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Protein

V-set and transmembrane domain-containing protein 4

Gene

VSTM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 4
Cleaved into the following chain:
Gene namesi
Name:VSTM4
Synonyms:C10orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:26470. VSTM4.

Subcellular locationi

Peptide Peptide Lv :
  • Secreted By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 180157ExtracellularSequence analysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Topological domaini202 – 320119CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889917.

Polymorphism and mutation databases

BioMutaiVSTM4.
DMDMi334302923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 320297V-set and transmembrane domain-containing protein 4PRO_0000274483Add
BLAST
Peptidei55 – 10450Peptide LvBy similarityPRO_0000431303Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi46 ↔ 127PROSITE-ProRule annotation
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Proteolytically cleaved to generate a bioactive peptide.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8IW00.
PaxDbiQ8IW00.
PeptideAtlasiQ8IW00.
PRIDEiQ8IW00.

PTM databases

iPTMnetiQ8IW00.
PhosphoSiteiQ8IW00.

Expressioni

Gene expression databases

BgeeiENSG00000165633.
CleanExiHS_C10orf72.
GenevisibleiQ8IW00. HS.

Organism-specific databases

HPAiHPA017279.

Interactioni

Protein-protein interaction databases

BioGridi128223. 1 interaction.
IntActiQ8IW00. 1 interaction.
STRINGi9606.ENSP00000331062.

Structurei

3D structure databases

ProteinModelPortaliQ8IW00.
SMRiQ8IW00. Positions 25-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 155132Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIWG. Eukaryota.
ENOG4111HIH. LUCA.
GeneTreeiENSGT00390000008566.
HOGENOMiHOG000261664.
HOVERGENiHBG081186.
InParanoidiQ8IW00.
OMAiEDLYVYA.
OrthoDBiEOG091G0FL3.
PhylomeDBiQ8IW00.
TreeFamiTF331374.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IW00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLALAAAA LLARAPAPEV CAALNVTVSP GPVVDYLEGE NATLLCHVSQ
60 70 80 90 100
KRRKDSLLAV RWFFAHSFDS QEALMVKMTK LRVVQYYGNF SRSAKRRRLR
110 120 130 140 150
LLEEQRGALY RLSVLTLQPS DQGHYVCRVQ EISRHRNKWT AWSNGSSATE
160 170 180 190 200
MRVISLKASE ESSFEKTKET WAFFEDLYVY AVLVCCVGIL SILLFMLVIV
210 220 230 240 250
WQSVFNKRKS RVRHYLVKCP QNSSGETVTS VTSLAPLQPK KGKRQKEKPD
260 270 280 290 300
IPPAVPAKAP IAPTFHKPKL LKPQRKVTLP KIAEENLTYA ELELIKPHRA
310 320
AKGAPTSTVY AQILFEENKL
Length:320
Mass (Da):36,146
Last modified:May 31, 2011 - v3
Checksum:iAC5F325CB8B0E1C7
GO
Isoform 2 (identifier: Q8IW00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-191: VISLKASEES...VLVCCVGILS → GVSSHPVERG...LTMASFLQSS
     192-320: Missing.

Show »
Length:191
Mass (Da):21,326
Checksum:iC0F6B2842EED5420
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951F → S in BAG60248 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681F → S.2 Publications
Corresponds to variant rs13088 [ dbSNP | Ensembl ].
VAR_030291
Natural varianti100 – 1001R → H in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs138454994 [ dbSNP | Ensembl ].
VAR_035539
Natural varianti243 – 2431K → R.1 Publication
Corresponds to variant rs17854124 [ dbSNP | Ensembl ].
VAR_065188

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei153 – 19139VISLK…VGILS → GVSSHPVERGAFLGISLVIL PHSLPFTADLTMASFLQSS in isoform 2. 1 PublicationVSP_022766Add
BLAST
Alternative sequencei192 – 320129Missing in isoform 2. 1 PublicationVSP_022767Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056299 mRNA. Translation: BAB71142.1.
AK297931 mRNA. Translation: BAG60248.1.
AC060234 Genomic DNA. No translation available.
AC084727 Genomic DNA. No translation available.
BC041414 mRNA. Translation: AAH41414.1.
CCDSiCCDS31198.1. [Q8IW00-1]
CCDS7228.1. [Q8IW00-2]
RefSeqiNP_001026916.2. NM_001031746.4. [Q8IW00-1]
NP_659421.1. NM_144984.3. [Q8IW00-2]
UniGeneiHs.522928.

Genome annotation databases

EnsembliENST00000298454; ENSP00000298454; ENSG00000165633. [Q8IW00-2]
ENST00000332853; ENSP00000331062; ENSG00000165633. [Q8IW00-1]
GeneIDi196740.
KEGGihsa:196740.
UCSCiuc001jhf.4. human. [Q8IW00-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056299 mRNA. Translation: BAB71142.1.
AK297931 mRNA. Translation: BAG60248.1.
AC060234 Genomic DNA. No translation available.
AC084727 Genomic DNA. No translation available.
BC041414 mRNA. Translation: AAH41414.1.
CCDSiCCDS31198.1. [Q8IW00-1]
CCDS7228.1. [Q8IW00-2]
RefSeqiNP_001026916.2. NM_001031746.4. [Q8IW00-1]
NP_659421.1. NM_144984.3. [Q8IW00-2]
UniGeneiHs.522928.

3D structure databases

ProteinModelPortaliQ8IW00.
SMRiQ8IW00. Positions 25-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128223. 1 interaction.
IntActiQ8IW00. 1 interaction.
STRINGi9606.ENSP00000331062.

PTM databases

iPTMnetiQ8IW00.
PhosphoSiteiQ8IW00.

Polymorphism and mutation databases

BioMutaiVSTM4.
DMDMi334302923.

Proteomic databases

MaxQBiQ8IW00.
PaxDbiQ8IW00.
PeptideAtlasiQ8IW00.
PRIDEiQ8IW00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298454; ENSP00000298454; ENSG00000165633. [Q8IW00-2]
ENST00000332853; ENSP00000331062; ENSG00000165633. [Q8IW00-1]
GeneIDi196740.
KEGGihsa:196740.
UCSCiuc001jhf.4. human. [Q8IW00-1]

Organism-specific databases

CTDi196740.
GeneCardsiVSTM4.
H-InvDBHIX0008810.
HGNCiHGNC:26470. VSTM4.
HPAiHPA017279.
neXtProtiNX_Q8IW00.
PharmGKBiPA134889917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIWG. Eukaryota.
ENOG4111HIH. LUCA.
GeneTreeiENSGT00390000008566.
HOGENOMiHOG000261664.
HOVERGENiHBG081186.
InParanoidiQ8IW00.
OMAiEDLYVYA.
OrthoDBiEOG091G0FL3.
PhylomeDBiQ8IW00.
TreeFamiTF331374.

Miscellaneous databases

ChiTaRSiVSTM4. human.
GenomeRNAii196740.
PROiQ8IW00.

Gene expression databases

BgeeiENSG00000165633.
CleanExiHS_C10orf72.
GenevisibleiQ8IW00. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSTM4_HUMAN
AccessioniPrimary (citable) accession number: Q8IW00
Secondary accession number(s): B4DNI6, Q96MX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 31, 2011
Last modified: September 7, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.