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Q8IVV8

- NKAI4_HUMAN

UniProt

Q8IVV8 - NKAI4_HUMAN

Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4

Gene

NKAIN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (26 Apr 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
    Short name:
    Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4
    Alternative name(s):
    Protein FAM77A
    Gene namesi
    Name:NKAIN4
    Synonyms:C20orf58, FAM77A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16191. NKAIN4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162397583.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4PRO_0000079437Add
    BLAST

    Proteomic databases

    PRIDEiQ8IVV8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IVV8.
    BgeeiQ8IVV8.
    CleanExiHS_NKAIN4.
    GenevestigatoriQ8IVV8.

    Organism-specific databases

    HPAiHPA029876.

    Interactioni

    Subunit structurei

    Interacts with ATP1B1.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359340.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IVV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NKAIN family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295349.
    HOGENOMiHOG000293382.
    HOVERGENiHBG108190.
    OMAiEVMHSSF.
    PhylomeDBiQ8IVV8.
    TreeFamiTF321348.

    Family and domain databases

    InterProiIPR008516. Na/K-Atpase_Interacting.
    [Graphical view]
    PANTHERiPTHR13084. PTHR13084. 1 hit.
    PfamiPF05640. NKAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IVV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSCSGRCAL VVLCAFQLVA ALERQVFDFL GYQWAPILAN FVHIIIVILG    50
    LFGTIQYRLR YVMVYTLWAA VWVTWNVFII CFYLEVGGLL KDSELLTFSL 100
    SRHRSWWRER WPGCLHEEVP AVGLGAPHGQ ALVSGAGCAL EPSYVEALHS 150
    CLQILIALLG FVCGCQVVSV FTEEEDSFDF IGGFDPFPLY HVNEKPSSLL 200
    SKQVYLPA 208
    Length:208
    Mass (Da):23,240
    Last modified:April 26, 2004 - v2
    Checksum:iFE55FE54F1863CC3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911K → Q.
    Corresponds to variant rs1129659 [ dbSNP | Ensembl ].
    VAR_037051
    Natural varianti131 – 1311A → D.
    Corresponds to variant rs2236194 [ dbSNP | Ensembl ].
    VAR_037052
    Natural varianti151 – 1511C → G.
    Corresponds to variant rs872808 [ dbSNP | Ensembl ].
    VAR_037053
    Natural varianti173 – 1731E → D.1 Publication
    Corresponds to variant rs11556207 [ dbSNP | Ensembl ].
    VAR_037054

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121827 Genomic DNA. No translation available.
    BC041812 mRNA. Translation: AAH41812.1.
    CCDSiCCDS13514.1.
    RefSeqiNP_690603.3. NM_152864.3.
    UniGeneiHs.46627.

    Genome annotation databases

    EnsembliENST00000370316; ENSP00000359340; ENSG00000101198.
    GeneIDi128414.
    KEGGihsa:128414.
    UCSCiuc002yek.3. human.

    Polymorphism databases

    DMDMi46576604.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121827 Genomic DNA. No translation available.
    BC041812 mRNA. Translation: AAH41812.1 .
    CCDSi CCDS13514.1.
    RefSeqi NP_690603.3. NM_152864.3.
    UniGenei Hs.46627.

    3D structure databases

    ProteinModelPortali Q8IVV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359340.

    Polymorphism databases

    DMDMi 46576604.

    Proteomic databases

    PRIDEi Q8IVV8.

    Protocols and materials databases

    DNASUi 128414.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370316 ; ENSP00000359340 ; ENSG00000101198 .
    GeneIDi 128414.
    KEGGi hsa:128414.
    UCSCi uc002yek.3. human.

    Organism-specific databases

    CTDi 128414.
    GeneCardsi GC20M061869.
    HGNCi HGNC:16191. NKAIN4.
    HPAi HPA029876.
    MIMi 612873. gene.
    neXtProti NX_Q8IVV8.
    PharmGKBi PA162397583.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295349.
    HOGENOMi HOG000293382.
    HOVERGENi HBG108190.
    OMAi EVMHSSF.
    PhylomeDBi Q8IVV8.
    TreeFami TF321348.

    Miscellaneous databases

    GenomeRNAii 128414.
    NextBioi 82345.
    PROi Q8IVV8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVV8.
    Bgeei Q8IVV8.
    CleanExi HS_NKAIN4.
    Genevestigatori Q8IVV8.

    Family and domain databases

    InterProi IPR008516. Na/K-Atpase_Interacting.
    [Graphical view ]
    PANTHERi PTHR13084. PTHR13084. 1 hit.
    Pfami PF05640. NKAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-173.
      Tissue: Brain and Muscle.

    Entry informationi

    Entry nameiNKAI4_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVV8
    Secondary accession number(s): Q4VXQ6, Q9BQU8, Q9BQU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3