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Protein

Coiled-coil domain-containing protein 60

Gene

CCDC60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 60
Gene namesi
Name:CCDC60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28610. CCDC60.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485413.

Polymorphism and mutation databases

BioMutaiCCDC60.
DMDMi296434427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Coiled-coil domain-containing protein 60PRO_0000239665Add
BLAST

Proteomic databases

EPDiQ8IWA6.
PaxDbiQ8IWA6.
PRIDEiQ8IWA6.

PTM databases

iPTMnetiQ8IWA6.
PhosphoSiteiQ8IWA6.

Expressioni

Gene expression databases

BgeeiQ8IWA6.
CleanExiHS_CCDC60.
ExpressionAtlasiQ8IWA6. baseline and differential.
GenevisibleiQ8IWA6. HS.

Organism-specific databases

HPAiHPA039048.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTUS2Q5JR593EBI-10262147,EBI-742948

Protein-protein interaction databases

BioGridi127766. 8 interactions.
IntActiQ8IWA6. 1 interaction.
STRINGi9606.ENSP00000333374.

Structurei

3D structure databases

ProteinModelPortaliQ8IWA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili71 – 9828Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJXB. Eukaryota.
ENOG4111UXH. LUCA.
GeneTreeiENSGT00390000015428.
HOGENOMiHOG000060292.
HOVERGENiHBG081044.
InParanoidiQ8IWA6.
OMAiAHVEPLF.
OrthoDBiEOG72JWGT.
PhylomeDBiQ8IWA6.
TreeFamiTF336372.

Family and domain databases

InterProiIPR031526. DUF4698.
[Graphical view]
PfamiPF15769. DUF4698. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVPATKKL QSSPNSGAVR PFYASENLRQ VPDKPMKSIK YMDKEIINLK
60 70 80 90 100
KDLIRSRFLI QSVKIGRGYF AILREETAKK KKQQQLQKLK EEERNKFQPA
110 120 130 140 150
EKISEIHYGD TLLSTYDDEK LKTLGARVTR RPFTPIHSCI ISPSLTEAHV
160 170 180 190 200
EPLFRQLCAL HWLLEALTID HTHHTMKPVI TCWNPKDPGG SKSTIKKINK
210 220 230 240 250
DKSMGQKWEH FITAPKTKKF KIPTMRVTNR KPSRRGSTLS LSRASGGSSP
260 270 280 290 300
QSSMISVNPG SDEPPSVNTQ VTSSKDIEDN ESSSTKPDEE PLYMNLQKLL
310 320 330 340 350
EMVREDARRT VTIENGMQRK APSILSVLKQ NKSNSAYKEM QTTLKSSERS
360 370 380 390 400
SSTSAESHIQ PVQKKSKNRT NCDINIHYKS GVCNTMRAKF YSVAQEAGFC
410 420 430 440 450
LQDKMEILMK RQEERGIQKF RAFVLVSNFQ KDIAKMRHHI SVVKGDAEEI
460 470 480 490 500
ADHWYFDLLS KLPEDLKNFR PAKKILVKLQ KFGENLDLRI RPHVLLKVLQ
510 520 530 540 550
DLRIWELCSP DIAVAIEFVR EHIIHMPQED YISWLQSRIN IPIGPYSALR
Length:550
Mass (Da):63,091
Last modified:May 18, 2010 - v2
Checksum:iDD48DC84933C3C61
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191K → E in AAH40553 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461I → V.
Corresponds to variant rs1064319 [ dbSNP | Ensembl ].
VAR_033667
Natural varianti115 – 1151T → A.
Corresponds to variant rs2519540 [ dbSNP | Ensembl ].
VAR_033668
Natural varianti393 – 3931V → I.
Corresponds to variant rs16949292 [ dbSNP | Ensembl ].
VAR_033669

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002070 Genomic DNA. No translation available.
AC084881 Genomic DNA. No translation available.
BC040553 mRNA. Translation: AAH40553.1.
CCDSiCCDS9190.1.
RefSeqiNP_848594.2. NM_178499.4.
UniGeneiHs.98188.

Genome annotation databases

EnsembliENST00000327554; ENSP00000333374; ENSG00000183273.
GeneIDi160777.
KEGGihsa:160777.
UCSCiuc001txe.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002070 Genomic DNA. No translation available.
AC084881 Genomic DNA. No translation available.
BC040553 mRNA. Translation: AAH40553.1.
CCDSiCCDS9190.1.
RefSeqiNP_848594.2. NM_178499.4.
UniGeneiHs.98188.

3D structure databases

ProteinModelPortaliQ8IWA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127766. 8 interactions.
IntActiQ8IWA6. 1 interaction.
STRINGi9606.ENSP00000333374.

PTM databases

iPTMnetiQ8IWA6.
PhosphoSiteiQ8IWA6.

Polymorphism and mutation databases

BioMutaiCCDC60.
DMDMi296434427.

Proteomic databases

EPDiQ8IWA6.
PaxDbiQ8IWA6.
PRIDEiQ8IWA6.

Protocols and materials databases

DNASUi160777.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327554; ENSP00000333374; ENSG00000183273.
GeneIDi160777.
KEGGihsa:160777.
UCSCiuc001txe.3. human.

Organism-specific databases

CTDi160777.
GeneCardsiCCDC60.
HGNCiHGNC:28610. CCDC60.
HPAiHPA039048.
neXtProtiNX_Q8IWA6.
PharmGKBiPA143485413.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJXB. Eukaryota.
ENOG4111UXH. LUCA.
GeneTreeiENSGT00390000015428.
HOGENOMiHOG000060292.
HOVERGENiHBG081044.
InParanoidiQ8IWA6.
OMAiAHVEPLF.
OrthoDBiEOG72JWGT.
PhylomeDBiQ8IWA6.
TreeFamiTF336372.

Miscellaneous databases

ChiTaRSiCCDC60. human.
GenomeRNAii160777.
PROiQ8IWA6.

Gene expression databases

BgeeiQ8IWA6.
CleanExiHS_CCDC60.
ExpressionAtlasiQ8IWA6. baseline and differential.
GenevisibleiQ8IWA6. HS.

Family and domain databases

InterProiIPR031526. DUF4698.
[Graphical view]
PfamiPF15769. DUF4698. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCD60_HUMAN
AccessioniPrimary (citable) accession number: Q8IWA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.