Q8IWC1 (MA7D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MAP7 domain-containing protein 3

Gene names

Name:

MAP7D3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	876 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton › spindle. Note: Localizes to the microtubules throughout mitosis. Ref.6
Sequence similarities	Belongs to the MAP7 family.
Sequence caution	The sequence AAH64350.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence CAM21578.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytoplasm Inferred from direct assay. Source: HPA microtubule Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay. Source: HPA spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWC1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWC1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     246-286: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8IWC1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     179-214: ANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKR → G

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8IWC1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MMADGAAAGAGGSPSLRELRARM → MTSPR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 876	876	MAP7 domain-containing protein 3		PRO_0000306812
Regions
	Coiled coil	65 – 144	80	Potential
	Coiled coil	558 – 640	83	Potential
	Coiled coil	689 – 724	36	Potential
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.13
	Modified residue	322	1	Phosphoserine Ref.7
	Modified residue	457	1	Phosphoserine Ref.7
	Modified residue	461	1	Phosphoserine Ref.7
	Modified residue	524	1	Phosphoserine Ref.7
	Modified residue	770	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 23	23	MMADG…LRARM → MTSPR in isoform 4.		VSP_045008
	Alternative sequence	179 – 214	36	ANKRS…SVAKR → G in isoform 3.		VSP_028498
	Alternative sequence	246 – 286	41	Missing in isoform 2.		VSP_028499
	Natural variant	502	1	E → A. Ref.5 Corresponds to variant rs1055497 [ dbSNP | Ensembl ].		VAR_035314
	Natural variant	628	1	Q → R. Ref.5 Corresponds to variant rs2273221 [ dbSNP | Ensembl ].		VAR_035315
Experimental info
	Sequence conflict	71	1	L → S in BAG62994. Ref.1
	Sequence conflict	447	1	K → R in BAG62994. Ref.1
	Sequence conflict	448	1	A → T in AAH40518. Ref.5
	Sequence conflict	623	1	R → Q in AL832120. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: C149899FB0002B39	FASTA	876	98,429
	10 20 30 40 50 60 MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI RSTFKPVIDG 70 80 90 100 110 120 SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL QYEKQMEERQ RKLKERKEKE 130 140 150 160 170 180 EQRRIAAEEK RHQKDEAQKE KFTAILYRTL ERRRLADDYQ QKRWSWGGSA MANSESKTAN 190 200 210 220 230 240 KRSASTEKLE QGTSALIRQM PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA 250 260 270 280 290 300 ERKPRVTGVT NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK 310 320 330 340 350 360 ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS TYDSEMSMDA 370 380 390 400 410 420 SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA LPEVSVEAAP EGSLEAPPKG 430 440 450 460 470 480 SAEVAPKESV KGSPKESMEA SPEAMVKASP KTSLEASMEA SPKAKARDAP KKSEMDKQAL 490 500 510 520 530 540 IPIAKKRLSS YTECYKWSSS PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY 550 560 570 580 590 600 KIMPIQHTLS VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT 610 620 630 640 650 660 KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL KLKDGQQQNE 670 680 690 700 710 720 TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI MLQNLQERLE RKKRIEEIMK 730 740 750 760 770 780 RTRKTDVNAS KVTETSSHDI YEEAEADNEE SDKDSLNEMF PSAILNGTGS PTKFKMPFNN 790 800 810 820 830 840 AKKMTHKLVF LEDGTSQVRK EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT 850 860 870 KTRKADETNT TSRSSAQTKS EGFHDILPKS SDTFRQ
	Isoform 2 [UniParc]. Checksum: 636105ADE4362780	FASTA	835	93,785
	10 20 30 40 50 60 MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI RSTFKPVIDG 70 80 90 100 110 120 SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL QYEKQMEERQ RKLKERKEKE 130 140 150 160 170 180 EQRRIAAEEK RHQKDEAQKE KFTAILYRTL ERRRLADDYQ QKRWSWGGSA MANSESKTAN 190 200 210 220 230 240 KRSASTEKLE QGTSALIRQM PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA 250 260 270 280 290 300 ERKPRVEESP LEKVETPPKA SVDAPPQVNV EVFCNTSMEA SPKAGVGMAP EVSTDSFPVV 310 320 330 340 350 360 SVDVSPVVST YDSEMSMDAS PELSIEALPK VDLETVPKVS IVASPEASLE APPEVSLEAL 370 380 390 400 410 420 PEVSVEAAPE GSLEAPPKGS AEVAPKESVK GSPKESMEAS PEAMVKASPK TSLEASMEAS 430 440 450 460 470 480 PKAKARDAPK KSEMDKQALI PIAKKRLSSY TECYKWSSSP ENACGLPSPI STNRQIQKNC 490 500 510 520 530 540 PPSPLPLISK QSPQTSFPYK IMPIQHTLSV QSASSTVKKK KETVSKTTNR CEALSQRHMI 550 560 570 580 590 600 YEESGNKSTA GIMNAEAATK ILTELRRLAR EQREKEEEER QREEMQQRVI KKSKDMAKEA 610 620 630 640 650 660 VGGQAEDHLK LKDGQQQNET KKKKGWLDQE DQEAPLQKGD AKIKAQEEAD KRKKEHERIM 670 680 690 700 710 720 LQNLQERLER KKRIEEIMKR TRKTDVNASK VTETSSHDIY EEAEADNEES DKDSLNEMFP 730 740 750 760 770 780 SAILNGTGSP TKFKMPFNNA KKMTHKLVFL EDGTSQVRKE PKTYFNGDLK NFRQKSMKDT 790 800 810 820 830 SIQEVVSRPS SKRMTSHTTK TRKADETNTT SRSSAQTKSE GFHDILPKSS DTFRQ
	Isoform 3 [UniParc]. Checksum: 991CB99A9EA667C2	FASTA	841	94,675
	10 20 30 40 50 60 MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI RSTFKPVIDG 70 80 90 100 110 120 SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL QYEKQMEERQ RKLKERKEKE 130 140 150 160 170 180 EQRRIAAEEK RHQKDEAQKE KFTAILYRTL ERRRLADDYQ QKRWSWGGSA MANSESKTGK 190 200 210 220 230 240 TDKERSSSLN RRDSNLHSST DKEQAERKPR VTGVTNYVMQ YVTVPLRKCT SDELRAVMFP 250 260 270 280 290 300 MSTMKIPPQT KVEESPLEKV ETPPKASVDA PPQVNVEVFC NTSMEASPKA GVGMAPEVST 310 320 330 340 350 360 DSFPVVSVDV SPVVSTYDSE MSMDASPELS IEALPKVDLE TVPKVSIVAS PEASLEAPPE 370 380 390 400 410 420 VSLEALPEVS VEAAPEGSLE APPKGSAEVA PKESVKGSPK ESMEASPEAM VKASPKTSLE 430 440 450 460 470 480 ASMEASPKAK ARDAPKKSEM DKQALIPIAK KRLSSYTECY KWSSSPENAC GLPSPISTNR 490 500 510 520 530 540 QIQKNCPPSP LPLISKQSPQ TSFPYKIMPI QHTLSVQSAS STVKKKKETV SKTTNRCEAL 550 560 570 580 590 600 SQRHMIYEES GNKSTAGIMN AEAATKILTE LRRLAREQRE KEEEERQREE MQQRVIKKSK 610 620 630 640 650 660 DMAKEAVGGQ AEDHLKLKDG QQQNETKKKK GWLDQEDQEA PLQKGDAKIK AQEEADKRKK 670 680 690 700 710 720 EHERIMLQNL QERLERKKRI EEIMKRTRKT DVNASKVTET SSHDIYEEAE ADNEESDKDS 730 740 750 760 770 780 LNEMFPSAIL NGTGSPTKFK MPFNNAKKMT HKLVFLEDGT SQVRKEPKTY FNGDLKNFRQ 790 800 810 820 830 840 KSMKDTSIQE VVSRPSSKRM TSHTTKTRKA DETNTTSRSS AQTKSEGFHD ILPKSSDTFR Q
	Isoform 4 [UniParc]. Checksum: 46B3C99CFE457147	FASTA	858	96,743
	10 20 30 40 50 60 MTSPRVAAAN EIAKERRKQD VVNRVATHSS NIRSTFKPVI DGSMLKNDIK QRLARERREE 70 80 90 100 110 120 KRRQQDANKE TQLLEKERKT KLQYEKQMEE RQRKLKERKE KEEQRRIAAE EKRHQKDEAQ 130 140 150 160 170 180 KEKFTAILYR TLERRRLADD YQQKRWSWGG SAMANSESKT ANKRSASTEK LEQGTSALIR 190 200 210 220 230 240 QMPLSSAGLQ NSVAKRKTDK ERSSSLNRRD SNLHSSTDKE QAERKPRVTG VTNYVMQYVT 250 260 270 280 290 300 VPLRKCTSDE LRAVMFPMST MKIPPQTKVE ESPLEKVETP PKASVDAPPQ VNVEVFCNTS 310 320 330 340 350 360 MEASPKAGVG MAPEVSTDSF PVVSVDVSPV VSTYDSEMSM DASPELSIEA LPKVDLETVP 370 380 390 400 410 420 KVSIVASPEA SLEAPPEVSL EALPEVSVEA APEGSLEAPP KGSAEVAPKE SVKGSPKESM 430 440 450 460 470 480 EASPEAMVKA SPKTSLEASM EASPKAKARD APKKSEMDKQ ALIPIAKKRL SSYTECYKWS 490 500 510 520 530 540 SSPENACGLP SPISTNRQIQ KNCPPSPLPL ISKQSPQTSF PYKIMPIQHT LSVQSASSTV 550 560 570 580 590 600 KKKKETVSKT TNRCEALSQR HMIYEESGNK STAGIMNAEA ATKILTELRR LAREQREKEE 610 620 630 640 650 660 EERQREEMQQ RVIKKSKDMA KEAVGGQAED HLKLKDGQQQ NETKKKKGWL DQEDQEAPLQ 670 680 690 700 710 720 KGDAKIKAQE EADKRKKEHE RIMLQNLQER LERKKRIEEI MKRTRKTDVN ASKVTETSSH 730 740 750 760 770 780 DIYEEAEADN EESDKDSLNE MFPSAILNGT GSPTKFKMPF NNAKKMTHKL VFLEDGTSQV 790 800 810 820 830 840 RKEPKTYFNG DLKNFRQKSM KDTSIQEVVS RPSSKRMTSH TTKTRKADET NTTSRSSAQT 850 KSEGFHDILP KSSDTFRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 701-876 (ISOFORMS 1/2/3). Tissue: Synovium and Teratocarcinoma.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Cervix.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ALA-502 AND ARG-628. Tissue: Brain and Prostate.
[6]	"Proteome analysis of the human mitotic spindle." Sauer G., Koerner R., Hanisch A., Ries A., Nigg E.A., Sillje H.H.W. Mol. Cell. Proteomics 4:35-43(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322; SER-457; SER-461 AND SER-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-770, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022711 mRNA. Translation: BAB14195.1. AK301478 mRNA. Translation: BAG62994.1. AL832120 mRNA. No translation available. AL078638 Genomic DNA. Translation: CAI41063.2. AL078638 Genomic DNA. Translation: CAI41064.2. AL078638 Genomic DNA. Translation: CAM21578.1. Sequence problems. CH471150 Genomic DNA. Translation: EAW88475.1. BC040518 mRNA. Translation: AAH40518.1. BC064350 mRNA. Translation: AAH64350.1. Sequence problems.
RefSeq	NP_001166987.1. NM_001173516.1. NP_001166988.1. NM_001173517.1. NP_078873.2. NM_024597.3.
UniGene	Hs.446275.
3D structure databases
ProteinModelPortal	Q8IWC1.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	122777. 4 interactions.
IntAct	Q8IWC1. 1 interaction.
MINT	MINT-4990235.
STRING	9606.ENSP00000318086.
PTM databases
PhosphoSite	Q8IWC1.
Polymorphism databases
DMDM	158705880.
Proteomic databases
PaxDb	Q8IWC1.
PRIDE	Q8IWC1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316077; ENSP00000318086; ENSG00000129680. [Q8IWC1-1] ENST00000370661; ENSP00000359695; ENSG00000129680. [Q8IWC1-3] ENST00000370663; ENSP00000359697; ENSG00000129680. [Q8IWC1-4]
GeneID	79649.
KEGG	hsa:79649.
UCSC	uc004ezs.3. human. [Q8IWC1-3] uc004ezt.3. human. [Q8IWC1-1] uc010nsa.2. human. [Q8IWC1-2]
Organism-specific databases
CTD	79649.
GeneCards	GC0XM135295.
H-InvDB	HIX0017079.
HGNC	HGNC:25742. MAP7D3.
HPA	HPA035598.
neXtProt	NX_Q8IWC1.
PharmGKB	PA162394972.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG113680.
HOVERGEN	HBG103577.
InParanoid	Q8IWC1.
KO	K16807.
OMA	QQDANKE.
OrthoDB	EOG761BTS.
PhylomeDB	Q8IWC1.
TreeFam	TF332273.
Gene expression databases
Bgee	Q8IWC1.
CleanEx	HS_MAP7D3.
Genevestigator	Q8IWC1.
Family and domain databases
InterPro	IPR008604. MAP7. [Graphical view]
PANTHER	PTHR15073. PTHR15073. 1 hit.
Pfam	PF05672. MAP7. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79649.
NextBio	68800.
PRO	Q8IWC1.

Entry information

Entry name

MA7D3_HUMAN

Accession

Primary (citable) accession number: Q8IWC1
Secondary accession number(s): A2A2J0 , A6NCZ7, A6NHR4, B4DWD2, H7BY77, Q5JXI5, Q5JXI6, Q6P2S1, Q9H9M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	April 16, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.