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Protein

Testis-expressed sequence 2 protein

Gene

TEX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • signal transduction Source: UniProtKB
  • sphingolipid metabolic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 2 protein
Alternative name(s):
Transmembrane protein 96
Gene namesi
Name:TEX2
Synonyms:KIAA1738, TMEM96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30884. TEX2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei475 – 49521HelicalSequence AnalysisAdd
BLAST
Transmembranei497 – 51721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670820.

Polymorphism and mutation databases

DMDMi109895136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11271127Testis-expressed sequence 2 proteinPRO_0000244479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961Phosphoserine1 Publication
Modified residuei262 – 2621PhosphothreonineBy similarity
Modified residuei265 – 2651PhosphoserineBy similarity
Modified residuei266 – 2661Phosphoserine2 Publications
Modified residuei270 – 2701Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine3 Publications
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Modified residuei732 – 7321Phosphoserine1 Publication
Modified residuei738 – 7381Phosphoserine1 Publication
Modified residuei744 – 7441Phosphoserine2 Publications
Modified residuei748 – 7481PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IWB9.
PaxDbiQ8IWB9.
PRIDEiQ8IWB9.

PTM databases

PhosphoSiteiQ8IWB9.

Miscellaneous databases

PMAP-CutDBQ8IWB9.

Expressioni

Gene expression databases

BgeeiQ8IWB9.
CleanExiHS_TEX2.
ExpressionAtlasiQ8IWB9. baseline and differential.
GenevisibleiQ8IWB9. HS.

Organism-specific databases

HPAiHPA020648.
HPA057116.

Interactioni

Protein-protein interaction databases

BioGridi120954. 1 interaction.
DIPiDIP-47321N.
IntActiQ8IWB9. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8IWB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 519Poly-Glu
Compositional biasi138 – 1414Poly-Ser
Compositional biasi159 – 1624Poly-Ser
Compositional biasi816 – 8216Poly-Glu
Compositional biasi1039 – 10424Poly-Pro

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300813.
GeneTreeiENSGT00390000000463.
HOGENOMiHOG000049176.
HOVERGENiHBG062867.
InParanoidiQ8IWB9.
OMAiMARCVPQ.
PhylomeDBiQ8IWB9.
TreeFamiTF314900.

Family and domain databases

InterProiIPR019411. DUF2404.
IPR001849. PH_domain.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE
60 70 80 90 100
EFREYFEEGL DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV
110 120 130 140 150
SQAPAILPVS KNTVKLLESP VPAAQVLSTV PLAVSPGSSS SGPLASSPSV
160 170 180 190 200
SSLSEQKTSS SSPLSSPSKS PILSSSASTS TLSSAKPFMS LVKSLSTEVE
210 220 230 240 250
PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS KLNLHLFKQF
260 270 280 290 300
TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE
310 320 330 340 350
PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE
360 370 380 390 400
CDSEGDGYGS DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL
410 420 430 440 450
VLEKCSLSAL VSKEDEEFCE LYTEDFDLET EGESKVDKLS DIPLKPEVLA
460 470 480 490 500
EDGVVLDSED EVDSAVQHPE LPVKTLGFFI MCVYVYLILP LPHYVSGLFL
510 520 530 540 550
GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD IKEPEILKGW
560 570 580 590 600
MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE
610 620 630 640 650
VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ
660 670 680 690 700
TDKETSEEKP PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW
710 720 730 740 750
FRRFILASKL KSEIKKSSGV SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG
760 770 780 790 800
SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM GRCVPQESRS PQRSPLQSAE
810 820 830 840 850
SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY WSDLVSKKIQ
860 870 880 890 900
MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY
910 920 930 940 950
NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES
960 970 980 990 1000
SSAGSSEEDD APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF
1010 1020 1030 1040 1050
QKATETEFIK KKIEEVSNTP LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF
1060 1070 1080 1090 1100
RKPPHVELKA RPKLGEREVT LVHVTDWIEK KLEQEFQKVF VMPNMDDVYI
1110 1120
TIMHSAMDPR STSCLLKDPP VEAADQP
Length:1,127
Mass (Da):125,303
Last modified:June 27, 2006 - v2
Checksum:i100D99905117CD57
GO
Isoform 2 (identifier: Q8IWB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     724-724: K → KPAPVFLA

Show »
Length:1,134
Mass (Da):125,999
Checksum:i6B3306E0BCBDC439
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531R → K in AAH40521 (PubMed:15489334).Curated
Sequence conflicti363 – 3631N → S in CAD38927 (PubMed:17974005).Curated
Sequence conflicti446 – 4461P → S in CAH10519 (PubMed:17974005).Curated
Sequence conflicti451 – 4511E → K in AAH40521 (PubMed:15489334).Curated
Sequence conflicti608 – 6081I → V in CAD38927 (PubMed:17974005).Curated
Sequence conflicti634 – 6341P → L in CAD38927 (PubMed:17974005).Curated
Sequence conflicti725 – 7295PGLLP → LRAFA in CAH10519 (PubMed:17974005).Curated
Sequence conflicti835 – 8351F → S in CAD38927 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581T → I.
Corresponds to variant rs28605685 [ dbSNP | Ensembl ].
VAR_061712

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei724 – 7241K → KPAPVFLA in isoform 2. 1 PublicationVSP_019569

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051525 mRNA. Translation: BAB21829.2.
AL834251 mRNA. Translation: CAD38927.1.
CR627433 mRNA. Translation: CAH10519.1.
BC040521 mRNA. Translation: AAH40521.1.
CCDSiCCDS11658.1. [Q8IWB9-2]
CCDS74131.1. [Q8IWB9-1]
RefSeqiNP_001275661.1. NM_001288732.1. [Q8IWB9-1]
NP_001275662.1. NM_001288733.1. [Q8IWB9-1]
NP_060939.3. NM_018469.4. [Q8IWB9-2]
UniGeneiHs.175414.

Genome annotation databases

EnsembliENST00000258991; ENSP00000258991; ENSG00000136478. [Q8IWB9-2]
ENST00000583097; ENSP00000462665; ENSG00000136478. [Q8IWB9-1]
ENST00000584379; ENSP00000463001; ENSG00000136478. [Q8IWB9-1]
GeneIDi55852.
KEGGihsa:55852.
UCSCiuc002jec.3. human. [Q8IWB9-1]
uc002jed.3. human. [Q8IWB9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051525 mRNA. Translation: BAB21829.2.
AL834251 mRNA. Translation: CAD38927.1.
CR627433 mRNA. Translation: CAH10519.1.
BC040521 mRNA. Translation: AAH40521.1.
CCDSiCCDS11658.1. [Q8IWB9-2]
CCDS74131.1. [Q8IWB9-1]
RefSeqiNP_001275661.1. NM_001288732.1. [Q8IWB9-1]
NP_001275662.1. NM_001288733.1. [Q8IWB9-1]
NP_060939.3. NM_018469.4. [Q8IWB9-2]
UniGeneiHs.175414.

3D structure databases

ProteinModelPortaliQ8IWB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120954. 1 interaction.
DIPiDIP-47321N.
IntActiQ8IWB9. 4 interactions.

PTM databases

PhosphoSiteiQ8IWB9.

Polymorphism and mutation databases

DMDMi109895136.

Proteomic databases

MaxQBiQ8IWB9.
PaxDbiQ8IWB9.
PRIDEiQ8IWB9.

Protocols and materials databases

DNASUi55852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258991; ENSP00000258991; ENSG00000136478. [Q8IWB9-2]
ENST00000583097; ENSP00000462665; ENSG00000136478. [Q8IWB9-1]
ENST00000584379; ENSP00000463001; ENSG00000136478. [Q8IWB9-1]
GeneIDi55852.
KEGGihsa:55852.
UCSCiuc002jec.3. human. [Q8IWB9-1]
uc002jed.3. human. [Q8IWB9-2]

Organism-specific databases

CTDi55852.
GeneCardsiGC17M062224.
H-InvDBHIX0014085.
HGNCiHGNC:30884. TEX2.
HPAiHPA020648.
HPA057116.
neXtProtiNX_Q8IWB9.
PharmGKBiPA142670820.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG300813.
GeneTreeiENSGT00390000000463.
HOGENOMiHOG000049176.
HOVERGENiHBG062867.
InParanoidiQ8IWB9.
OMAiMARCVPQ.
PhylomeDBiQ8IWB9.
TreeFamiTF314900.

Miscellaneous databases

ChiTaRSiTEX2. human.
GenomeRNAii55852.
NextBioi61119.
PMAP-CutDBQ8IWB9.
PROiQ8IWB9.

Gene expression databases

BgeeiQ8IWB9.
CleanExiHS_TEX2.
ExpressionAtlasiQ8IWB9. baseline and differential.
GenevisibleiQ8IWB9. HS.

Family and domain databases

InterProiIPR019411. DUF2404.
IPR001849. PH_domain.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-266; SER-270 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-744, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266; SER-295; SER-732; SER-738 AND SER-744, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTEX2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB9
Secondary accession number(s): Q6AHZ5, Q8N3L0, Q9C0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 24, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.