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Protein

SLIT and NTRK-like protein 4

Gene

SLITRK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Suppresses neurite outgrowth.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 4
Gene namesi
Name:SLITRK4
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23502. SLITRK4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 618600ExtracellularSequence analysisAdd
BLAST
Transmembranei619 – 63921HelicalSequence analysisAdd
BLAST
Topological domaini640 – 837198CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134926932.

Polymorphism and mutation databases

BioMutaiSLITRK4.
DMDMi46396931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 837819SLIT and NTRK-like protein 4Sequence analysisPRO_0000032679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IW52.
MaxQBiQ8IW52.
PaxDbiQ8IW52.
PRIDEiQ8IW52.

PTM databases

iPTMnetiQ8IW52.
PhosphoSiteiQ8IW52.

Expressioni

Tissue specificityi

Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors.1 Publication

Gene expression databases

BgeeiQ8IW52.
CleanExiHS_SLITRK4.
GenevisibleiQ8IW52. HS.

Organism-specific databases

HPAiHPA001039.

Interactioni

Protein-protein interaction databases

BioGridi126540. 2 interactions.
STRINGi9606.ENSP00000336627.

Structurei

3D structure databases

ProteinModelPortaliQ8IW52.
SMRiQ8IW52. Positions 29-263, 343-581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati60 – 8122LRR 1Add
BLAST
Repeati84 – 10522LRR 2Add
BLAST
Repeati108 – 12922LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati179 – 20022LRR 6Add
BLAST
Domaini213 – 26452LRRCT 1Add
BLAST
Domaini333 – 37543LRRNTAdd
BLAST
Repeati378 – 39922LRR 7Add
BLAST
Repeati402 – 42322LRR 8Add
BLAST
Repeati426 – 44722LRR 9Add
BLAST
Repeati450 – 47122LRR 10Add
BLAST
Repeati474 – 49522LRR 11Add
BLAST
Repeati497 – 51822LRR 12Add
BLAST
Domaini531 – 58252LRRCT 2Add
BLAST

Sequence similaritiesi

Belongs to the SLITRK family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ8IW52.
OMAiRYPEKQQ.
OrthoDBiEOG7W9RT2.
PhylomeDBiQ8IW52.
TreeFamiTF326378.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IW52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLWLFLILS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR
60 70 80 90 100
PNQLKPPWSN FYHLNFQNNF LNILYPNTFL NFSHAVSLHL GNNKLQNIEG
110 120 130 140 150
GAFLGLSALK QLHLNNNELK ILRADTFLGI ENLEYLQADY NLIKYIERGA
160 170 180 190 200
FNKLHKLKVL ILNDNLISFL PDNIFRFASL THLDIRGNRI QKLPYIGVLE
210 220 230 240 250
HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA ICETPSDLYG
260 270 280 290 300
RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV
310 320 330 340 350
TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCFCKT
360 370 380 390 400
HPSDLGLSVN CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDVSDFTDF
410 420 430 440 450
EGLDLLHLGS NQITVIKGDV FHNLTNLRRL YLNGNQIERL YPEIFSGLHN
460 470 480 490 500
LQYLYLEYNL IKEISAGTFD SMPNLQLLYL NNNLLKSLPV YIFSGAPLAR
510 520 530 540 550
LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV ALKLWVEKLS
560 570 580 590 600
DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF
610 620 630 640 650
TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT
660 670 680 690 700
VKHEGLGNPD CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC
710 720 730 740 750
GLKESETGFM FSDPPGQKVV MRNVADKEKD LLHVDTRKRL STIDELDELF
760 770 780 790 800
PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR YPEKQPDKKS KKSLIGGNHS
810 820 830
KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI
Length:837
Mass (Da):94,331
Last modified:March 1, 2003 - v1
Checksum:iF25E3BBAF78F9299
GO

Sequence cautioni

The sequence BAB71535.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti206 – 2061V → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036602

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080239 Genomic DNA. Translation: CAI41650.1.
CH471170 Genomic DNA. Translation: EAW78020.1.
BC040986 mRNA. Translation: AAH40986.1.
AL713693 mRNA. Translation: CAD28493.1.
AK057619 mRNA. Translation: BAB71535.1. Different initiation.
CCDSiCCDS14679.1.
RefSeqiNP_001171678.1. NM_001184749.2.
NP_001171679.1. NM_001184750.2.
NP_775101.1. NM_173078.4.
XP_005262422.1. XM_005262365.3.
XP_011529567.1. XM_011531265.1.
UniGeneiHs.272284.

Genome annotation databases

EnsembliENST00000338017; ENSP00000336627; ENSG00000179542.
ENST00000356928; ENSP00000349400; ENSG00000179542.
ENST00000596188; ENSP00000469205; ENSG00000179542.
GeneIDi139065.
KEGGihsa:139065.
UCSCiuc022cfm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080239 Genomic DNA. Translation: CAI41650.1.
CH471170 Genomic DNA. Translation: EAW78020.1.
BC040986 mRNA. Translation: AAH40986.1.
AL713693 mRNA. Translation: CAD28493.1.
AK057619 mRNA. Translation: BAB71535.1. Different initiation.
CCDSiCCDS14679.1.
RefSeqiNP_001171678.1. NM_001184749.2.
NP_001171679.1. NM_001184750.2.
NP_775101.1. NM_173078.4.
XP_005262422.1. XM_005262365.3.
XP_011529567.1. XM_011531265.1.
UniGeneiHs.272284.

3D structure databases

ProteinModelPortaliQ8IW52.
SMRiQ8IW52. Positions 29-263, 343-581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126540. 2 interactions.
STRINGi9606.ENSP00000336627.

PTM databases

iPTMnetiQ8IW52.
PhosphoSiteiQ8IW52.

Polymorphism and mutation databases

BioMutaiSLITRK4.
DMDMi46396931.

Proteomic databases

EPDiQ8IW52.
MaxQBiQ8IW52.
PaxDbiQ8IW52.
PRIDEiQ8IW52.

Protocols and materials databases

DNASUi139065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338017; ENSP00000336627; ENSG00000179542.
ENST00000356928; ENSP00000349400; ENSG00000179542.
ENST00000596188; ENSP00000469205; ENSG00000179542.
GeneIDi139065.
KEGGihsa:139065.
UCSCiuc022cfm.2. human.

Organism-specific databases

CTDi139065.
GeneCardsiSLITRK4.
HGNCiHGNC:23502. SLITRK4.
HPAiHPA001039.
MIMi300562. gene.
neXtProtiNX_Q8IW52.
PharmGKBiPA134926932.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ8IW52.
OMAiRYPEKQQ.
OrthoDBiEOG7W9RT2.
PhylomeDBiQ8IW52.
TreeFamiTF326378.

Miscellaneous databases

GenomeRNAii139065.
PROiQ8IW52.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IW52.
CleanExiHS_SLITRK4.
GenevisibleiQ8IW52. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-837.
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-837.
    Tissue: TracheaImported.
  6. "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue."
    Aruga J., Yokota N., Mikoshiba K.
    Gene 315:87-94(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    Tissue: Brain1 Publication and Brain tumor1 Publication.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-206.

Entry informationi

Entry nameiSLIK4_HUMAN
AccessioniPrimary (citable) accession number: Q8IW52
Secondary accession number(s): Q5JXG3, Q8TCM8, Q96DL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.