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Q8IWB9 (TEX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-expressed sequence 2 protein
Alternative name(s):
Transmembrane protein 96
Gene names
Name:TEX2
Synonyms:KIAA1738, TMEM96
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1127 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IWB9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IWB9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     724-724: K → KPAPVFLA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11271127Testis-expressed sequence 2 protein
PRO_0000244479

Regions

Transmembrane475 – 49521Helical; Potential
Transmembrane497 – 51721Helical; Potential
Compositional bias43 – 519Poly-Glu
Compositional bias138 – 1414Poly-Ser
Compositional bias159 – 1624Poly-Ser
Compositional bias816 – 8216Poly-Glu
Compositional bias1039 – 10424Poly-Pro

Amino acid modifications

Modified residue1961Phosphoserine Ref.4
Modified residue2621Phosphothreonine By similarity
Modified residue2651Phosphoserine By similarity
Modified residue2661Phosphoserine Ref.4
Modified residue2701Phosphoserine Ref.4
Modified residue2951Phosphoserine Ref.4 Ref.5
Modified residue7441Phosphoserine Ref.6
Modified residue7481Phosphoserine By similarity
Glycosylation3301N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence7241K → KPAPVFLA in isoform 2.
VSP_019569
Natural variant1581T → I.
Corresponds to variant rs28605685 [ dbSNP | Ensembl ].
VAR_061712

Experimental info

Sequence conflict531R → K in AAH40521. Ref.3
Sequence conflict3631N → S in CAD38927. Ref.2
Sequence conflict4461P → S in CAH10519. Ref.2
Sequence conflict4511E → K in AAH40521. Ref.3
Sequence conflict6081I → V in CAD38927. Ref.2
Sequence conflict6341P → L in CAD38927. Ref.2
Sequence conflict725 – 7295PGLLP → LRAFA in CAH10519. Ref.2
Sequence conflict8351F → S in CAD38927. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: 100D99905117CD57

FASTA1,127125,303
        10         20         30         40         50         60 
MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE EFREYFEEGL 

        70         80         90        100        110        120 
DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV SQAPAILPVS KNTVKLLESP 

       130        140        150        160        170        180 
VPAAQVLSTV PLAVSPGSSS SGPLASSPSV SSLSEQKTSS SSPLSSPSKS PILSSSASTS 

       190        200        210        220        230        240 
TLSSAKPFMS LVKSLSTEVE PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS 

       250        260        270        280        290        300 
KLNLHLFKQF TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE 

       310        320        330        340        350        360 
PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE CDSEGDGYGS 

       370        380        390        400        410        420 
DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL VLEKCSLSAL VSKEDEEFCE 

       430        440        450        460        470        480 
LYTEDFDLET EGESKVDKLS DIPLKPEVLA EDGVVLDSED EVDSAVQHPE LPVKTLGFFI 

       490        500        510        520        530        540 
MCVYVYLILP LPHYVSGLFL GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD 

       550        560        570        580        590        600 
IKEPEILKGW MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE 

       610        620        630        640        650        660 
VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ TDKETSEEKP 

       670        680        690        700        710        720 
PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW FRRFILASKL KSEIKKSSGV 

       730        740        750        760        770        780 
SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM 

       790        800        810        820        830        840 
GRCVPQESRS PQRSPLQSAE SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY 

       850        860        870        880        890        900 
WSDLVSKKIQ MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY 

       910        920        930        940        950        960 
NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES SSAGSSEEDD 

       970        980        990       1000       1010       1020 
APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF QKATETEFIK KKIEEVSNTP 

      1030       1040       1050       1060       1070       1080 
LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF RKPPHVELKA RPKLGEREVT LVHVTDWIEK 

      1090       1100       1110       1120 
KLEQEFQKVF VMPNMDDVYI TIMHSAMDPR STSCLLKDPP VEAADQP 

« Hide

Isoform 2 [UniParc].

Checksum: 6B3306E0BCBDC439
Show »

FASTA1,134125,999

References

[1]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skeletal muscle and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-266; SER-270 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-744, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051525 mRNA. Translation: BAB21829.2.
AL834251 mRNA. Translation: CAD38927.1.
CR627433 mRNA. Translation: CAH10519.1.
BC040521 mRNA. Translation: AAH40521.1.
CCDSCCDS11658.1. [Q8IWB9-2]
RefSeqNP_001275661.1. NM_001288732.1. [Q8IWB9-1]
NP_001275662.1. NM_001288733.1. [Q8IWB9-1]
NP_060939.3. NM_018469.4. [Q8IWB9-2]
UniGeneHs.175414.

3D structure databases

ProteinModelPortalQ8IWB9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120954. 1 interaction.
DIPDIP-47321N.
IntActQ8IWB9. 3 interactions.
STRING9606.ENSP00000258991.

PTM databases

PhosphoSiteQ8IWB9.

Polymorphism databases

DMDM109895136.

Proteomic databases

MaxQBQ8IWB9.
PaxDbQ8IWB9.
PRIDEQ8IWB9.

Protocols and materials databases

DNASU55852.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258991; ENSP00000258991; ENSG00000136478. [Q8IWB9-2]
ENST00000571438; ENSP00000459081; ENSG00000263185. [Q8IWB9-2]
ENST00000580023; ENSP00000462409; ENSG00000263185. [Q8IWB9-1]
ENST00000580932; ENSP00000461913; ENSG00000263185. [Q8IWB9-1]
ENST00000583097; ENSP00000462665; ENSG00000136478. [Q8IWB9-1]
ENST00000584379; ENSP00000463001; ENSG00000136478. [Q8IWB9-1]
GeneID55852.
KEGGhsa:55852.
UCSCuc002jec.3. human. [Q8IWB9-1]
uc002jed.3. human. [Q8IWB9-2]

Organism-specific databases

CTD55852.
GeneCardsGC17M062224.
H-InvDBHIX0014085.
HGNCHGNC:30884. TEX2.
HPAHPA020648.
neXtProtNX_Q8IWB9.
PharmGKBPA142670820.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG300813.
HOGENOMHOG000049176.
HOVERGENHBG062867.
InParanoidQ8IWB9.
OMATAVCMIW.
PhylomeDBQ8IWB9.
TreeFamTF314900.

Gene expression databases

ArrayExpressQ8IWB9.
BgeeQ8IWB9.
CleanExHS_TEX2.
GenevestigatorQ8IWB9.

Family and domain databases

InterProIPR019411. DUF2404.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF10296. DUF2404. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTEX2. human.
GenomeRNAi55852.
NextBio61119.
PMAP-CutDBQ8IWB9.
PROQ8IWB9.

Entry information

Entry nameTEX2_HUMAN
AccessionPrimary (citable) accession number: Q8IWB9
Secondary accession number(s): Q6AHZ5, Q8N3L0, Q9C0C5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM