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Q8IVW4

- CDKL3_HUMAN

UniProt

Q8IVW4 - CDKL3_HUMAN

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Protein

Cyclin-dependent kinase-like 3

Gene

CDKL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein kinase activity Source: ProtInc

GO - Biological processi

  1. cellular protein modification process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IVW4.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase NKIAMRE
Gene namesi
Name:CDKL3
Synonyms:NKIAMRE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:15483. CDKL3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Cyclin-dependent kinase-like 3PRO_0000085820Add
BLAST

Proteomic databases

MaxQBiQ8IVW4.
PaxDbiQ8IVW4.
PRIDEiQ8IVW4.

PTM databases

PhosphoSiteiQ8IVW4.

Expressioni

Gene expression databases

BgeeiQ8IVW4.
ExpressionAtlasiQ8IVW4. differential.
GenevestigatoriQ8IVW4.

Organism-specific databases

HPAiHPA007446.
HPA027751.

Interactioni

Protein-protein interaction databases

BioGridi119419. 9 interactions.
IntActiQ8IVW4. 5 interactions.

Structurei

Secondary structure

1
592
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 1310Combined sources
Beta strandi16 – 238Combined sources
Turni24 – 263Combined sources
Beta strandi29 – 346Combined sources
Helixi45 – 5612Combined sources
Beta strandi65 – 695Combined sources
Beta strandi72 – 743Combined sources
Beta strandi76 – 805Combined sources
Beta strandi83 – 853Combined sources
Helixi86 – 927Combined sources
Helixi99 – 11820Combined sources
Helixi128 – 1303Combined sources
Beta strandi131 – 1333Combined sources
Beta strandi139 – 1413Combined sources
Helixi161 – 1644Combined sources
Helixi169 – 1724Combined sources
Helixi181 – 19616Combined sources
Helixi206 – 21611Combined sources
Helixi222 – 2309Combined sources
Helixi232 – 2343Combined sources
Helixi248 – 2514Combined sources
Helixi257 – 26610Combined sources
Helixi271 – 2733Combined sources
Helixi277 – 2815Combined sources
Helixi284 – 2874Combined sources
Helixi291 – 30818Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZDUX-ray2.20A1-324[»]
ProteinModelPortaliQ8IVW4.
SMRiQ8IVW4. Positions 1-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 507[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ8IVW4.
KOiK08824.
OMAiCKHKNTG.
OrthoDBiEOG7992PS.
PhylomeDBiQ8IVW4.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVW4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE
60 70 80 90 100
IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK
310 320 330 340 350
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE
360 370 380 390 400
KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL
410 420 430 440 450
VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF
460 470 480 490 500
HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH
510 520 530 540 550
SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE
560 570 580 590
SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW
Length:592
Mass (Da):67,514
Last modified:March 1, 2003 - v1
Checksum:i2B1AF08906EB7697
GO
Isoform 2 (identifier: Q8IVW4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     456-592: Missing.

Note: No experimental confirmation available.

Show »
Length:455
Mass (Da):51,566
Checksum:iB2046F84A9C95AC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti345 – 3451K → E in AAF36509. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti394 – 3941M → T.1 Publication
Corresponds to variant rs35687772 [ dbSNP | Ensembl ].
VAR_041991

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei456 – 592137Missing in isoform 2. 1 PublicationVSP_016148Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130372 mRNA. Translation: AAF36509.1.
CH471062 Genomic DNA. Translation: EAW62263.1.
CH471062 Genomic DNA. Translation: EAW62264.1.
CH471062 Genomic DNA. Translation: EAW62265.1.
CH471062 Genomic DNA. Translation: EAW62266.1.
BC041799 mRNA. Translation: AAH41799.1.
CCDSiCCDS47264.1. [Q8IVW4-1]
CCDS47265.1. [Q8IVW4-2]
RefSeqiNP_001107047.1. NM_001113575.1. [Q8IVW4-1]
NP_001287782.1. NM_001300853.1.
NP_057592.2. NM_016508.3. [Q8IVW4-2]
UniGeneiHs.719926.

Genome annotation databases

EnsembliENST00000265334; ENSP00000265334; ENSG00000006837. [Q8IVW4-1]
ENST00000523832; ENSP00000430496; ENSG00000006837. [Q8IVW4-2]
GeneIDi51265.
KEGGihsa:51265.
UCSCiuc003kzf.4. human. [Q8IVW4-1]
uc011cxr.1. human. [Q8IVW4-2]

Polymorphism databases

DMDMi74762479.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130372 mRNA. Translation: AAF36509.1 .
CH471062 Genomic DNA. Translation: EAW62263.1 .
CH471062 Genomic DNA. Translation: EAW62264.1 .
CH471062 Genomic DNA. Translation: EAW62265.1 .
CH471062 Genomic DNA. Translation: EAW62266.1 .
BC041799 mRNA. Translation: AAH41799.1 .
CCDSi CCDS47264.1. [Q8IVW4-1 ]
CCDS47265.1. [Q8IVW4-2 ]
RefSeqi NP_001107047.1. NM_001113575.1. [Q8IVW4-1 ]
NP_001287782.1. NM_001300853.1.
NP_057592.2. NM_016508.3. [Q8IVW4-2 ]
UniGenei Hs.719926.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZDU X-ray 2.20 A 1-324 [» ]
ProteinModelPortali Q8IVW4.
SMRi Q8IVW4. Positions 1-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119419. 9 interactions.
IntActi Q8IVW4. 5 interactions.

Chemistry

BindingDBi Q8IVW4.
ChEMBLi CHEMBL1163117.
GuidetoPHARMACOLOGYi 1984.

PTM databases

PhosphoSitei Q8IVW4.

Polymorphism databases

DMDMi 74762479.

Proteomic databases

MaxQBi Q8IVW4.
PaxDbi Q8IVW4.
PRIDEi Q8IVW4.

Protocols and materials databases

DNASUi 51265.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265334 ; ENSP00000265334 ; ENSG00000006837 . [Q8IVW4-1 ]
ENST00000523832 ; ENSP00000430496 ; ENSG00000006837 . [Q8IVW4-2 ]
GeneIDi 51265.
KEGGi hsa:51265.
UCSCi uc003kzf.4. human. [Q8IVW4-1 ]
uc011cxr.1. human. [Q8IVW4-2 ]

Organism-specific databases

CTDi 51265.
GeneCardsi GC05M133541.
HGNCi HGNC:15483. CDKL3.
HPAi HPA007446.
HPA027751.
MIMi 608459. gene.
neXtProti NX_Q8IVW4.
PharmGKBi PA26319.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119242.
HOGENOMi HOG000233024.
HOVERGENi HBG080204.
InParanoidi Q8IVW4.
KOi K08824.
OMAi CKHKNTG.
OrthoDBi EOG7992PS.
PhylomeDBi Q8IVW4.
TreeFami TF101031.

Enzyme and pathway databases

SignaLinki Q8IVW4.

Miscellaneous databases

GenomeRNAii 51265.
NextBioi 54449.
PROi Q8IVW4.
SOURCEi Search...

Gene expression databases

Bgeei Q8IVW4.
ExpressionAtlasi Q8IVW4. differential.
Genevestigatori Q8IVW4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NKIAMRE a novel kinase deleted in human leukemia."
    Midmer M., Haq R., Zanke B.W.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fetal heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-394.

Entry informationi

Entry nameiCDKL3_HUMAN
AccessioniPrimary (citable) accession number: Q8IVW4
Secondary accession number(s): D3DQA0, D3DQA1, Q9P114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3