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Q8IW93

- ARHGJ_HUMAN

UniProt

Q8IW93 - ARHGJ_HUMAN

Protein

Rho guanine nucleotide exchange factor 19

Gene

ARHGEF19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. regulation of actin cytoskeleton organization Source: MGI
    2. wound healing Source: Ensembl

    Keywords - Molecular functioni

    GTPase activation, Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 19
    Alternative name(s):
    Ephexin-2
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26604. ARHGEF19.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134887028.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 802802Rho guanine nucleotide exchange factor 19PRO_0000285131Add
    BLAST

    Proteomic databases

    PaxDbiQ8IW93.
    PRIDEiQ8IW93.

    PTM databases

    PhosphoSiteiQ8IW93.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IW93.
    BgeeiQ8IW93.
    CleanExiHS_ARHGEF19.
    GenevestigatoriQ8IW93.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RHOAP615862EBI-7799822,EBI-446668

    Protein-protein interaction databases

    BioGridi126104. 1 interaction.
    IntActiQ8IW93. 4 interactions.
    MINTiMINT-6504085.
    STRINGi9606.ENSP00000270747.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IW93.
    SMRiQ8IW93. Positions 376-703, 716-779.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini376 – 560185DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini592 – 704113PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini715 – 77662SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5422.
    HOGENOMiHOG000007536.
    HOVERGENiHBG058673.
    InParanoidiQ8IW93.
    OMAiSGGMRPS.
    OrthoDBiEOG7H4DSV.
    PhylomeDBiQ8IW93.
    TreeFamiTF316357.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IW93-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDCGPPATLQ PHLTGPPGTA HHPVAVCQQE SLSFAELPAL KPPSPVCLDL    50
    FPVAPEELRA PGSRWSLGTP APLQGLLWPL SPGGSDTEIT SGGMRPSRAG 100
    SWPHCPGAQP PALEGPWSPR HTQPQRRASH GSEKKSAWRK MRVYQREEVP 150
    GCPEAHAVFL EPGQVVQEQA LSTEEPRVEL SGSTRVSLEG PERRRFSASE 200
    LMTRLHSSLR LGRNSAARAL ISGSGTGAAR EGKASGMEAR SVEMSGDRVS 250
    RPAPGDSREG DWSEPRLDTQ EEPPLGSRST NERRQSRFLL NSVLYQEYSD 300
    VASARELRRQ QREEEGPGDE AEGAEEGPGP PRANLSPSSS FRAQRSARGS 350
    TFSLWQDIPD VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG 400
    HFLGSAELSE CLGAQDKQWL FSKLPEVKST SERFLQDLEQ RLEADVLRFS 450
    VCDVVLDHCP AFRRVYLPYV TNQAYQERTY QRLLLENPRF PGILARLEES 500
    PVCQRLPLTS FLILPFQRIT RLKMLVENIL KRTAQGSEDE DMATKAFNAL 550
    KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV 600
    ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHAKMAE 650
    LQVRDLSLKL QGIPGHVFLL QLLHGQHMKH QFLLRARTES EKQRWISALC 700
    PSSPQEDKEV ISEGEDCPQV QCVRTYKALH PDELTLEKTD ILSVRTWTSD 750
    GWLEGVRLAD GEKGWVPQAY VEEISSLSAR LRNLRENKRV TSATSKLGEA 800
    PV 802
    Length:802
    Mass (Da):89,197
    Last modified:March 1, 2003 - v1
    Checksum:i7A334F386AC7A562
    GO
    Isoform 2 (identifier: Q8IW93-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         484-783: Missing.

    Show »
    Length:502
    Mass (Da):55,022
    Checksum:iA9DE31EE02DB2AC0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti163 – 1631G → R.1 Publication
    Corresponds to variant rs221058 [ dbSNP | Ensembl ].
    VAR_031950
    Natural varianti238 – 2381E → Q.1 Publication
    Corresponds to variant rs221057 [ dbSNP | Ensembl ].
    VAR_031951

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei484 – 783300Missing in isoform 2. 1 PublicationVSP_024827Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091281 mRNA. Translation: BAC03627.1.
    AL109627 Genomic DNA. Translation: CAI22566.1.
    AL109627 Genomic DNA. Translation: CAI22567.1.
    BC012982 mRNA. Translation: AAH12982.1.
    BC040640 mRNA. Translation: AAH40640.1.
    CCDSiCCDS170.1. [Q8IW93-1]
    RefSeqiNP_694945.2. NM_153213.3. [Q8IW93-1]
    UniGeneiHs.591532.

    Genome annotation databases

    EnsembliENST00000270747; ENSP00000270747; ENSG00000142632. [Q8IW93-1]
    GeneIDi128272.
    KEGGihsa:128272.
    UCSCiuc001ayc.1. human. [Q8IW93-1]

    Polymorphism databases

    DMDMi74750701.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091281 mRNA. Translation: BAC03627.1 .
    AL109627 Genomic DNA. Translation: CAI22566.1 .
    AL109627 Genomic DNA. Translation: CAI22567.1 .
    BC012982 mRNA. Translation: AAH12982.1 .
    BC040640 mRNA. Translation: AAH40640.1 .
    CCDSi CCDS170.1. [Q8IW93-1 ]
    RefSeqi NP_694945.2. NM_153213.3. [Q8IW93-1 ]
    UniGenei Hs.591532.

    3D structure databases

    ProteinModelPortali Q8IW93.
    SMRi Q8IW93. Positions 376-703, 716-779.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126104. 1 interaction.
    IntActi Q8IW93. 4 interactions.
    MINTi MINT-6504085.
    STRINGi 9606.ENSP00000270747.

    PTM databases

    PhosphoSitei Q8IW93.

    Polymorphism databases

    DMDMi 74750701.

    Proteomic databases

    PaxDbi Q8IW93.
    PRIDEi Q8IW93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270747 ; ENSP00000270747 ; ENSG00000142632 . [Q8IW93-1 ]
    GeneIDi 128272.
    KEGGi hsa:128272.
    UCSCi uc001ayc.1. human. [Q8IW93-1 ]

    Organism-specific databases

    CTDi 128272.
    GeneCardsi GC01M016524.
    HGNCi HGNC:26604. ARHGEF19.
    MIMi 612496. gene.
    neXtProti NX_Q8IW93.
    PharmGKBi PA134887028.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5422.
    HOGENOMi HOG000007536.
    HOVERGENi HBG058673.
    InParanoidi Q8IW93.
    OMAi SGGMRPS.
    OrthoDBi EOG7H4DSV.
    PhylomeDBi Q8IW93.
    TreeFami TF316357.

    Miscellaneous databases

    GenomeRNAii 128272.
    NextBioi 82262.
    PROi Q8IW93.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IW93.
    Bgeei Q8IW93.
    CleanExi HS_ARHGEF19.
    Genevestigatori Q8IW93.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-163 AND GLN-238.
      Tissue: Tongue.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-802 (ISOFORM 1).
      Tissue: Colon and Pancreas.

    Entry informationi

    Entry nameiARHGJ_HUMAN
    AccessioniPrimary (citable) accession number: Q8IW93
    Secondary accession number(s): A6NJ04
    , Q5TEV2, Q6PJQ4, Q8N244
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3