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Protein

ADP-ribosylation factor-like protein 17

Gene

ARL17A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31508-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 17
Alternative name(s):
ADP-ribosylation factor 7 variant
Gene namesi
Name:ARL17A
Synonyms:ARL17P1
AND
Name:ARL17B
Synonyms:ARF1P2, ARL17A
ORF Names:PRO2667
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24096. ARL17A.
HGNC:32387. ARL17B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185829.
ENSG00000228696.
ENSG00000275748.
ENSG00000276276.
PharmGKBiPA165431478.

Polymorphism and mutation databases

BioMutaiARL17A.
DMDMi93141230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074822 – 177ADP-ribosylation factor-like protein 17Add BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ8IVW1.
PaxDbiQ8IVW1.
PeptideAtlasiQ8IVW1.
PRIDEiQ8IVW1.

PTM databases

iPTMnetiQ8IVW1.
PhosphoSitePlusiQ8IVW1.

Expressioni

Gene expression databases

BgeeiENSG00000185829.
CleanExiHS_ARL17.
ExpressionAtlasiQ8IVW1. baseline and differential.
GenevisibleiQ8IVW1. HS.

Organism-specific databases

HPAiHPA046814.

Interactioni

Protein-protein interaction databases

BioGridi119475. 2 interactors.
STRINGi9606.ENSP00000337478.

Structurei

3D structure databases

ProteinModelPortaliQ8IVW1.
SMRiQ8IVW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000134110.
HOVERGENiHBG002073.
InParanoidiQ8IVW1.
OrthoDBiEOG091G0R1S.
PhylomeDBiQ8IVW1.
TreeFamiTF300808.
TF341532.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031687. ARL17_C.
IPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
PF15840. ARL17. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG
60 70 80 90 100
FCVETVEYKN NTFAVWDVGS HFKIRPLWQH FFQNTKGARS PGSTHQGSLA
110 120 130 140 150
SGVLPIKCSH VEFGMWKGGR SHPFLPHSSR CAGSGGQLDS ILPHQSPAWG
160 170
PWGCKDLSSG FPSFLTSSIL WKSAVVK
Length:177
Mass (Da):19,388
Last modified:April 18, 2006 - v2
Checksum:iD9AE68B0C19ABBAE
GO
Isoform 2 (identifier: Q8IVW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-177: GARSPGSTHQ...SILWKSAVVK → ELSASQFAQF...TSYPSHLLDR

Show »
Length:125
Mass (Da):14,028
Checksum:iFFAC838B026D4045
GO
Isoform 4 (identifier: Q8IVW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-177: VK → SYQLPSLHNSSRNYAGSPAQMMRHLLEA

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,302
Checksum:i322F3ABF9AB0B5D8
GO

Sequence cautioni

The sequence AAF64278 differs from that shown. Reason: Frameshift at position 114.Curated
The sequence AAF69643 differs from that shown. Reason: Frameshift at position 17.Curated
The sequence AAH30570 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92581 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75R → G in AAF64278 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017170170L → I.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00875387 – 177GARSP…SAVVK → ELSASQFAQFIKKLCGVTGT NDEASPGSLTSYPSHLLDR in isoform 2. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_008756176 – 177VK → SYQLPSLHNSSRNYAGSPAQ MMRHLLEA in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119889 mRNA. Translation: AAF69643.1. Frameshift.
AF208864 mRNA. Translation: AAF64278.1. Frameshift.
AF493886 mRNA. Translation: AAM12600.1.
AK315857 mRNA. Translation: BAF98748.1.
AB209344 mRNA. Translation: BAD92581.1. Different initiation.
BC030570 mRNA. Translation: AAH30570.1. Different initiation.
BC041803 mRNA. Translation: AAH41803.1.
CCDSiCCDS54137.1. [Q8IVW1-2]
CCDS58557.1. [Q8IVW1-1]
RefSeqiNP_001034172.3. NM_001039083.3. [Q8IVW1-1]
NP_001096624.1. NM_001103154.1. [Q8IVW1-2]
NP_001107210.1. NM_001113738.1. [Q8IVW1-1]
NP_001275741.1. NM_001288812.1. [Q8IVW1-2]
NP_057716.2. NM_016632.2. [Q8IVW1-2]
XP_005256975.1. XM_005256918.4. [Q8IVW1-2]
XP_005257496.1. XM_005257439.4. [Q8IVW1-2]
XP_006725347.1. XM_006725284.3. [Q8IVW1-2]
XP_011523177.1. XM_011524875.2. [Q8IVW1-4]
UniGeneiHs.559259.
Hs.655261.
Hs.720599.
Hs.720602.
Hs.733127.

Genome annotation databases

EnsembliENST00000336125; ENSP00000337478; ENSG00000185829. [Q8IVW1-1]
ENST00000434041; ENSP00000391751; ENSG00000228696. [Q8IVW1-2]
ENST00000445552; ENSP00000416535; ENSG00000185829. [Q8IVW1-2]
ENST00000450673; ENSP00000404247; ENSG00000228696. [Q8IVW1-1]
ENST00000570618; ENSP00000459151; ENSG00000228696. [Q8IVW1-2]
ENST00000613440; ENSP00000482789; ENSG00000275748. [Q8IVW1-2]
ENST00000615623; ENSP00000482856; ENSG00000276276. [Q8IVW1-2]
ENST00000617818; ENSP00000479224; ENSG00000276276. [Q8IVW1-2]
ENST00000618729; ENSP00000483271; ENSG00000276276. [Q8IVW1-1]
ENST00000622165; ENSP00000481838; ENSG00000275748. [Q8IVW1-1]
ENST00000626328; ENSP00000487334; ENSG00000275748. [Q8IVW1-2]
ENST00000634170; ENSP00000487605; ENSG00000276276. [Q8IVW1-2]
GeneIDi100506084.
100996709.
51326.
KEGGihsa:100506084.
hsa:100996709.
hsa:51326.
UCSCiuc002ikk.4. human. [Q8IVW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119889 mRNA. Translation: AAF69643.1. Frameshift.
AF208864 mRNA. Translation: AAF64278.1. Frameshift.
AF493886 mRNA. Translation: AAM12600.1.
AK315857 mRNA. Translation: BAF98748.1.
AB209344 mRNA. Translation: BAD92581.1. Different initiation.
BC030570 mRNA. Translation: AAH30570.1. Different initiation.
BC041803 mRNA. Translation: AAH41803.1.
CCDSiCCDS54137.1. [Q8IVW1-2]
CCDS58557.1. [Q8IVW1-1]
RefSeqiNP_001034172.3. NM_001039083.3. [Q8IVW1-1]
NP_001096624.1. NM_001103154.1. [Q8IVW1-2]
NP_001107210.1. NM_001113738.1. [Q8IVW1-1]
NP_001275741.1. NM_001288812.1. [Q8IVW1-2]
NP_057716.2. NM_016632.2. [Q8IVW1-2]
XP_005256975.1. XM_005256918.4. [Q8IVW1-2]
XP_005257496.1. XM_005257439.4. [Q8IVW1-2]
XP_006725347.1. XM_006725284.3. [Q8IVW1-2]
XP_011523177.1. XM_011524875.2. [Q8IVW1-4]
UniGeneiHs.559259.
Hs.655261.
Hs.720599.
Hs.720602.
Hs.733127.

3D structure databases

ProteinModelPortaliQ8IVW1.
SMRiQ8IVW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119475. 2 interactors.
STRINGi9606.ENSP00000337478.

PTM databases

iPTMnetiQ8IVW1.
PhosphoSitePlusiQ8IVW1.

Polymorphism and mutation databases

BioMutaiARL17A.
DMDMi93141230.

Proteomic databases

MaxQBiQ8IVW1.
PaxDbiQ8IVW1.
PeptideAtlasiQ8IVW1.
PRIDEiQ8IVW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336125; ENSP00000337478; ENSG00000185829. [Q8IVW1-1]
ENST00000434041; ENSP00000391751; ENSG00000228696. [Q8IVW1-2]
ENST00000445552; ENSP00000416535; ENSG00000185829. [Q8IVW1-2]
ENST00000450673; ENSP00000404247; ENSG00000228696. [Q8IVW1-1]
ENST00000570618; ENSP00000459151; ENSG00000228696. [Q8IVW1-2]
ENST00000613440; ENSP00000482789; ENSG00000275748. [Q8IVW1-2]
ENST00000615623; ENSP00000482856; ENSG00000276276. [Q8IVW1-2]
ENST00000617818; ENSP00000479224; ENSG00000276276. [Q8IVW1-2]
ENST00000618729; ENSP00000483271; ENSG00000276276. [Q8IVW1-1]
ENST00000622165; ENSP00000481838; ENSG00000275748. [Q8IVW1-1]
ENST00000626328; ENSP00000487334; ENSG00000275748. [Q8IVW1-2]
ENST00000634170; ENSP00000487605; ENSG00000276276. [Q8IVW1-2]
GeneIDi100506084.
100996709.
51326.
KEGGihsa:100506084.
hsa:100996709.
hsa:51326.
UCSCiuc002ikk.4. human. [Q8IVW1-1]

Organism-specific databases

CTDi100506084.
51326.
GeneCardsiARL17A.
ARL17B.
H-InvDBHIX0174152.
HGNCiHGNC:24096. ARL17A.
HGNC:32387. ARL17B.
HPAiHPA046814.
neXtProtiNX_Q8IVW1.
OpenTargetsiENSG00000185829.
ENSG00000228696.
ENSG00000275748.
ENSG00000276276.
PharmGKBiPA165431478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000134110.
HOVERGENiHBG002073.
InParanoidiQ8IVW1.
OrthoDBiEOG091G0R1S.
PhylomeDBiQ8IVW1.
TreeFamiTF300808.
TF341532.

Enzyme and pathway databases

BioCyciZFISH:G66-31508-MONOMER.

Miscellaneous databases

ChiTaRSiARL17A. human.

Gene expression databases

BgeeiENSG00000185829.
CleanExiHS_ARL17.
ExpressionAtlasiQ8IVW1. baseline and differential.
GenevisibleiQ8IVW1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031687. ARL17_C.
IPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
PF15840. ARL17. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL17_HUMAN
AccessioniPrimary (citable) accession number: Q8IVW1
Secondary accession number(s): B0AZR6
, Q59FW5, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: April 18, 2006
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.