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Protein

Beta-galactosidase-1-like protein 2

Gene

GLB1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011Proton donorBy similarity
Active sitei277 – 2771NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase-1-like protein 2 (EC:3.2.1.-)
Gene namesi
Name:GLB1L2
ORF Names:MSTP014, UNQ210/PRO236
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25129. GLB1L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389761.

Polymorphism and mutation databases

BioMutaiGLB1L2.
DMDMi74728154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 636604Beta-galactosidase-1-like protein 2PRO_0000317513Add
BLAST

Proteomic databases

MaxQBiQ8IW92.
PaxDbiQ8IW92.
PRIDEiQ8IW92.

PTM databases

iPTMnetiQ8IW92.
PhosphoSiteiQ8IW92.

Expressioni

Gene expression databases

BgeeiQ8IW92.
CleanExiHS_GLB1L2.
ExpressionAtlasiQ8IW92. baseline and differential.
GenevisibleiQ8IW92. HS.

Organism-specific databases

HPAiHPA054808.
HPA059955.

Interactioni

Protein-protein interaction databases

BioGridi124647. 27 interactions.
STRINGi9606.ENSP00000344659.

Structurei

3D structure databases

ProteinModelPortaliQ8IW92.
SMRiQ8IW92. Positions 53-613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
GeneTreeiENSGT00390000006586.
HOVERGENiHBG004841.
InParanoidiQ8IW92.
OMAiATVNFQK.
OrthoDBiEOG7GXPCD.
PhylomeDBiQ8IW92.
TreeFamiTF354299.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IW92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTWSLRRRP ARTLGLLLLV VLGFLVLRRL DWSTLVPLRL RHRQLGLQAK
60 70 80 90 100
GWNFMLEDST FWIFGGSIHY FRVPREYWRD RLLKMKACGL NTLTTYVPWN
110 120 130 140 150
LHEPERGKFD FSGNLDLEAF VLMAAEIGLW VILRPGPYIC SEMDLGGLPS
160 170 180 190 200
WLLQDPGMRL RTTYKGFTEA VDLYFDHLMS RVVPLQYKRG GPIIAVQVEN
210 220 230 240 250
EYGSYNKDPA YMPYVKKALE DRGIVELLLT SDNKDGLSKG IVQGVLATIN
260 270 280 290 300
LQSTHELQLL TTFLFNVQGT QPKMVMEYWT GWFDSWGGPH NILDSSEVLK
310 320 330 340 350
TVSAIVDAGS SINLYMFHGG TNFGFMNGAM HFHDYKSDVT SYDYDAVLTE
360 370 380 390 400
AGDYTAKYMK LRDFFGSISG IPLPPPPDLL PKMPYEPLTP VLYLSLWDAL
410 420 430 440 450
KYLGEPIKSE KPINMENLPV NGGNGQSFGY ILYETSITSS GILSGHVHDR
460 470 480 490 500
GQVFVNTVSI GFLDYKTTKI AVPLIQGYTV LRILVENRGR VNYGENIDDQ
510 520 530 540 550
RKGLIGNLYL NDSPLKNFRI YSLDMKKSFF QRFGLDKWSS LPETPTLPAF
560 570 580 590 600
FLGSLSISST PCDTFLKLEG WEKGVVFING QNLGRYWNIG PQKTLYLPGP
610 620 630
WLSSGINQVI VFEETMAGPA LQFTETPHLG RNQYIK
Length:636
Mass (Da):72,079
Last modified:March 1, 2003 - v1
Checksum:i3661AB67B0C99811
GO

Sequence cautioni

The sequence AAQ13636.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC11149.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501K → M in BAC11309 (PubMed:14702039).Curated
Sequence conflicti117 – 1171L → Q in BAC11309 (PubMed:14702039).Curated
Sequence conflicti448 – 4481H → R in BAC11247 (PubMed:16303743).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358497 mRNA. Translation: AAQ88861.1.
AK074703 mRNA. Translation: BAC11149.1. Different initiation.
AK074947 mRNA. Translation: BAC11309.1.
AK074855 mRNA. Translation: BAC11247.1.
AP003971 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67843.1.
BC008326 mRNA. Translation: AAH08326.1.
BC040641 mRNA. Translation: AAH40641.1.
AF173889 mRNA. Translation: AAQ13636.1. Different initiation.
CCDSiCCDS31724.1.
RefSeqiNP_612351.2. NM_138342.3.
XP_006719000.1. XM_006718937.1.
UniGeneiHs.436178.

Genome annotation databases

EnsembliENST00000339772; ENSP00000344659; ENSG00000149328.
ENST00000535456; ENSP00000444628; ENSG00000149328.
GeneIDi89944.
KEGGihsa:89944.
UCSCiuc001qhp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358497 mRNA. Translation: AAQ88861.1.
AK074703 mRNA. Translation: BAC11149.1. Different initiation.
AK074947 mRNA. Translation: BAC11309.1.
AK074855 mRNA. Translation: BAC11247.1.
AP003971 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67843.1.
BC008326 mRNA. Translation: AAH08326.1.
BC040641 mRNA. Translation: AAH40641.1.
AF173889 mRNA. Translation: AAQ13636.1. Different initiation.
CCDSiCCDS31724.1.
RefSeqiNP_612351.2. NM_138342.3.
XP_006719000.1. XM_006718937.1.
UniGeneiHs.436178.

3D structure databases

ProteinModelPortaliQ8IW92.
SMRiQ8IW92. Positions 53-613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124647. 27 interactions.
STRINGi9606.ENSP00000344659.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

PTM databases

iPTMnetiQ8IW92.
PhosphoSiteiQ8IW92.

Polymorphism and mutation databases

BioMutaiGLB1L2.
DMDMi74728154.

Proteomic databases

MaxQBiQ8IW92.
PaxDbiQ8IW92.
PRIDEiQ8IW92.

Protocols and materials databases

DNASUi89944.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339772; ENSP00000344659; ENSG00000149328.
ENST00000535456; ENSP00000444628; ENSG00000149328.
GeneIDi89944.
KEGGihsa:89944.
UCSCiuc001qhp.3. human.

Organism-specific databases

CTDi89944.
GeneCardsiGLB1L2.
H-InvDBHIX0026148.
HGNCiHGNC:25129. GLB1L2.
HPAiHPA054808.
HPA059955.
neXtProtiNX_Q8IW92.
PharmGKBiPA162389761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
GeneTreeiENSGT00390000006586.
HOVERGENiHBG004841.
InParanoidiQ8IW92.
OMAiATVNFQK.
OrthoDBiEOG7GXPCD.
PhylomeDBiQ8IW92.
TreeFamiTF354299.

Miscellaneous databases

ChiTaRSiGLB1L2. human.
GenomeRNAii89944.
NextBioi76449.
PROiQ8IW92.

Gene expression databases

BgeeiQ8IW92.
CleanExiHS_GLB1L2.
ExpressionAtlasiQ8IW92. baseline and differential.
GenevisibleiQ8IW92. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  7. "Homo sapiens normal aorta mRNA MST114."
    Liu B., Zhao B., Wang X.Y., Liu Y.Q., Sheng H., Qin B.M., Zhang Q., Zheng W.Y., Xu H.S., Liu B.H., Lu H., Gong Q., Hui R.T.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-636.
    Tissue: Aorta.

Entry informationi

Entry nameiGLBL2_HUMAN
AccessioniPrimary (citable) accession number: Q8IW92
Secondary accession number(s): A6NCE6
, Q6UX60, Q8NC62, Q8NCB3, Q8NCJ1, Q96HP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.