Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 695

Gene

ZNF695

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 695
Alternative name(s):
Zinc finger protein SBZF3
Gene namesi
Name:ZNF695
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30954. ZNF695.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670493.

Polymorphism and mutation databases

BioMutaiZNF695.
DMDMi284018174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Zinc finger protein 695PRO_0000233282Add
BLAST

Proteomic databases

EPDiQ8IW36.
MaxQBiQ8IW36.
PaxDbiQ8IW36.
PRIDEiQ8IW36.

PTM databases

iPTMnetiQ8IW36.
PhosphoSiteiQ8IW36.

Expressioni

Gene expression databases

BgeeiQ8IW36.
CleanExiHS_ZNF695.
ExpressionAtlasiQ8IW36. baseline and differential.
GenevisibleiQ8IW36. HS.

Organism-specific databases

HPAiHPA024743.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-10261951,EBI-10172134

Protein-protein interaction databases

BioGridi121380. 11 interactions.
IntActiQ8IW36. 1 interaction.
STRINGi9606.ENSP00000341236.

Structurei

3D structure databases

ProteinModelPortaliQ8IW36.
SMRiQ8IW36. Positions 4-44, 154-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8784KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ8IW36.
OMAiFTWFSYL.
PhylomeDBiQ8IW36.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: Q8IW36-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLAFRDVA LEFSPEEWEC LDPAQRSLYR DVMLENYRNL ISLGEDSFNM
60 70 80 90 100
QFLFHSLAMS KPELIICLEA RKEPWNVNTE KTARHSVLSS YLTEDILPEQ
110 120 130 140 150
GLQVSFQKVM LRRYERCCLE KLRLRNDWEI VGEWKGQKAS YNGLDLCSAT
160 170 180 190 200
THSKNFQCNK CVKGFSKFAN LNKCKISHTG EKPFKCKECG NVSCMSLIMT
210 220 230 240 250
QQQRIHIGEN PYQCKKCGKA FNECSCFTDC KRIHVGEKHC KCEECNNIFK
260 270 280 290 300
SCSSLAVVEK NHTEKKTYRC EECGKAFNLC SVLTKHKKIH TGEKPYKCEE
310 320 330 340 350
CGKSFKLFPY LTQHKRIHSR EKPYKCEECG KVFKLLSYLT QHRRIHTGEK
360 370 380 390 400
TFRCEECGKA FNQSSHLTEH RRIHTGEKPY KCEECGKAFT WFSYLIQHKR
410 420 430 440 450
IHTGQKPYKC EECGKAFTWF SYLTQHKRIH TGEKPYKCDE CGKAFNWFSY
460 470 480 490 500
LTNHKRIHTG EKPYKCEECG KAFGQSSHLS KHKTIHTREK PYKCEECGKA
510
FNHSAQLAVH EKTHT
Length:515
Mass (Da):60,149
Last modified:January 19, 2010 - v4
Checksum:iB37EA43D0B16E8B5
GO
Isoform 1 (identifier: Q8IW36-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-172: VGEWKGQKAS...KGFSKFANLN → PCEDVLASPL...PVQSSTIELL
     173-515: Missing.

Show »
Length:172
Mass (Da):20,056
Checksum:iCB9E86EC6447A085
GO
Isoform 2 (identifier: Q8IW36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: GE → AM
     134-515: Missing.

Show »
Length:133
Mass (Da):15,749
Checksum:i0312791F4F4DF485
GO
Isoform 3 (identifier: Q8IW36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-88: L → M
     89-515: Missing.

Show »
Length:88
Mass (Da):10,324
Checksum:i08B9ED6E13BD857B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841R → K.1 Publication
Corresponds to variant rs2642973 [ dbSNP | Ensembl ].
VAR_057446
Natural varianti87 – 871V → A.1 Publication
Corresponds to variant rs2642992 [ dbSNP | Ensembl ].
VAR_057447
Natural varianti110 – 1101M → I.
Corresponds to variant rs55762230 [ dbSNP | Ensembl ].
VAR_061963

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 881L → M in isoform 3. 1 PublicationVSP_018106
Alternative sequencei89 – 515427Missing in isoform 3. 1 PublicationVSP_018107Add
BLAST
Alternative sequencei131 – 17242VGEWK…FANLN → PCEDVLASPLPSAMILSFLR PPQKQKHVKPTEPVQSSTIE LL in isoform 1. 1 PublicationVSP_038548Add
BLAST
Alternative sequencei132 – 1332GE → AM in isoform 2. 1 PublicationVSP_018108
Alternative sequencei134 – 515382Missing in isoform 2. 1 PublicationVSP_018109Add
BLAST
Alternative sequencei173 – 515343Missing in isoform 1. 1 PublicationVSP_038549Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512637, AC113174 Genomic DNA. Translation: CAI15612.1.
BC023527 mRNA. No translation available.
BC041082 mRNA. Translation: AAH41082.2.
BC055096 mRNA. No translation available.
CCDSiCCDS44344.1. [Q8IW36-4]
CCDS55694.1. [Q8IW36-1]
RefSeqiNP_001191150.1. NM_001204221.1.
UniGeneiHs.669893.

Genome annotation databases

EnsembliENST00000339986; ENSP00000341236; ENSG00000197472. [Q8IW36-4]
ENST00000366504; ENSP00000355460; ENSG00000197472. [Q8IW36-2]
ENST00000487338; ENSP00000429736; ENSG00000197472. [Q8IW36-1]
GeneIDi57116.
KEGGihsa:57116.
UCSCiuc001ibx.4. human. [Q8IW36-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512637, AC113174 Genomic DNA. Translation: CAI15612.1.
BC023527 mRNA. No translation available.
BC041082 mRNA. Translation: AAH41082.2.
BC055096 mRNA. No translation available.
CCDSiCCDS44344.1. [Q8IW36-4]
CCDS55694.1. [Q8IW36-1]
RefSeqiNP_001191150.1. NM_001204221.1.
UniGeneiHs.669893.

3D structure databases

ProteinModelPortaliQ8IW36.
SMRiQ8IW36. Positions 4-44, 154-515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121380. 11 interactions.
IntActiQ8IW36. 1 interaction.
STRINGi9606.ENSP00000341236.

PTM databases

iPTMnetiQ8IW36.
PhosphoSiteiQ8IW36.

Polymorphism and mutation databases

BioMutaiZNF695.
DMDMi284018174.

Proteomic databases

EPDiQ8IW36.
MaxQBiQ8IW36.
PaxDbiQ8IW36.
PRIDEiQ8IW36.

Protocols and materials databases

DNASUi57116.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339986; ENSP00000341236; ENSG00000197472. [Q8IW36-4]
ENST00000366504; ENSP00000355460; ENSG00000197472. [Q8IW36-2]
ENST00000487338; ENSP00000429736; ENSG00000197472. [Q8IW36-1]
GeneIDi57116.
KEGGihsa:57116.
UCSCiuc001ibx.4. human. [Q8IW36-4]

Organism-specific databases

CTDi57116.
GeneCardsiZNF695.
HGNCiHGNC:30954. ZNF695.
HPAiHPA024743.
MIMi616348. gene.
neXtProtiNX_Q8IW36.
PharmGKBiPA142670493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ8IW36.
OMAiFTWFSYL.
PhylomeDBiQ8IW36.
TreeFamiTF342117.

Miscellaneous databases

ChiTaRSiZNF695. human.
GenomeRNAii57116.
PROiQ8IW36.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IW36.
CleanExiHS_ZNF695.
ExpressionAtlasiQ8IW36. baseline and differential.
GenevisibleiQ8IW36. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANTS LYS-84 AND ALA-87.
    Tissue: Leiomyosarcoma and Lung carcinoma.

Entry informationi

Entry nameiZN695_HUMAN
AccessioniPrimary (citable) accession number: Q8IW36
Secondary accession number(s): Q5T0N9
, Q5T0P1, Q5T0P3, Q7Z2W8, Q7Z648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 19, 2010
Last modified: June 8, 2016
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.