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Protein

Glucose-induced degradation protein 4 homolog

Gene

GID4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-induced degradation protein 4 homolog
Alternative name(s):
Vacuolar import and degradation protein 24 homolog
Gene namesi
Name:GID4
Synonyms:C17orf39, VID24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141034.9.
HGNCiHGNC:28453. GID4.
MIMi617699. gene.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141034.
PharmGKBiPA134994398.

Polymorphism and mutation databases

BioMutaiGID4.
DMDMi73620594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793021 – 300Glucose-induced degradation protein 4 homologAdd BLAST300

Proteomic databases

EPDiQ8IVV7.
MaxQBiQ8IVV7.
PaxDbiQ8IVV7.
PeptideAtlasiQ8IVV7.
PRIDEiQ8IVV7.

PTM databases

iPTMnetiQ8IVV7.
PhosphoSitePlusiQ8IVV7.

Expressioni

Gene expression databases

BgeeiENSG00000141034.
CleanExiHS_C17orf39.
ExpressionAtlasiQ8IVV7. baseline and differential.
GenevisibleiQ8IVV7. HS.

Organism-specific databases

HPAiHPA044348.

Interactioni

Protein-protein interaction databases

BioGridi122487. 51 interactors.
IntActiQ8IVV7. 8 interactors.
STRINGi9606.ENSP00000268719.

Structurei

3D structure databases

ProteinModelPortaliQ8IVV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 109Pro-richAdd BLAST68

Sequence similaritiesi

Belongs to the GID4/VID24 family.Curated

Phylogenomic databases

eggNOGiKOG4635. Eukaryota.
COG5073. LUCA.
GeneTreeiENSGT00500000044930.
HOGENOMiHOG000207439.
HOVERGENiHBG081322.
InParanoidiQ8IVV7.
PhylomeDBiQ8IVV7.
TreeFamiTF323749.

Family and domain databases

InterProiView protein in InterPro
IPR018618. Vacuolar_import/degrad_Vid24.
PfamiView protein in Pfam
PF09783. Vac_ImportDeg. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IVV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCARGQVGRG TQLRTGRPCS QVPGSRWRPE RLLRRQRAGG RPSRPHPARA
60 70 80 90 100
RPGLSLPATL LGSRAAAAVP LPLPPALAPG DPAMPVRTEC PPPAGASAAS
110 120 130 140 150
AASLIPPPPI NTQQPGVATS LLYSGSKFRG HQKSKGNSYD VEVVLQHVDT
160 170 180 190 200
GNSYLCGYLK IKGLTEEYPT LTTFFEGEII SKKHPFLTRK WDADEDVDRK
210 220 230 240 250
HWGKFLAFYQ YAKSFNSDDF DYEELKNGDY VFMRWKEQFL VPDHTIKDIS
260 270 280 290 300
GASFAGFYYI CFQKSAASIE GYYYHRSSEW YQSLNLTHVP EHSAPIYEFR
Length:300
Mass (Da):33,514
Last modified:March 1, 2003 - v1
Checksum:i9FE12824E9C46CD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146Q → R in BAB85036 (PubMed:14702039).Curated1
Sequence conflicti272Y → H in BAB85036 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074284 mRNA. Translation: BAB85036.1.
AC087164 Genomic DNA. No translation available.
BC000636 mRNA. Translation: AAH00636.2.
BC041829 mRNA. Translation: AAH41829.1.
CCDSiCCDS11190.1.
RefSeqiNP_076957.3. NM_024052.4.
UniGeneiHs.187422.

Genome annotation databases

EnsembliENST00000268719; ENSP00000268719; ENSG00000141034.
GeneIDi79018.
KEGGihsa:79018.
UCSCiuc002gsg.2. human.

Similar proteinsi

Entry informationi

Entry nameiGID4_HUMAN
AccessioniPrimary (citable) accession number: Q8IVV7
Secondary accession number(s): Q8TEB5, Q9BW50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families