Reviewed,
UniProtKB/Swiss-Prot Q8IW45 (CARKD_HUMAN)
Last modified
November 24, 2009.
Version 41.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Carbohydrate kinase domain-containing protein | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 347 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the YjeF family. Contains 1 YjeF C-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal |
| PTM | Glycoprotein Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8IW45-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8IW45-2) The sequence of this isoform differs from the canonical sequence as follows: 299-347: SSPLLVAAFG...GAAFSKLFET → GISDLKLTIW...RGGGRLQQAL | ||||||
| Isoform 3 (identifier: Q8IW45-3) The sequence of this isoform differs from the canonical sequence as follows: 1-221: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Potential | ||||||
| Chain | 26 – 347 | 322 | Carbohydrate kinase domain-containing protein | PRO_0000337021 | |||||
Regions | |||||||||
| Domain | 53 – 344 | 292 | YjeF C-terminal | ||||||
Amino acid modifications | |||||||||
| Modified residue | 85 | 1 | Phosphotyrosine Ref.5 Ref.7 | ||||||
| Glycosylation | 240 | 1 | N-linked (GlcNAc...) Ref.6 | ||||||
| Glycosylation | 297 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 221 | 221 | Missing in isoform 3. | VSP_033829 | |||||
| Alternative sequence | 299 – 347 | 49 | SSPLL…KLFET → GISDLKLTIWGPEIETGVKT RAQGSCGPRTTTPTSPHLLL SPSPQVQPSPGGRVWRLLSH QAVQPPSLPEARSLHHHLRH DRRGGGRLQQAL in isoform 2. | VSP_033830 | |||||
| Natural variant | 140 | 1 | K → E: dbSNP rs3742191. | VAR_043564 | |||||
| Natural variant | 149 | 1 | V → I: dbSNP rs3742192. | VAR_043565 | |||||
| Natural variant | 152 | 1 | P → T: dbSNP rs1044112. | VAR_043566 | |||||
Experimental info | |||||||||
| Sequence conflict | 206 | 1 | N → D in BAA91797. Ref.1 | ||||||
| Sequence conflict | 253 | 1 | S → P in BAB14863. Ref.1 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). |
| [2] | "The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T.Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [5] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-85, MASS SPECTROMETRY. |
| [6] | "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-240, MASS SPECTROMETRY. Tissue: Liver. |
| [7] | "An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-85, MASS SPECTROMETRY. Tissue: Mammary epithelium. |
Cross-references
Sequence databases | |
|---|---|
| AK001631 mRNA. Translation: BAA91797.1. AK024260 mRNA. Translation: BAB14863.1. AL139385 Genomic DNA. Translation: CAI17008.1. CH471085 Genomic DNA. Translation: EAX09121.1. CH471085 Genomic DNA. Translation: EAX09125.1. BC041028 mRNA. Translation: AAH41028.1. | |
| IPI | IPI00645172. IPI00873027. IPI00940060. |
| RefSeq | NP_060680.2. |
| UniGene | Hs.408324 |
3D structure databases | |
| ModBase | Search... |
2-D gel databases | |
| REPRODUCTION-2DPAGE | Q8IW45. |
Proteomic databases | |
| PRIDE | Q8IW45. |
Genome annotation databases | |
| GeneID | 55739. |
| KEGG | hsa:55739. |
| UCSC | uc001vrb.1. human. uc001vrc.1. human. |
Organism-specific databases | |
| CTD | 55739. |
| GeneCards | GC13P110067. |
| HGNC | HGNC:25576. CARKD. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q8IW45. |
Gene expression databases | |
| CleanEx | HS_CARKD. |
| Genevestigator | Q8IW45. |
Family and domain databases | |
| InterPro | IPR000631. UPF_carb_kinase-rel. [Graphical view] |
| Pfam | PF01256. Carb_kinase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00196. yjeF_cterm. 1 hit. |
| PROSITE | PS01049. YJEF_C_1. False negative. PS01050. YJEF_C_2. False negative. PS51383. YJEF_C_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 60690. |
Entry information
| Entry name | CARKD_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8IW45 Secondary accession number(s): Q5T9X3, Q9H7W1, Q9NVF5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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