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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4

Gene

NKAIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4
Alternative name(s):
Protein FAM77A
Gene namesi
Name:NKAIN4
Synonyms:C20orf58, FAM77A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16191. NKAIN4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4PRO_0000079437Add
BLAST

Proteomic databases

PRIDEiQ8IVV8.

Expressioni

Gene expression databases

BgeeiQ8IVV8.
CleanExiHS_NKAIN4.
ExpressionAtlasiQ8IVV8. baseline and differential.
GenevestigatoriQ8IVV8.

Organism-specific databases

HPAiHPA029876.

Interactioni

Subunit structurei

Interacts with ATP1B1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000359340.

Structurei

3D structure databases

ProteinModelPortaliQ8IVV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295349.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ8IVV8.
OMAiTVWAAVW.
PhylomeDBiQ8IVV8.
TreeFamiTF321348.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCSGRCAL VVLCAFQLVA ALERQVFDFL GYQWAPILAN FVHIIIVILG
60 70 80 90 100
LFGTIQYRLR YVMVYTLWAA VWVTWNVFII CFYLEVGGLL KDSELLTFSL
110 120 130 140 150
SRHRSWWRER WPGCLHEEVP AVGLGAPHGQ ALVSGAGCAL EPSYVEALHS
160 170 180 190 200
CLQILIALLG FVCGCQVVSV FTEEEDSFDF IGGFDPFPLY HVNEKPSSLL

SKQVYLPA
Length:208
Mass (Da):23,240
Last modified:April 25, 2004 - v2
Checksum:iFE55FE54F1863CC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911K → Q.
Corresponds to variant rs1129659 [ dbSNP | Ensembl ].
VAR_037051
Natural varianti131 – 1311A → D.
Corresponds to variant rs2236194 [ dbSNP | Ensembl ].
VAR_037052
Natural varianti151 – 1511C → G.
Corresponds to variant rs872808 [ dbSNP | Ensembl ].
VAR_037053
Natural varianti173 – 1731E → D.1 Publication
Corresponds to variant rs11556207 [ dbSNP | Ensembl ].
VAR_037054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121827 Genomic DNA. No translation available.
BC041812 mRNA. Translation: AAH41812.1.
CCDSiCCDS13514.1.
RefSeqiNP_690603.3. NM_152864.3.
UniGeneiHs.46627.

Genome annotation databases

EnsembliENST00000370316; ENSP00000359340; ENSG00000101198.
GeneIDi128414.
KEGGihsa:128414.
UCSCiuc002yek.3. human.

Polymorphism databases

DMDMi46576604.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121827 Genomic DNA. No translation available.
BC041812 mRNA. Translation: AAH41812.1.
CCDSiCCDS13514.1.
RefSeqiNP_690603.3. NM_152864.3.
UniGeneiHs.46627.

3D structure databases

ProteinModelPortaliQ8IVV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000359340.

Polymorphism databases

DMDMi46576604.

Proteomic databases

PRIDEiQ8IVV8.

Protocols and materials databases

DNASUi128414.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370316; ENSP00000359340; ENSG00000101198.
GeneIDi128414.
KEGGihsa:128414.
UCSCiuc002yek.3. human.

Organism-specific databases

CTDi128414.
GeneCardsiGC20M061869.
HGNCiHGNC:16191. NKAIN4.
HPAiHPA029876.
MIMi612873. gene.
neXtProtiNX_Q8IVV8.
PharmGKBiPA162397583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295349.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ8IVV8.
OMAiTVWAAVW.
PhylomeDBiQ8IVV8.
TreeFamiTF321348.

Miscellaneous databases

ChiTaRSiNKAIN4. human.
GenomeRNAii128414.
NextBioi82345.
PROiQ8IVV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IVV8.
CleanExiHS_NKAIN4.
ExpressionAtlasiQ8IVV8. baseline and differential.
GenevestigatoriQ8IVV8.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-173.
    Tissue: Brain and Muscle.

Entry informationi

Entry nameiNKAI4_HUMAN
AccessioniPrimary (citable) accession number: Q8IVV8
Secondary accession number(s): Q4VXQ6, Q9BQU8, Q9BQU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 25, 2004
Last sequence update: April 25, 2004
Last modified: January 6, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.