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Protein

Zinc finger protein 695

Gene

ZNF695

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 695
Alternative name(s):
Zinc finger protein SBZF3
Gene namesi
Name:ZNF695
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197472.14
HGNCiHGNC:30954 ZNF695
MIMi616348 gene
neXtProtiNX_Q8IW36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57116
OpenTargetsiENSG00000197472
PharmGKBiPA142670493

Polymorphism and mutation databases

BioMutaiZNF695
DMDMi284018174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332821 – 515Zinc finger protein 695Add BLAST515

Proteomic databases

EPDiQ8IW36
PaxDbiQ8IW36
PeptideAtlasiQ8IW36
PRIDEiQ8IW36

PTM databases

iPTMnetiQ8IW36
PhosphoSitePlusiQ8IW36

Expressioni

Gene expression databases

BgeeiENSG00000197472
CleanExiHS_ZNF695
ExpressionAtlasiQ8IW36 baseline and differential
GenevisibleiQ8IW36 HS

Organism-specific databases

HPAiHPA024743

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-10261951,EBI-748397

Protein-protein interaction databases

BioGridi121380, 14 interactors
IntActiQ8IW36, 1 interactor
STRINGi9606.ENSP00000341236

Structurei

3D structure databases

ProteinModelPortaliQ8IW36
SMRiQ8IW36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 87KRABPROSITE-ProRule annotationAdd BLAST84

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000231475
HOVERGENiHBG067759
InParanoidiQ8IW36
OMAiFTWFSYL
OrthoDBiEOG091G02KC
PhylomeDBiQ8IW36
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: Q8IW36-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLAFRDVA LEFSPEEWEC LDPAQRSLYR DVMLENYRNL ISLGEDSFNM
60 70 80 90 100
QFLFHSLAMS KPELIICLEA RKEPWNVNTE KTARHSVLSS YLTEDILPEQ
110 120 130 140 150
GLQVSFQKVM LRRYERCCLE KLRLRNDWEI VGEWKGQKAS YNGLDLCSAT
160 170 180 190 200
THSKNFQCNK CVKGFSKFAN LNKCKISHTG EKPFKCKECG NVSCMSLIMT
210 220 230 240 250
QQQRIHIGEN PYQCKKCGKA FNECSCFTDC KRIHVGEKHC KCEECNNIFK
260 270 280 290 300
SCSSLAVVEK NHTEKKTYRC EECGKAFNLC SVLTKHKKIH TGEKPYKCEE
310 320 330 340 350
CGKSFKLFPY LTQHKRIHSR EKPYKCEECG KVFKLLSYLT QHRRIHTGEK
360 370 380 390 400
TFRCEECGKA FNQSSHLTEH RRIHTGEKPY KCEECGKAFT WFSYLIQHKR
410 420 430 440 450
IHTGQKPYKC EECGKAFTWF SYLTQHKRIH TGEKPYKCDE CGKAFNWFSY
460 470 480 490 500
LTNHKRIHTG EKPYKCEECG KAFGQSSHLS KHKTIHTREK PYKCEECGKA
510
FNHSAQLAVH EKTHT
Length:515
Mass (Da):60,149
Last modified:January 19, 2010 - v4
Checksum:iB37EA43D0B16E8B5
GO
Isoform 1 (identifier: Q8IW36-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-172: VGEWKGQKAS...KGFSKFANLN → PCEDVLASPL...PVQSSTIELL
     173-515: Missing.

Show »
Length:172
Mass (Da):20,056
Checksum:iCB9E86EC6447A085
GO
Isoform 2 (identifier: Q8IW36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: GE → AM
     134-515: Missing.

Show »
Length:133
Mass (Da):15,749
Checksum:i0312791F4F4DF485
GO
Isoform 3 (identifier: Q8IW36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-88: L → M
     89-515: Missing.

Show »
Length:88
Mass (Da):10,324
Checksum:i08B9ED6E13BD857B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05744684R → K1 PublicationCorresponds to variant dbSNP:rs2642973Ensembl.1
Natural variantiVAR_05744787V → A1 PublicationCorresponds to variant dbSNP:rs2642992Ensembl.1
Natural variantiVAR_061963110M → I. Corresponds to variant dbSNP:rs55762230Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01810688L → M in isoform 3. 1 Publication1
Alternative sequenceiVSP_01810789 – 515Missing in isoform 3. 1 PublicationAdd BLAST427
Alternative sequenceiVSP_038548131 – 172VGEWK…FANLN → PCEDVLASPLPSAMILSFLR PPQKQKHVKPTEPVQSSTIE LL in isoform 1. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_018108132 – 133GE → AM in isoform 2. 1 Publication2
Alternative sequenceiVSP_018109134 – 515Missing in isoform 2. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_038549173 – 515Missing in isoform 1. 1 PublicationAdd BLAST343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113174 Genomic DNA No translation available.
AL512637 Genomic DNA No translation available.
BC023527 mRNA No translation available.
BC041082 mRNA Translation: AAH41082.2
BC055096 mRNA No translation available.
CCDSiCCDS44344.1 [Q8IW36-4]
CCDS55694.1 [Q8IW36-1]
RefSeqiNP_001191150.1, NM_001204221.1
UniGeneiHs.669893

Genome annotation databases

EnsembliENST00000339986; ENSP00000341236; ENSG00000197472 [Q8IW36-4]
ENST00000366504; ENSP00000355460; ENSG00000197472 [Q8IW36-2]
ENST00000487338; ENSP00000429736; ENSG00000197472 [Q8IW36-1]
GeneIDi57116
KEGGihsa:57116
UCSCiuc001ibx.4 human [Q8IW36-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN695_HUMAN
AccessioniPrimary (citable) accession number: Q8IW36
Secondary accession number(s): Q5T0N9
, Q5T0P1, Q5T0P3, Q7Z2W8, Q7Z648
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 19, 2010
Last modified: May 23, 2018
This is version 124 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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