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Protein

Inositol 1,4,5-trisphosphate receptor-interacting protein

Gene

ITPRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances Ca2+-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca2+ release.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor-interacting protein
Alternative name(s):
Protein DANGER
Gene namesi
Name:ITPRIP
Synonyms:DANGER, KIAA1754
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29370. ITPRIP.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392344.

Polymorphism and mutation databases

DMDMi74750704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 547532Inositol 1,4,5-trisphosphate receptor-interacting proteinPRO_0000293728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Modified residuei547 – 5471PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8IWB1.
MaxQBiQ8IWB1.
PaxDbiQ8IWB1.
PRIDEiQ8IWB1.
TopDownProteomicsiQ8IWB1.

PTM databases

iPTMnetiQ8IWB1.
PhosphoSiteiQ8IWB1.

Expressioni

Tissue specificityi

Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level).1 Publication

Gene expression databases

BgeeiQ8IWB1.
CleanExiHS_ITPRIP.
ExpressionAtlasiQ8IWB1. baseline and differential.
GenevisibleiQ8IWB1. HS.

Organism-specific databases

HPAiHPA043626.

Interactioni

Subunit structurei

Interacts with ITPR.1 Publication

Protein-protein interaction databases

BioGridi124535. 21 interactions.
IntActiQ8IWB1. 6 interactions.
STRINGi9606.ENSP00000278071.

Structurei

3D structure databases

ProteinModelPortaliQ8IWB1.
SMRiQ8IWB1. Positions 365-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 8251Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi437 – 4437Poly-Leu

Sequence similaritiesi

Belongs to the ITPRIP family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IFEJ. Eukaryota.
ENOG4110247. LUCA.
GeneTreeiENSGT00530000063794.
HOGENOMiHOG000113093.
HOVERGENiHBG108007.
InParanoidiQ8IWB1.
OMAiTDWLLSF.
OrthoDBiEOG7VX8VH.
PhylomeDBiQ8IWB1.
TreeFamiTF332277.

Family and domain databases

InterProiIPR024797. IP3R-int.
IPR026250. ITPRIP_fam.
IPR024810. Mab-21_dom.
[Graphical view]
PANTHERiPTHR10656:SF8. PTHR10656:SF8. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
PRINTSiPR02107. INOS145TPRIP.
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IWB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMGLFRVCL VVVTAIINHP LLFPRENATV PENEEEIIRK MQAHQEKLQL
60 70 80 90 100
EQLRLEEEVA RLAAEKEALE QVAEEGRQQN ETRVAWDLWS TLCMILFLMI
110 120 130 140 150
EVWRQDHQEG PSPECLGGEE DELPGLGGAP LQGLTLPNKA TLGHFYERCI
160 170 180 190 200
RGATADAART REFLEGFVDD LLEALRSLCN RDTDMEVEDF IGVDSMYENW
210 220 230 240 250
QVDRPLLCHL FVPFTPPEPY RFHPELWCSG RSVPLDRQGY GQIKVVRADG
260 270 280 290 300
DTLSCICGKT KLGEDMLCLL HGRNSMAPPC GDMENLLCAT DSLYLDTMQV
310 320 330 340 350
MKWFQTALTR AWKGIAHKYE FDLAFGQLDS PGSLKIKFRS GKFMPFNLIP
360 370 380 390 400
VIQCDDSDLY FVSHLPREPS EGTPASSTDW LLSFAVYERH FLRTTLKALP
410 420 430 440 450
EGACHLSCLQ IASFLLSKQS RLTGPSGLSS YHLKTALLHL LLLRQAADWK
460 470 480 490 500
AGQLDARLHE LLCFLEKSLL QKKLHHFFIG NRKVPEAMGL PEAVLRAEPL
510 520 530 540
NLFRPFVLQR SLYRKTLDSF YEMLKNAPAL ISEYSLHVPS DQPTPKS
Length:547
Mass (Da):62,060
Last modified:March 1, 2003 - v1
Checksum:i7DDD6CA06FE494AA
GO

Sequence cautioni

The sequence BAB21845.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051541 mRNA. Translation: BAB21845.1. Different initiation.
AK056526 mRNA. Translation: BAB71204.1.
AL162742 Genomic DNA. Translation: CAI12108.1.
AL162742 Genomic DNA. Translation: CAI12109.1.
CH471066 Genomic DNA. Translation: EAW49596.1.
CH471066 Genomic DNA. Translation: EAW49597.1.
BC040536 mRNA. Translation: AAH40536.1.
BC070108 mRNA. Translation: AAH70108.1.
CCDSiCCDS7557.1.
RefSeqiNP_001258941.1. NM_001272012.1.
NP_001258942.1. NM_001272013.1.
NP_203755.1. NM_033397.3.
UniGeneiHs.523252.
Hs.745171.

Genome annotation databases

EnsembliENST00000278071; ENSP00000278071; ENSG00000148841.
ENST00000337478; ENSP00000337178; ENSG00000148841.
ENST00000358187; ENSP00000350915; ENSG00000148841.
GeneIDi85450.
KEGGihsa:85450.
UCSCiuc001kye.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051541 mRNA. Translation: BAB21845.1. Different initiation.
AK056526 mRNA. Translation: BAB71204.1.
AL162742 Genomic DNA. Translation: CAI12108.1.
AL162742 Genomic DNA. Translation: CAI12109.1.
CH471066 Genomic DNA. Translation: EAW49596.1.
CH471066 Genomic DNA. Translation: EAW49597.1.
BC040536 mRNA. Translation: AAH40536.1.
BC070108 mRNA. Translation: AAH70108.1.
CCDSiCCDS7557.1.
RefSeqiNP_001258941.1. NM_001272012.1.
NP_001258942.1. NM_001272013.1.
NP_203755.1. NM_033397.3.
UniGeneiHs.523252.
Hs.745171.

3D structure databases

ProteinModelPortaliQ8IWB1.
SMRiQ8IWB1. Positions 365-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124535. 21 interactions.
IntActiQ8IWB1. 6 interactions.
STRINGi9606.ENSP00000278071.

PTM databases

iPTMnetiQ8IWB1.
PhosphoSiteiQ8IWB1.

Polymorphism and mutation databases

DMDMi74750704.

Proteomic databases

EPDiQ8IWB1.
MaxQBiQ8IWB1.
PaxDbiQ8IWB1.
PRIDEiQ8IWB1.
TopDownProteomicsiQ8IWB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278071; ENSP00000278071; ENSG00000148841.
ENST00000337478; ENSP00000337178; ENSG00000148841.
ENST00000358187; ENSP00000350915; ENSG00000148841.
GeneIDi85450.
KEGGihsa:85450.
UCSCiuc001kye.5. human.

Organism-specific databases

CTDi85450.
GeneCardsiITPRIP.
HGNCiHGNC:29370. ITPRIP.
HPAiHPA043626.
neXtProtiNX_Q8IWB1.
PharmGKBiPA162392344.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFEJ. Eukaryota.
ENOG4110247. LUCA.
GeneTreeiENSGT00530000063794.
HOGENOMiHOG000113093.
HOVERGENiHBG108007.
InParanoidiQ8IWB1.
OMAiTDWLLSF.
OrthoDBiEOG7VX8VH.
PhylomeDBiQ8IWB1.
TreeFamiTF332277.

Miscellaneous databases

ChiTaRSiITPRIP. human.
GenomeRNAii85450.
NextBioi76057.
PROiQ8IWB1.

Gene expression databases

BgeeiQ8IWB1.
CleanExiHS_ITPRIP.
ExpressionAtlasiQ8IWB1. baseline and differential.
GenevisibleiQ8IWB1. HS.

Family and domain databases

InterProiIPR024797. IP3R-int.
IPR026250. ITPRIP_fam.
IPR024810. Mab-21_dom.
[Graphical view]
PANTHERiPTHR10656:SF8. PTHR10656:SF8. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
PRINTSiPR02107. INOS145TPRIP.
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiIPRI_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB1
Secondary accession number(s): D3DRA5
, Q5JU17, Q96MS8, Q9C0A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.