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Protein

Centrosomal protein of 97 kDa

Gene

CEP97

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ciliary basal body-plasma membrane docking Source: Reactome
  • negative regulation of cilium assembly Source: UniProtKB
  • regulation of mitotic spindle assembly Source: UniProtKB

Keywordsi

Molecular functionCalmodulin-binding
Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 97 kDa
Short name:
Cep97
Alternative name(s):
Leucine-rich repeat and IQ domain-containing protein 2
Gene namesi
Name:CEP97
Synonyms:LRRIQ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000182504.10.
HGNCiHGNC:26244. CEP97.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi79598.
OpenTargetsiENSG00000182504.
PharmGKBiPA162382176.

Polymorphism and mutation databases

BioMutaiCEP97.
DMDMi74762481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637051 – 865Centrosomal protein of 97 kDaAdd BLAST865

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei308PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei530PhosphoserineBy similarity1
Modified residuei542PhosphothreonineCombined sources1
Modified residuei763PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IW35.
MaxQBiQ8IW35.
PaxDbiQ8IW35.
PeptideAtlasiQ8IW35.
PRIDEiQ8IW35.

PTM databases

iPTMnetiQ8IW35.
PhosphoSitePlusiQ8IW35.

Expressioni

Gene expression databases

BgeeiENSG00000182504.
CleanExiHS_CEP97.
ExpressionAtlasiQ8IW35. baseline and differential.
GenevisibleiQ8IW35. HS.

Organism-specific databases

HPAiHPA002980.

Interactioni

Subunit structurei

Interacts with CALM1, CEP76, CCP110, KIF24, TALPID3. Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122737. 59 interactors.
IntActiQ8IW35. 54 interactors.
MINTiMINT-8392027.
STRINGi9606.ENSP00000342510.

Structurei

3D structure databases

ProteinModelPortaliQ8IW35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 58LRR 1Add BLAST22
Repeati59 – 80LRR 2Add BLAST22
Repeati81 – 102LRR 3Add BLAST22
Repeati103 – 124LRR 4Add BLAST22
Repeati125 – 146LRR 5Add BLAST22
Repeati147 – 168LRR 6Add BLAST22
Repeati171 – 192LRR 7Add BLAST22
Repeati196 – 205LRR 810
Domaini211 – 249LRRCTAdd BLAST39
Domaini558 – 587IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni300 – 750CCP110-bindingAdd BLAST451

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00830000128399.
HOGENOMiHOG000111550.
HOVERGENiHBG061575.
InParanoidiQ8IW35.
KOiK16717.
OMAiKGRSYRP.
OrthoDBiEOG091G02EC.
PhylomeDBiQ8IW35.
TreeFamiTF320816.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR000048. IQ_motif_EF-hand-BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS50096. IQ. 1 hit.
PS51450. LRR. 7 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IW35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVARVDAAL PPGEGSVVNW SGQGLQKLGP NLPCEADIHT LILDKNQIIK
60 70 80 90 100
LENLEKCKRL IQLSVANNRL VRMMGVAKLT LLRVLNLPHN SIGCVEGLKE
110 120 130 140 150
LVHLEWLNLA GNNLKAMEQI NSCTALQHLD LSDNNISQIG DLSKLVSLKT
160 170 180 190 200
LLLHGNIITS LRMAPAYLPR SLAILSLAEN EIRDLNEISF LASLTELEQL
210 220 230 240 250
SIMNNPCVMA TPSIPGFDYR PYIVSWCLNL RVLDGYVISQ KESLKAEWLY
260 270 280 290 300
SQGKGRAYRP GQHIQLVQYL ATVCPLTSTL GLQTAEDAKL EKILSKQRFH
310 320 330 340 350
QRQLMNQSQN EELSPLVPVE TRASLIPEHS SPVQDCQISQ ESEPVIQVNS
360 370 380 390 400
WVGINSNDDQ LFAVKNNFPA SVHTTRYSRN DLHLEDIQTD EDKLNCSLLS
410 420 430 440 450
SESTFMPVAS GLSPLSPTVE LRLQGINLGL EDDGVADESV KGLESQVLDK
460 470 480 490 500
EEEQPLWAAN ENSVQMMRSE INTEVNEKAG LLPCPEPTII SAILKDDNHS
510 520 530 540 550
LTFFPESTEQ KQSDIKKPEN TQPENKETIS QATSEKLPMI LTQRSVALGQ
560 570 580 590 600
DKVALQKLND AATKLQACWR GFYARNYNPQ AKDVRYEIRL RRMQEHIVCL
610 620 630 640 650
TDEIRRLRKE RDEERIKKFV QEEAFRFLWN QVRSLQVWQQ TVDQRLSSWH
660 670 680 690 700
TDVPPISSTL VPSKHPLFTQ SQESSCDQNA DWFIASDVAP QEKSLPEFPD
710 720 730 740 750
SGFHSSLTEQ VHSLQHSLDF EKSSTEGSES SIMGNSIDTV RYGKESDLGD
760 770 780 790 800
VSEEHGEWNK ESSNNEQDNS LLEQYLTSVQ QLEDADERTN FDTETRDSKL
810 820 830 840 850
HIACFPVQLD TLSDGASVDE SHGISPPLQG EISQTQENSK LNAEVQGQQP
860
ECDSTFQLLH VGVTV
Length:865
Mass (Da):96,981
Last modified:March 1, 2003 - v1
Checksum:i98B1C230DF586DF7
GO
Isoform 2 (identifier: Q8IW35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     631-631: Q → QKWGLAILPRPVSNFWAQAVFPPQPPK

Note: No experimental confirmation available. Sequence incomplete.
Show »
Length:891
Mass (Da):99,909
Checksum:i7A3DA414E33B7E6C
GO

Sequence cautioni

The sequence BAB15531 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04055 differs from that shown. Reason: Frameshift at position 303.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299 – 300Missing in BAC04055 (PubMed:14702039).Curated2
Sequence conflicti399L → F in BAC04055 (PubMed:14702039).Curated1
Sequence conflicti758Missing in BAB15531 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031155631Q → QKWGLAILPRPVSNFWAQAV FPPQPPK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084198 Genomic DNA. No translation available.
BC041085 mRNA. Translation: AAH41085.1.
AK026700 mRNA. Translation: BAB15531.1. Different initiation.
AK093100 mRNA. Translation: BAC04055.1. Frameshift.
CCDSiCCDS2944.1. [Q8IW35-1]
RefSeqiNP_001290330.1. NM_001303401.1.
NP_078824.2. NM_024548.3. [Q8IW35-1]
UniGeneiHs.444135.

Genome annotation databases

EnsembliENST00000341893; ENSP00000342510; ENSG00000182504. [Q8IW35-1]
GeneIDi79598.
KEGGihsa:79598.
UCSCiuc003dvk.2. human. [Q8IW35-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCEP97_HUMAN
AccessioniPrimary (citable) accession number: Q8IW35
Secondary accession number(s): B5MDY8, Q8NA71, Q9H5T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot