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Q8IVW6

- ARI3B_HUMAN

UniProt

Q8IVW6 - ARI3B_HUMAN

Protein

AT-rich interactive domain-containing protein 3B

Gene

ARID3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.2 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AT-rich interactive domain-containing protein 3B
    Short name:
    ARID domain-containing protein 3B
    Alternative name(s):
    Bright and dead ringer protein
    Bright-like protein
    Gene namesi
    Name:ARID3B
    Synonyms:BDP, DRIL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:14350. ARID3B.

    Subcellular locationi

    Nucleus 2 PublicationsPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi240 – 2401P → H: Impairs binding to RB1. 1 Publication
    Mutagenesisi271 – 2711W → S: Impairs binding to RB1. 1 Publication

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA134896829.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561AT-rich interactive domain-containing protein 3BPRO_0000295162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei89 – 891Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8IVW6.
    PaxDbiQ8IVW6.
    PRIDEiQ8IVW6.

    PTM databases

    PhosphoSiteiQ8IVW6.

    Expressioni

    Tissue specificityi

    Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ8IVW6.
    BgeeiQ8IVW6.
    CleanExiHS_ARID3B.
    GenevestigatoriQ8IVW6.

    Organism-specific databases

    HPAiHPA050320.

    Interactioni

    Subunit structurei

    Heterodimer with ARID3A. Interacts with unphosphorylated RB1.2 Publications

    Protein-protein interaction databases

    BioGridi115865. 9 interactions.
    STRINGi9606.ENSP00000343126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IVW6.
    SMRiQ8IVW6. Positions 176-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini215 – 30793ARIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini419 – 51799REKLESPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni203 – 365163Interaction with RB1Add
    BLAST
    Regioni490 – 51324Interaction with ARID3AAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 4945Gln-richAdd
    BLAST
    Compositional biasi341 – 35313Poly-AlaAdd
    BLAST
    Compositional biasi523 – 56038Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ARID domain.PROSITE-ProRule annotation
    Contains 1 REKLES domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327790.
    HOGENOMiHOG000236281.
    HOVERGENiHBG103680.
    InParanoidiQ8IVW6.
    OMAiFHVQKVA.
    OrthoDBiEOG77DJ6W.
    PhylomeDBiQ8IVW6.
    TreeFamiTF320364.

    Family and domain databases

    Gene3Di1.10.150.60. 1 hit.
    InterProiIPR001606. ARID/BRIGHT_DNA-bd.
    IPR023334. REKLES_domain.
    [Graphical view]
    PfamiPF01388. ARID. 1 hit.
    [Graphical view]
    SMARTiSM00501. BRIGHT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46774. SSF46774. 1 hit.
    PROSITEiPS51011. ARID. 1 hit.
    PS51486. REKLES. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IVW6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPLQQQQQQ QQQQQKQPHL APLQMDAREK QGQQMREAQF LYAQKLVTQP    50
    TLLSATAGRP SGSTPLGPLA RVPPTAAVAQ VFERGNMNSE PEEEDGGLED 100
    EDGDDEVAEV AEKETQAASK YFHVQKVARQ DPRVAPMSNL LPAPGLPPHG 150
    QQAKEDHTKD ASKASPSVST AGQPNWNLDE QLKQNGGLAW SDDADGGRGR 200
    EISRDFAKLY ELDGDPERKE FLDDLFVFMQ KRGTPINRIP IMAKQILDLY 250
    MLYKLVTEKG GLVEIINKKI WREITKGLNL PTSITSAAFT LRTQYMKYLY 300
    AYECEKKALS SPAELQAAID GNRREGRRPS YSSSLFGYSP AAATAAAAAG 350
    APALLSPPKI RFPILGLGSS SGTNTSSPRI SPATTLRKGD GAPVTTVPVP 400
    NRLAVPVTLA SQQAGTRTAA LEQLRERLES GEPAEKKASR LSEEEQRLVQ 450
    QAFQRNFFSM ARQLPMKIRI NGRAEDRAEA SAAALNLTTS SIGSINMSVD 500
    IDGTTYAGVL FAQKPVVHLI TGSAPQSLGS SASSSSSSHC SPSPTSSRGT 550
    PSAEPSTSWS L 561
    Length:561
    Mass (Da):60,637
    Last modified:July 10, 2007 - v2
    Checksum:i5F0CFF83BAFC12D2
    GO
    Isoform 3 (identifier: Q8IVW6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         390-471: DGAPVTTVPV...RQLPMKIRIN → QQGSWGRRKK...PVPLQVMEPQ
         472-561: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:435
    Mass (Da):47,661
    Checksum:i10364C23137AFDB9
    GO
    Isoform 4 (identifier: Q8IVW6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         474-474: Missing.

    Show »
    Length:560
    Mass (Da):60,566
    Checksum:i93A741BF1B631B6A
    GO

    Sequence cautioni

    The sequence BAD92067.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71Q → QQ in AAH41792. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei390 – 47182DGAPV…KIRIN → QQGSWGRRKKGRKGCQFPVF KTGVLGQEGQLWIGPAPVPL QVMEPQ in isoform 3. 1 PublicationVSP_026773Add
    BLAST
    Alternative sequencei472 – 56190Missing in isoform 3. 1 PublicationVSP_026774Add
    BLAST
    Alternative sequencei474 – 4741Missing in isoform 4. 1 PublicationVSP_039860

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116846 mRNA. Translation: AAD09133.1.
    AB208830 mRNA. Translation: BAD92067.1. Different initiation.
    AC100835 Genomic DNA. No translation available.
    BC041792 mRNA. Translation: AAH41792.1.
    CCDSiCCDS10264.1. [Q8IVW6-4]
    RefSeqiNP_006456.1. NM_006465.2. [Q8IVW6-4]
    XP_005254186.1. XM_005254129.1. [Q8IVW6-1]
    UniGeneiHs.655532.

    Genome annotation databases

    EnsembliENST00000346246; ENSP00000343126; ENSG00000179361. [Q8IVW6-4]
    GeneIDi10620.
    KEGGihsa:10620.
    UCSCiuc002ayc.3. human. [Q8IVW6-3]
    uc002ayd.3. human. [Q8IVW6-4]
    uc002aye.3. human. [Q8IVW6-1]

    Polymorphism databases

    DMDMi152013359.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116846 mRNA. Translation: AAD09133.1 .
    AB208830 mRNA. Translation: BAD92067.1 . Different initiation.
    AC100835 Genomic DNA. No translation available.
    BC041792 mRNA. Translation: AAH41792.1 .
    CCDSi CCDS10264.1. [Q8IVW6-4 ]
    RefSeqi NP_006456.1. NM_006465.2. [Q8IVW6-4 ]
    XP_005254186.1. XM_005254129.1. [Q8IVW6-1 ]
    UniGenei Hs.655532.

    3D structure databases

    ProteinModelPortali Q8IVW6.
    SMRi Q8IVW6. Positions 176-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115865. 9 interactions.
    STRINGi 9606.ENSP00000343126.

    PTM databases

    PhosphoSitei Q8IVW6.

    Polymorphism databases

    DMDMi 152013359.

    Proteomic databases

    MaxQBi Q8IVW6.
    PaxDbi Q8IVW6.
    PRIDEi Q8IVW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000346246 ; ENSP00000343126 ; ENSG00000179361 . [Q8IVW6-4 ]
    GeneIDi 10620.
    KEGGi hsa:10620.
    UCSCi uc002ayc.3. human. [Q8IVW6-3 ]
    uc002ayd.3. human. [Q8IVW6-4 ]
    uc002aye.3. human. [Q8IVW6-1 ]

    Organism-specific databases

    CTDi 10620.
    GeneCardsi GC15P074833.
    HGNCi HGNC:14350. ARID3B.
    HPAi HPA050320.
    MIMi 612457. gene.
    neXtProti NX_Q8IVW6.
    PharmGKBi PA134896829.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327790.
    HOGENOMi HOG000236281.
    HOVERGENi HBG103680.
    InParanoidi Q8IVW6.
    OMAi FHVQKVA.
    OrthoDBi EOG77DJ6W.
    PhylomeDBi Q8IVW6.
    TreeFami TF320364.

    Miscellaneous databases

    GeneWikii ARID3B.
    GenomeRNAii 10620.
    NextBioi 40352.
    PROi Q8IVW6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVW6.
    Bgeei Q8IVW6.
    CleanExi HS_ARID3B.
    Genevestigatori Q8IVW6.

    Family and domain databases

    Gene3Di 1.10.150.60. 1 hit.
    InterProi IPR001606. ARID/BRIGHT_DNA-bd.
    IPR023334. REKLES_domain.
    [Graphical view ]
    Pfami PF01388. ARID. 1 hit.
    [Graphical view ]
    SMARTi SM00501. BRIGHT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46774. SSF46774. 1 hit.
    PROSITEi PS51011. ARID. 1 hit.
    PS51486. REKLES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product."
      Numata S., Claudio P.P., Dean C., Giordano A., Croce C.M.
      Cancer Res. 59:3741-3747(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DNA-BINDING, INTERACTION WITH RB1, MUTAGENESIS OF PRO-240 AND TRP-271.
      Tissue: Testis.
    2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. "ARID3B induces malignant transformation of mouse embryonic fibroblasts and is strongly associated with malignant neuroblastoma."
      Kobayashi K., Era T., Takebe A., Jakt L.M., Nishikawa S.
      Cancer Res. 66:8331-8336(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    6. "REKLES is an ARID3-restricted multifunctional domain."
      Kim D., Probst L., Das C., Tucker P.W.
      J. Biol. Chem. 282:15768-15777(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARID3A, SUBCELLULAR LOCATION, FUNCTION.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARI3B_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVW6
    Secondary accession number(s): O95443, Q59HC9, Q6P9C9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3