Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8IW93 (ARHGJ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho guanine nucleotide exchange factor 19
Alternative name(s):
Ephexin-2
Gene names
Name:ARHGEF19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length802 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase By similarity.

Sequence similarities

Contains 1 DH (DBL-homology) domain.

Contains 1 PH domain.

Contains 1 SH3 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RHOAP615862EBI-7799822,EBI-446668

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IW93-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IW93-2)

The sequence of this isoform differs from the canonical sequence as follows:
     484-783: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 802802Rho guanine nucleotide exchange factor 19
PRO_0000285131

Regions

Domain376 – 560185DH
Domain592 – 704113PH
Domain715 – 77662SH3

Natural variations

Alternative sequence484 – 783300Missing in isoform 2.
VSP_024827
Natural variant1631G → R. Ref.1
Corresponds to variant rs221058 [ dbSNP | Ensembl ].
VAR_031950
Natural variant2381E → Q. Ref.1
Corresponds to variant rs221057 [ dbSNP | Ensembl ].
VAR_031951

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7A334F386AC7A562

FASTA80289,197
        10         20         30         40         50         60 
MDCGPPATLQ PHLTGPPGTA HHPVAVCQQE SLSFAELPAL KPPSPVCLDL FPVAPEELRA 

        70         80         90        100        110        120 
PGSRWSLGTP APLQGLLWPL SPGGSDTEIT SGGMRPSRAG SWPHCPGAQP PALEGPWSPR 

       130        140        150        160        170        180 
HTQPQRRASH GSEKKSAWRK MRVYQREEVP GCPEAHAVFL EPGQVVQEQA LSTEEPRVEL 

       190        200        210        220        230        240 
SGSTRVSLEG PERRRFSASE LMTRLHSSLR LGRNSAARAL ISGSGTGAAR EGKASGMEAR 

       250        260        270        280        290        300 
SVEMSGDRVS RPAPGDSREG DWSEPRLDTQ EEPPLGSRST NERRQSRFLL NSVLYQEYSD 

       310        320        330        340        350        360 
VASARELRRQ QREEEGPGDE AEGAEEGPGP PRANLSPSSS FRAQRSARGS TFSLWQDIPD 

       370        380        390        400        410        420 
VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG HFLGSAELSE CLGAQDKQWL 

       430        440        450        460        470        480 
FSKLPEVKST SERFLQDLEQ RLEADVLRFS VCDVVLDHCP AFRRVYLPYV TNQAYQERTY 

       490        500        510        520        530        540 
QRLLLENPRF PGILARLEES PVCQRLPLTS FLILPFQRIT RLKMLVENIL KRTAQGSEDE 

       550        560        570        580        590        600 
DMATKAFNAL KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV 

       610        620        630        640        650        660 
ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHAKMAE LQVRDLSLKL 

       670        680        690        700        710        720 
QGIPGHVFLL QLLHGQHMKH QFLLRARTES EKQRWISALC PSSPQEDKEV ISEGEDCPQV 

       730        740        750        760        770        780 
QCVRTYKALH PDELTLEKTD ILSVRTWTSD GWLEGVRLAD GEKGWVPQAY VEEISSLSAR 

       790        800 
LRNLRENKRV TSATSKLGEA PV 

« Hide

Isoform 2 [UniParc].

Checksum: A9DE31EE02DB2AC0
Show »

FASTA50255,022

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-163 AND GLN-238.
Tissue: Tongue.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-802 (ISOFORM 1).
Tissue: Colon and Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK091281 mRNA. Translation: BAC03627.1.
AL109627 Genomic DNA. Translation: CAI22566.1.
AL109627 Genomic DNA. Translation: CAI22567.1.
BC012982 mRNA. Translation: AAH12982.1.
BC040640 mRNA. Translation: AAH40640.1.
CCDSCCDS170.1. [Q8IW93-1]
RefSeqNP_694945.2. NM_153213.3. [Q8IW93-1]
UniGeneHs.591532.

3D structure databases

ProteinModelPortalQ8IW93.
SMRQ8IW93. Positions 376-703, 716-779.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126104. 1 interaction.
IntActQ8IW93. 4 interactions.
MINTMINT-6504085.
STRING9606.ENSP00000270747.

PTM databases

PhosphoSiteQ8IW93.

Polymorphism databases

DMDM74750701.

Proteomic databases

PaxDbQ8IW93.
PRIDEQ8IW93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270747; ENSP00000270747; ENSG00000142632. [Q8IW93-1]
GeneID128272.
KEGGhsa:128272.
UCSCuc001ayc.1. human. [Q8IW93-1]

Organism-specific databases

CTD128272.
GeneCardsGC01M016524.
HGNCHGNC:26604. ARHGEF19.
MIM612496. gene.
neXtProtNX_Q8IW93.
PharmGKBPA134887028.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5422.
HOGENOMHOG000007536.
HOVERGENHBG058673.
InParanoidQ8IW93.
OMASGGMRPS.
OrthoDBEOG7H4DSV.
PhylomeDBQ8IW93.
TreeFamTF316357.

Gene expression databases

ArrayExpressQ8IW93.
BgeeQ8IW93.
CleanExHS_ARHGEF19.
GenevestigatorQ8IW93.

Family and domain databases

Gene3D1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR000219. DH-domain.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi128272.
NextBio82262.
PROQ8IW93.
SOURCESearch...

Entry information

Entry nameARHGJ_HUMAN
AccessionPrimary (citable) accession number: Q8IW93
Secondary accession number(s): A6NJ04 expand/collapse secondary AC list , Q5TEV2, Q6PJQ4, Q8N244
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM