Reviewed, UniProtKB/Swiss-Prot Q8IW75 (SPA12_HUMAN)

Names and origin

Protein names

Recommended name:
    Serpin A12
Alternative name(s):
    Visceral adipose tissue-derived serine protease inhibitor
      Short name=Vaspin
    Visceral adipose-specific serpin
    OL-64

Gene names

Name:

SERPINA12

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. Ref.1
Subcellular location	Secreted Potential.
Tissue specificity	Expressed in visceral adipose tissues. Ref.1
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 414	394	Serpin A12		PRO_0000041976
Amino acid modifications
	Glycosylation	221	1	N-linked (GlcNAc...) Potential
	Glycosylation	233	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	142	1	Q → K: dbSNP rs17090972.		VAR_051943
	Natural variant	394	1	I → V: dbSNP rs34519784.		VAR_051944

Sequences

	Sequence		Length	Mass (Da)
	Q8IW75-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5C70F1AB5935661C	FASTA	414	47,175
	10 20 30 40 50 60 MNPTLGLAIF LAVLLTVKGL LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL 70 80 90 100 110 120 KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII 130 140 150 160 170 180 HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF 190 200 210 220 230 240 ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM 250 260 270 280 290 300 MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS 310 320 330 340 350 360 RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM 370 380 390 400 410 DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity." Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A., Hashimoto I., Okada T., Yasuhara A., Nakatsuka A., Shikata K., Hourai S., Futami J., Watanabe E., Matsuki Y., Hiramatsu R., Akagi S., Makino H., Kanwar Y.S. Proc. Natl. Acad. Sci. U.S.A. 102:10610-10615(2005) [PubMed: 16030142] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	Chen S., Guo J.H., Yu L. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY326420 mRNA. Translation: AAP88384.1. AY177692 mRNA. Translation: AAO18649.1. BC040857 mRNA. Translation: AAH40857.1.
IPI	IPI00219476.
RefSeq	NP_776249.1.
UniGene	Hs.99476
3D structure databases
HSSP	HSSP built from PDB template 1QMB based on UniProtKB P01009.
ModBase	Search...
Protein family/group databases
MEROPS	I04.965.
Proteomic databases
PRIDE	Q8IW75.
Genome annotation databases
Ensembl	ENSG00000165953. Homo sapiens. [Contig view]
GeneID	145264.
KEGG	hsa:145264.
Organism-specific databases
GeneCards	GC14M094023.
H-InvDB	HIX0026658.
HGNC	HGNC:18359. SERPINA12.
PharmGKB	PA134863157.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8IW75.
HOVERGEN	Q8IW75.
OMA	Q8IW75. AQTLPME.
Gene expression databases
ArrayExpress	Q8IW75.
Bgee	Q8IW75.
CleanEx	HS_SERPINA12.
GermOnline	ENSG00000165953. Homo sapiens.
Family and domain databases
InterPro	IPR000215. Protease_inhib_I4_serpin. [Graphical view]
PANTHER	PTHR11461. Prot_inh_serpin. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
PROSITE	PS00284. SERPIN. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	85065.

Entry information

Entry name

SPA12_HUMAN

Accession

Primary (citable) accession number: Q8IW75

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)