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Q8IVV8 (NKAI4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4

Short name=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4
Alternative name(s):
Protein FAM77A
Gene names
Name:NKAIN4
Synonyms:C20orf58, FAM77A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with ATP1B1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the NKAIN family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
PRO_0000079437

Regions

Transmembrane35 – 5521Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane151 – 17121Helical; Potential

Natural variations

Natural variant911K → Q.
Corresponds to variant rs1129659 [ dbSNP | Ensembl ].
VAR_037051
Natural variant1311A → D.
Corresponds to variant rs2236194 [ dbSNP | Ensembl ].
VAR_037052
Natural variant1511C → G.
Corresponds to variant rs872808 [ dbSNP | Ensembl ].
VAR_037053
Natural variant1731E → D. Ref.2
Corresponds to variant rs11556207 [ dbSNP | Ensembl ].
VAR_037054

Sequences

Sequence LengthMass (Da)Tools
Q8IVV8 [UniParc].

Last modified April 26, 2004. Version 2.
Checksum: FE55FE54F1863CC3

FASTA20823,240
        10         20         30         40         50         60 
MGSCSGRCAL VVLCAFQLVA ALERQVFDFL GYQWAPILAN FVHIIIVILG LFGTIQYRLR 

        70         80         90        100        110        120 
YVMVYTLWAA VWVTWNVFII CFYLEVGGLL KDSELLTFSL SRHRSWWRER WPGCLHEEVP 

       130        140        150        160        170        180 
AVGLGAPHGQ ALVSGAGCAL EPSYVEALHS CLQILIALLG FVCGCQVVSV FTEEEDSFDF 

       190        200 
IGGFDPFPLY HVNEKPSSLL SKQVYLPA 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-173.
Tissue: Brain and Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL121827 Genomic DNA. No translation available.
BC041812 mRNA. Translation: AAH41812.1.
RefSeqNP_690603.3. NM_152864.3.
UniGeneHs.46627.

3D structure databases

ProteinModelPortalQ8IVV8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000359340.

Polymorphism databases

DMDM46576604.

Proteomic databases

PRIDEQ8IVV8.

Protocols and materials databases

DNASU128414.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370316; ENSP00000359340; ENSG00000101198.
GeneID128414.
KEGGhsa:128414.
UCSCuc002yek.3. human.

Organism-specific databases

CTD128414.
GeneCardsGC20M061869.
HGNCHGNC:16191. NKAIN4.
HPAHPA029876.
MIM612873. gene.
neXtProtNX_Q8IVV8.
PharmGKBPA162397583.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295349.
HOGENOMHOG000293382.
HOVERGENHBG108190.
OMAWAAVWVT.
PhylomeDBQ8IVV8.
TreeFamTF321348.

Gene expression databases

ArrayExpressQ8IVV8.
BgeeQ8IVV8.
CleanExHS_NKAIN4.
GenevestigatorQ8IVV8.

Family and domain databases

InterProIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERPTHR13084. PTHR13084. 1 hit.
PfamPF05640. NKAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi128414.
NextBio82345.
PROQ8IVV8.
SOURCESearch...

Entry information

Entry nameNKAI4_HUMAN
AccessionPrimary (citable) accession number: Q8IVV8
Secondary accession number(s): Q4VXQ6, Q9BQU8, Q9BQU9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 19, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM