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Protein

Cyclin-dependent kinase-like 3

Gene

CDKL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • protein kinase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IVW4.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase NKIAMRE
Gene namesi
Name:CDKL3
Synonyms:NKIAMRE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:15483. CDKL3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51265.
OpenTargetsiENSG00000006837.
PharmGKBiPA26319.

Chemistry databases

ChEMBLiCHEMBL1163117.
GuidetoPHARMACOLOGYi1984.

Polymorphism and mutation databases

BioMutaiCDKL3.
DMDMi74762479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858201 – 592Cyclin-dependent kinase-like 3Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineBy similarity1
Modified residuei160PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IVW4.
MaxQBiQ8IVW4.
PaxDbiQ8IVW4.
PeptideAtlasiQ8IVW4.
PRIDEiQ8IVW4.

PTM databases

iPTMnetiQ8IVW4.
PhosphoSitePlusiQ8IVW4.

Expressioni

Gene expression databases

BgeeiENSG00000006837.
ExpressionAtlasiQ8IVW4. baseline and differential.
GenevisibleiQ8IVW4. HS.

Organism-specific databases

HPAiHPA027751.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119419. 21 interactors.
IntActiQ8IVW4. 30 interactors.
STRINGi9606.ENSP00000265334.

Chemistry databases

BindingDBiQ8IVW4.

Structurei

Secondary structure

1592
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 13Combined sources10
Beta strandi16 – 23Combined sources8
Turni24 – 26Combined sources3
Beta strandi29 – 34Combined sources6
Helixi45 – 56Combined sources12
Beta strandi65 – 69Combined sources5
Beta strandi72 – 74Combined sources3
Beta strandi76 – 80Combined sources5
Beta strandi83 – 85Combined sources3
Helixi86 – 92Combined sources7
Helixi99 – 118Combined sources20
Helixi128 – 130Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi139 – 141Combined sources3
Helixi161 – 164Combined sources4
Helixi169 – 172Combined sources4
Helixi181 – 196Combined sources16
Helixi206 – 216Combined sources11
Helixi222 – 230Combined sources9
Helixi232 – 234Combined sources3
Helixi248 – 251Combined sources4
Helixi257 – 266Combined sources10
Helixi271 – 273Combined sources3
Helixi277 – 281Combined sources5
Helixi284 – 287Combined sources4
Helixi291 – 308Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZDUX-ray2.20A1-324[»]
ProteinModelPortaliQ8IVW4.
SMRiQ8IVW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 50[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ8IVW4.
KOiK08824.
OMAiMTMPPIN.
OrthoDBiEOG091G0BZP.
PhylomeDBiQ8IVW4.
TreeFamiTF101031.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE
60 70 80 90 100
IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK
310 320 330 340 350
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE
360 370 380 390 400
KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL
410 420 430 440 450
VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF
460 470 480 490 500
HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH
510 520 530 540 550
SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE
560 570 580 590
SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW
Length:592
Mass (Da):67,514
Last modified:March 1, 2003 - v1
Checksum:i2B1AF08906EB7697
GO
Isoform 2 (identifier: Q8IVW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     456-592: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):51,566
Checksum:iB2046F84A9C95AC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345K → E in AAF36509 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041991394M → T1 PublicationCorresponds to variant dbSNP:rs35687772Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016148456 – 592Missing in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130372 mRNA. Translation: AAF36509.1.
CH471062 Genomic DNA. Translation: EAW62263.1.
CH471062 Genomic DNA. Translation: EAW62264.1.
CH471062 Genomic DNA. Translation: EAW62265.1.
CH471062 Genomic DNA. Translation: EAW62266.1.
BC041799 mRNA. Translation: AAH41799.1.
CCDSiCCDS47264.1. [Q8IVW4-1]
CCDS47265.1. [Q8IVW4-2]
RefSeqiNP_001107047.1. NM_001113575.1. [Q8IVW4-1]
NP_001287782.1. NM_001300853.1.
NP_057592.2. NM_016508.3. [Q8IVW4-2]
XP_016865024.1. XM_017009535.1. [Q8IVW4-1]
UniGeneiHs.719926.

Genome annotation databases

EnsembliENST00000265334; ENSP00000265334; ENSG00000006837. [Q8IVW4-1]
ENST00000523832; ENSP00000430496; ENSG00000006837. [Q8IVW4-2]
GeneIDi51265.
KEGGihsa:51265.
UCSCiuc003kzf.5. human. [Q8IVW4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCDKL3_HUMAN
AccessioniPrimary (citable) accession number: Q8IVW4
Secondary accession number(s): D3DQA0, D3DQA1, Q9P114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families