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Protein
Submitted name:

eIF2AK2 protein

Gene

EIF2AK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
eIF2AK2 proteinImported
Gene namesi
Name:EIF2AK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33779

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 77DRBMInterPro annotationAdd BLAST69
Domaini100 – 167DRBMInterPro annotationAdd BLAST68
Domaini267 – 513Protein kinaseInterPro annotationAdd BLAST247

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili58 – 80Sequence analysisAdd BLAST23
Coiled coili295 – 315Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1033 Eukaryota
ENOG410XS0B LUCA
HOVERGENiHBG051430
KOiK16195

Family and domain databases

InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011009 Kinase-like_dom_sf
IPR033366 PKR
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR11042:SF102 PTHR11042:SF102, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8IW76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDLSAGFF MEELNTYRQK QGVVLKYQEL PNSGPPHDRR FTFQVIIDGR
60 70 80 90 100
EFPEGEGRSK KEAKNAAAKL AVEILNKEKK AVSPLLLTTT NSSEGLSMGN
110 120 130 140 150
YIGLINRIAQ KKRLTVNYEQ CASGVHGPEG FHYKCKMGQK EYSIGTGSTK
160 170 180 190 200
QEAKQLAAKL AYLQILSEET SVKSDYLSSG SFATTCESQS NSLVTSTLAS
210 220 230 240 250
ESSSEGDFSA DTSEINSNSD SLNSSSLLMN GLRNNQRKAK RSLAPRFDLP
260 270 280 290 300
DMKETKYTVD KRFGMDFKEI ELIGSGGFGQ VFKAKHRIDG KTYVIKRVKY
310 320 330 340 350
NNEKAEREVK ALAKLDHVNI VHYNGCWDGF DYDPETSDDS LESSDYDPEN
360 370 380 390 400
SKNSSRSKTK CLFIQMEFCD KGTLEQWIEK RRGEKLDKVL ALELFEQITK
410 420 430 440 450
GVDYIHSKKL IHRDLKPSNI FLVDTKQVKI GDFGLVTSLK NDGKRTRSKG
460 470 480 490 500
TLRYMSPEQI SSQDYGKEVD LYALGLILAE LLHVCDTAFE TSKFFTDLRD
510
GIISDIFDKK KKK
Length:513
Mass (Da):57,620
Last modified:March 1, 2003 - v1
Checksum:i9AE10C04358E0699
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei513Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040851 mRNA Translation: AAH40851.1
BC057805 mRNA Translation: AAH57805.1
RefSeqiNP_001129123.1, NM_001135651.2
NP_002750.1, NM_002759.3
UniGeneiHs.131431

Genome annotation databases

GeneIDi5610
KEGGihsa:5610

Similar proteinsi

Entry informationi

Entry nameiQ8IW76_HUMAN
AccessioniPrimary (citable) accession number: Q8IW76
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.