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Protein

Glucose-induced degradation protein 4 homolog

Gene

GID4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-induced degradation protein 4 homolog
Alternative name(s):
Vacuolar import and degradation protein 24 homolog
Gene namesi
Name:GID4
Synonyms:C17orf39, VID24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000141034.9
HGNCiHGNC:28453 GID4
MIMi617699 gene
neXtProtiNX_Q8IVV7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141034
PharmGKBiPA134994398

Polymorphism and mutation databases

BioMutaiGID4
DMDMi73620594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793021 – 300Glucose-induced degradation protein 4 homologAdd BLAST300

Proteomic databases

EPDiQ8IVV7
MaxQBiQ8IVV7
PaxDbiQ8IVV7
PeptideAtlasiQ8IVV7
PRIDEiQ8IVV7

PTM databases

iPTMnetiQ8IVV7
PhosphoSitePlusiQ8IVV7

Expressioni

Gene expression databases

BgeeiENSG00000141034
CleanExiHS_C17orf39
ExpressionAtlasiQ8IVV7 baseline and differential
GenevisibleiQ8IVV7 HS

Organism-specific databases

HPAiHPA044348

Interactioni

Protein-protein interaction databases

BioGridi122487, 52 interactors
IntActiQ8IVV7, 8 interactors
STRINGi9606.ENSP00000268719

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi127 – 133Combined sources7
Beta strandi138 – 149Combined sources12
Turni150 – 153Combined sources4
Beta strandi154 – 167Combined sources14
Beta strandi169 – 179Combined sources11
Beta strandi181 – 184Combined sources4
Helixi195 – 202Combined sources8
Helixi206 – 210Combined sources5
Turni212 – 216Combined sources5
Turni217 – 219Combined sources3
Helixi222 – 227Combined sources6
Beta strandi228 – 242Combined sources15
Beta strandi251 – 253Combined sources3
Beta strandi256 – 263Combined sources8
Turni264 – 267Combined sources4
Beta strandi268 – 274Combined sources7
Beta strandi283 – 289Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CCRX-ray1.60A116-300[»]
6CCTX-ray2.40A124-289[»]
6CCUX-ray1.75A116-300[»]
6CD8X-ray1.60A/B124-289[»]
6CD9X-ray1.55A124-289[»]
6CDCX-ray1.75A124-289[»]
6CDGX-ray1.60A124-289[»]
ProteinModelPortaliQ8IVV7
SMRiQ8IVV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 109Pro-richAdd BLAST68

Sequence similaritiesi

Belongs to the GID4/VID24 family.Curated

Phylogenomic databases

eggNOGiKOG4635 Eukaryota
COG5073 LUCA
GeneTreeiENSGT00500000044930
HOGENOMiHOG000207439
HOVERGENiHBG081322
InParanoidiQ8IVV7
PhylomeDBiQ8IVV7
TreeFamiTF323749

Family and domain databases

InterProiView protein in InterPro
IPR018618 Vacuolar_import/degrad_Vid24
PfamiView protein in Pfam
PF09783 Vac_ImportDeg, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IVV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCARGQVGRG TQLRTGRPCS QVPGSRWRPE RLLRRQRAGG RPSRPHPARA
60 70 80 90 100
RPGLSLPATL LGSRAAAAVP LPLPPALAPG DPAMPVRTEC PPPAGASAAS
110 120 130 140 150
AASLIPPPPI NTQQPGVATS LLYSGSKFRG HQKSKGNSYD VEVVLQHVDT
160 170 180 190 200
GNSYLCGYLK IKGLTEEYPT LTTFFEGEII SKKHPFLTRK WDADEDVDRK
210 220 230 240 250
HWGKFLAFYQ YAKSFNSDDF DYEELKNGDY VFMRWKEQFL VPDHTIKDIS
260 270 280 290 300
GASFAGFYYI CFQKSAASIE GYYYHRSSEW YQSLNLTHVP EHSAPIYEFR
Length:300
Mass (Da):33,514
Last modified:March 1, 2003 - v1
Checksum:i9FE12824E9C46CD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146Q → R in BAB85036 (PubMed:14702039).Curated1
Sequence conflicti272Y → H in BAB85036 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074284 mRNA Translation: BAB85036.1
AC087164 Genomic DNA No translation available.
BC000636 mRNA Translation: AAH00636.2
BC041829 mRNA Translation: AAH41829.1
CCDSiCCDS11190.1
RefSeqiNP_076957.3, NM_024052.4
UniGeneiHs.187422

Genome annotation databases

EnsembliENST00000268719; ENSP00000268719; ENSG00000141034
GeneIDi79018
KEGGihsa:79018
UCSCiuc002gsg.2 human

Similar proteinsi

Entry informationi

Entry nameiGID4_HUMAN
AccessioniPrimary (citable) accession number: Q8IVV7
Secondary accession number(s): Q8TEB5, Q9BW50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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