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Protein

SLIT and NTRK-like protein 4

Gene

SLITRK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Suppresses neurite outgrowth.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 4
Gene namesi
Name:SLITRK4
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23502. SLITRK4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 618ExtracellularSequence analysisAdd BLAST600
Transmembranei619 – 639HelicalSequence analysisAdd BLAST21
Topological domaini640 – 837CytoplasmicSequence analysisAdd BLAST198

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179542.
PharmGKBiPA134926932.

Polymorphism and mutation databases

BioMutaiSLITRK4.
DMDMi46396931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003267919 – 837SLIT and NTRK-like protein 4Sequence analysisAdd BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IW52.
MaxQBiQ8IW52.
PaxDbiQ8IW52.
PeptideAtlasiQ8IW52.
PRIDEiQ8IW52.

PTM databases

iPTMnetiQ8IW52.
PhosphoSitePlusiQ8IW52.

Expressioni

Tissue specificityi

Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors.1 Publication

Gene expression databases

BgeeiENSG00000179542.
CleanExiHS_SLITRK4.
GenevisibleiQ8IW52. HS.

Organism-specific databases

HPAiHPA000431.
HPA001039.

Interactioni

Protein-protein interaction databases

BioGridi126540. 2 interactors.
STRINGi9606.ENSP00000336627.

Structurei

3D structure databases

ProteinModelPortaliQ8IW52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 81LRR 1Add BLAST22
Repeati84 – 105LRR 2Add BLAST22
Repeati108 – 129LRR 3Add BLAST22
Repeati132 – 153LRR 4Add BLAST22
Repeati156 – 177LRR 5Add BLAST22
Repeati179 – 200LRR 6Add BLAST22
Domaini213 – 264LRRCT 1Add BLAST52
Domaini333 – 375LRRNTAdd BLAST43
Repeati378 – 399LRR 7Add BLAST22
Repeati402 – 423LRR 8Add BLAST22
Repeati426 – 447LRR 9Add BLAST22
Repeati450 – 471LRR 10Add BLAST22
Repeati474 – 495LRR 11Add BLAST22
Repeati497 – 518LRR 12Add BLAST22
Domaini531 – 582LRRCT 2Add BLAST52

Sequence similaritiesi

Belongs to the SLITRK family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ8IW52.
OMAiRYPEKQQ.
OrthoDBiEOG091G02AI.
PhylomeDBiQ8IW52.
TreeFamiTF326378.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IW52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLWLFLILS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR
60 70 80 90 100
PNQLKPPWSN FYHLNFQNNF LNILYPNTFL NFSHAVSLHL GNNKLQNIEG
110 120 130 140 150
GAFLGLSALK QLHLNNNELK ILRADTFLGI ENLEYLQADY NLIKYIERGA
160 170 180 190 200
FNKLHKLKVL ILNDNLISFL PDNIFRFASL THLDIRGNRI QKLPYIGVLE
210 220 230 240 250
HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA ICETPSDLYG
260 270 280 290 300
RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV
310 320 330 340 350
TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCFCKT
360 370 380 390 400
HPSDLGLSVN CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDVSDFTDF
410 420 430 440 450
EGLDLLHLGS NQITVIKGDV FHNLTNLRRL YLNGNQIERL YPEIFSGLHN
460 470 480 490 500
LQYLYLEYNL IKEISAGTFD SMPNLQLLYL NNNLLKSLPV YIFSGAPLAR
510 520 530 540 550
LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV ALKLWVEKLS
560 570 580 590 600
DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF
610 620 630 640 650
TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT
660 670 680 690 700
VKHEGLGNPD CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC
710 720 730 740 750
GLKESETGFM FSDPPGQKVV MRNVADKEKD LLHVDTRKRL STIDELDELF
760 770 780 790 800
PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR YPEKQPDKKS KKSLIGGNHS
810 820 830
KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI
Length:837
Mass (Da):94,331
Last modified:March 1, 2003 - v1
Checksum:iF25E3BBAF78F9299
GO

Sequence cautioni

The sequence BAB71535 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036602206V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs143575705dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080239 Genomic DNA. Translation: CAI41650.1.
CH471170 Genomic DNA. Translation: EAW78020.1.
BC040986 mRNA. Translation: AAH40986.1.
AL713693 mRNA. Translation: CAD28493.1.
AK057619 mRNA. Translation: BAB71535.1. Different initiation.
CCDSiCCDS14679.1.
RefSeqiNP_001171678.1. NM_001184749.2.
NP_001171679.1. NM_001184750.2.
NP_775101.1. NM_173078.4.
XP_005262422.1. XM_005262365.4.
XP_011529567.1. XM_011531265.2.
UniGeneiHs.272284.

Genome annotation databases

EnsembliENST00000338017; ENSP00000336627; ENSG00000179542.
ENST00000356928; ENSP00000349400; ENSG00000179542.
ENST00000596188; ENSP00000469205; ENSG00000179542.
GeneIDi139065.
KEGGihsa:139065.
UCSCiuc022cfm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080239 Genomic DNA. Translation: CAI41650.1.
CH471170 Genomic DNA. Translation: EAW78020.1.
BC040986 mRNA. Translation: AAH40986.1.
AL713693 mRNA. Translation: CAD28493.1.
AK057619 mRNA. Translation: BAB71535.1. Different initiation.
CCDSiCCDS14679.1.
RefSeqiNP_001171678.1. NM_001184749.2.
NP_001171679.1. NM_001184750.2.
NP_775101.1. NM_173078.4.
XP_005262422.1. XM_005262365.4.
XP_011529567.1. XM_011531265.2.
UniGeneiHs.272284.

3D structure databases

ProteinModelPortaliQ8IW52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126540. 2 interactors.
STRINGi9606.ENSP00000336627.

PTM databases

iPTMnetiQ8IW52.
PhosphoSitePlusiQ8IW52.

Polymorphism and mutation databases

BioMutaiSLITRK4.
DMDMi46396931.

Proteomic databases

EPDiQ8IW52.
MaxQBiQ8IW52.
PaxDbiQ8IW52.
PeptideAtlasiQ8IW52.
PRIDEiQ8IW52.

Protocols and materials databases

DNASUi139065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338017; ENSP00000336627; ENSG00000179542.
ENST00000356928; ENSP00000349400; ENSG00000179542.
ENST00000596188; ENSP00000469205; ENSG00000179542.
GeneIDi139065.
KEGGihsa:139065.
UCSCiuc022cfm.2. human.

Organism-specific databases

CTDi139065.
GeneCardsiSLITRK4.
HGNCiHGNC:23502. SLITRK4.
HPAiHPA000431.
HPA001039.
MIMi300562. gene.
neXtProtiNX_Q8IW52.
OpenTargetsiENSG00000179542.
PharmGKBiPA134926932.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ8IW52.
OMAiRYPEKQQ.
OrthoDBiEOG091G02AI.
PhylomeDBiQ8IW52.
TreeFamiTF326378.

Miscellaneous databases

GenomeRNAii139065.
PROiQ8IW52.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179542.
CleanExiHS_SLITRK4.
GenevisibleiQ8IW52. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIK4_HUMAN
AccessioniPrimary (citable) accession number: Q8IW52
Secondary accession number(s): Q5JXG3, Q8TCM8, Q96DL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.