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Protein

Inositol 1,4,5-trisphosphate receptor-interacting protein

Gene

ITPRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances Ca2+-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca2+ release.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor-interacting protein
Alternative name(s):
Protein DANGER
Gene namesi
Name:ITPRIP
Synonyms:DANGER, KIAA1754
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148841.15.
HGNCiHGNC:29370. ITPRIP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi85450.
OpenTargetsiENSG00000148841.
PharmGKBiPA162392344.

Polymorphism and mutation databases

DMDMi74750704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000029372816 – 547Inositol 1,4,5-trisphosphate receptor-interacting proteinAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei547PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8IWB1.
MaxQBiQ8IWB1.
PaxDbiQ8IWB1.
PeptideAtlasiQ8IWB1.
PRIDEiQ8IWB1.
TopDownProteomicsiQ8IWB1.

PTM databases

iPTMnetiQ8IWB1.
PhosphoSitePlusiQ8IWB1.

Expressioni

Tissue specificityi

Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000148841.
CleanExiHS_ITPRIP.
ExpressionAtlasiQ8IWB1. baseline and differential.
GenevisibleiQ8IWB1. HS.

Organism-specific databases

HPAiHPA043626.

Interactioni

Subunit structurei

Interacts with ITPR.1 Publication

Protein-protein interaction databases

BioGridi124535. 26 interactors.
IntActiQ8IWB1. 7 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8IWB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 82Sequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi437 – 443Poly-Leu7

Sequence similaritiesi

Belongs to the ITPRIP family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IFEJ. Eukaryota.
ENOG4110247. LUCA.
GeneTreeiENSGT00530000063794.
HOGENOMiHOG000113093.
HOVERGENiHBG108007.
InParanoidiQ8IWB1.
OMAiSGKFMPF.
OrthoDBiEOG091G04II.
PhylomeDBiQ8IWB1.
TreeFamiTF332277.

Family and domain databases

InterProiView protein in InterPro
IPR024797. IP3R-int.
IPR026250. ITPRIP_fam.
IPR024810. Mab-21_dom.
PANTHERiPTHR10656:SF55. PTHR10656:SF55. 1 hit.
PfamiView protein in Pfam
PF03281. Mab-21. 1 hit.
PRINTSiPR02107. INOS145TPRIP.
SMARTiView protein in SMART
SM01265. Mab-21. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IWB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMGLFRVCL VVVTAIINHP LLFPRENATV PENEEEIIRK MQAHQEKLQL
60 70 80 90 100
EQLRLEEEVA RLAAEKEALE QVAEEGRQQN ETRVAWDLWS TLCMILFLMI
110 120 130 140 150
EVWRQDHQEG PSPECLGGEE DELPGLGGAP LQGLTLPNKA TLGHFYERCI
160 170 180 190 200
RGATADAART REFLEGFVDD LLEALRSLCN RDTDMEVEDF IGVDSMYENW
210 220 230 240 250
QVDRPLLCHL FVPFTPPEPY RFHPELWCSG RSVPLDRQGY GQIKVVRADG
260 270 280 290 300
DTLSCICGKT KLGEDMLCLL HGRNSMAPPC GDMENLLCAT DSLYLDTMQV
310 320 330 340 350
MKWFQTALTR AWKGIAHKYE FDLAFGQLDS PGSLKIKFRS GKFMPFNLIP
360 370 380 390 400
VIQCDDSDLY FVSHLPREPS EGTPASSTDW LLSFAVYERH FLRTTLKALP
410 420 430 440 450
EGACHLSCLQ IASFLLSKQS RLTGPSGLSS YHLKTALLHL LLLRQAADWK
460 470 480 490 500
AGQLDARLHE LLCFLEKSLL QKKLHHFFIG NRKVPEAMGL PEAVLRAEPL
510 520 530 540
NLFRPFVLQR SLYRKTLDSF YEMLKNAPAL ISEYSLHVPS DQPTPKS
Length:547
Mass (Da):62,060
Last modified:March 1, 2003 - v1
Checksum:i7DDD6CA06FE494AA
GO

Sequence cautioni

The sequence BAB21845 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051541 mRNA. Translation: BAB21845.1. Different initiation.
AK056526 mRNA. Translation: BAB71204.1.
AL162742 Genomic DNA. Translation: CAI12108.1.
AL162742 Genomic DNA. Translation: CAI12109.1.
CH471066 Genomic DNA. Translation: EAW49596.1.
CH471066 Genomic DNA. Translation: EAW49597.1.
BC040536 mRNA. Translation: AAH40536.1.
BC070108 mRNA. Translation: AAH70108.1.
CCDSiCCDS7557.1.
RefSeqiNP_001258941.1. NM_001272012.1.
NP_001258942.1. NM_001272013.1.
NP_203755.1. NM_033397.3.
UniGeneiHs.523252.
Hs.745171.

Genome annotation databases

EnsembliENST00000278071; ENSP00000278071; ENSG00000148841.
ENST00000337478; ENSP00000337178; ENSG00000148841.
ENST00000358187; ENSP00000350915; ENSG00000148841.
GeneIDi85450.
KEGGihsa:85450.
UCSCiuc001kye.5. human.

Similar proteinsi

Entry informationi

Entry nameiIPRI_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB1
Secondary accession number(s): D3DRA5
, Q5JU17, Q96MS8, Q9C0A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries