ID   NKAI4_HUMAN             Reviewed;         208 AA.
AC   Q8IVV8; Q4VXQ6; Q9BQU8; Q9BQU9;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   27-MAR-2024, entry version 141.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4;
DE            Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4;
DE   AltName: Full=Protein FAM77A;
GN   Name=NKAIN4; Synonyms=C20orf58, FAM77A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-173.
RC   TISSUE=Brain, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with ATP1B1. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8IVV8; P21145: MAL; NbExp=3; IntAct=EBI-17791123, EBI-3932027;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}.
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DR   EMBL; AL121827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC041812; AAH41812.1; -; mRNA.
DR   CCDS; CCDS13514.1; -.
DR   RefSeq; NP_690603.3; NM_152864.3.
DR   AlphaFoldDB; Q8IVV8; -.
DR   SMR; Q8IVV8; -.
DR   BioGRID; 126120; 4.
DR   IntAct; Q8IVV8; 1.
DR   STRING; 9606.ENSP00000359340; -.
DR   TCDB; 8.A.118.1.5; the na+k+-atpase beta-subunit interacting nkain (nkain) family.
DR   PhosphoSitePlus; Q8IVV8; -.
DR   BioMuta; NKAIN4; -.
DR   DMDM; 46576604; -.
DR   PaxDb; 9606-ENSP00000359340; -.
DR   PeptideAtlas; Q8IVV8; -.
DR   Antibodypedia; 29667; 141 antibodies from 19 providers.
DR   DNASU; 128414; -.
DR   Ensembl; ENST00000370316.8; ENSP00000359340.3; ENSG00000101198.15.
DR   GeneID; 128414; -.
DR   KEGG; hsa:128414; -.
DR   MANE-Select; ENST00000370316.8; ENSP00000359340.3; NM_152864.4; NP_690603.3.
DR   UCSC; uc002yek.3; human.
DR   AGR; HGNC:16191; -.
DR   CTD; 128414; -.
DR   DisGeNET; 128414; -.
DR   GeneCards; NKAIN4; -.
DR   HGNC; HGNC:16191; NKAIN4.
DR   HPA; ENSG00000101198; Group enriched (brain, kidney).
DR   MIM; 612873; gene.
DR   neXtProt; NX_Q8IVV8; -.
DR   OpenTargets; ENSG00000101198; -.
DR   PharmGKB; PA162397583; -.
DR   VEuPathDB; HostDB:ENSG00000101198; -.
DR   eggNOG; KOG4556; Eukaryota.
DR   GeneTree; ENSGT00940000157989; -.
DR   HOGENOM; CLU_090781_0_0_1; -.
DR   InParanoid; Q8IVV8; -.
DR   OMA; IGCTVEY; -.
DR   OrthoDB; 2898160at2759; -.
DR   PhylomeDB; Q8IVV8; -.
DR   TreeFam; TF321348; -.
DR   PathwayCommons; Q8IVV8; -.
DR   SignaLink; Q8IVV8; -.
DR   BioGRID-ORCS; 128414; 10 hits in 1141 CRISPR screens.
DR   ChiTaRS; NKAIN4; human.
DR   GenomeRNAi; 128414; -.
DR   Pharos; Q8IVV8; Tdark.
DR   PRO; PR:Q8IVV8; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q8IVV8; Protein.
DR   Bgee; ENSG00000101198; Expressed in nucleus accumbens and 142 other cell types or tissues.
DR   ExpressionAtlas; Q8IVV8; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central.
DR   InterPro; IPR008516; Na/K-Atpase_Interacting.
DR   PANTHER; PTHR13084:SF5; SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 4; 1.
DR   PANTHER; PTHR13084; T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED; 1.
DR   Pfam; PF05640; NKAIN; 1.
DR   Genevisible; Q8IVV8; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..208
FT                   /note="Sodium/potassium-transporting ATPase subunit beta-1-
FT                   interacting protein 4"
FT                   /id="PRO_0000079437"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         91
FT                   /note="K -> Q (in dbSNP:rs1129659)"
FT                   /id="VAR_037051"
FT   VARIANT         131
FT                   /note="A -> D (in dbSNP:rs2236194)"
FT                   /id="VAR_037052"
FT   VARIANT         151
FT                   /note="C -> G (in dbSNP:rs872808)"
FT                   /id="VAR_037053"
FT   VARIANT         173
FT                   /note="E -> D (in dbSNP:rs11556207)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037054"
SQ   SEQUENCE   208 AA;  23240 MW;  FE55FE54F1863CC3 CRC64;
     MGSCSGRCAL VVLCAFQLVA ALERQVFDFL GYQWAPILAN FVHIIIVILG LFGTIQYRLR
     YVMVYTLWAA VWVTWNVFII CFYLEVGGLL KDSELLTFSL SRHRSWWRER WPGCLHEEVP
     AVGLGAPHGQ ALVSGAGCAL EPSYVEALHS CLQILIALLG FVCGCQVVSV FTEEEDSFDF
     IGGFDPFPLY HVNEKPSSLL SKQVYLPA
//