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Q8IWB7

- WDFY1_HUMAN

UniProt

Q8IWB7 - WDFY1_HUMAN

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Protein

WD repeat and FYVE domain-containing protein 1

Gene
WDFY1, KIAA1435, WDF1, ZFYVE17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri281 – 35272FYVE-typeAdd
BLAST

GO - Molecular functioni

  1. 1-phosphatidylinositol binding Source: UniProtKB
  2. zinc ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ8IWB7.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and FYVE domain-containing protein 1
Alternative name(s):
FENS-1
Phosphoinositide-binding protein 1
WD40- and FYVE domain-containing protein 1
Zinc finger FYVE domain-containing protein 17
Gene namesi
Name:WDFY1
Synonyms:KIAA1435, WDF1, ZFYVE17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20451. WDFY1.

Subcellular locationi

Early endosome 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410WD repeat and FYVE domain-containing protein 1PRO_0000051335Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei408 – 4081Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IWB7.
PaxDbiQ8IWB7.
PeptideAtlasiQ8IWB7.
PRIDEiQ8IWB7.

PTM databases

PhosphoSiteiQ8IWB7.

Expressioni

Gene expression databases

ArrayExpressiQ8IWB7.
BgeeiQ8IWB7.
CleanExiHS_WDFY1.
GenevestigatoriQ8IWB7.

Organism-specific databases

HPAiHPA050603.

Interactioni

Subunit structurei

Binds PtdIns3P in vitro with high specificity over other phosphoinositides.

Protein-protein interaction databases

BioGridi121641. 6 interactions.
MINTiMINT-5004828.
STRINGi9606.ENSP00000233055.

Structurei

3D structure databases

ProteinModelPortaliQ8IWB7.
SMRiQ8IWB7. Positions 16-351, 360-409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 6140WD 1Add
BLAST
Repeati66 – 10540WD 2Add
BLAST
Repeati112 – 15039WD 3Add
BLAST
Repeati153 – 19240WD 4Add
BLAST
Repeati197 – 23640WD 5Add
BLAST
Repeati240 – 27940WD 6Add
BLAST
Repeati364 – 40340WD 7Add
BLAST

Domaini

The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions.1 Publication

Sequence similaritiesi

Contains 7 WD repeats.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri281 – 35272FYVE-typeAdd
BLAST

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000007835.
HOVERGENiHBG054128.
InParanoidiQ8IWB7.
OMAiEAPQWLD.
OrthoDBiEOG7W153N.
PhylomeDBiQ8IWB7.
TreeFamiTF314470.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00064. FYVE. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWB7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV    50
WLKRDSGQYW PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED 100
FNKMNFIKTY PAHQNRVSAI IFSLATEWVI STGHDKCVSW MCTRSGNMLG 150
RHFFTSWASC LQYDFDTQYA FVGDYSGQIT LLKLEQNTCS VITTLKGHEG 200
SVACLWWDPI QRLLFSGASD NSIIMWDIGG RKGRTLLLQG HHDKVQSLCY 250
LQLTRQLVSC SSDGGIAVWN MDVSREEAPQ WLESDSCQKC EQPFFWNIKQ 300
MWDTKTLGLR QHHCRKCGQA VCGKCSSKRS SYPVMGFEFQ VRVCDSCYDS 350
IKDEDRTSLA TFHEGKHNIS HMSMDIARGL MVTCGTDRIV KIWDMTPVVG 400
CSLATGFSPH 410
Length:410
Mass (Da):46,324
Last modified:March 1, 2003 - v1
Checksum:i25D981799D918BE3
GO

Sequence cautioni

The sequence BAA92673.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310568 mRNA. Translation: CAC83947.1.
AF411977 mRNA. Translation: AAL04161.1.
AB037856 mRNA. Translation: BAA92673.1. Different initiation.
AK022888 mRNA. Translation: BAB14294.1.
AC073641 Genomic DNA. Translation: AAY14924.1.
CH471063 Genomic DNA. Translation: EAW70817.1.
BC040525 mRNA. Translation: AAH40525.1.
BC065934 mRNA. Translation: AAH65934.1.
CCDSiCCDS33387.1.
RefSeqiNP_065881.1. NM_020830.3.
UniGeneiHs.368359.

Genome annotation databases

EnsembliENST00000233055; ENSP00000233055; ENSG00000085449.
GeneIDi57590.
KEGGihsa:57590.
UCSCiuc002vnq.3. human.

Polymorphism databases

DMDMi51316866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310568 mRNA. Translation: CAC83947.1 .
AF411977 mRNA. Translation: AAL04161.1 .
AB037856 mRNA. Translation: BAA92673.1 . Different initiation.
AK022888 mRNA. Translation: BAB14294.1 .
AC073641 Genomic DNA. Translation: AAY14924.1 .
CH471063 Genomic DNA. Translation: EAW70817.1 .
BC040525 mRNA. Translation: AAH40525.1 .
BC065934 mRNA. Translation: AAH65934.1 .
CCDSi CCDS33387.1.
RefSeqi NP_065881.1. NM_020830.3.
UniGenei Hs.368359.

3D structure databases

ProteinModelPortali Q8IWB7.
SMRi Q8IWB7. Positions 16-351, 360-409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121641. 6 interactions.
MINTi MINT-5004828.
STRINGi 9606.ENSP00000233055.

PTM databases

PhosphoSitei Q8IWB7.

Polymorphism databases

DMDMi 51316866.

Proteomic databases

MaxQBi Q8IWB7.
PaxDbi Q8IWB7.
PeptideAtlasi Q8IWB7.
PRIDEi Q8IWB7.

Protocols and materials databases

DNASUi 57590.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233055 ; ENSP00000233055 ; ENSG00000085449 .
GeneIDi 57590.
KEGGi hsa:57590.
UCSCi uc002vnq.3. human.

Organism-specific databases

CTDi 57590.
GeneCardsi GC02M224704.
HGNCi HGNC:20451. WDFY1.
HPAi HPA050603.
neXtProti NX_Q8IWB7.
PharmGKBi PA134929936.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000007835.
HOVERGENi HBG054128.
InParanoidi Q8IWB7.
OMAi EAPQWLD.
OrthoDBi EOG7W153N.
PhylomeDBi Q8IWB7.
TreeFami TF314470.

Enzyme and pathway databases

SignaLinki Q8IWB7.

Miscellaneous databases

GenomeRNAii 57590.
NextBioi 64174.
PROi Q8IWB7.

Gene expression databases

ArrayExpressi Q8IWB7.
Bgeei Q8IWB7.
CleanExi HS_WDFY1.
Genevestigatori Q8IWB7.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00064. FYVE. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments."
    Ridley S.H., Ktistakis N., Davidson K., Anderson K.E., Manifava M., Ellson C.D., Lipp P., Bootman M., Coadwell J., Nazarian A., Erdjument-Bromage H., Tempst P., Cooper M.A., Thuring J.W.J.F., Lim Z.-Y., Holmes A.B., Stephens L.R., Hawkins P.T.
    J. Cell Sci. 114:3991-4000(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, BINDING TO PHOSPHOINOSITIDES.
  2. "WD40- and FYVE-domain containing protein 1 (WDF1)."
    Hong W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  8. Cited for: DOMAIN FYVE-TYPE ZINC-FINGER.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDFY1_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB7
Secondary accession number(s): Q53S17, Q9H9D5, Q9P2B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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