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Protein

Type III endosome membrane protein TEMP

Gene

C1orf210

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in membrane trafficking between endosomes and plasma membrane.

Enzyme and pathway databases

BioCyciZFISH:G66-31964-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III endosome membrane protein TEMPBy similarity
Short name:
TEMPBy similarity
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28755. C1orf210.

Subcellular locationi

  • Membrane Curated; Single-pass type III membrane protein Curated
  • Early endosome By similarity
  • Recycling endosome By similarity
  • Cell membrane By similarity

  • Note: Also localizes to tubular endosome structures.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 50Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini51 – 113CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253313.
PharmGKBiPA144596510.

Polymorphism and mutation databases

BioMutaiC1orf210.
DMDMi74728100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710101 – 113Type III endosome membrane protein TEMPAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IVY1.
PaxDbiQ8IVY1.
PeptideAtlasiQ8IVY1.
PRIDEiQ8IVY1.

PTM databases

iPTMnetiQ8IVY1.
PhosphoSitePlusiQ8IVY1.

Expressioni

Gene expression databases

BgeeiENSG00000253313.
CleanExiHS_C1orf210.
GenevisibleiQ8IVY1. HS.

Organism-specific databases

HPAiHPA013788.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000429399.

Structurei

3D structure databases

ProteinModelPortaliQ8IVY1.
SMRiQ8IVY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J31G. Eukaryota.
ENOG41115PT. LUCA.
GeneTreeiENSGT00510000048988.
HOGENOMiHOG000232184.
HOVERGENiHBG080780.
InParanoidiQ8IVY1.
OMAiCHLCRKY.
OrthoDBiEOG091G14QZ.
PhylomeDBiQ8IVY1.
TreeFamiTF338695.

Family and domain databases

InterProiIPR033604. TEMP.
[Graphical view]
PANTHERiPTHR31450:SF3. PTHR31450:SF3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IVY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNETNKTLVG PSELPTASAV APGPGTGARA WPVLVGFVLG AVVLSLLIAL
60 70 80 90 100
AAKCHLCRRY HASYRHRPLP ETGRGGRPQV AEDEDDDGFI EDNYIQPGTG
110
ELGTEGSRDH FSL
Length:113
Mass (Da):12,024
Last modified:March 1, 2003 - v1
Checksum:i55492589C5DDF35D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03365512S → L.Corresponds to variant rs35465732dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA. Translation: EAX07108.1.
CH471059 Genomic DNA. Translation: EAX07109.1.
BC041633 mRNA. Translation: AAH41633.1.
CCDSiCCDS481.1.
RefSeqiNP_001158301.1. NM_001164829.1.
NP_872323.1. NM_182517.2.
XP_011539104.1. XM_011540802.1.
UniGeneiHs.158963.

Genome annotation databases

EnsembliENST00000423420; ENSP00000429399; ENSG00000253313.
ENST00000523677; ENSP00000430918; ENSG00000253313.
GeneIDi149466.
KEGGihsa:149466.
UCSCiuc001cit.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA. Translation: EAX07108.1.
CH471059 Genomic DNA. Translation: EAX07109.1.
BC041633 mRNA. Translation: AAH41633.1.
CCDSiCCDS481.1.
RefSeqiNP_001158301.1. NM_001164829.1.
NP_872323.1. NM_182517.2.
XP_011539104.1. XM_011540802.1.
UniGeneiHs.158963.

3D structure databases

ProteinModelPortaliQ8IVY1.
SMRiQ8IVY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000429399.

PTM databases

iPTMnetiQ8IVY1.
PhosphoSitePlusiQ8IVY1.

Polymorphism and mutation databases

BioMutaiC1orf210.
DMDMi74728100.

Proteomic databases

EPDiQ8IVY1.
PaxDbiQ8IVY1.
PeptideAtlasiQ8IVY1.
PRIDEiQ8IVY1.

Protocols and materials databases

DNASUi149466.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423420; ENSP00000429399; ENSG00000253313.
ENST00000523677; ENSP00000430918; ENSG00000253313.
GeneIDi149466.
KEGGihsa:149466.
UCSCiuc001cit.5. human.

Organism-specific databases

CTDi149466.
GeneCardsiC1orf210.
HGNCiHGNC:28755. C1orf210.
HPAiHPA013788.
neXtProtiNX_Q8IVY1.
OpenTargetsiENSG00000253313.
PharmGKBiPA144596510.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J31G. Eukaryota.
ENOG41115PT. LUCA.
GeneTreeiENSGT00510000048988.
HOGENOMiHOG000232184.
HOVERGENiHBG080780.
InParanoidiQ8IVY1.
OMAiCHLCRKY.
OrthoDBiEOG091G14QZ.
PhylomeDBiQ8IVY1.
TreeFamiTF338695.

Enzyme and pathway databases

BioCyciZFISH:G66-31964-MONOMER.

Miscellaneous databases

ChiTaRSiC1orf210. human.
GenomeRNAii149466.
PROiQ8IVY1.

Gene expression databases

BgeeiENSG00000253313.
CleanExiHS_C1orf210.
GenevisibleiQ8IVY1. HS.

Family and domain databases

InterProiIPR033604. TEMP.
[Graphical view]
PANTHERiPTHR31450:SF3. PTHR31450:SF3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCA210_HUMAN
AccessioniPrimary (citable) accession number: Q8IVY1
Secondary accession number(s): D3DPX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.