Q8IVV8 (NKAI4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
Short name=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4

Alternative name(s):
Protein FAM77A

Gene names

Name:	NKAIN4
Synonyms:	C20orf58, FAM77A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts with ATP1B1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the NKAIN family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4		PRO_0000079437
Regions
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	151 – 171	21	Helical; Potential
Natural variations
	Natural variant	91	1	K → Q. Corresponds to variant rs1129659 [ dbSNP | Ensembl ].		VAR_037051
	Natural variant	131	1	A → D. Corresponds to variant rs2236194 [ dbSNP | Ensembl ].		VAR_037052
	Natural variant	151	1	C → G. Corresponds to variant rs872808 [ dbSNP | Ensembl ].		VAR_037053
	Natural variant	173	1	E → D. Ref.2 Corresponds to variant rs11556207 [ dbSNP | Ensembl ].		VAR_037054

Sequences

	Sequence		Length	Mass (Da)
	Q8IVV8 [UniParc]. Last modified April 26, 2004. Version 2. Checksum: FE55FE54F1863CC3	FASTA	208	23,240
	10 20 30 40 50 60 MGSCSGRCAL VVLCAFQLVA ALERQVFDFL GYQWAPILAN FVHIIIVILG LFGTIQYRLR 70 80 90 100 110 120 YVMVYTLWAA VWVTWNVFII CFYLEVGGLL KDSELLTFSL SRHRSWWRER WPGCLHEEVP 130 140 150 160 170 180 AVGLGAPHGQ ALVSGAGCAL EPSYVEALHS CLQILIALLG FVCGCQVVSV FTEEEDSFDF 190 200 IGGFDPFPLY HVNEKPSSLL SKQVYLPA

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-173. Tissue: Brain and Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL121827 Genomic DNA. No translation available. BC041812 mRNA. Translation: AAH41812.1.
IPI	IPI00383441.
RefSeq	NP_690603.3. NM_152864.3.
UniGene	Hs.46627.
3D structure databases
ProteinModelPortal	Q8IVV8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359340.
Polymorphism databases
DMDM	46576604.
Proteomic databases
PRIDE	Q8IVV8.
Protocols and materials databases
DNASU	128414.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370316; ENSP00000359340; ENSG00000101198.
GeneID	128414.
KEGG	hsa:128414.
UCSC	uc002yek.3. human.
Organism-specific databases
CTD	128414.
GeneCards	GC20M061869.
HGNC	HGNC:16191. NKAIN4.
HPA	HPA029876.
MIM	612873. gene.
neXtProt	NX_Q8IVV8.
PharmGKB	PA162397583.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295349.
HOGENOM	HOG000293382.
HOVERGEN	HBG108190.
OMA	TVWAAVW.
OrthoDB	EOG40GCRW.
PhylomeDB	Q8IVV8.
Gene expression databases
ArrayExpress	Q8IVV8.
Bgee	Q8IVV8.
CleanEx	HS_NKAIN4.
Genevestigator	Q8IVV8.
GermOnline	ENSG00000101198. Homo sapiens.
Family and domain databases
InterPro	IPR008516. Na/K-Atpase_Interacting. [Graphical view]
PANTHER	PTHR13084. PTHR13084. 1 hit.
Pfam	PF05640. NKAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	128414.
NextBio	82345.
SOURCE	Search...

Entry information

Entry name

NKAI4_HUMAN

Accession

Primary (citable) accession number: Q8IVV8
Secondary accession number(s): Q4VXQ6, Q9BQU8, Q9BQU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.