Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Testis-expressed protein 2

Gene

TEX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • lipid transport Source: UniProtKB-KW
  • signal transduction Source: UniProtKB
  • sphingolipid metabolic process Source: UniProtKB

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 2
Alternative name(s):
Transmembrane protein 96
Gene namesi
Name:TEX2
Synonyms:KIAA1738, TMEM96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136478.7
HGNCiHGNC:30884 TEX2
neXtProtiNX_Q8IWB9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136478
PharmGKBiPA142670820

Polymorphism and mutation databases

DMDMi109895136

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444791 – 1127Testis-expressed protein 2Add BLAST1127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1
Modified residuei262PhosphothreonineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei266PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei732PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei748PhosphoserineBy similarity1
Modified residuei751PhosphoserineBy similarity1
Modified residuei798PhosphoserineBy similarity1
Modified residuei815PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IWB9
PaxDbiQ8IWB9
PeptideAtlasiQ8IWB9
PRIDEiQ8IWB9

PTM databases

iPTMnetiQ8IWB9
PhosphoSitePlusiQ8IWB9

Miscellaneous databases

PMAP-CutDBiQ8IWB9

Expressioni

Gene expression databases

BgeeiENSG00000136478
CleanExiHS_TEX2
ExpressionAtlasiQ8IWB9 baseline and differential
GenevisibleiQ8IWB9 HS

Organism-specific databases

HPAiHPA020648
HPA057116

Interactioni

Protein-protein interaction databases

BioGridi120954, 8 interactors
DIPiDIP-47321N
IntActiQ8IWB9, 8 interactors
STRINGi9606.ENSP00000258991

Structurei

3D structure databases

ProteinModelPortaliQ8IWB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini816 – 1101SMP-LTDPROSITE-ProRule annotationAdd BLAST286

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 51Poly-Glu9
Compositional biasi138 – 141Poly-Ser4
Compositional biasi159 – 162Poly-Ser4
Compositional biasi816 – 821Poly-Glu6
Compositional biasi1039 – 1042Poly-Pro4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2238 Eukaryota
ENOG410Z3SZ LUCA
GeneTreeiENSGT00390000000463
HOGENOMiHOG000049176
HOVERGENiHBG062867
InParanoidiQ8IWB9
OMAiLGRIFWD
OrthoDBiEOG091G01R4
PhylomeDBiQ8IWB9
TreeFamiTF314900

Family and domain databases

InterProiView protein in InterPro
IPR031468 SMP_LBD
PROSITEiView protein in PROSITE
PS51847 SMP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE
60 70 80 90 100
EFREYFEEGL DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV
110 120 130 140 150
SQAPAILPVS KNTVKLLESP VPAAQVLSTV PLAVSPGSSS SGPLASSPSV
160 170 180 190 200
SSLSEQKTSS SSPLSSPSKS PILSSSASTS TLSSAKPFMS LVKSLSTEVE
210 220 230 240 250
PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS KLNLHLFKQF
260 270 280 290 300
TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE
310 320 330 340 350
PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE
360 370 380 390 400
CDSEGDGYGS DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL
410 420 430 440 450
VLEKCSLSAL VSKEDEEFCE LYTEDFDLET EGESKVDKLS DIPLKPEVLA
460 470 480 490 500
EDGVVLDSED EVDSAVQHPE LPVKTLGFFI MCVYVYLILP LPHYVSGLFL
510 520 530 540 550
GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD IKEPEILKGW
560 570 580 590 600
MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE
610 620 630 640 650
VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ
660 670 680 690 700
TDKETSEEKP PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW
710 720 730 740 750
FRRFILASKL KSEIKKSSGV SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG
760 770 780 790 800
SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM GRCVPQESRS PQRSPLQSAE
810 820 830 840 850
SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY WSDLVSKKIQ
860 870 880 890 900
MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY
910 920 930 940 950
NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES
960 970 980 990 1000
SSAGSSEEDD APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF
1010 1020 1030 1040 1050
QKATETEFIK KKIEEVSNTP LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF
1060 1070 1080 1090 1100
RKPPHVELKA RPKLGEREVT LVHVTDWIEK KLEQEFQKVF VMPNMDDVYI
1110 1120
TIMHSAMDPR STSCLLKDPP VEAADQP
Length:1,127
Mass (Da):125,303
Last modified:June 27, 2006 - v2
Checksum:i100D99905117CD57
GO
Isoform 2 (identifier: Q8IWB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     724-724: K → KPAPVFLA

Show »
Length:1,134
Mass (Da):125,999
Checksum:i6B3306E0BCBDC439
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53R → K in AAH40521 (PubMed:15489334).Curated1
Sequence conflicti363N → S in CAD38927 (PubMed:17974005).Curated1
Sequence conflicti446P → S in CAH10519 (PubMed:17974005).Curated1
Sequence conflicti451E → K in AAH40521 (PubMed:15489334).Curated1
Sequence conflicti608I → V in CAD38927 (PubMed:17974005).Curated1
Sequence conflicti634P → L in CAD38927 (PubMed:17974005).Curated1
Sequence conflicti725 – 729PGLLP → LRAFA in CAH10519 (PubMed:17974005).Curated5
Sequence conflicti835F → S in CAD38927 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061712158T → I. Corresponds to variant dbSNP:rs28605685Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019569724K → KPAPVFLA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051525 mRNA Translation: BAB21829.2
AL834251 mRNA Translation: CAD38927.1
CR627433 mRNA Translation: CAH10519.1
BC040521 mRNA Translation: AAH40521.1
CCDSiCCDS11658.1 [Q8IWB9-2]
CCDS74131.1 [Q8IWB9-1]
RefSeqiNP_001275661.1, NM_001288732.1 [Q8IWB9-1]
NP_001275662.1, NM_001288733.1 [Q8IWB9-1]
NP_060939.3, NM_018469.4 [Q8IWB9-2]
XP_011523300.1, XM_011524998.1 [Q8IWB9-2]
XP_011523301.1, XM_011524999.1 [Q8IWB9-2]
UniGeneiHs.175414

Genome annotation databases

EnsembliENST00000258991; ENSP00000258991; ENSG00000136478 [Q8IWB9-2]
ENST00000583097; ENSP00000462665; ENSG00000136478 [Q8IWB9-1]
ENST00000584379; ENSP00000463001; ENSG00000136478 [Q8IWB9-1]
GeneIDi55852
KEGGihsa:55852
UCSCiuc002jec.5 human [Q8IWB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTEX2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB9
Secondary accession number(s): Q6AHZ5, Q8N3L0, Q9C0C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health