Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-set and transmembrane domain-containing protein 4

Gene

VSTM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 4
Cleaved into the following chain:
Gene namesi
Name:VSTM4
Synonyms:C10orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165633.12.
HGNCiHGNC:26470. VSTM4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 180ExtracellularSequence analysisAdd BLAST157
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 320CytoplasmicSequence analysisAdd BLAST119

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi196740.
OpenTargetsiENSG00000165633.
PharmGKBiPA134889917.

Polymorphism and mutation databases

BioMutaiVSTM4.
DMDMi334302923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000027448324 – 320V-set and transmembrane domain-containing protein 4Add BLAST297
PeptideiPRO_000043130355 – 104Peptide LvBy similarityAdd BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi46 ↔ 127PROSITE-ProRule annotation
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Proteolytically cleaved to generate a bioactive peptide.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8IW00.
PaxDbiQ8IW00.
PeptideAtlasiQ8IW00.
PRIDEiQ8IW00.

PTM databases

iPTMnetiQ8IW00.
PhosphoSitePlusiQ8IW00.

Expressioni

Gene expression databases

BgeeiENSG00000165633.
CleanExiHS_C10orf72.
GenevisibleiQ8IW00. HS.

Organism-specific databases

HPAiHPA017279.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STX1AQ166234EBI-4311759,EBI-712466

Protein-protein interaction databases

BioGridi128223. 1 interactor.
IntActiQ8IW00. 7 interactors.
STRINGi9606.ENSP00000331062.

Structurei

3D structure databases

ProteinModelPortaliQ8IW00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 155Ig-likeAdd BLAST132

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIWG. Eukaryota.
ENOG4111HIH. LUCA.
GeneTreeiENSGT00390000008566.
HOGENOMiHOG000261664.
HOVERGENiHBG081186.
InParanoidiQ8IW00.
OMAiEDLYVYA.
OrthoDBiEOG091G0FL3.
PhylomeDBiQ8IW00.
TreeFamiTF331374.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IW00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLALAAAA LLARAPAPEV CAALNVTVSP GPVVDYLEGE NATLLCHVSQ
60 70 80 90 100
KRRKDSLLAV RWFFAHSFDS QEALMVKMTK LRVVQYYGNF SRSAKRRRLR
110 120 130 140 150
LLEEQRGALY RLSVLTLQPS DQGHYVCRVQ EISRHRNKWT AWSNGSSATE
160 170 180 190 200
MRVISLKASE ESSFEKTKET WAFFEDLYVY AVLVCCVGIL SILLFMLVIV
210 220 230 240 250
WQSVFNKRKS RVRHYLVKCP QNSSGETVTS VTSLAPLQPK KGKRQKEKPD
260 270 280 290 300
IPPAVPAKAP IAPTFHKPKL LKPQRKVTLP KIAEENLTYA ELELIKPHRA
310 320
AKGAPTSTVY AQILFEENKL
Length:320
Mass (Da):36,146
Last modified:May 31, 2011 - v3
Checksum:iAC5F325CB8B0E1C7
GO
Isoform 2 (identifier: Q8IW00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-191: VISLKASEES...VLVCCVGILS → GVSSHPVERG...LTMASFLQSS
     192-320: Missing.

Show »
Length:191
Mass (Da):21,326
Checksum:iC0F6B2842EED5420
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195F → S in BAG60248 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03029168F → S2 PublicationsCorresponds to variant dbSNP:rs13088Ensembl.1
Natural variantiVAR_035539100R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138454994Ensembl.1
Natural variantiVAR_065188243K → R1 PublicationCorresponds to variant dbSNP:rs17854124Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022766153 – 191VISLK…VGILS → GVSSHPVERGAFLGISLVIL PHSLPFTADLTMASFLQSS in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_022767192 – 320Missing in isoform 2. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056299 mRNA. Translation: BAB71142.1.
AK297931 mRNA. Translation: BAG60248.1.
AC060234 Genomic DNA. No translation available.
AC084727 Genomic DNA. No translation available.
BC041414 mRNA. Translation: AAH41414.1.
CCDSiCCDS31198.1. [Q8IW00-1]
CCDS7228.1. [Q8IW00-2]
RefSeqiNP_001026916.2. NM_001031746.4. [Q8IW00-1]
NP_659421.1. NM_144984.3. [Q8IW00-2]
UniGeneiHs.522928.

Genome annotation databases

EnsembliENST00000298454; ENSP00000298454; ENSG00000165633. [Q8IW00-2]
ENST00000332853; ENSP00000331062; ENSG00000165633. [Q8IW00-1]
GeneIDi196740.
KEGGihsa:196740.
UCSCiuc001jhf.4. human. [Q8IW00-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVSTM4_HUMAN
AccessioniPrimary (citable) accession number: Q8IW00
Secondary accession number(s): B4DNI6, Q96MX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 31, 2011
Last modified: October 25, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations