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Q8IVW4 (CDKL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 3

EC=2.7.11.22
Alternative name(s):
Serine/threonine-protein kinase NKIAMRE
Gene names
Name:CDKL3
Synonyms:NKIAMRE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity.

Domain

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IVW4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IVW4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     456-592: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 592592Cyclin-dependent kinase-like 3
PRO_0000085820

Regions

Domain4 – 286283Protein kinase
Nucleotide binding10 – 189ATP By similarity
Motif44 – 507[NKR]KIAxRE

Sites

Active site1251Proton acceptor By similarity
Binding site331ATP By similarity

Natural variations

Alternative sequence456 – 592137Missing in isoform 2.
VSP_016148
Natural variant3941M → T. Ref.4
Corresponds to variant rs35687772 [ dbSNP | Ensembl ].
VAR_041991

Experimental info

Sequence conflict3451K → E in AAF36509. Ref.1

Secondary structure

.................................................. 592
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2B1AF08906EB7697

FASTA59267,514
        10         20         30         40         50         60 
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE IKFLKQFHHE 

        70         80         90        100        110        120 
NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIDYLHSNN 

       130        140        150        160        170        180 
IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDIYTDY VATRWYRAPE LVLKDTSYGK 

       190        200        210        220        230        240 
PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP 

       250        260        270        280        290        300 
QVQHPKNARK KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK 

       310        320        330        340        350        360 
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE KKPKEIKVRV 

       370        380        390        400        410        420 
IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL VTIEPPNPIN PSTNCNGLKE 

       430        440        450        460        470        480 
NPHCGGSVTM PPINLTNSNL MAANLSSNLF HPSVRLTERA KKRRTSSQSI GQVMPNSRQE 

       490        500        510        520        530        540 
DPGPIQSQME KGIFNERTGH SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME 

       550        560        570        580        590 
VKQIKMLKRE SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW 

« Hide

Isoform 2 [UniParc].

Checksum: B2046F84A9C95AC0
Show »

FASTA45551,566

References

« Hide 'large scale' references
[1]"NKIAMRE a novel kinase deleted in human leukemia."
Midmer M., Haq R., Zanke B.W.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Fetal heart.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[4]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-394.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF130372 mRNA. Translation: AAF36509.1.
CH471062 Genomic DNA. Translation: EAW62263.1.
CH471062 Genomic DNA. Translation: EAW62264.1.
CH471062 Genomic DNA. Translation: EAW62265.1.
CH471062 Genomic DNA. Translation: EAW62266.1.
BC041799 mRNA. Translation: AAH41799.1.
RefSeqNP_001107047.1. NM_001113575.1.
NP_057592.2. NM_016508.3.
UniGeneHs.719926.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZDUX-ray2.20A1-324[»]
ProteinModelPortalQ8IVW4.
SMRQ8IVW4. Positions 1-380.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119419. 8 interactions.
IntActQ8IVW4. 5 interactions.

Chemistry

BindingDBQ8IVW4.
ChEMBLCHEMBL1163117.
GuidetoPHARMACOLOGY1984.

PTM databases

PhosphoSiteQ8IVW4.

Polymorphism databases

DMDM74762479.

Proteomic databases

PaxDbQ8IVW4.
PRIDEQ8IVW4.

Protocols and materials databases

DNASU51265.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265334; ENSP00000265334; ENSG00000006837. [Q8IVW4-1]
ENST00000435211; ENSP00000395559; ENSG00000006837. [Q8IVW4-2]
ENST00000523832; ENSP00000430496; ENSG00000006837. [Q8IVW4-2]
GeneID51265.
KEGGhsa:51265.
UCSCuc003kzf.4. human. [Q8IVW4-1]
uc011cxr.1. human. [Q8IVW4-2]

Organism-specific databases

CTD51265.
GeneCardsGC05M133541.
HGNCHGNC:15483. CDKL3.
HPAHPA007446.
HPA027751.
MIM608459. gene.
neXtProtNX_Q8IVW4.
PharmGKBPA26319.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG080204.
InParanoidQ8IVW4.
KOK08824.
OMACKHKNTG.
OrthoDBEOG7992PS.
PhylomeDBQ8IVW4.
TreeFamTF101031.

Enzyme and pathway databases

SignaLinkQ8IVW4.

Gene expression databases

ArrayExpressQ8IVW4.
BgeeQ8IVW4.
GenevestigatorQ8IVW4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi51265.
NextBio54449.
PROQ8IVW4.
SOURCESearch...

Entry information

Entry nameCDKL3_HUMAN
AccessionPrimary (citable) accession number: Q8IVW4
Secondary accession number(s): D3DQA0, D3DQA1, Q9P114
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM