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Q8IWB7

- WDFY1_HUMAN

UniProt

Q8IWB7 - WDFY1_HUMAN

Protein

WD repeat and FYVE domain-containing protein 1

Gene

WDFY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri281 – 35272FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ8IWB7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat and FYVE domain-containing protein 1
    Alternative name(s):
    FENS-1
    Phosphoinositide-binding protein 1
    WD40- and FYVE domain-containing protein 1
    Zinc finger FYVE domain-containing protein 17
    Gene namesi
    Name:WDFY1
    Synonyms:KIAA1435, WDF1, ZFYVE17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20451. WDFY1.

    Subcellular locationi

    Early endosome 1 Publication

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. early endosome Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Endosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134929936.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410WD repeat and FYVE domain-containing protein 1PRO_0000051335Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei408 – 4081Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IWB7.
    PaxDbiQ8IWB7.
    PeptideAtlasiQ8IWB7.
    PRIDEiQ8IWB7.

    PTM databases

    PhosphoSiteiQ8IWB7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IWB7.
    BgeeiQ8IWB7.
    CleanExiHS_WDFY1.
    GenevestigatoriQ8IWB7.

    Organism-specific databases

    HPAiHPA050603.

    Interactioni

    Subunit structurei

    Binds PtdIns3P in vitro with high specificity over other phosphoinositides.

    Protein-protein interaction databases

    BioGridi121641. 6 interactions.
    MINTiMINT-5004828.
    STRINGi9606.ENSP00000233055.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IWB7.
    SMRiQ8IWB7. Positions 16-351, 360-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati22 – 6140WD 1Add
    BLAST
    Repeati66 – 10540WD 2Add
    BLAST
    Repeati112 – 15039WD 3Add
    BLAST
    Repeati153 – 19240WD 4Add
    BLAST
    Repeati197 – 23640WD 5Add
    BLAST
    Repeati240 – 27940WD 6Add
    BLAST
    Repeati364 – 40340WD 7Add
    BLAST

    Domaini

    The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions.1 Publication

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri281 – 35272FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, WD repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000007835.
    HOVERGENiHBG054128.
    InParanoidiQ8IWB7.
    OMAiEAPQWLD.
    OrthoDBiEOG7W153N.
    PhylomeDBiQ8IWB7.
    TreeFamiTF314470.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF00400. WD40. 4 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00064. FYVE. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IWB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV    50
    WLKRDSGQYW PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED 100
    FNKMNFIKTY PAHQNRVSAI IFSLATEWVI STGHDKCVSW MCTRSGNMLG 150
    RHFFTSWASC LQYDFDTQYA FVGDYSGQIT LLKLEQNTCS VITTLKGHEG 200
    SVACLWWDPI QRLLFSGASD NSIIMWDIGG RKGRTLLLQG HHDKVQSLCY 250
    LQLTRQLVSC SSDGGIAVWN MDVSREEAPQ WLESDSCQKC EQPFFWNIKQ 300
    MWDTKTLGLR QHHCRKCGQA VCGKCSSKRS SYPVMGFEFQ VRVCDSCYDS 350
    IKDEDRTSLA TFHEGKHNIS HMSMDIARGL MVTCGTDRIV KIWDMTPVVG 400
    CSLATGFSPH 410
    Length:410
    Mass (Da):46,324
    Last modified:March 1, 2003 - v1
    Checksum:i25D981799D918BE3
    GO

    Sequence cautioni

    The sequence BAA92673.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310568 mRNA. Translation: CAC83947.1.
    AF411977 mRNA. Translation: AAL04161.1.
    AB037856 mRNA. Translation: BAA92673.1. Different initiation.
    AK022888 mRNA. Translation: BAB14294.1.
    AC073641 Genomic DNA. Translation: AAY14924.1.
    CH471063 Genomic DNA. Translation: EAW70817.1.
    BC040525 mRNA. Translation: AAH40525.1.
    BC065934 mRNA. Translation: AAH65934.1.
    CCDSiCCDS33387.1.
    RefSeqiNP_065881.1. NM_020830.3.
    UniGeneiHs.368359.

    Genome annotation databases

    EnsembliENST00000233055; ENSP00000233055; ENSG00000085449.
    GeneIDi57590.
    KEGGihsa:57590.
    UCSCiuc002vnq.3. human.

    Polymorphism databases

    DMDMi51316866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310568 mRNA. Translation: CAC83947.1 .
    AF411977 mRNA. Translation: AAL04161.1 .
    AB037856 mRNA. Translation: BAA92673.1 . Different initiation.
    AK022888 mRNA. Translation: BAB14294.1 .
    AC073641 Genomic DNA. Translation: AAY14924.1 .
    CH471063 Genomic DNA. Translation: EAW70817.1 .
    BC040525 mRNA. Translation: AAH40525.1 .
    BC065934 mRNA. Translation: AAH65934.1 .
    CCDSi CCDS33387.1.
    RefSeqi NP_065881.1. NM_020830.3.
    UniGenei Hs.368359.

    3D structure databases

    ProteinModelPortali Q8IWB7.
    SMRi Q8IWB7. Positions 16-351, 360-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121641. 6 interactions.
    MINTi MINT-5004828.
    STRINGi 9606.ENSP00000233055.

    PTM databases

    PhosphoSitei Q8IWB7.

    Polymorphism databases

    DMDMi 51316866.

    Proteomic databases

    MaxQBi Q8IWB7.
    PaxDbi Q8IWB7.
    PeptideAtlasi Q8IWB7.
    PRIDEi Q8IWB7.

    Protocols and materials databases

    DNASUi 57590.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233055 ; ENSP00000233055 ; ENSG00000085449 .
    GeneIDi 57590.
    KEGGi hsa:57590.
    UCSCi uc002vnq.3. human.

    Organism-specific databases

    CTDi 57590.
    GeneCardsi GC02M224704.
    HGNCi HGNC:20451. WDFY1.
    HPAi HPA050603.
    neXtProti NX_Q8IWB7.
    PharmGKBi PA134929936.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000007835.
    HOVERGENi HBG054128.
    InParanoidi Q8IWB7.
    OMAi EAPQWLD.
    OrthoDBi EOG7W153N.
    PhylomeDBi Q8IWB7.
    TreeFami TF314470.

    Enzyme and pathway databases

    SignaLinki Q8IWB7.

    Miscellaneous databases

    GenomeRNAii 57590.
    NextBioi 64174.
    PROi Q8IWB7.

    Gene expression databases

    ArrayExpressi Q8IWB7.
    Bgeei Q8IWB7.
    CleanExi HS_WDFY1.
    Genevestigatori Q8IWB7.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF00400. WD40. 4 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00064. FYVE. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments."
      Ridley S.H., Ktistakis N., Davidson K., Anderson K.E., Manifava M., Ellson C.D., Lipp P., Bootman M., Coadwell J., Nazarian A., Erdjument-Bromage H., Tempst P., Cooper M.A., Thuring J.W.J.F., Lim Z.-Y., Holmes A.B., Stephens L.R., Hawkins P.T.
      J. Cell Sci. 114:3991-4000(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, BINDING TO PHOSPHOINOSITIDES.
    2. "WD40- and FYVE-domain containing protein 1 (WDF1)."
      Hong W.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Skin.
    8. Cited for: DOMAIN FYVE-TYPE ZINC-FINGER.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDFY1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IWB7
    Secondary accession number(s): Q53S17, Q9H9D5, Q9P2B3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3