##gff-version 3
Q8IW41	UniProtKB	Chain	1	473	.	.	.	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5	
Q8IW41	UniProtKB	Domain	22	304	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
Q8IW41	UniProtKB	Coiled coil	409	440	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8IW41	UniProtKB	Active site	148	148	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027	
Q8IW41	UniProtKB	Binding site	28	36	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
Q8IW41	UniProtKB	Binding site	51	51	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
Q8IW41	UniProtKB	Modified residue	115	115	.	.	.	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O54992	
Q8IW41	UniProtKB	Modified residue	182	182	.	.	.	Note=Phosphothreonine%3B by MAPK11%2C MAPK14%2C MAPK4%2C MAPK6 and PKA;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:9628874,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163,PMID:9628874	
Q8IW41	UniProtKB	Modified residue	212	212	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808055;Dbxref=PMID:12808055	
Q8IW41	UniProtKB	Modified residue	354	354	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163	
Q8IW41	UniProtKB	Alternative sequence	407	408	.	.	.	ID=VSP_011597;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005	
Q8IW41	UniProtKB	Natural variant	67	67	.	.	.	ID=VAR_040758;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34132040,PMID:17344846	
Q8IW41	UniProtKB	Natural variant	282	282	.	.	.	ID=VAR_040759;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34843470,PMID:17344846	
Q8IW41	UniProtKB	Mutagenesis	51	51	.	.	.	Note=Kinase defective mutant%2C abolishes activity. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808055;Dbxref=PMID:12808055	
Q8IW41	UniProtKB	Mutagenesis	182	182	.	.	.	Note=No p38-beta/MAPK11-induced activation. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12808055,ECO:0000269|PubMed:21329882,ECO:0000269|PubMed:9628874;Dbxref=PMID:12808055,PMID:21329882,PMID:9628874	
Q8IW41	UniProtKB	Mutagenesis	182	182	.	.	.	Note=Mimicks phosphorylation state and induces constitutive protein kinase activity. T->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12808055,ECO:0000269|PubMed:21329882,ECO:0000269|PubMed:9628874;Dbxref=PMID:12808055,PMID:21329882,PMID:9628874	
Q8IW41	UniProtKB	Mutagenesis	212	212	.	.	.	Note=Mimicks phosphorylation state and displays a slightly higher protein kinase activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808055;Dbxref=PMID:12808055	
Q8IW41	UniProtKB	Mutagenesis	337	337	.	.	.	Note=Induces constitutive protein kinase activity. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21329882;Dbxref=PMID:21329882	
Q8IW41	UniProtKB	Sequence conflict	273	273	.	.	.	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IW41	UniProtKB	Sequence conflict	291	291	.	.	.	Note=E->R;Ontology_term=ECO:0000305;evidence=ECO:0000305