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Protein

Testis-expressed sequence 2 protein

Gene

TEX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • signal transduction Source: UniProtKB
  • sphingolipid metabolic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 2 protein
Alternative name(s):
Transmembrane protein 96
Gene namesi
Name:TEX2
Synonyms:KIAA1738, TMEM96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30884. TEX2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: GO_Central
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136478.
PharmGKBiPA142670820.

Polymorphism and mutation databases

DMDMi109895136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444791 – 1127Testis-expressed sequence 2 proteinAdd BLAST1127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1
Modified residuei262PhosphothreonineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei266PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Modified residuei732PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei748PhosphoserineBy similarity1
Modified residuei751PhosphoserineBy similarity1
Modified residuei798PhosphoserineBy similarity1
Modified residuei815PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IWB9.
PaxDbiQ8IWB9.
PeptideAtlasiQ8IWB9.
PRIDEiQ8IWB9.

PTM databases

iPTMnetiQ8IWB9.
PhosphoSitePlusiQ8IWB9.

Miscellaneous databases

PMAP-CutDBQ8IWB9.

Expressioni

Gene expression databases

BgeeiENSG00000136478.
CleanExiHS_TEX2.
ExpressionAtlasiQ8IWB9. baseline and differential.
GenevisibleiQ8IWB9. HS.

Organism-specific databases

HPAiHPA020648.
HPA057116.

Interactioni

Protein-protein interaction databases

BioGridi120954. 6 interactors.
DIPiDIP-47321N.
IntActiQ8IWB9. 6 interactors.
STRINGi9606.ENSP00000258991.

Structurei

3D structure databases

ProteinModelPortaliQ8IWB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 51Poly-Glu9
Compositional biasi138 – 141Poly-Ser4
Compositional biasi159 – 162Poly-Ser4
Compositional biasi816 – 821Poly-Glu6
Compositional biasi1039 – 1042Poly-Pro4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2238. Eukaryota.
ENOG410Z3SZ. LUCA.
GeneTreeiENSGT00390000000463.
HOGENOMiHOG000049176.
HOVERGENiHBG062867.
InParanoidiQ8IWB9.
OMAiMSKAQTD.
OrthoDBiEOG091G01R4.
PhylomeDBiQ8IWB9.
TreeFamiTF314900.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE
60 70 80 90 100
EFREYFEEGL DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV
110 120 130 140 150
SQAPAILPVS KNTVKLLESP VPAAQVLSTV PLAVSPGSSS SGPLASSPSV
160 170 180 190 200
SSLSEQKTSS SSPLSSPSKS PILSSSASTS TLSSAKPFMS LVKSLSTEVE
210 220 230 240 250
PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS KLNLHLFKQF
260 270 280 290 300
TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE
310 320 330 340 350
PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE
360 370 380 390 400
CDSEGDGYGS DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL
410 420 430 440 450
VLEKCSLSAL VSKEDEEFCE LYTEDFDLET EGESKVDKLS DIPLKPEVLA
460 470 480 490 500
EDGVVLDSED EVDSAVQHPE LPVKTLGFFI MCVYVYLILP LPHYVSGLFL
510 520 530 540 550
GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD IKEPEILKGW
560 570 580 590 600
MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE
610 620 630 640 650
VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ
660 670 680 690 700
TDKETSEEKP PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW
710 720 730 740 750
FRRFILASKL KSEIKKSSGV SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG
760 770 780 790 800
SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM GRCVPQESRS PQRSPLQSAE
810 820 830 840 850
SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY WSDLVSKKIQ
860 870 880 890 900
MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY
910 920 930 940 950
NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES
960 970 980 990 1000
SSAGSSEEDD APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF
1010 1020 1030 1040 1050
QKATETEFIK KKIEEVSNTP LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF
1060 1070 1080 1090 1100
RKPPHVELKA RPKLGEREVT LVHVTDWIEK KLEQEFQKVF VMPNMDDVYI
1110 1120
TIMHSAMDPR STSCLLKDPP VEAADQP
Length:1,127
Mass (Da):125,303
Last modified:June 27, 2006 - v2
Checksum:i100D99905117CD57
GO
Isoform 2 (identifier: Q8IWB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     724-724: K → KPAPVFLA

Show »
Length:1,134
Mass (Da):125,999
Checksum:i6B3306E0BCBDC439
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53R → K in AAH40521 (PubMed:15489334).Curated1
Sequence conflicti363N → S in CAD38927 (PubMed:17974005).Curated1
Sequence conflicti446P → S in CAH10519 (PubMed:17974005).Curated1
Sequence conflicti451E → K in AAH40521 (PubMed:15489334).Curated1
Sequence conflicti608I → V in CAD38927 (PubMed:17974005).Curated1
Sequence conflicti634P → L in CAD38927 (PubMed:17974005).Curated1
Sequence conflicti725 – 729PGLLP → LRAFA in CAH10519 (PubMed:17974005).Curated5
Sequence conflicti835F → S in CAD38927 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061712158T → I.Corresponds to variant rs28605685dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019569724K → KPAPVFLA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051525 mRNA. Translation: BAB21829.2.
AL834251 mRNA. Translation: CAD38927.1.
CR627433 mRNA. Translation: CAH10519.1.
BC040521 mRNA. Translation: AAH40521.1.
CCDSiCCDS11658.1. [Q8IWB9-2]
CCDS74131.1. [Q8IWB9-1]
RefSeqiNP_001275661.1. NM_001288732.1. [Q8IWB9-1]
NP_001275662.1. NM_001288733.1. [Q8IWB9-1]
NP_060939.3. NM_018469.4. [Q8IWB9-2]
XP_011523300.1. XM_011524998.1. [Q8IWB9-2]
XP_011523301.1. XM_011524999.1. [Q8IWB9-2]
UniGeneiHs.175414.

Genome annotation databases

EnsembliENST00000258991; ENSP00000258991; ENSG00000136478. [Q8IWB9-2]
ENST00000583097; ENSP00000462665; ENSG00000136478. [Q8IWB9-1]
ENST00000584379; ENSP00000463001; ENSG00000136478. [Q8IWB9-1]
GeneIDi55852.
KEGGihsa:55852.
UCSCiuc002jec.5. human. [Q8IWB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051525 mRNA. Translation: BAB21829.2.
AL834251 mRNA. Translation: CAD38927.1.
CR627433 mRNA. Translation: CAH10519.1.
BC040521 mRNA. Translation: AAH40521.1.
CCDSiCCDS11658.1. [Q8IWB9-2]
CCDS74131.1. [Q8IWB9-1]
RefSeqiNP_001275661.1. NM_001288732.1. [Q8IWB9-1]
NP_001275662.1. NM_001288733.1. [Q8IWB9-1]
NP_060939.3. NM_018469.4. [Q8IWB9-2]
XP_011523300.1. XM_011524998.1. [Q8IWB9-2]
XP_011523301.1. XM_011524999.1. [Q8IWB9-2]
UniGeneiHs.175414.

3D structure databases

ProteinModelPortaliQ8IWB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120954. 6 interactors.
DIPiDIP-47321N.
IntActiQ8IWB9. 6 interactors.
STRINGi9606.ENSP00000258991.

PTM databases

iPTMnetiQ8IWB9.
PhosphoSitePlusiQ8IWB9.

Polymorphism and mutation databases

DMDMi109895136.

Proteomic databases

MaxQBiQ8IWB9.
PaxDbiQ8IWB9.
PeptideAtlasiQ8IWB9.
PRIDEiQ8IWB9.

Protocols and materials databases

DNASUi55852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258991; ENSP00000258991; ENSG00000136478. [Q8IWB9-2]
ENST00000583097; ENSP00000462665; ENSG00000136478. [Q8IWB9-1]
ENST00000584379; ENSP00000463001; ENSG00000136478. [Q8IWB9-1]
GeneIDi55852.
KEGGihsa:55852.
UCSCiuc002jec.5. human. [Q8IWB9-1]

Organism-specific databases

CTDi55852.
GeneCardsiTEX2.
H-InvDBHIX0014085.
HGNCiHGNC:30884. TEX2.
HPAiHPA020648.
HPA057116.
neXtProtiNX_Q8IWB9.
OpenTargetsiENSG00000136478.
PharmGKBiPA142670820.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2238. Eukaryota.
ENOG410Z3SZ. LUCA.
GeneTreeiENSGT00390000000463.
HOGENOMiHOG000049176.
HOVERGENiHBG062867.
InParanoidiQ8IWB9.
OMAiMSKAQTD.
OrthoDBiEOG091G01R4.
PhylomeDBiQ8IWB9.
TreeFamiTF314900.

Miscellaneous databases

ChiTaRSiTEX2. human.
GenomeRNAii55852.
PMAP-CutDBQ8IWB9.
PROiQ8IWB9.

Gene expression databases

BgeeiENSG00000136478.
CleanExiHS_TEX2.
ExpressionAtlasiQ8IWB9. baseline and differential.
GenevisibleiQ8IWB9. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTEX2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB9
Secondary accession number(s): Q6AHZ5, Q8N3L0, Q9C0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.