SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IW93

- ARHGJ_HUMAN

UniProt

Q8IW93 - ARHGJ_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Rho guanine nucleotide exchange factor 19

Gene
ARHGEF19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. positive regulation of Rho GTPase activity Source: Ensembl
  2. regulation of actin cytoskeleton organization Source: MGI
  3. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 19
Alternative name(s):
Ephexin-2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26604. ARHGEF19.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Rho guanine nucleotide exchange factor 19PRO_0000285131Add
BLAST

Proteomic databases

PaxDbiQ8IW93.
PRIDEiQ8IW93.

PTM databases

PhosphoSiteiQ8IW93.

Expressioni

Gene expression databases

ArrayExpressiQ8IW93.
BgeeiQ8IW93.
CleanExiHS_ARHGEF19.
GenevestigatoriQ8IW93.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RHOAP615862EBI-7799822,EBI-446668

Protein-protein interaction databases

BioGridi126104. 1 interaction.
IntActiQ8IW93. 4 interactions.
MINTiMINT-6504085.
STRINGi9606.ENSP00000270747.

Structurei

3D structure databases

ProteinModelPortaliQ8IW93.
SMRiQ8IW93. Positions 376-703, 716-779.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini376 – 560185DHAdd
BLAST
Domaini592 – 704113PHAdd
BLAST
Domaini715 – 77662SH3Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5422.
HOGENOMiHOG000007536.
HOVERGENiHBG058673.
InParanoidiQ8IW93.
OMAiSGGMRPS.
OrthoDBiEOG7H4DSV.
PhylomeDBiQ8IW93.
TreeFamiTF316357.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IW93-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDCGPPATLQ PHLTGPPGTA HHPVAVCQQE SLSFAELPAL KPPSPVCLDL    50
FPVAPEELRA PGSRWSLGTP APLQGLLWPL SPGGSDTEIT SGGMRPSRAG 100
SWPHCPGAQP PALEGPWSPR HTQPQRRASH GSEKKSAWRK MRVYQREEVP 150
GCPEAHAVFL EPGQVVQEQA LSTEEPRVEL SGSTRVSLEG PERRRFSASE 200
LMTRLHSSLR LGRNSAARAL ISGSGTGAAR EGKASGMEAR SVEMSGDRVS 250
RPAPGDSREG DWSEPRLDTQ EEPPLGSRST NERRQSRFLL NSVLYQEYSD 300
VASARELRRQ QREEEGPGDE AEGAEEGPGP PRANLSPSSS FRAQRSARGS 350
TFSLWQDIPD VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG 400
HFLGSAELSE CLGAQDKQWL FSKLPEVKST SERFLQDLEQ RLEADVLRFS 450
VCDVVLDHCP AFRRVYLPYV TNQAYQERTY QRLLLENPRF PGILARLEES 500
PVCQRLPLTS FLILPFQRIT RLKMLVENIL KRTAQGSEDE DMATKAFNAL 550
KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV 600
ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHAKMAE 650
LQVRDLSLKL QGIPGHVFLL QLLHGQHMKH QFLLRARTES EKQRWISALC 700
PSSPQEDKEV ISEGEDCPQV QCVRTYKALH PDELTLEKTD ILSVRTWTSD 750
GWLEGVRLAD GEKGWVPQAY VEEISSLSAR LRNLRENKRV TSATSKLGEA 800
PV 802
Length:802
Mass (Da):89,197
Last modified:March 1, 2003 - v1
Checksum:i7A334F386AC7A562
GO
Isoform 2 (identifier: Q8IW93-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     484-783: Missing.

Show »
Length:502
Mass (Da):55,022
Checksum:iA9DE31EE02DB2AC0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631G → R.1 Publication
Corresponds to variant rs221058 [ dbSNP | Ensembl ].
VAR_031950
Natural varianti238 – 2381E → Q.1 Publication
Corresponds to variant rs221057 [ dbSNP | Ensembl ].
VAR_031951

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei484 – 783300Missing in isoform 2. VSP_024827Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091281 mRNA. Translation: BAC03627.1.
AL109627 Genomic DNA. Translation: CAI22566.1.
AL109627 Genomic DNA. Translation: CAI22567.1.
BC012982 mRNA. Translation: AAH12982.1.
BC040640 mRNA. Translation: AAH40640.1.
CCDSiCCDS170.1. [Q8IW93-1]
RefSeqiNP_694945.2. NM_153213.3. [Q8IW93-1]
UniGeneiHs.591532.

Genome annotation databases

EnsembliENST00000270747; ENSP00000270747; ENSG00000142632. [Q8IW93-1]
GeneIDi128272.
KEGGihsa:128272.
UCSCiuc001ayc.1. human. [Q8IW93-1]

Polymorphism databases

DMDMi74750701.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091281 mRNA. Translation: BAC03627.1 .
AL109627 Genomic DNA. Translation: CAI22566.1 .
AL109627 Genomic DNA. Translation: CAI22567.1 .
BC012982 mRNA. Translation: AAH12982.1 .
BC040640 mRNA. Translation: AAH40640.1 .
CCDSi CCDS170.1. [Q8IW93-1 ]
RefSeqi NP_694945.2. NM_153213.3. [Q8IW93-1 ]
UniGenei Hs.591532.

3D structure databases

ProteinModelPortali Q8IW93.
SMRi Q8IW93. Positions 376-703, 716-779.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126104. 1 interaction.
IntActi Q8IW93. 4 interactions.
MINTi MINT-6504085.
STRINGi 9606.ENSP00000270747.

PTM databases

PhosphoSitei Q8IW93.

Polymorphism databases

DMDMi 74750701.

Proteomic databases

PaxDbi Q8IW93.
PRIDEi Q8IW93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270747 ; ENSP00000270747 ; ENSG00000142632 . [Q8IW93-1 ]
GeneIDi 128272.
KEGGi hsa:128272.
UCSCi uc001ayc.1. human. [Q8IW93-1 ]

Organism-specific databases

CTDi 128272.
GeneCardsi GC01M016524.
HGNCi HGNC:26604. ARHGEF19.
MIMi 612496. gene.
neXtProti NX_Q8IW93.
PharmGKBi PA134887028.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
HOGENOMi HOG000007536.
HOVERGENi HBG058673.
InParanoidi Q8IW93.
OMAi SGGMRPS.
OrthoDBi EOG7H4DSV.
PhylomeDBi Q8IW93.
TreeFami TF316357.

Miscellaneous databases

GenomeRNAii 128272.
NextBioi 82262.
PROi Q8IW93.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IW93.
Bgeei Q8IW93.
CleanExi HS_ARHGEF19.
Genevestigatori Q8IW93.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-163 AND GLN-238.
    Tissue: Tongue.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-802 (ISOFORM 1).
    Tissue: Colon and Pancreas.

Entry informationi

Entry nameiARHGJ_HUMAN
AccessioniPrimary (citable) accession number: Q8IW93
Secondary accession number(s): A6NJ04
, Q5TEV2, Q6PJQ4, Q8N244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi