8IWC1 |
PeptideAtlasi | Q8IWC1 |
PRIDEi | Q8IWC1 |
PTM databases
iPTMneti | Q8IWC1 |
PhosphoSitePlusi | Q8IWC1 |
Expressioni
Inductioni
Expression is cell cycle dependent with the highest levels during G1, S, and M phases, and low level in G2 phase.1 Publication
Gene expression databases
Bgeei | ENSG00000129680 |
CleanExi | HS_MAP7D3 |
ExpressionAtlasi | Q8IWC1 baseline and differential |
Genevisiblei | Q8IWC1 HS |
Organism-specific databases
HPAi | HPA035598 HPA058101 |
Interactioni
Subunit structurei
Interacts (via N-terminus coiled coil domains) with tubulin and microtubules.2 Publications
GO - Molecular functioni
- microtubule binding Source: UniProtKB
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 12277739 interactors. |
IntActi | Q8IWC1 31 interactors. |
MINTi | Q8IWC1 |
STRINGi | 9606.ENSP00000318086 |
Structurei
3D structure databases
ProteinModelPortali | Q8IWC1 |
SMRi | Q8IWC1 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 65 – 144 | Sequence analysisAdd BLAST | 80 | |
Coiled coili | 558 – 640 | Sequence analysisAdd BLAST | 83 | |
Coiled coili | 689 – 724 | Sequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the MAP7 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG410IIZ9 Eukaryota ENOG410YMWJ LUCA |
GeneTreei | ENSGT00660000095160 |
HOVERGENi | HBG103577 |
InParanoidi | Q8IWC1 |
KOi | K16807 |
OMAi | SAMANSE |
OrthoDBi | EOG091G05LZ |
PhylomeDBi | Q8IWC1 |
TreeFami | TF332273 |
Family and domain databases
InterProi | View protein in InterPro IPR008604 MAP7_fam |
PANTHERi | PTHR15073 PTHR15073, 1 hit |
Pfami | View protein in Pfam PF05672 MAP7, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IWC1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI
60 70 80 90 100
RSTFKPVIDG SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL
110 120 130 140 150
QYEKQMEERQ RKLKERKEKE EQRRIAAEEK RHQKDEAQKE KFTAILYRTL
160 170 180 190 200
ERRRLADDYQ QKRWSWGGSA MANSESKTAN KRSASTEKLE QGTSALIRQM
210 220 230 240 250
PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA ERKPRVTGVT
260 270 280 290 300
NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK
310 320 330 340 350
ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS
360 370 380 390 400
TYDSEMSMDA SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA
410 420 430 440 450
LPEVSVEAAP EGSLEAPPKG SAEVAPKESV KGSPKESMEA SPEAMVKASP
460 470 480 490 500
KTSLEASMEA SPKAKARDAP KKSEMDKQAL IPIAKKRLSS YTECYKWSSS
510 520 530 540 550
PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY KIMPIQHTLS
560 570 580 590 600
VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT
610 620 630 640 650
KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL
660 670 680 690 700
KLKDGQQQNE TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI
710 720 730 740 750
MLQNLQERLE RKKRIEEIMK RTRKTDVNAS KVTETSSHDI YEEAEADNEE
760 770 780 790 800
SDKDSLNEMF PSAILNGTGS PTKFKMPFNN AKKMTHKLVF LEDGTSQVRK
810 820 830 840 850
EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT KTRKADETNT
860 870
TSRSSAQTKS EGFHDILPKS SDTFRQ
Sequence cautioni
The sequence AAH64350 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAM21578 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | L → S in BAG62994 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 447 | K → R in BAG62994 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 448 | A → T in AAH40518 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 623 | R → Q in AL832120 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035314 | 502 | E → A1 PublicationCorresponds to variant dbSNP:rs1055497Ensembl. | 1 | |
Natural variantiVAR_077003 | 561 | K → R1 PublicationCorresponds to variant dbSNP:rs748582851Ensembl. | 1 | |
Natural variantiVAR_035315 | 628 | Q → R1 PublicationCorresponds to variant dbSNP:rs2273221Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045008 | 1 – 23 | MMADG…LRARM → MTSPR in isoform 4. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_028498 | 179 – 214 | ANKRS…SVAKR → G in isoform 3. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_028499 | 246 – 286 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022711 mRNA Translation: BAB14195.1 AK301478 mRNA Translation: BAG62994.1 AL832120 mRNA No translation available. AL078638 Genomic DNA Translation: CAI41063.2 AL078638 Genomic DNA Translation: CAI41064.2 AL078638 Genomic DNA Translation: CAM21578.1 Sequence problems. CH471150 Genomic DNA Translation: EAW88475.1 BC040518 mRNA Translation: AAH40518.1 BC064350 mRNA Translation: AAH64350.1 Sequence problems. |
CCDSi | CCDS44004.1 [Q8IWC1-1] CCDS55508.1 [Q8IWC1-3] CCDS55509.1 [Q8IWC1-4] |
RefSeqi | NP_001166987.1, NM_001173516.1 [Q8IWC1-4] NP_001166988.1, NM_001173517.1 [Q8IWC1-3] NP_078873.2, NM_024597.3 [Q8IWC1-1] |
UniGenei | Hs.446275 |
Genome annotation databases
Ensembli | ENST00000316077; ENSP00000318086; ENSG00000129680 [Q8IWC1-1] ENST00000370661; ENSP00000359695; ENSG00000129680 [Q8IWC1-3] ENST00000370663; ENSP00000359697; ENSG00000129680 [Q8IWC1-4] |
GeneIDi | 79649 |
KEGGi | hsa:79649 |
UCSCi | uc004ezs.4 human [Q8IWC1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MA7D3_HUMAN | |
Accessioni | Q8IWC1Primary (citable) accession number: Q8IWC1 Secondary accession number(s): A2A2J0 Q9H9M8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | March 28, 2018 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |