Q8IWA4 (MFN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitofusin-1
EC=3.6.5.-

Alternative name(s):
Fzo homolog
Transmembrane GTPase MFN1

Gene names

Name:

MFN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. Ref.1 Ref.10 Ref.11
Catalytic activity	GTP + H2O = GDP + phosphate.
Subunit structure	Forms homomultimers and heteromultimers with MFN2. Multimerization, which is mediated by the second coiled coil region, may play an essential role in mitochondrion fusion By similarity. Participates in a high molecular weight multiprotein complex. Interacts with VAT1 By similarity.
Subcellular location	Mitochondrion outer membrane; Multi-pass membrane protein Probable Ref.8 Ref.11. Isoform 2: Cytoplasm Ref.8 Ref.11.
Tissue specificity	Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. Ref.8 Ref.9 Ref.11
Post-translational modification	Ubiquitinated by MARCH5. Ref.12
Sequence similarities	Belongs to the mitofusin family.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Mitochondrion Mitochondrion outer membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial fusion Inferred from direct assay PubMed 20436456. Source: BHF-UCL
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IWA4-1)

Also known as: TG741;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IWA4-2)

Also known as: TG370;

The sequence of this isoform differs from the canonical sequence as follows:
     367-370: HYSV → FHVQ
     371-741: Missing.

Isoform 3 (identifier: Q8IWA4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     444-554: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 741	741	Mitofusin-1		PRO_0000127672
Regions
	Topological domain	1 – 584	584	Cytoplasmic Potential
	Transmembrane	585 – 605	21	Helical; Name=1; Potential
	Topological domain	606 – 608	3	Mitochondrial intermembrane Potential
	Transmembrane	609 – 629	21	Helical; Name=2; Potential
	Topological domain	630 – 741	112	Cytoplasmic Potential
	Nucleotide binding	82 – 89	8	GTP Probable
	Nucleotide binding	178 – 182	5	GTP Probable
	Nucleotide binding	237 – 240	4	GTP Probable
	Coiled coil	371 – 408	38	Potential
	Coiled coil	679 – 734	56	Potential
Natural variations
	Alternative sequence	367 – 370	4	HYSV → FHVQ in isoform 2.		VSP_010362
	Alternative sequence	371 – 741	371	Missing in isoform 2.		VSP_010363
	Alternative sequence	444 – 554	111	Missing in isoform 3.		VSP_010364
	Natural variant	415	1	D → H in a colorectal cancer sample; somatic mutation. Ref.14		VAR_036115
	Natural variant	523	1	P → R. Ref.1 Ref.2 Ref.4 Ref.5 Ref.7 Corresponds to variant rs7637065 [ dbSNP | Ensembl ].		VAR_018606
Experimental info
	Mutagenesis	88	1	K → T: Induces a strong decrease in mitochondrial clustering. Ref.11
	Mutagenesis	109	1	T → A: Acts as a dominant negative mutant; induces fragmentation of mitochondria. Ref.11
	Sequence conflict	17	1	A → G in AAK06840. Ref.1
	Sequence conflict	21	1	I → V in BAA91327. Ref.2
	Sequence conflict	162	1	W → C in AAB64220. Ref.6
	Sequence conflict	226	1	R → W in AAK06840. Ref.1
	Sequence conflict	271	1	V → A in AAK06840. Ref.1
	Sequence conflict	406	1	A → P in AAB64220. Ref.6
	Sequence conflict	688	1	Q → H in AAB64220. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TG741) [UniParc]. Last modified June 26, 2007. Version 2. Checksum: C4C1F56561D44A79	FASTA	741	84,100
	10 20 30 40 50 60 MAEPVSPLKH FVLAKKAITA IFDQLLEFVT EGSHFVEATY KNPELDRIAT EDDLVEMQGY 70 80 90 100 110 120 KDKLSIIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV LPSGIGHITN CFLSVEGTDG 130 140 150 160 170 180 DKAYLMTEGS DEKKSVKTVN QLAHALHMDK DLKAGCLVRV FWPKAKCALL RDDLVLVDSP 190 200 210 220 230 240 GTDVTTELDS WIDKFCLDAD VFVLVANSES TLMNTEKHFF HKVNERLSKP NIFILNNRWD 250 260 270 280 290 300 ASASEPEYME DVRRQHMERC LHFLVEELKV VNALEAQNRI FFVSAKEVLS ARKQKAQGMP 310 320 330 340 350 360 ESGVALAEGF HARLQEFQNF EQIFEECISQ SAVKTKFEQH TIRAKQILAT VKNIMDSVNL 370 380 390 400 410 420 AAEDKRHYSV EEREDQIDRL DFIRNQMNLL TLDVKKKIKE VTEEVANKVS CAMTDEICRL 430 440 450 460 470 480 SVLVDEFCSE FHPNPDVLKI YKSELNKHIE DGMGRNLADR CTDEVNALVL QTQQEIIENL 490 500 510 520 530 540 KPLLPAGIQD KLHTLIPCKK FDLSYNLNYH KLCSDFQEDI VFPFSLGWSS LVHRFLGPRN 550 560 570 580 590 600 AQRVLLGLSE PIFQLPRSLA STPTAPTTPA TPDNASQEEL MITLVTGLAS VTSRTSMGII 610 620 630 640 650 660 IVGGVIWKTI GWKLLSVSLT MYGALYLYER LSWTTHAKER AFKQQFVNYA TEKLRMIVSS 670 680 690 700 710 720 TSANCSHQVK QQIATTFARL CQQVDITQKQ LEEEIARLPK EIDQLEKIQN NSKLLRNKAV 730 740 QLENELENFT KQFLPSSNEE S
	Isoform 2 (TG370) [UniParc]. Checksum: 187B06EA1E971C6E	FASTA	370	41,883
	10 20 30 40 50 60 MAEPVSPLKH FVLAKKAITA IFDQLLEFVT EGSHFVEATY KNPELDRIAT EDDLVEMQGY 70 80 90 100 110 120 KDKLSIIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV LPSGIGHITN CFLSVEGTDG 130 140 150 160 170 180 DKAYLMTEGS DEKKSVKTVN QLAHALHMDK DLKAGCLVRV FWPKAKCALL RDDLVLVDSP 190 200 210 220 230 240 GTDVTTELDS WIDKFCLDAD VFVLVANSES TLMNTEKHFF HKVNERLSKP NIFILNNRWD 250 260 270 280 290 300 ASASEPEYME DVRRQHMERC LHFLVEELKV VNALEAQNRI FFVSAKEVLS ARKQKAQGMP 310 320 330 340 350 360 ESGVALAEGF HARLQEFQNF EQIFEECISQ SAVKTKFEQH TIRAKQILAT VKNIMDSVNL 370 AAEDKRFHVQ
	Isoform 3 [UniParc]. Checksum: D173A310365208BD	FASTA	630	71,401
	10 20 30 40 50 60 MAEPVSPLKH FVLAKKAITA IFDQLLEFVT EGSHFVEATY KNPELDRIAT EDDLVEMQGY 70 80 90 100 110 120 KDKLSIIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV LPSGIGHITN CFLSVEGTDG 130 140 150 160 170 180 DKAYLMTEGS DEKKSVKTVN QLAHALHMDK DLKAGCLVRV FWPKAKCALL RDDLVLVDSP 190 200 210 220 230 240 GTDVTTELDS WIDKFCLDAD VFVLVANSES TLMNTEKHFF HKVNERLSKP NIFILNNRWD 250 260 270 280 290 300 ASASEPEYME DVRRQHMERC LHFLVEELKV VNALEAQNRI FFVSAKEVLS ARKQKAQGMP 310 320 330 340 350 360 ESGVALAEGF HARLQEFQNF EQIFEECISQ SAVKTKFEQH TIRAKQILAT VKNIMDSVNL 370 380 390 400 410 420 AAEDKRHYSV EEREDQIDRL DFIRNQMNLL TLDVKKKIKE VTEEVANKVS CAMTDEICRL 430 440 450 460 470 480 SVLVDEFCSE FHPNPDVLKI YKSLPRSLAS TPTAPTTPAT PDNASQEELM ITLVTGLASV 490 500 510 520 530 540 TSRTSMGIII VGGVIWKTIG WKLLSVSLTM YGALYLYERL SWTTHAKERA FKQQFVNYAT 550 560 570 580 590 600 EKLRMIVSST SANCSHQVKQ QIATTFARLC QQVDITQKQL EEEIARLPKE IDQLEKIQNN 610 620 630 SKLLRNKAVQ LENELENFTK QFLPSSNEES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Control of mitochondrial morphology by a human mitofusin." Santel A., Fuller M.T. J. Cell Sci. 114:867-874(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT ARG-523. Tissue: Heart.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-523. Tissue: Ileal mucosa and Trachea.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-523.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-523. Tissue: Testis.
[6]	"Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase." Hales K.G., Fuller M.T. Cell 90:121-129(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-741 (ISOFORM 3). Tissue: Brain.
[7]	Yu W., Gibbs R.A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 374-741, VARIANT ARG-523. Tissue: Brain.
[8]	"Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display." Chung J.-G., Yeh K.-T., Wu S.-L., Hsu N.-Y., Chen G.-W., Yeh Y.-W., Ho H.-C. Cancer Res. 61:8873-8879(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[9]	"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo." Rojo M., Legros F., Chateau D., Lombes A. J. Cell Sci. 115:1663-1674(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[10]	"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins." Legros F., Lombes A., Frachon P., Rojo M. Mol. Biol. Cell 13:4343-4354(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells." Santel A., Frank S., Gaume B., Herrler M., Youle R.J., Fuller M.T. J. Cell Sci. 116:2763-2774(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-88 AND THR-109.
[12]	"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1." Park Y.Y., Lee S., Karbowski M., Neutzner A., Youle R.J., Cho H. J. Cell Sci. 123:619-626(2010) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION BY MARCH5.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-415.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF329637 mRNA. Translation: AAK06840.1. AK000700 mRNA. Translation: BAA91327.1. AK314306 mRNA. Translation: BAG36958.1. AC007823 Genomic DNA. No translation available. AC007620 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78406.1. CH471052 Genomic DNA. Translation: EAW78410.1. CH471052 Genomic DNA. Translation: EAW78411.1. BC040557 mRNA. Translation: AAH40557.1. U95822 mRNA. Translation: AAB64220.1. AF054986 mRNA. Translation: AAC09347.1.
IPI	IPI00293073. IPI00395973. IPI00412274.
RefSeq	NP_284941.2. NM_033540.2.
UniGene	Hs.478383.
3D structure databases
ProteinModelPortal	Q8IWA4.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-50289N.
IntAct	Q8IWA4. 1 interaction.
MINT	MINT-6940236.
STRING	9606.ENSP00000263969.
Protein family/group databases
TCDB	9.B.25.2.1. mitochondrial inner/outer membrane fusion (MMF) family.
PTM databases
PhosphoSite	Q8IWA4.
Polymorphism databases
DMDM	150421594.
Proteomic databases
PaxDb	Q8IWA4.
PRIDE	Q8IWA4.
Protocols and materials databases
DNASU	55669.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263969; ENSP00000263969; ENSG00000171109. ENST00000280653; ENSP00000280653; ENSG00000171109. ENST00000357390; ENSP00000349963; ENSG00000171109. ENST00000471841; ENSP00000420617; ENSG00000171109.
GeneID	55669.
KEGG	hsa:55669.
UCSC	uc003fjs.3. human. uc010hxc.3. human.
Organism-specific databases
CTD	55669.
GeneCards	GC03P179065.
HGNC	HGNC:18262. MFN1.
HPA	CAB033437.
MIM	608506. gene.
neXtProt	NX_Q8IWA4.
PharmGKB	PA134945973.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0699.
HOVERGEN	HBG052465.
InParanoid	Q8IWA4.
KO	K06030.
OMA	AQNRIFF.
OrthoDB	EOG43JC43.
PhylomeDB	Q8IWA4.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q8IWA4.
Bgee	Q8IWA4.
CleanEx	HS_MFN1.
Genevestigator	Q8IWA4.
GermOnline	ENSG00000171109. Homo sapiens.
Family and domain databases
InterPro	IPR001401. Dynamin_GTPase. IPR006884. Fzo/mitofusin_HR2. IPR027088. Mitofusin-1. IPR027094. Mitofusin_fam. IPR027417. P-loop_NTPase. [Graphical view]
PANTHER	PTHR10465. PTHR10465. 1 hit. PTHR10465:SF2. PTHR10465:SF2. 1 hit.
Pfam	PF00350. Dynamin_N. 1 hit. PF04799. Fzo_mitofusin. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55669.
NextBio	60436.
SOURCE	Search...

Entry information

Entry name

MFN1_HUMAN

Accession

Primary (citable) accession number: Q8IWA4
Secondary accession number(s): B2RAR1 , D3DNR6, O15323, O60639, Q9BZB5, Q9NWQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	June 26, 2007
Last modified:	May 29, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.