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Q8IVW4

- CDKL3_HUMAN

UniProt

Q8IVW4 - CDKL3_HUMAN

Protein

Cyclin-dependent kinase-like 3

Gene

CDKL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein kinase activity Source: ProtInc

    GO - Biological processi

    1. cellular protein modification process Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8IVW4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
    Alternative name(s):
    Serine/threonine-protein kinase NKIAMRE
    Gene namesi
    Name:CDKL3
    Synonyms:NKIAMRE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:15483. CDKL3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26319.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 592592Cyclin-dependent kinase-like 3PRO_0000085820Add
    BLAST

    Proteomic databases

    MaxQBiQ8IVW4.
    PaxDbiQ8IVW4.
    PRIDEiQ8IVW4.

    PTM databases

    PhosphoSiteiQ8IVW4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IVW4.
    BgeeiQ8IVW4.
    GenevestigatoriQ8IVW4.

    Organism-specific databases

    HPAiHPA007446.
    HPA027751.

    Interactioni

    Protein-protein interaction databases

    BioGridi119419. 8 interactions.
    IntActiQ8IVW4. 5 interactions.

    Structurei

    Secondary structure

    1
    592
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 1310
    Beta strandi16 – 238
    Turni24 – 263
    Beta strandi29 – 346
    Helixi45 – 5612
    Beta strandi65 – 695
    Beta strandi72 – 743
    Beta strandi76 – 805
    Beta strandi83 – 853
    Helixi86 – 927
    Helixi99 – 11820
    Helixi128 – 1303
    Beta strandi131 – 1333
    Beta strandi139 – 1413
    Helixi161 – 1644
    Helixi169 – 1724
    Helixi181 – 19616
    Helixi206 – 21611
    Helixi222 – 2309
    Helixi232 – 2343
    Helixi248 – 2514
    Helixi257 – 26610
    Helixi271 – 2733
    Helixi277 – 2815
    Helixi284 – 2874
    Helixi291 – 30818

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZDUX-ray2.20A1-324[»]
    ProteinModelPortaliQ8IVW4.
    SMRiQ8IVW4. Positions 1-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 507[NKR]KIAxRE

    Domaini

    The [NKR]KIAxRE motif seems to be a cyclin-binding region.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG080204.
    InParanoidiQ8IVW4.
    KOiK08824.
    OMAiCKHKNTG.
    OrthoDBiEOG7992PS.
    PhylomeDBiQ8IVW4.
    TreeFamiTF101031.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IVW4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE    50
    IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK 100
    RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL 150
    AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY 200
    LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK 250
    KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK 300
    AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE 350
    KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL 400
    VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF 450
    HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH 500
    SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE 550
    SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW 592
    Length:592
    Mass (Da):67,514
    Last modified:March 1, 2003 - v1
    Checksum:i2B1AF08906EB7697
    GO
    Isoform 2 (identifier: Q8IVW4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         456-592: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:455
    Mass (Da):51,566
    Checksum:iB2046F84A9C95AC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti345 – 3451K → E in AAF36509. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti394 – 3941M → T.1 Publication
    Corresponds to variant rs35687772 [ dbSNP | Ensembl ].
    VAR_041991

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei456 – 592137Missing in isoform 2. 1 PublicationVSP_016148Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130372 mRNA. Translation: AAF36509.1.
    CH471062 Genomic DNA. Translation: EAW62263.1.
    CH471062 Genomic DNA. Translation: EAW62264.1.
    CH471062 Genomic DNA. Translation: EAW62265.1.
    CH471062 Genomic DNA. Translation: EAW62266.1.
    BC041799 mRNA. Translation: AAH41799.1.
    CCDSiCCDS47264.1. [Q8IVW4-1]
    CCDS47265.1. [Q8IVW4-2]
    RefSeqiNP_001107047.1. NM_001113575.1. [Q8IVW4-1]
    NP_057592.2. NM_016508.3. [Q8IVW4-2]
    UniGeneiHs.719926.

    Genome annotation databases

    EnsembliENST00000265334; ENSP00000265334; ENSG00000006837. [Q8IVW4-1]
    ENST00000523832; ENSP00000430496; ENSG00000006837. [Q8IVW4-2]
    GeneIDi51265.
    KEGGihsa:51265.
    UCSCiuc003kzf.4. human. [Q8IVW4-1]
    uc011cxr.1. human. [Q8IVW4-2]

    Polymorphism databases

    DMDMi74762479.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130372 mRNA. Translation: AAF36509.1 .
    CH471062 Genomic DNA. Translation: EAW62263.1 .
    CH471062 Genomic DNA. Translation: EAW62264.1 .
    CH471062 Genomic DNA. Translation: EAW62265.1 .
    CH471062 Genomic DNA. Translation: EAW62266.1 .
    BC041799 mRNA. Translation: AAH41799.1 .
    CCDSi CCDS47264.1. [Q8IVW4-1 ]
    CCDS47265.1. [Q8IVW4-2 ]
    RefSeqi NP_001107047.1. NM_001113575.1. [Q8IVW4-1 ]
    NP_057592.2. NM_016508.3. [Q8IVW4-2 ]
    UniGenei Hs.719926.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZDU X-ray 2.20 A 1-324 [» ]
    ProteinModelPortali Q8IVW4.
    SMRi Q8IVW4. Positions 1-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119419. 8 interactions.
    IntActi Q8IVW4. 5 interactions.

    Chemistry

    BindingDBi Q8IVW4.
    ChEMBLi CHEMBL1163117.
    GuidetoPHARMACOLOGYi 1984.

    PTM databases

    PhosphoSitei Q8IVW4.

    Polymorphism databases

    DMDMi 74762479.

    Proteomic databases

    MaxQBi Q8IVW4.
    PaxDbi Q8IVW4.
    PRIDEi Q8IVW4.

    Protocols and materials databases

    DNASUi 51265.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265334 ; ENSP00000265334 ; ENSG00000006837 . [Q8IVW4-1 ]
    ENST00000523832 ; ENSP00000430496 ; ENSG00000006837 . [Q8IVW4-2 ]
    GeneIDi 51265.
    KEGGi hsa:51265.
    UCSCi uc003kzf.4. human. [Q8IVW4-1 ]
    uc011cxr.1. human. [Q8IVW4-2 ]

    Organism-specific databases

    CTDi 51265.
    GeneCardsi GC05M133541.
    HGNCi HGNC:15483. CDKL3.
    HPAi HPA007446.
    HPA027751.
    MIMi 608459. gene.
    neXtProti NX_Q8IVW4.
    PharmGKBi PA26319.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG080204.
    InParanoidi Q8IVW4.
    KOi K08824.
    OMAi CKHKNTG.
    OrthoDBi EOG7992PS.
    PhylomeDBi Q8IVW4.
    TreeFami TF101031.

    Enzyme and pathway databases

    SignaLinki Q8IVW4.

    Miscellaneous databases

    GenomeRNAii 51265.
    NextBioi 54449.
    PROi Q8IVW4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVW4.
    Bgeei Q8IVW4.
    Genevestigatori Q8IVW4.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NKIAMRE a novel kinase deleted in human leukemia."
      Midmer M., Haq R., Zanke B.W.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Fetal heart.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-394.

    Entry informationi

    Entry nameiCDKL3_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVW4
    Secondary accession number(s): D3DQA0, D3DQA1, Q9P114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3