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Q8IWB9

- TEX2_HUMAN

UniProt

Q8IWB9 - TEX2_HUMAN

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Protein
Testis-expressed sequence 2 protein
Gene
TEX2, KIAA1738, TMEM96
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. signal transduction Source: UniProtKB
  2. sphingolipid metabolic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 2 protein
Alternative name(s):
Transmembrane protein 96
Gene namesi
Name:TEX2
Synonyms:KIAA1738, TMEM96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:30884. TEX2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei475 – 49521Helical; Reviewed prediction
Add
BLAST
Transmembranei497 – 51721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11271127Testis-expressed sequence 2 protein
PRO_0000244479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961Phosphoserine1 Publication
Modified residuei262 – 2621Phosphothreonine By similarity
Modified residuei265 – 2651Phosphoserine By similarity
Modified residuei266 – 2661Phosphoserine1 Publication
Modified residuei270 – 2701Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine2 Publications
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
Modified residuei744 – 7441Phosphoserine1 Publication
Modified residuei748 – 7481Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IWB9.
PaxDbiQ8IWB9.
PRIDEiQ8IWB9.

PTM databases

PhosphoSiteiQ8IWB9.

Miscellaneous databases

PMAP-CutDBQ8IWB9.

Expressioni

Gene expression databases

ArrayExpressiQ8IWB9.
BgeeiQ8IWB9.
CleanExiHS_TEX2.
GenevestigatoriQ8IWB9.

Organism-specific databases

HPAiHPA020648.

Interactioni

Protein-protein interaction databases

BioGridi120954. 1 interaction.
DIPiDIP-47321N.
IntActiQ8IWB9. 3 interactions.
STRINGi9606.ENSP00000258991.

Structurei

3D structure databases

ProteinModelPortaliQ8IWB9.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 519Poly-Glu
Compositional biasi138 – 1414Poly-Ser
Compositional biasi159 – 1624Poly-Ser
Compositional biasi816 – 8216Poly-Glu
Compositional biasi1039 – 10424Poly-Pro

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300813.
HOGENOMiHOG000049176.
HOVERGENiHBG062867.
InParanoidiQ8IWB9.
OMAiTAVCMIW.
PhylomeDBiQ8IWB9.
TreeFamiTF314900.

Family and domain databases

InterProiIPR019411. DUF2404.
IPR001849. PH_domain.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IWB9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE     50
EFREYFEEGL DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV 100
SQAPAILPVS KNTVKLLESP VPAAQVLSTV PLAVSPGSSS SGPLASSPSV 150
SSLSEQKTSS SSPLSSPSKS PILSSSASTS TLSSAKPFMS LVKSLSTEVE 200
PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS KLNLHLFKQF 250
TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE 300
PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE 350
CDSEGDGYGS DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL 400
VLEKCSLSAL VSKEDEEFCE LYTEDFDLET EGESKVDKLS DIPLKPEVLA 450
EDGVVLDSED EVDSAVQHPE LPVKTLGFFI MCVYVYLILP LPHYVSGLFL 500
GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD IKEPEILKGW 550
MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE 600
VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ 650
TDKETSEEKP PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW 700
FRRFILASKL KSEIKKSSGV SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG 750
SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM GRCVPQESRS PQRSPLQSAE 800
SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY WSDLVSKKIQ 850
MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY 900
NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES 950
SSAGSSEEDD APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF 1000
QKATETEFIK KKIEEVSNTP LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF 1050
RKPPHVELKA RPKLGEREVT LVHVTDWIEK KLEQEFQKVF VMPNMDDVYI 1100
TIMHSAMDPR STSCLLKDPP VEAADQP 1127
Length:1,127
Mass (Da):125,303
Last modified:June 27, 2006 - v2
Checksum:i100D99905117CD57
GO
Isoform 2 (identifier: Q8IWB9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     724-724: K → KPAPVFLA

Show »
Length:1,134
Mass (Da):125,999
Checksum:i6B3306E0BCBDC439
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581T → I.
Corresponds to variant rs28605685 [ dbSNP | Ensembl ].
VAR_061712

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei724 – 7241K → KPAPVFLA in isoform 2.
VSP_019569

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531R → K in AAH40521. 1 Publication
Sequence conflicti363 – 3631N → S in CAD38927. 1 Publication
Sequence conflicti446 – 4461P → S in CAH10519. 1 Publication
Sequence conflicti451 – 4511E → K in AAH40521. 1 Publication
Sequence conflicti608 – 6081I → V in CAD38927. 1 Publication
Sequence conflicti634 – 6341P → L in CAD38927. 1 Publication
Sequence conflicti725 – 7295PGLLP → LRAFA in CAH10519. 1 Publication
Sequence conflicti835 – 8351F → S in CAD38927. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051525 mRNA. Translation: BAB21829.2.
AL834251 mRNA. Translation: CAD38927.1.
CR627433 mRNA. Translation: CAH10519.1.
BC040521 mRNA. Translation: AAH40521.1.
CCDSiCCDS11658.1. [Q8IWB9-2]
RefSeqiNP_001275661.1. NM_001288732.1. [Q8IWB9-1]
NP_001275662.1. NM_001288733.1. [Q8IWB9-1]
NP_060939.3. NM_018469.4. [Q8IWB9-2]
UniGeneiHs.175414.

Genome annotation databases

EnsembliENST00000258991; ENSP00000258991; ENSG00000136478. [Q8IWB9-2]
ENST00000571438; ENSP00000459081; ENSG00000263185. [Q8IWB9-2]
ENST00000580023; ENSP00000462409; ENSG00000263185. [Q8IWB9-1]
ENST00000580932; ENSP00000461913; ENSG00000263185. [Q8IWB9-1]
ENST00000583097; ENSP00000462665; ENSG00000136478. [Q8IWB9-1]
ENST00000584379; ENSP00000463001; ENSG00000136478. [Q8IWB9-1]
GeneIDi55852.
KEGGihsa:55852.
UCSCiuc002jec.3. human. [Q8IWB9-1]
uc002jed.3. human. [Q8IWB9-2]

Polymorphism databases

DMDMi109895136.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051525 mRNA. Translation: BAB21829.2 .
AL834251 mRNA. Translation: CAD38927.1 .
CR627433 mRNA. Translation: CAH10519.1 .
BC040521 mRNA. Translation: AAH40521.1 .
CCDSi CCDS11658.1. [Q8IWB9-2 ]
RefSeqi NP_001275661.1. NM_001288732.1. [Q8IWB9-1 ]
NP_001275662.1. NM_001288733.1. [Q8IWB9-1 ]
NP_060939.3. NM_018469.4. [Q8IWB9-2 ]
UniGenei Hs.175414.

3D structure databases

ProteinModelPortali Q8IWB9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120954. 1 interaction.
DIPi DIP-47321N.
IntActi Q8IWB9. 3 interactions.
STRINGi 9606.ENSP00000258991.

PTM databases

PhosphoSitei Q8IWB9.

Polymorphism databases

DMDMi 109895136.

Proteomic databases

MaxQBi Q8IWB9.
PaxDbi Q8IWB9.
PRIDEi Q8IWB9.

Protocols and materials databases

DNASUi 55852.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258991 ; ENSP00000258991 ; ENSG00000136478 . [Q8IWB9-2 ]
ENST00000571438 ; ENSP00000459081 ; ENSG00000263185 . [Q8IWB9-2 ]
ENST00000580023 ; ENSP00000462409 ; ENSG00000263185 . [Q8IWB9-1 ]
ENST00000580932 ; ENSP00000461913 ; ENSG00000263185 . [Q8IWB9-1 ]
ENST00000583097 ; ENSP00000462665 ; ENSG00000136478 . [Q8IWB9-1 ]
ENST00000584379 ; ENSP00000463001 ; ENSG00000136478 . [Q8IWB9-1 ]
GeneIDi 55852.
KEGGi hsa:55852.
UCSCi uc002jec.3. human. [Q8IWB9-1 ]
uc002jed.3. human. [Q8IWB9-2 ]

Organism-specific databases

CTDi 55852.
GeneCardsi GC17M062224.
H-InvDB HIX0014085.
HGNCi HGNC:30884. TEX2.
HPAi HPA020648.
neXtProti NX_Q8IWB9.
PharmGKBi PA142670820.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300813.
HOGENOMi HOG000049176.
HOVERGENi HBG062867.
InParanoidi Q8IWB9.
OMAi TAVCMIW.
PhylomeDBi Q8IWB9.
TreeFami TF314900.

Miscellaneous databases

ChiTaRSi TEX2. human.
GenomeRNAii 55852.
NextBioi 61119.
PMAP-CutDB Q8IWB9.
PROi Q8IWB9.

Gene expression databases

ArrayExpressi Q8IWB9.
Bgeei Q8IWB9.
CleanExi HS_TEX2.
Genevestigatori Q8IWB9.

Family and domain databases

InterProi IPR019411. DUF2404.
IPR001849. PH_domain.
[Graphical view ]
Pfami PF10296. DUF2404. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-266; SER-270 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-744, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTEX2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB9
Secondary accession number(s): Q6AHZ5, Q8N3L0, Q9C0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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