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Protein

Type III endosome membrane protein TEMP

Gene

C1orf210

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in membrane trafficking between endosomes and plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III endosome membrane protein TEMPBy similarity
Short name:
TEMPBy similarity
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000253313.5
HGNCiHGNC:28755 C1orf210
neXtProtiNX_Q8IVY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 50Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini51 – 113CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi149466
OpenTargetsiENSG00000253313
PharmGKBiPA144596510

Polymorphism and mutation databases

BioMutaiC1orf210
DMDMi74728100

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710101 – 113Type III endosome membrane protein TEMPAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IVY1
PaxDbiQ8IVY1
PeptideAtlasiQ8IVY1
PRIDEiQ8IVY1
ProteomicsDBi70791

PTM databases

iPTMnetiQ8IVY1
PhosphoSitePlusiQ8IVY1

Expressioni

Gene expression databases

BgeeiENSG00000253313
CleanExiHS_C1orf210
GenevisibleiQ8IVY1 HS

Organism-specific databases

HPAiHPA013788

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000429399

Structurei

3D structure databases

ProteinModelPortaliQ8IVY1
SMRiQ8IVY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J31G Eukaryota
ENOG41115PT LUCA
GeneTreeiENSGT00510000048988
HOGENOMiHOG000232184
HOVERGENiHBG080780
InParanoidiQ8IVY1
OMAiHLCRKYR
OrthoDBiEOG091G14QZ
PhylomeDBiQ8IVY1
TreeFamiTF338695

Family and domain databases

InterProiView protein in InterPro
IPR033604 TEMP
PANTHERiPTHR31450 PTHR31450, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IVY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNETNKTLVG PSELPTASAV APGPGTGARA WPVLVGFVLG AVVLSLLIAL
60 70 80 90 100
AAKCHLCRRY HASYRHRPLP ETGRGGRPQV AEDEDDDGFI EDNYIQPGTG
110
ELGTEGSRDH FSL
Length:113
Mass (Da):12,024
Last modified:March 1, 2003 - v1
Checksum:i55492589C5DDF35D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03365512S → L. Corresponds to variant dbSNP:rs35465732Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA Translation: EAX07108.1
CH471059 Genomic DNA Translation: EAX07109.1
BC041633 mRNA Translation: AAH41633.1
CCDSiCCDS481.1
RefSeqiNP_001158301.1, NM_001164829.1
NP_872323.1, NM_182517.2
XP_011539104.1, XM_011540802.1
UniGeneiHs.158963

Genome annotation databases

EnsembliENST00000423420; ENSP00000429399; ENSG00000253313
ENST00000523677; ENSP00000430918; ENSG00000253313
GeneIDi149466
KEGGihsa:149466
UCSCiuc001cit.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCA210_HUMAN
AccessioniPrimary (citable) accession number: Q8IVY1
Secondary accession number(s): D3DPX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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