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Protein

WD repeat-containing protein 75

Gene

WDR75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • transcription cofactor activity Source: GO_Central

GO - Biological processi

  • histone acetylation Source: GO_Central
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • regulation of mitophagy Source: ParkinsonsUK-UCL
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • rRNA processing Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ8IWA0.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 75
Alternative name(s):
U3 small nucleolar RNA-associated protein 17 homolog
Gene namesi
Name:WDR75
Synonyms:UTP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25725. WDR75.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670579.

Polymorphism and mutation databases

BioMutaiWDR75.
DMDMi73622083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830WD repeat-containing protein 75PRO_0000051430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki427 – 427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei466 – 4661N6-acetyllysineCombined sources
Modified residuei664 – 6641PhosphoserineCombined sources
Modified residuei672 – 6721PhosphoserineCombined sources
Modified residuei779 – 7791PhosphoserineCombined sources
Modified residuei782 – 7821PhosphoserineCombined sources
Modified residuei796 – 7961PhosphoserineCombined sources
Modified residuei811 – 8111PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IWA0.
MaxQBiQ8IWA0.
PaxDbiQ8IWA0.
PeptideAtlasiQ8IWA0.
PRIDEiQ8IWA0.

2D gel databases

SWISS-2DPAGEQ8IWA0.

PTM databases

iPTMnetiQ8IWA0.
PhosphoSiteiQ8IWA0.
SwissPalmiQ8IWA0.

Expressioni

Gene expression databases

BgeeiENSG00000115368.
CleanExiHS_WDR75.
ExpressionAtlasiQ8IWA0. baseline and differential.
GenevisibleiQ8IWA0. HS.

Organism-specific databases

HPAiHPA038199.

Interactioni

Subunit structurei

Forms a complex with UTP4, NOL11, UTP15 and WDR43.1 Publication

Protein-protein interaction databases

BioGridi123901. 25 interactions.
IntActiQ8IWA0. 11 interactions.
MINTiMINT-4728442.
STRINGi9606.ENSP00000314193.

Structurei

3D structure databases

ProteinModelPortaliQ8IWA0.
SMRiQ8IWA0. Positions 22-88, 204-231, 247-282, 441-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 5239WD 1Add
BLAST
Repeati55 – 9541WD 2Add
BLAST
Repeati201 – 24040WD 3Add
BLAST
Repeati246 – 28540WD 4Add
BLAST
Repeati288 – 32841WD 5Add
BLAST
Repeati332 – 37140WD 6Add
BLAST
Repeati440 – 48344WD 7Add
BLAST
Repeati496 – 53439WD 8Add
BLAST
Repeati537 – 57842WD 9Add
BLAST

Sequence similaritiesi

Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1963. Eukaryota.
ENOG410YY9G. LUCA.
GeneTreeiENSGT00390000006303.
HOGENOMiHOG000043113.
HOVERGENiHBG061237.
InParanoidiQ8IWA0.
KOiK14552.
OMAiYFKVWIL.
OrthoDBiEOG091G02TD.
PhylomeDBiQ8IWA0.
TreeFamiTF323469.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV
60 70 80 90 100
HILHGHRNLV TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC
110 120 130 140 150
KLHALFTLAQ AEDSVFVIVN KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV
160 170 180 190 200
LDYINQSPKC IAFGNEGVYV AAVREFYLSV YFFKKKTTSR FTLSSSRNKK
210 220 230 240 250
HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT YTCLHWHHDM
260 270 280 290 300
VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP
310 320 330 340 350
AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV
360 370 380 390 400
LNGKPGHLQF YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN
410 420 430 440 450
WLATVEQRQE KETELELQMK LWMYNKKTQG FILNTKINMP HEDCITALCF
460 470 480 490 500
CNAEKSEQPT LVTASKDGYF KVWILTDDSD IYKKAVGWTC DFVGSYHKYQ
510 520 530 540 550
ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG KIRHLCFGRL
560 570 580 590 600
TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ
610 620 630 640 650
SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW
660 670 680 690 700
LNRSQFYFLT KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG
710 720 730 740 750
KHRQQQDEKL NETLENELVQ LPLTENIPAI SELLHTPAHV LPSAAFLCSM
760 770 780 790 800
FVNSLLLSKE TKSAKEIPED VDMEEEKESE DSDEENDFTE KVQDTSNTGL
810 820 830
GEDIIHQLSK SEEKELRKFR KIDYSWIAAL
Length:830
Mass (Da):94,499
Last modified:March 1, 2003 - v1
Checksum:iAE2A3C2C156C0939
GO

Sequence cautioni

The sequence BAB14503 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161F → L in BAB14503 (PubMed:14702039).Curated
Sequence conflicti125 – 1251D → N in BAB14111 (PubMed:14702039).Curated
Sequence conflicti250 – 2501M → T in BAB14111 (PubMed:14702039).Curated
Sequence conflicti279 – 2791T → I in BAB14503 (PubMed:14702039).Curated
Sequence conflicti393 – 3931A → T in BAB14111 (PubMed:14702039).Curated
Sequence conflicti479 – 4791S → T in BAB14126 (PubMed:14702039).Curated
Sequence conflicti733 – 7331L → H in BAB14126 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122097 mRNA. Translation: CAB59265.1.
CR749440 mRNA. Translation: CAH18278.1.
AC013439 Genomic DNA. Translation: AAX93081.1.
BC040567 mRNA. Translation: AAH40567.1.
BC006816 mRNA. Translation: AAH06816.1.
AK022581 mRNA. Translation: BAB14111.1.
AK022607 mRNA. Translation: BAB14126.1.
AK023276 mRNA. Translation: BAB14503.1. Different initiation.
CCDSiCCDS2298.1.
PIRiT34531.
RefSeqiNP_001290025.1. NM_001303096.1.
NP_115544.1. NM_032168.2.
UniGeneiHs.399984.

Genome annotation databases

EnsembliENST00000314761; ENSP00000314193; ENSG00000115368.
GeneIDi84128.
KEGGihsa:84128.
UCSCiuc002uql.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122097 mRNA. Translation: CAB59265.1.
CR749440 mRNA. Translation: CAH18278.1.
AC013439 Genomic DNA. Translation: AAX93081.1.
BC040567 mRNA. Translation: AAH40567.1.
BC006816 mRNA. Translation: AAH06816.1.
AK022581 mRNA. Translation: BAB14111.1.
AK022607 mRNA. Translation: BAB14126.1.
AK023276 mRNA. Translation: BAB14503.1. Different initiation.
CCDSiCCDS2298.1.
PIRiT34531.
RefSeqiNP_001290025.1. NM_001303096.1.
NP_115544.1. NM_032168.2.
UniGeneiHs.399984.

3D structure databases

ProteinModelPortaliQ8IWA0.
SMRiQ8IWA0. Positions 22-88, 204-231, 247-282, 441-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123901. 25 interactions.
IntActiQ8IWA0. 11 interactions.
MINTiMINT-4728442.
STRINGi9606.ENSP00000314193.

PTM databases

iPTMnetiQ8IWA0.
PhosphoSiteiQ8IWA0.
SwissPalmiQ8IWA0.

Polymorphism and mutation databases

BioMutaiWDR75.
DMDMi73622083.

2D gel databases

SWISS-2DPAGEQ8IWA0.

Proteomic databases

EPDiQ8IWA0.
MaxQBiQ8IWA0.
PaxDbiQ8IWA0.
PeptideAtlasiQ8IWA0.
PRIDEiQ8IWA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314761; ENSP00000314193; ENSG00000115368.
GeneIDi84128.
KEGGihsa:84128.
UCSCiuc002uql.2. human.

Organism-specific databases

CTDi84128.
GeneCardsiWDR75.
HGNCiHGNC:25725. WDR75.
HPAiHPA038199.
neXtProtiNX_Q8IWA0.
PharmGKBiPA142670579.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1963. Eukaryota.
ENOG410YY9G. LUCA.
GeneTreeiENSGT00390000006303.
HOGENOMiHOG000043113.
HOVERGENiHBG061237.
InParanoidiQ8IWA0.
KOiK14552.
OMAiYFKVWIL.
OrthoDBiEOG091G02TD.
PhylomeDBiQ8IWA0.
TreeFamiTF323469.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ8IWA0.

Miscellaneous databases

ChiTaRSiWDR75. human.
GenomeRNAii84128.
PROiQ8IWA0.

Gene expression databases

BgeeiENSG00000115368.
CleanExiHS_WDR75.
ExpressionAtlasiQ8IWA0. baseline and differential.
GenevisibleiQ8IWA0. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR75_HUMAN
AccessioniPrimary (citable) accession number: Q8IWA0
Secondary accession number(s): Q96J10
, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.