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Protein

Cyclin-dependent kinase-like 3

Gene

CDKL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • protein kinase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IVW4

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3Curated (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase NKIAMRE
Gene namesi
Name:CDKL3Imported
Synonyms:NKIAMRE1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000006837.11
HGNCiHGNC:15483 CDKL3
MIMi608459 gene
neXtProtiNX_Q8IVW4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51265
OpenTargetsiENSG00000006837
PharmGKBiPA26319

Chemistry databases

ChEMBLiCHEMBL1163117
GuidetoPHARMACOLOGYi1984

Polymorphism and mutation databases

BioMutaiCDKL3
DMDMi74762479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858201 – 592Cyclin-dependent kinase-like 3Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineBy similarity1
Modified residuei160PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IVW4
PaxDbiQ8IVW4
PeptideAtlasiQ8IVW4
PRIDEiQ8IVW4
ProteomicsDBi70783
70784 [Q8IVW4-2]

PTM databases

iPTMnetiQ8IVW4
PhosphoSitePlusiQ8IVW4

Expressioni

Gene expression databases

BgeeiENSG00000006837
ExpressionAtlasiQ8IVW4 baseline and differential
GenevisibleiQ8IVW4 HS

Organism-specific databases

HPAiHPA027751

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119419, 21 interactors
IntActiQ8IVW4, 30 interactors
STRINGi9606.ENSP00000265334

Chemistry databases

BindingDBiQ8IVW4

Structurei

Secondary structure

1592
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 13Combined sources10
Beta strandi16 – 23Combined sources8
Turni24 – 26Combined sources3
Beta strandi29 – 34Combined sources6
Helixi45 – 56Combined sources12
Beta strandi65 – 69Combined sources5
Beta strandi72 – 74Combined sources3
Beta strandi76 – 80Combined sources5
Beta strandi83 – 85Combined sources3
Helixi86 – 92Combined sources7
Helixi99 – 118Combined sources20
Helixi128 – 130Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi139 – 141Combined sources3
Helixi161 – 164Combined sources4
Helixi169 – 172Combined sources4
Helixi181 – 196Combined sources16
Helixi206 – 216Combined sources11
Helixi222 – 230Combined sources9
Helixi232 – 234Combined sources3
Helixi248 – 251Combined sources4
Helixi257 – 266Combined sources10
Helixi271 – 273Combined sources3
Helixi277 – 281Combined sources5
Helixi284 – 287Combined sources4
Helixi291 – 308Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZDUX-ray2.20A1-324[»]
ProteinModelPortaliQ8IVW4
SMRiQ8IVW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 50[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262
HOGENOMiHOG000233024
HOVERGENiHBG080204
InParanoidiQ8IVW4
KOiK08824
OMAiMTMPPIN
OrthoDBiEOG091G0BZP
PhylomeDBiQ8IVW4
TreeFamiTF101031

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE
60 70 80 90 100
IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK
310 320 330 340 350
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE
360 370 380 390 400
KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL
410 420 430 440 450
VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF
460 470 480 490 500
HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH
510 520 530 540 550
SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE
560 570 580 590
SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW
Length:592
Mass (Da):67,514
Last modified:March 1, 2003 - v1
Checksum:i2B1AF08906EB7697
GO
Isoform 2 (identifier: Q8IVW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     456-592: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):51,566
Checksum:iB2046F84A9C95AC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345K → E in AAF36509 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041991394M → T1 PublicationCorresponds to variant dbSNP:rs35687772Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016148456 – 592Missing in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130372 mRNA Translation: AAF36509.1
CH471062 Genomic DNA Translation: EAW62263.1
CH471062 Genomic DNA Translation: EAW62264.1
CH471062 Genomic DNA Translation: EAW62265.1
CH471062 Genomic DNA Translation: EAW62266.1
BC041799 mRNA Translation: AAH41799.1
CCDSiCCDS47264.1 [Q8IVW4-1]
CCDS47265.1 [Q8IVW4-2]
RefSeqiNP_001107047.1, NM_001113575.1 [Q8IVW4-1]
NP_001287782.1, NM_001300853.1
NP_057592.2, NM_016508.3 [Q8IVW4-2]
XP_016865024.1, XM_017009535.1 [Q8IVW4-1]
UniGeneiHs.719926

Genome annotation databases

EnsembliENST00000265334; ENSP00000265334; ENSG00000006837 [Q8IVW4-1]
ENST00000523832; ENSP00000430496; ENSG00000006837 [Q8IVW4-2]
GeneIDi51265
KEGGihsa:51265
UCSCiuc003kzf.5 human [Q8IVW4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDKL3_HUMAN
AccessioniPrimary (citable) accession number: Q8IVW4
Secondary accession number(s): D3DQA0, D3DQA1, Q9P114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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