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Q8IWB9

- TEX2_HUMAN

UniProt

Q8IWB9 - TEX2_HUMAN

Protein

Testis-expressed sequence 2 protein

Gene

TEX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. signal transduction Source: UniProtKB
    2. sphingolipid metabolic process Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-expressed sequence 2 protein
    Alternative name(s):
    Transmembrane protein 96
    Gene namesi
    Name:TEX2
    Synonyms:KIAA1738, TMEM96
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30884. TEX2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670820.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11271127Testis-expressed sequence 2 proteinPRO_0000244479Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei196 – 1961Phosphoserine1 Publication
    Modified residuei262 – 2621PhosphothreonineBy similarity
    Modified residuei265 – 2651PhosphoserineBy similarity
    Modified residuei266 – 2661Phosphoserine1 Publication
    Modified residuei270 – 2701Phosphoserine1 Publication
    Modified residuei295 – 2951Phosphoserine2 Publications
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Modified residuei744 – 7441Phosphoserine1 Publication
    Modified residuei748 – 7481PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8IWB9.
    PaxDbiQ8IWB9.
    PRIDEiQ8IWB9.

    PTM databases

    PhosphoSiteiQ8IWB9.

    Miscellaneous databases

    PMAP-CutDBQ8IWB9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IWB9.
    BgeeiQ8IWB9.
    CleanExiHS_TEX2.
    GenevestigatoriQ8IWB9.

    Organism-specific databases

    HPAiHPA020648.

    Interactioni

    Protein-protein interaction databases

    BioGridi120954. 1 interaction.
    DIPiDIP-47321N.
    IntActiQ8IWB9. 4 interactions.
    STRINGi9606.ENSP00000258991.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWB9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei497 – 51721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi43 – 519Poly-Glu
    Compositional biasi138 – 1414Poly-Ser
    Compositional biasi159 – 1624Poly-Ser
    Compositional biasi816 – 8216Poly-Glu
    Compositional biasi1039 – 10424Poly-Pro

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300813.
    HOGENOMiHOG000049176.
    HOVERGENiHBG062867.
    InParanoidiQ8IWB9.
    OMAiTAVCMIW.
    PhylomeDBiQ8IWB9.
    TreeFamiTF314900.

    Family and domain databases

    InterProiIPR019411. DUF2404.
    IPR001849. PH_domain.
    [Graphical view]
    PfamiPF10296. DUF2404. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IWB9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE     50
    EFREYFEEGL DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV 100
    SQAPAILPVS KNTVKLLESP VPAAQVLSTV PLAVSPGSSS SGPLASSPSV 150
    SSLSEQKTSS SSPLSSPSKS PILSSSASTS TLSSAKPFMS LVKSLSTEVE 200
    PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS KLNLHLFKQF 250
    TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE 300
    PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE 350
    CDSEGDGYGS DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL 400
    VLEKCSLSAL VSKEDEEFCE LYTEDFDLET EGESKVDKLS DIPLKPEVLA 450
    EDGVVLDSED EVDSAVQHPE LPVKTLGFFI MCVYVYLILP LPHYVSGLFL 500
    GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD IKEPEILKGW 550
    MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE 600
    VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ 650
    TDKETSEEKP PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW 700
    FRRFILASKL KSEIKKSSGV SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG 750
    SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM GRCVPQESRS PQRSPLQSAE 800
    SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY WSDLVSKKIQ 850
    MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY 900
    NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES 950
    SSAGSSEEDD APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF 1000
    QKATETEFIK KKIEEVSNTP LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF 1050
    RKPPHVELKA RPKLGEREVT LVHVTDWIEK KLEQEFQKVF VMPNMDDVYI 1100
    TIMHSAMDPR STSCLLKDPP VEAADQP 1127
    Length:1,127
    Mass (Da):125,303
    Last modified:June 27, 2006 - v2
    Checksum:i100D99905117CD57
    GO
    Isoform 2 (identifier: Q8IWB9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         724-724: K → KPAPVFLA

    Show »
    Length:1,134
    Mass (Da):125,999
    Checksum:i6B3306E0BCBDC439
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531R → K in AAH40521. (PubMed:15489334)Curated
    Sequence conflicti363 – 3631N → S in CAD38927. (PubMed:17974005)Curated
    Sequence conflicti446 – 4461P → S in CAH10519. (PubMed:17974005)Curated
    Sequence conflicti451 – 4511E → K in AAH40521. (PubMed:15489334)Curated
    Sequence conflicti608 – 6081I → V in CAD38927. (PubMed:17974005)Curated
    Sequence conflicti634 – 6341P → L in CAD38927. (PubMed:17974005)Curated
    Sequence conflicti725 – 7295PGLLP → LRAFA in CAH10519. (PubMed:17974005)Curated
    Sequence conflicti835 – 8351F → S in CAD38927. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1581T → I.
    Corresponds to variant rs28605685 [ dbSNP | Ensembl ].
    VAR_061712

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei724 – 7241K → KPAPVFLA in isoform 2. 1 PublicationVSP_019569

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051525 mRNA. Translation: BAB21829.2.
    AL834251 mRNA. Translation: CAD38927.1.
    CR627433 mRNA. Translation: CAH10519.1.
    BC040521 mRNA. Translation: AAH40521.1.
    CCDSiCCDS11658.1. [Q8IWB9-2]
    RefSeqiNP_001275661.1. NM_001288732.1. [Q8IWB9-1]
    NP_001275662.1. NM_001288733.1. [Q8IWB9-1]
    NP_060939.3. NM_018469.4. [Q8IWB9-2]
    UniGeneiHs.175414.

    Genome annotation databases

    EnsembliENST00000258991; ENSP00000258991; ENSG00000136478. [Q8IWB9-2]
    ENST00000583097; ENSP00000462665; ENSG00000136478. [Q8IWB9-1]
    ENST00000584379; ENSP00000463001; ENSG00000136478. [Q8IWB9-1]
    GeneIDi55852.
    KEGGihsa:55852.
    UCSCiuc002jec.3. human. [Q8IWB9-1]
    uc002jed.3. human. [Q8IWB9-2]

    Polymorphism databases

    DMDMi109895136.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051525 mRNA. Translation: BAB21829.2 .
    AL834251 mRNA. Translation: CAD38927.1 .
    CR627433 mRNA. Translation: CAH10519.1 .
    BC040521 mRNA. Translation: AAH40521.1 .
    CCDSi CCDS11658.1. [Q8IWB9-2 ]
    RefSeqi NP_001275661.1. NM_001288732.1. [Q8IWB9-1 ]
    NP_001275662.1. NM_001288733.1. [Q8IWB9-1 ]
    NP_060939.3. NM_018469.4. [Q8IWB9-2 ]
    UniGenei Hs.175414.

    3D structure databases

    ProteinModelPortali Q8IWB9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120954. 1 interaction.
    DIPi DIP-47321N.
    IntActi Q8IWB9. 4 interactions.
    STRINGi 9606.ENSP00000258991.

    PTM databases

    PhosphoSitei Q8IWB9.

    Polymorphism databases

    DMDMi 109895136.

    Proteomic databases

    MaxQBi Q8IWB9.
    PaxDbi Q8IWB9.
    PRIDEi Q8IWB9.

    Protocols and materials databases

    DNASUi 55852.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258991 ; ENSP00000258991 ; ENSG00000136478 . [Q8IWB9-2 ]
    ENST00000583097 ; ENSP00000462665 ; ENSG00000136478 . [Q8IWB9-1 ]
    ENST00000584379 ; ENSP00000463001 ; ENSG00000136478 . [Q8IWB9-1 ]
    GeneIDi 55852.
    KEGGi hsa:55852.
    UCSCi uc002jec.3. human. [Q8IWB9-1 ]
    uc002jed.3. human. [Q8IWB9-2 ]

    Organism-specific databases

    CTDi 55852.
    GeneCardsi GC17M062224.
    H-InvDB HIX0014085.
    HGNCi HGNC:30884. TEX2.
    HPAi HPA020648.
    neXtProti NX_Q8IWB9.
    PharmGKBi PA142670820.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300813.
    HOGENOMi HOG000049176.
    HOVERGENi HBG062867.
    InParanoidi Q8IWB9.
    OMAi TAVCMIW.
    PhylomeDBi Q8IWB9.
    TreeFami TF314900.

    Miscellaneous databases

    ChiTaRSi TEX2. human.
    GenomeRNAii 55852.
    NextBioi 61119.
    PMAP-CutDB Q8IWB9.
    PROi Q8IWB9.

    Gene expression databases

    ArrayExpressi Q8IWB9.
    Bgeei Q8IWB9.
    CleanExi HS_TEX2.
    Genevestigatori Q8IWB9.

    Family and domain databases

    InterProi IPR019411. DUF2404.
    IPR001849. PH_domain.
    [Graphical view ]
    Pfami PF10296. DUF2404. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-266; SER-270 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-744, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTEX2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWB9
    Secondary accession number(s): Q6AHZ5, Q8N3L0, Q9C0C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3