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Protein

Type III endosome membrane protein TEMP

Gene

C1orf210

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in membrane trafficking between endosomes and plasma membrane.

GO - Biological processi

  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Type III endosome membrane protein TEMPBy similarity
Short name:
TEMPBy similarity
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28755. C1orf210.

Subcellular locationi

  • Membrane Curated; Single-pass type III membrane protein Curated
  • Early endosome By similarity
  • Recycling endosome By similarity
  • Cell membrane By similarity

  • Note: Also localizes to tubular endosome structures.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularBy similarityAdd
BLAST
Transmembranei30 – 5021Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
BLAST
Topological domaini51 – 11363CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596510.

Polymorphism and mutation databases

BioMutaiC1orf210.
DMDMi74728100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Type III endosome membrane protein TEMPPRO_0000271010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

PTM databases

PhosphoSiteiQ8IVY1.

Expressioni

Gene expression databases

BgeeiQ8IVY1.
CleanExiHS_C1orf210.
GenevisibleiQ8IVY1. HS.

Organism-specific databases

HPAiHPA013788.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000429399.

Structurei

3D structure databases

ProteinModelPortaliQ8IVY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000048988.
HOGENOMiHOG000232184.
HOVERGENiHBG080780.
InParanoidiQ8IVY1.
OMAiCHLCRKY.
OrthoDBiEOG75TMGB.
PhylomeDBiQ8IVY1.
TreeFamiTF338695.

Sequencei

Sequence statusi: Complete.

Q8IVY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNETNKTLVG PSELPTASAV APGPGTGARA WPVLVGFVLG AVVLSLLIAL
60 70 80 90 100
AAKCHLCRRY HASYRHRPLP ETGRGGRPQV AEDEDDDGFI EDNYIQPGTG
110
ELGTEGSRDH FSL
Length:113
Mass (Da):12,024
Last modified:March 1, 2003 - v1
Checksum:i55492589C5DDF35D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121S → L.
Corresponds to variant rs35465732 [ dbSNP | Ensembl ].
VAR_033655

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA. Translation: EAX07108.1.
CH471059 Genomic DNA. Translation: EAX07109.1.
BC041633 mRNA. Translation: AAH41633.1.
CCDSiCCDS481.1.
RefSeqiNP_001158301.1. NM_001164829.1.
NP_872323.1. NM_182517.2.
UniGeneiHs.158963.

Genome annotation databases

EnsembliENST00000423420; ENSP00000429399; ENSG00000253313.
ENST00000523677; ENSP00000430918; ENSG00000253313.
GeneIDi149466.
KEGGihsa:149466.
UCSCiuc001cit.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA. Translation: EAX07108.1.
CH471059 Genomic DNA. Translation: EAX07109.1.
BC041633 mRNA. Translation: AAH41633.1.
CCDSiCCDS481.1.
RefSeqiNP_001158301.1. NM_001164829.1.
NP_872323.1. NM_182517.2.
UniGeneiHs.158963.

3D structure databases

ProteinModelPortaliQ8IVY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000429399.

PTM databases

PhosphoSiteiQ8IVY1.

Polymorphism and mutation databases

BioMutaiC1orf210.
DMDMi74728100.

Protocols and materials databases

DNASUi149466.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423420; ENSP00000429399; ENSG00000253313.
ENST00000523677; ENSP00000430918; ENSG00000253313.
GeneIDi149466.
KEGGihsa:149466.
UCSCiuc001cit.4. human.

Organism-specific databases

CTDi149466.
GeneCardsiGC01M043747.
HGNCiHGNC:28755. C1orf210.
HPAiHPA013788.
neXtProtiNX_Q8IVY1.
PharmGKBiPA144596510.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000048988.
HOGENOMiHOG000232184.
HOVERGENiHBG080780.
InParanoidiQ8IVY1.
OMAiCHLCRKY.
OrthoDBiEOG75TMGB.
PhylomeDBiQ8IVY1.
TreeFamiTF338695.

Miscellaneous databases

ChiTaRSiC1orf210. human.
GenomeRNAii149466.
NextBioi86164.
PROiQ8IVY1.

Gene expression databases

BgeeiQ8IVY1.
CleanExiHS_C1orf210.
GenevisibleiQ8IVY1. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiCA210_HUMAN
AccessioniPrimary (citable) accession number: Q8IVY1
Secondary accession number(s): D3DPX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.