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Q8IVW6

- ARI3B_HUMAN

UniProt

Q8IVW6 - ARI3B_HUMAN

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Protein

AT-rich interactive domain-containing protein 3B

Gene

ARID3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 3B
Short name:
ARID domain-containing protein 3B
Alternative name(s):
Bright and dead ringer protein
Bright-like protein
Gene namesi
Name:ARID3B
Synonyms:BDP, DRIL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:14350. ARID3B.

Subcellular locationi

Nucleus 2 PublicationsPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi240 – 2401P → H: Impairs binding to RB1. 1 Publication
Mutagenesisi271 – 2711W → S: Impairs binding to RB1. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134896829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561AT-rich interactive domain-containing protein 3BPRO_0000295162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei89 – 891Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8IVW6.
PaxDbiQ8IVW6.
PRIDEiQ8IVW6.

PTM databases

PhosphoSiteiQ8IVW6.

Expressioni

Tissue specificityi

Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level).2 Publications

Gene expression databases

BgeeiQ8IVW6.
CleanExiHS_ARID3B.
ExpressionAtlasiQ8IVW6. baseline and differential.
GenevestigatoriQ8IVW6.

Organism-specific databases

HPAiHPA050320.

Interactioni

Subunit structurei

Heterodimer with ARID3A. Interacts with unphosphorylated RB1.2 Publications

Protein-protein interaction databases

BioGridi115865. 12 interactions.
STRINGi9606.ENSP00000343126.

Structurei

3D structure databases

ProteinModelPortaliQ8IVW6.
SMRiQ8IVW6. Positions 176-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 30793ARIDPROSITE-ProRule annotationAdd
BLAST
Domaini419 – 51799REKLESPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni203 – 365163Interaction with RB1Add
BLAST
Regioni490 – 51324Interaction with ARID3AAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 4945Gln-richAdd
BLAST
Compositional biasi341 – 35313Poly-AlaAdd
BLAST
Compositional biasi523 – 56038Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation
Contains 1 REKLES domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327790.
GeneTreeiENSGT00550000074575.
HOGENOMiHOG000236281.
HOVERGENiHBG103680.
InParanoidiQ8IVW6.
OMAiFHVQKVA.
OrthoDBiEOG77DJ6W.
PhylomeDBiQ8IVW6.
TreeFamiTF320364.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID/BRIGHT_DNA-bd.
IPR023334. REKLES_domain.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
PS51486. REKLES. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVW6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPLQQQQQQ QQQQQKQPHL APLQMDAREK QGQQMREAQF LYAQKLVTQP
60 70 80 90 100
TLLSATAGRP SGSTPLGPLA RVPPTAAVAQ VFERGNMNSE PEEEDGGLED
110 120 130 140 150
EDGDDEVAEV AEKETQAASK YFHVQKVARQ DPRVAPMSNL LPAPGLPPHG
160 170 180 190 200
QQAKEDHTKD ASKASPSVST AGQPNWNLDE QLKQNGGLAW SDDADGGRGR
210 220 230 240 250
EISRDFAKLY ELDGDPERKE FLDDLFVFMQ KRGTPINRIP IMAKQILDLY
260 270 280 290 300
MLYKLVTEKG GLVEIINKKI WREITKGLNL PTSITSAAFT LRTQYMKYLY
310 320 330 340 350
AYECEKKALS SPAELQAAID GNRREGRRPS YSSSLFGYSP AAATAAAAAG
360 370 380 390 400
APALLSPPKI RFPILGLGSS SGTNTSSPRI SPATTLRKGD GAPVTTVPVP
410 420 430 440 450
NRLAVPVTLA SQQAGTRTAA LEQLRERLES GEPAEKKASR LSEEEQRLVQ
460 470 480 490 500
QAFQRNFFSM ARQLPMKIRI NGRAEDRAEA SAAALNLTTS SIGSINMSVD
510 520 530 540 550
IDGTTYAGVL FAQKPVVHLI TGSAPQSLGS SASSSSSSHC SPSPTSSRGT
560
PSAEPSTSWS L
Length:561
Mass (Da):60,637
Last modified:July 10, 2007 - v2
Checksum:i5F0CFF83BAFC12D2
GO
Isoform 3 (identifier: Q8IVW6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-471: DGAPVTTVPV...RQLPMKIRIN → QQGSWGRRKK...PVPLQVMEPQ
     472-561: Missing.

Note: No experimental confirmation available.

Show »
Length:435
Mass (Da):47,661
Checksum:i10364C23137AFDB9
GO
Isoform 4 (identifier: Q8IVW6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-474: Missing.

Show »
Length:560
Mass (Da):60,566
Checksum:i93A741BF1B631B6A
GO

Sequence cautioni

The sequence BAD92067.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71Q → QQ in AAH41792. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei390 – 47182DGAPV…KIRIN → QQGSWGRRKKGRKGCQFPVF KTGVLGQEGQLWIGPAPVPL QVMEPQ in isoform 3. 1 PublicationVSP_026773Add
BLAST
Alternative sequencei472 – 56190Missing in isoform 3. 1 PublicationVSP_026774Add
BLAST
Alternative sequencei474 – 4741Missing in isoform 4. 1 PublicationVSP_039860

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116846 mRNA. Translation: AAD09133.1.
AB208830 mRNA. Translation: BAD92067.1. Different initiation.
AC100835 Genomic DNA. No translation available.
BC041792 mRNA. Translation: AAH41792.1.
CCDSiCCDS10264.1. [Q8IVW6-4]
RefSeqiNP_006456.1. NM_006465.2. [Q8IVW6-4]
XP_005254186.1. XM_005254129.1. [Q8IVW6-1]
UniGeneiHs.655532.

Genome annotation databases

EnsembliENST00000346246; ENSP00000343126; ENSG00000179361. [Q8IVW6-4]
ENST00000622429; ENSP00000477878; ENSG00000179361. [Q8IVW6-1]
GeneIDi10620.
KEGGihsa:10620.
UCSCiuc002ayc.3. human. [Q8IVW6-3]
uc002ayd.3. human. [Q8IVW6-4]
uc002aye.3. human. [Q8IVW6-1]

Polymorphism databases

DMDMi152013359.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116846 mRNA. Translation: AAD09133.1 .
AB208830 mRNA. Translation: BAD92067.1 . Different initiation.
AC100835 Genomic DNA. No translation available.
BC041792 mRNA. Translation: AAH41792.1 .
CCDSi CCDS10264.1. [Q8IVW6-4 ]
RefSeqi NP_006456.1. NM_006465.2. [Q8IVW6-4 ]
XP_005254186.1. XM_005254129.1. [Q8IVW6-1 ]
UniGenei Hs.655532.

3D structure databases

ProteinModelPortali Q8IVW6.
SMRi Q8IVW6. Positions 176-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115865. 12 interactions.
STRINGi 9606.ENSP00000343126.

PTM databases

PhosphoSitei Q8IVW6.

Polymorphism databases

DMDMi 152013359.

Proteomic databases

MaxQBi Q8IVW6.
PaxDbi Q8IVW6.
PRIDEi Q8IVW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346246 ; ENSP00000343126 ; ENSG00000179361 . [Q8IVW6-4 ]
ENST00000622429 ; ENSP00000477878 ; ENSG00000179361 . [Q8IVW6-1 ]
GeneIDi 10620.
KEGGi hsa:10620.
UCSCi uc002ayc.3. human. [Q8IVW6-3 ]
uc002ayd.3. human. [Q8IVW6-4 ]
uc002aye.3. human. [Q8IVW6-1 ]

Organism-specific databases

CTDi 10620.
GeneCardsi GC15P074833.
HGNCi HGNC:14350. ARID3B.
HPAi HPA050320.
MIMi 612457. gene.
neXtProti NX_Q8IVW6.
PharmGKBi PA134896829.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327790.
GeneTreei ENSGT00550000074575.
HOGENOMi HOG000236281.
HOVERGENi HBG103680.
InParanoidi Q8IVW6.
OMAi FHVQKVA.
OrthoDBi EOG77DJ6W.
PhylomeDBi Q8IVW6.
TreeFami TF320364.

Miscellaneous databases

GeneWikii ARID3B.
GenomeRNAii 10620.
NextBioi 40352.
PROi Q8IVW6.
SOURCEi Search...

Gene expression databases

Bgeei Q8IVW6.
CleanExi HS_ARID3B.
ExpressionAtlasi Q8IVW6. baseline and differential.
Genevestigatori Q8IVW6.

Family and domain databases

Gene3Di 1.10.150.60. 1 hit.
InterProi IPR001606. ARID/BRIGHT_DNA-bd.
IPR023334. REKLES_domain.
[Graphical view ]
Pfami PF01388. ARID. 1 hit.
[Graphical view ]
SMARTi SM00501. BRIGHT. 1 hit.
[Graphical view ]
SUPFAMi SSF46774. SSF46774. 1 hit.
PROSITEi PS51011. ARID. 1 hit.
PS51486. REKLES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product."
    Numata S., Claudio P.P., Dean C., Giordano A., Croce C.M.
    Cancer Res. 59:3741-3747(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DNA-BINDING, INTERACTION WITH RB1, MUTAGENESIS OF PRO-240 AND TRP-271.
    Tissue: Testis.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "ARID3B induces malignant transformation of mouse embryonic fibroblasts and is strongly associated with malignant neuroblastoma."
    Kobayashi K., Era T., Takebe A., Jakt L.M., Nishikawa S.
    Cancer Res. 66:8331-8336(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "REKLES is an ARID3-restricted multifunctional domain."
    Kim D., Probst L., Das C., Tucker P.W.
    J. Biol. Chem. 282:15768-15777(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARID3A, SUBCELLULAR LOCATION, FUNCTION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARI3B_HUMAN
AccessioniPrimary (citable) accession number: Q8IVW6
Secondary accession number(s): O95443, Q59HC9, Q6P9C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3