ID   SPA12_HUMAN             Reviewed;         414 AA.
AC   Q8IW75;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=Serpin A12;
DE   AltName: Full=Visceral adipose tissue-derived serine protease inhibitor;
DE            Short=Vaspin;
DE   AltName: Full=Visceral adipose-specific serpin;
DE   AltName: Full=OL-64;
DE   Flags: Precursor;
GN   Name=SERPINA12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16030142; DOI=10.1073/pnas.0504703102;
RA   Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A.,
RA   Hashimoto I., Okada T., Yasuhara A., Nakatsuka A., Shikata K.,
RA   Hourai S., Futami J., Watanabe E., Matsuki Y., Hiramatsu R., Akagi S.,
RA   Makino H., Kanwar Y.S.;
RT   "Visceral adipose tissue-derived serine protease inhibitor: a unique
RT   insulin-sensitizing adipocytokine in obesity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:10610-10615(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RA   Chen S., Guo J.H., Yu L.;
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May modulates insulin action conceivably only in the
CC       presence of its yet undefined target proteases in white adipose
CC       tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed in visceral adipose tissues.
CC   -!- SIMILARITY: Belongs to the serpin family.
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DR   EMBL; AY326420; AAP88384.1; -; mRNA.
DR   EMBL; AY177692; AAO18649.1; -; mRNA.
DR   EMBL; BC040857; AAH40857.1; -; mRNA.
DR   IPI; IPI00219476; -.
DR   RefSeq; NP_776249.1; -.
DR   UniGene; Hs.99476; -.
DR   HSSP; P01009; 1QMB.
DR   MEROPS; I04.965; -.
DR   PRIDE; Q8IW75; -.
DR   Ensembl; ENSG00000165953; Homo sapiens.
DR   GeneID; 145264; -.
DR   KEGG; hsa:145264; -.
DR   GeneCards; GC14M094023; -.
DR   H-InvDB; HIX0026658; -.
DR   HGNC; HGNC:18359; SERPINA12.
DR   PharmGKB; PA134863157; -.
DR   HOGENOM; Q8IW75; -.
DR   HOVERGEN; Q8IW75; -.
DR   OMA; Q8IW75; AQTLPME.
DR   NextBio; 85065; -.
DR   ArrayExpress; Q8IW75; -.
DR   Bgee; Q8IW75; -.
DR   CleanEx; HS_SERPINA12; -.
DR   GermOnline; ENSG00000165953; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000215; Protease_inhib_I4_serpin.
DR   PANTHER; PTHR11461; Prot_inh_serpin; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   PROSITE; PS00284; SERPIN; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Polymorphism; Protease inhibitor; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL        1     20       By similarity.
FT   CHAIN        21    414       Serpin A12.
FT                                /FTId=PRO_0000041976.
FT   CARBOHYD    221    221       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    233    233       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    267    267       N-linked (GlcNAc...) (Potential).
FT   VARIANT     142    142       Q -> K (in dbSNP:rs17090972).
FT                                /FTId=VAR_051943.
FT   VARIANT     394    394       I -> V (in dbSNP:rs34519784).
FT                                /FTId=VAR_051944.
SQ   SEQUENCE   414 AA;  47175 MW;  5C70F1AB5935661C CRC64;
     MNPTLGLAIF LAVLLTVKGL LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL
     KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII
     HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF
     ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM
     MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS
     RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM
     DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK
//