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Protein

Rho guanine nucleotide exchange factor 19

Gene

ARHGEF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. regulation of actin cytoskeleton organization Source: MGI
  2. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 19
Alternative name(s):
Ephexin-2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26604. ARHGEF19.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Rho guanine nucleotide exchange factor 19PRO_0000285131Add
BLAST

Proteomic databases

PaxDbiQ8IW93.
PRIDEiQ8IW93.

PTM databases

PhosphoSiteiQ8IW93.

Expressioni

Gene expression databases

BgeeiQ8IW93.
CleanExiHS_ARHGEF19.
ExpressionAtlasiQ8IW93. baseline and differential.
GenevestigatoriQ8IW93.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RHOAP615862EBI-7799822,EBI-446668

Protein-protein interaction databases

BioGridi126104. 1 interaction.
IntActiQ8IW93. 4 interactions.
MINTiMINT-6504085.
STRINGi9606.ENSP00000270747.

Structurei

3D structure databases

ProteinModelPortaliQ8IW93.
SMRiQ8IW93. Positions 376-703, 716-779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini376 – 560185DHPROSITE-ProRule annotationAdd
BLAST
Domaini592 – 704113PHPROSITE-ProRule annotationAdd
BLAST
Domaini715 – 77662SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5422.
GeneTreeiENSGT00550000074493.
HOGENOMiHOG000007536.
HOVERGENiHBG058673.
InParanoidiQ8IW93.
OMAiSGGMRPS.
OrthoDBiEOG7H4DSV.
PhylomeDBiQ8IW93.
TreeFamiTF316357.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IW93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCGPPATLQ PHLTGPPGTA HHPVAVCQQE SLSFAELPAL KPPSPVCLDL
60 70 80 90 100
FPVAPEELRA PGSRWSLGTP APLQGLLWPL SPGGSDTEIT SGGMRPSRAG
110 120 130 140 150
SWPHCPGAQP PALEGPWSPR HTQPQRRASH GSEKKSAWRK MRVYQREEVP
160 170 180 190 200
GCPEAHAVFL EPGQVVQEQA LSTEEPRVEL SGSTRVSLEG PERRRFSASE
210 220 230 240 250
LMTRLHSSLR LGRNSAARAL ISGSGTGAAR EGKASGMEAR SVEMSGDRVS
260 270 280 290 300
RPAPGDSREG DWSEPRLDTQ EEPPLGSRST NERRQSRFLL NSVLYQEYSD
310 320 330 340 350
VASARELRRQ QREEEGPGDE AEGAEEGPGP PRANLSPSSS FRAQRSARGS
360 370 380 390 400
TFSLWQDIPD VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG
410 420 430 440 450
HFLGSAELSE CLGAQDKQWL FSKLPEVKST SERFLQDLEQ RLEADVLRFS
460 470 480 490 500
VCDVVLDHCP AFRRVYLPYV TNQAYQERTY QRLLLENPRF PGILARLEES
510 520 530 540 550
PVCQRLPLTS FLILPFQRIT RLKMLVENIL KRTAQGSEDE DMATKAFNAL
560 570 580 590 600
KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV
610 620 630 640 650
ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHAKMAE
660 670 680 690 700
LQVRDLSLKL QGIPGHVFLL QLLHGQHMKH QFLLRARTES EKQRWISALC
710 720 730 740 750
PSSPQEDKEV ISEGEDCPQV QCVRTYKALH PDELTLEKTD ILSVRTWTSD
760 770 780 790 800
GWLEGVRLAD GEKGWVPQAY VEEISSLSAR LRNLRENKRV TSATSKLGEA

PV
Length:802
Mass (Da):89,197
Last modified:March 1, 2003 - v1
Checksum:i7A334F386AC7A562
GO
Isoform 2 (identifier: Q8IW93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     484-783: Missing.

Show »
Length:502
Mass (Da):55,022
Checksum:iA9DE31EE02DB2AC0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631G → R.1 Publication
Corresponds to variant rs221058 [ dbSNP | Ensembl ].
VAR_031950
Natural varianti238 – 2381E → Q.1 Publication
Corresponds to variant rs221057 [ dbSNP | Ensembl ].
VAR_031951

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei484 – 783300Missing in isoform 2. 1 PublicationVSP_024827Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091281 mRNA. Translation: BAC03627.1.
AL109627 Genomic DNA. Translation: CAI22566.1.
AL109627 Genomic DNA. Translation: CAI22567.1.
BC012982 mRNA. Translation: AAH12982.1.
BC040640 mRNA. Translation: AAH40640.1.
CCDSiCCDS170.1. [Q8IW93-1]
RefSeqiNP_694945.2. NM_153213.3. [Q8IW93-1]
UniGeneiHs.591532.

Genome annotation databases

EnsembliENST00000270747; ENSP00000270747; ENSG00000142632. [Q8IW93-1]
GeneIDi128272.
KEGGihsa:128272.
UCSCiuc001ayc.1. human. [Q8IW93-1]

Polymorphism databases

DMDMi74750701.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091281 mRNA. Translation: BAC03627.1.
AL109627 Genomic DNA. Translation: CAI22566.1.
AL109627 Genomic DNA. Translation: CAI22567.1.
BC012982 mRNA. Translation: AAH12982.1.
BC040640 mRNA. Translation: AAH40640.1.
CCDSiCCDS170.1. [Q8IW93-1]
RefSeqiNP_694945.2. NM_153213.3. [Q8IW93-1]
UniGeneiHs.591532.

3D structure databases

ProteinModelPortaliQ8IW93.
SMRiQ8IW93. Positions 376-703, 716-779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126104. 1 interaction.
IntActiQ8IW93. 4 interactions.
MINTiMINT-6504085.
STRINGi9606.ENSP00000270747.

PTM databases

PhosphoSiteiQ8IW93.

Polymorphism databases

DMDMi74750701.

Proteomic databases

PaxDbiQ8IW93.
PRIDEiQ8IW93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270747; ENSP00000270747; ENSG00000142632. [Q8IW93-1]
GeneIDi128272.
KEGGihsa:128272.
UCSCiuc001ayc.1. human. [Q8IW93-1]

Organism-specific databases

CTDi128272.
GeneCardsiGC01M016524.
HGNCiHGNC:26604. ARHGEF19.
MIMi612496. gene.
neXtProtiNX_Q8IW93.
PharmGKBiPA134887028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5422.
GeneTreeiENSGT00550000074493.
HOGENOMiHOG000007536.
HOVERGENiHBG058673.
InParanoidiQ8IW93.
OMAiSGGMRPS.
OrthoDBiEOG7H4DSV.
PhylomeDBiQ8IW93.
TreeFamiTF316357.

Miscellaneous databases

GenomeRNAii128272.
NextBioi82262.
PROiQ8IW93.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IW93.
CleanExiHS_ARHGEF19.
ExpressionAtlasiQ8IW93. baseline and differential.
GenevestigatoriQ8IW93.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-163 AND GLN-238.
    Tissue: Tongue.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-802 (ISOFORM 1).
    Tissue: Colon and Pancreas.

Entry informationi

Entry nameiARHGJ_HUMAN
AccessioniPrimary (citable) accession number: Q8IW93
Secondary accession number(s): A6NJ04
, Q5TEV2, Q6PJQ4, Q8N244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.