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UniProtKB - Q8IWC1 (MA7D3_HUMAN)

UniProt

Q8IWC1 - MA7D3_HUMAN

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Protein

MAP7 domain-containing protein 3

Gene

MAP7D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the assembly and stability of microtubules.2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • structural molecule activity Source: GO_Central
  • tubulin binding Source: UniProtKB

GO - Biological processi

  • microtubule cytoskeleton organization Source: UniProtKB
  • microtubule polymerization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAP7 domain-containing protein 3
Gene namesi
Name:MAP7D3
Synonyms:MDP31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25742. MAP7D3.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • centrosome Source: HPA
  • cytoplasm Source: HPA
  • membrane Source: UniProtKB
  • microtubule cytoskeleton Source: GO_Central
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394972.

Polymorphism and mutation databases

BioMutaiMAP7D3.
DMDMi158705880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876MAP7 domain-containing protein 3PRO_0000306812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei185 – 1851PhosphoserineCombined sources
Modified residuei322 – 3221PhosphoserineCombined sources
Modified residuei441 – 4411PhosphoserineCombined sources
Modified residuei457 – 4571PhosphoserineCombined sources
Modified residuei461 – 4611PhosphoserineCombined sources
Modified residuei490 – 4901PhosphoserineCombined sources
Modified residuei524 – 5241PhosphoserineCombined sources
Modified residuei770 – 7701PhosphoserineCombined sources
Modified residuei817 – 8171PhosphoserineCombined sources
Modified residuei832 – 8321PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IWC1.
MaxQBiQ8IWC1.
PaxDbiQ8IWC1.
PeptideAtlasiQ8IWC1.
PRIDEiQ8IWC1.

PTM databases

iPTMnetiQ8IWC1.
PhosphoSiteiQ8IWC1.

Expressioni

Inductioni

Expression is cell cycle dependent with the highest levels during G1, S, and M phases, and low level in G2 phase.1 Publication

Gene expression databases

BgeeiENSG00000129680.
CleanExiHS_MAP7D3.
ExpressionAtlasiQ8IWC1. baseline and differential.
GenevisibleiQ8IWC1. HS.

Organism-specific databases

HPAiHPA035598.
HPA058101.

Interactioni

Subunit structurei

Interacts (via N-terminus coiled coil domains) with tubulin and microtubules.2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122777. 34 interactions.
IntActiQ8IWC1. 24 interactions.
MINTiMINT-4990235.
STRINGi9606.ENSP00000318086.

Structurei

3D structure databases

ProteinModelPortaliQ8IWC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili65 – 14480Sequence analysisAdd
BLAST
Coiled coili558 – 64083Sequence analysisAdd
BLAST
Coiled coili689 – 72436Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the MAP7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIZ9. Eukaryota.
ENOG410YMWJ. LUCA.
GeneTreeiENSGT00660000095160.
HOVERGENiHBG103577.
InParanoidiQ8IWC1.
KOiK16807.
OMAiQQDANKE.
OrthoDBiEOG091G05LZ.
PhylomeDBiQ8IWC1.
TreeFamiTF332273.

Family and domain databases

InterProiIPR008604. MAP7_fam.
[Graphical view]
PANTHERiPTHR15073. PTHR15073. 4 hits.
PfamiPF05672. MAP7. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI 
        60         70         80         90        100
RSTFKPVIDG SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL 
       110        120        130        140        150
QYEKQMEERQ RKLKERKEKE EQRRIAAEEK RHQKDEAQKE KFTAILYRTL 
       160        170        180        190        200
ERRRLADDYQ QKRWSWGGSA MANSESKTAN KRSASTEKLE QGTSALIRQM 
       210        220        230        240        250
PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA ERKPRVTGVT 
       260        270        280        290        300
NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK 
       310        320        330        340        350
ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS 
       360        370        380        390        400
TYDSEMSMDA SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA 
       410        420        430        440        450
LPEVSVEAAP EGSLEAPPKG SAEVAPKESV KGSPKESMEA SPEAMVKASP 
       460        470        480        490        500
KTSLEASMEA SPKAKARDAP KKSEMDKQAL IPIAKKRLSS YTECYKWSSS 
       510        520        530        540        550
PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY KIMPIQHTLS 
       560        570        580        590        600
VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT 
       610        620        630        640        650
KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL 
       660        670        680        690        700
KLKDGQQQNE TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI 
       710        720        730        740        750
MLQNLQERLE RKKRIEEIMK RTRKTDVNAS KVTETSSHDI YEEAEADNEE 
       760        770        780        790        800
SDKDSLNEMF PSAILNGTGS PTKFKMPFNN AKKMTHKLVF LEDGTSQVRK 
       810        820        830        840        850
EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT KTRKADETNT 
       860        870 
TSRSSAQTKS EGFHDILPKS SDTFRQ
Length:876
Mass (Da):98,429
Last modified:October 2, 2007 - v2
Checksum:iC149899FB0002B39
GO
Isoform 2 (identifier: Q8IWC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-286: Missing.

Note: No experimental confirmation available.
Show »
Length:835
Mass (Da):93,785
Checksum:i636105ADE4362780
GO
Isoform 3 (identifier: Q8IWC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-214: ANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKR → G

Note: No experimental confirmation available.
Show »
Length:841
Mass (Da):94,675
Checksum:i991CB99A9EA667C2
GO
Isoform 4 (identifier: Q8IWC1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MMADGAAAGAGGSPSLRELRARM → MTSPR

Note: No experimental confirmation available.
Show »
Length:858
Mass (Da):96,743
Checksum:i46B3C99CFE457147
GO

Sequence cautioni

The sequence AAH64350 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAM21578 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711L → S in BAG62994 (PubMed:14702039).Curated
Sequence conflicti447 – 4471K → R in BAG62994 (PubMed:14702039).Curated
Sequence conflicti448 – 4481A → T in AAH40518 (PubMed:15489334).Curated
Sequence conflicti623 – 6231R → Q in AL832120 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti502 – 5021E → A.1 Publication
Corresponds to variant rs1055497 [ dbSNP | Ensembl ].		VAR_035314
Natural varianti628 – 6281Q → R.1 Publication
Corresponds to variant rs2273221 [ dbSNP | Ensembl ].		VAR_035315

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MMADG…LRARM → MTSPR in isoform 4. 1 PublicationVSP_045008Add
BLAST
Alternative sequencei179 – 21436ANKRS…SVAKR → G in isoform 3. 1 PublicationVSP_028498Add
BLAST
Alternative sequencei246 – 28641Missing in isoform 2. 1 PublicationVSP_028499Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022711 mRNA. Translation: BAB14195.1.
AK301478 mRNA. Translation: BAG62994.1.
AL832120 mRNA. No translation available.
AL078638 Genomic DNA. Translation: CAI41063.2.
AL078638 Genomic DNA. Translation: CAI41064.2.
AL078638 Genomic DNA. Translation: CAM21578.1. Sequence problems.
CH471150 Genomic DNA. Translation: EAW88475.1.
BC040518 mRNA. Translation: AAH40518.1.
BC064350 mRNA. Translation: AAH64350.1. Sequence problems.
CCDSiCCDS44004.1. [Q8IWC1-1]
CCDS55508.1. [Q8IWC1-3]
CCDS55509.1. [Q8IWC1-4]
RefSeqiNP_001166987.1. NM_001173516.1. [Q8IWC1-4]
NP_001166988.1. NM_001173517.1. [Q8IWC1-3]
NP_078873.2. NM_024597.3. [Q8IWC1-1]
UniGeneiHs.446275.

Genome annotation databases

EnsembliENST00000316077; ENSP00000318086; ENSG00000129680. [Q8IWC1-1]
ENST00000370661; ENSP00000359695; ENSG00000129680. [Q8IWC1-3]
ENST00000370663; ENSP00000359697; ENSG00000129680. [Q8IWC1-4]
GeneIDi79649.
KEGGihsa:79649.
UCSCiuc004ezs.4. human. [Q8IWC1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022711 mRNA. Translation: BAB14195.1.
AK301478 mRNA. Translation: BAG62994.1.
AL832120 mRNA. No translation available.
AL078638 Genomic DNA. Translation: CAI41063.2.
AL078638 Genomic DNA. Translation: CAI41064.2.
AL078638 Genomic DNA. Translation: CAM21578.1. Sequence problems.
CH471150 Genomic DNA. Translation: EAW88475.1.
BC040518 mRNA. Translation: AAH40518.1.
BC064350 mRNA. Translation: AAH64350.1. Sequence problems.
CCDSiCCDS44004.1. [Q8IWC1-1]
CCDS55508.1. [Q8IWC1-3]
CCDS55509.1. [Q8IWC1-4]
RefSeqiNP_001166987.1. NM_001173516.1. [Q8IWC1-4]
NP_001166988.1. NM_001173517.1. [Q8IWC1-3]
NP_078873.2. NM_024597.3. [Q8IWC1-1]
UniGeneiHs.446275.

3D structure databases

ProteinModelPortaliQ8IWC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122777. 34 interactions.
IntActiQ8IWC1. 24 interactions.
MINTiMINT-4990235.
STRINGi9606.ENSP00000318086.

PTM databases

iPTMnetiQ8IWC1.
PhosphoSiteiQ8IWC1.

Polymorphism and mutation databases

BioMutaiMAP7D3.
DMDMi158705880.

Proteomic databases

EPDiQ8IWC1.
MaxQBiQ8IWC1.
PaxDbiQ8IWC1.
PeptideAtlasiQ8IWC1.
PRIDEiQ8IWC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316077; ENSP00000318086; ENSG00000129680. [Q8IWC1-1]
ENST00000370661; ENSP00000359695; ENSG00000129680. [Q8IWC1-3]
ENST00000370663; ENSP00000359697; ENSG00000129680. [Q8IWC1-4]
GeneIDi79649.
KEGGihsa:79649.
UCSCiuc004ezs.4. human. [Q8IWC1-1]

Organism-specific databases

CTDi79649.
GeneCardsiMAP7D3.
H-InvDBHIX0017079.
HGNCiHGNC:25742. MAP7D3.
HPAiHPA035598.
HPA058101.
MIMi300930. gene.
neXtProtiNX_Q8IWC1.
PharmGKBiPA162394972.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZ9. Eukaryota.
ENOG410YMWJ. LUCA.
GeneTreeiENSGT00660000095160.
HOVERGENiHBG103577.
InParanoidiQ8IWC1.
KOiK16807.
OMAiQQDANKE.
OrthoDBiEOG091G05LZ.
PhylomeDBiQ8IWC1.
TreeFamiTF332273.

Miscellaneous databases

ChiTaRSiMAP7D3. human.
GenomeRNAii79649.
PROiQ8IWC1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129680.
CleanExiHS_MAP7D3.
ExpressionAtlasiQ8IWC1. baseline and differential.
GenevisibleiQ8IWC1. HS.

Family and domain databases

InterProiIPR008604. MAP7_fam.
[Graphical view]
PANTHERiPTHR15073. PTHR15073. 4 hits.
PfamiPF05672. MAP7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMA7D3_HUMAN
AccessioniPrimary (citable) accession number: Q8IWC1
Secondary accession number(s): A2A2J0
, A6NCZ7, A6NHR4, B4DWD2, H7BY77, Q5JXI5, Q5JXI6, Q6P2S1, Q9H9M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.