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Protein

WD repeat-containing protein 75

Gene

WDR75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • transcription cofactor activity Source: GO_Central

GO - Biological processi

  • histone acetylation Source: GO_Central
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • regulation of mitophagy Source: ParkinsonsUK-UCL
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • rRNA processing Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
SignaLinkiQ8IWA0.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 75
Alternative name(s):
U3 small nucleolar RNA-associated protein 17 homolog
Gene namesi
Name:WDR75
Synonyms:UTP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25725. WDR75.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115368.
PharmGKBiPA142670579.

Polymorphism and mutation databases

BioMutaiWDR75.
DMDMi73622083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514301 – 830WD repeat-containing protein 75Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei466N6-acetyllysineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei779PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei796PhosphoserineCombined sources1
Modified residuei811PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IWA0.
MaxQBiQ8IWA0.
PaxDbiQ8IWA0.
PeptideAtlasiQ8IWA0.
PRIDEiQ8IWA0.

2D gel databases

SWISS-2DPAGEQ8IWA0.

PTM databases

iPTMnetiQ8IWA0.
PhosphoSitePlusiQ8IWA0.
SwissPalmiQ8IWA0.

Expressioni

Gene expression databases

BgeeiENSG00000115368.
CleanExiHS_WDR75.
ExpressionAtlasiQ8IWA0. baseline and differential.
GenevisibleiQ8IWA0. HS.

Organism-specific databases

HPAiHPA038199.

Interactioni

Subunit structurei

Forms a complex with UTP4, NOL11, UTP15 and WDR43.1 Publication

Protein-protein interaction databases

BioGridi123901. 25 interactors.
IntActiQ8IWA0. 11 interactors.
MINTiMINT-4728442.
STRINGi9606.ENSP00000314193.

Structurei

3D structure databases

ProteinModelPortaliQ8IWA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 52WD 1Add BLAST39
Repeati55 – 95WD 2Add BLAST41
Repeati201 – 240WD 3Add BLAST40
Repeati246 – 285WD 4Add BLAST40
Repeati288 – 328WD 5Add BLAST41
Repeati332 – 371WD 6Add BLAST40
Repeati440 – 483WD 7Add BLAST44
Repeati496 – 534WD 8Add BLAST39
Repeati537 – 578WD 9Add BLAST42

Sequence similaritiesi

Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1963. Eukaryota.
ENOG410YY9G. LUCA.
GeneTreeiENSGT00390000006303.
HOGENOMiHOG000043113.
HOVERGENiHBG061237.
InParanoidiQ8IWA0.
KOiK14552.
OMAiYFKVWIL.
OrthoDBiEOG091G02TD.
PhylomeDBiQ8IWA0.
TreeFamiTF323469.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IWA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV
60 70 80 90 100
HILHGHRNLV TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC
110 120 130 140 150
KLHALFTLAQ AEDSVFVIVN KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV
160 170 180 190 200
LDYINQSPKC IAFGNEGVYV AAVREFYLSV YFFKKKTTSR FTLSSSRNKK
210 220 230 240 250
HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT YTCLHWHHDM
260 270 280 290 300
VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP
310 320 330 340 350
AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV
360 370 380 390 400
LNGKPGHLQF YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN
410 420 430 440 450
WLATVEQRQE KETELELQMK LWMYNKKTQG FILNTKINMP HEDCITALCF
460 470 480 490 500
CNAEKSEQPT LVTASKDGYF KVWILTDDSD IYKKAVGWTC DFVGSYHKYQ
510 520 530 540 550
ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG KIRHLCFGRL
560 570 580 590 600
TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ
610 620 630 640 650
SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW
660 670 680 690 700
LNRSQFYFLT KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG
710 720 730 740 750
KHRQQQDEKL NETLENELVQ LPLTENIPAI SELLHTPAHV LPSAAFLCSM
760 770 780 790 800
FVNSLLLSKE TKSAKEIPED VDMEEEKESE DSDEENDFTE KVQDTSNTGL
810 820 830
GEDIIHQLSK SEEKELRKFR KIDYSWIAAL
Length:830
Mass (Da):94,499
Last modified:March 1, 2003 - v1
Checksum:iAE2A3C2C156C0939
GO

Sequence cautioni

The sequence BAB14503 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116F → L in BAB14503 (PubMed:14702039).Curated1
Sequence conflicti125D → N in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti250M → T in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti279T → I in BAB14503 (PubMed:14702039).Curated1
Sequence conflicti393A → T in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti479S → T in BAB14126 (PubMed:14702039).Curated1
Sequence conflicti733L → H in BAB14126 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122097 mRNA. Translation: CAB59265.1.
CR749440 mRNA. Translation: CAH18278.1.
AC013439 Genomic DNA. Translation: AAX93081.1.
BC040567 mRNA. Translation: AAH40567.1.
BC006816 mRNA. Translation: AAH06816.1.
AK022581 mRNA. Translation: BAB14111.1.
AK022607 mRNA. Translation: BAB14126.1.
AK023276 mRNA. Translation: BAB14503.1. Different initiation.
CCDSiCCDS2298.1.
PIRiT34531.
RefSeqiNP_001290025.1. NM_001303096.1.
NP_115544.1. NM_032168.2.
UniGeneiHs.399984.

Genome annotation databases

EnsembliENST00000314761; ENSP00000314193; ENSG00000115368.
GeneIDi84128.
KEGGihsa:84128.
UCSCiuc002uql.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122097 mRNA. Translation: CAB59265.1.
CR749440 mRNA. Translation: CAH18278.1.
AC013439 Genomic DNA. Translation: AAX93081.1.
BC040567 mRNA. Translation: AAH40567.1.
BC006816 mRNA. Translation: AAH06816.1.
AK022581 mRNA. Translation: BAB14111.1.
AK022607 mRNA. Translation: BAB14126.1.
AK023276 mRNA. Translation: BAB14503.1. Different initiation.
CCDSiCCDS2298.1.
PIRiT34531.
RefSeqiNP_001290025.1. NM_001303096.1.
NP_115544.1. NM_032168.2.
UniGeneiHs.399984.

3D structure databases

ProteinModelPortaliQ8IWA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123901. 25 interactors.
IntActiQ8IWA0. 11 interactors.
MINTiMINT-4728442.
STRINGi9606.ENSP00000314193.

PTM databases

iPTMnetiQ8IWA0.
PhosphoSitePlusiQ8IWA0.
SwissPalmiQ8IWA0.

Polymorphism and mutation databases

BioMutaiWDR75.
DMDMi73622083.

2D gel databases

SWISS-2DPAGEQ8IWA0.

Proteomic databases

EPDiQ8IWA0.
MaxQBiQ8IWA0.
PaxDbiQ8IWA0.
PeptideAtlasiQ8IWA0.
PRIDEiQ8IWA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314761; ENSP00000314193; ENSG00000115368.
GeneIDi84128.
KEGGihsa:84128.
UCSCiuc002uql.2. human.

Organism-specific databases

CTDi84128.
GeneCardsiWDR75.
HGNCiHGNC:25725. WDR75.
HPAiHPA038199.
neXtProtiNX_Q8IWA0.
OpenTargetsiENSG00000115368.
PharmGKBiPA142670579.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1963. Eukaryota.
ENOG410YY9G. LUCA.
GeneTreeiENSGT00390000006303.
HOGENOMiHOG000043113.
HOVERGENiHBG061237.
InParanoidiQ8IWA0.
KOiK14552.
OMAiYFKVWIL.
OrthoDBiEOG091G02TD.
PhylomeDBiQ8IWA0.
TreeFamiTF323469.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
SignaLinkiQ8IWA0.

Miscellaneous databases

ChiTaRSiWDR75. human.
GenomeRNAii84128.
PROiQ8IWA0.

Gene expression databases

BgeeiENSG00000115368.
CleanExiHS_WDR75.
ExpressionAtlasiQ8IWA0. baseline and differential.
GenevisibleiQ8IWA0. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR75_HUMAN
AccessioniPrimary (citable) accession number: Q8IWA0
Secondary accession number(s): Q96J10
, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.