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Protein

Probable E3 ubiquitin-protein ligase HERC6

Gene

HERC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei985Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC6 (EC:2.3.2.26)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 6
HECT-type E3 ubiquitin transferase HERC6
Gene namesi
Name:HERC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138642.14
HGNCiHGNC:26072 HERC6
MIMi609249 gene
neXtProtiNX_Q8IVU3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55008
OpenTargetsiENSG00000138642
PharmGKBiPA134894313

Polymorphism and mutation databases

BioMutaiHERC6
DMDMi74750679

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782191 – 1022Probable E3 ubiquitin-protein ligase HERC6Add BLAST1022

Proteomic databases

MaxQBiQ8IVU3
PaxDbiQ8IVU3
PeptideAtlasiQ8IVU3
PRIDEiQ8IVU3

PTM databases

iPTMnetiQ8IVU3
PhosphoSitePlusiQ8IVU3

Expressioni

Tissue specificityi

Detected in brain, heart, placenta and testis.1 Publication

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000138642
ExpressionAtlasiQ8IVU3 baseline and differential
GenevisibleiQ8IVU3 HS

Organism-specific databases

HPAiHPA035846

Interactioni

Protein-protein interaction databases

BioGridi120340, 9 interactors
IntActiQ8IVU3, 1 interactor
STRINGi9606.ENSP00000264346

Structurei

3D structure databases

ProteinModelPortaliQ8IVU3
SMRiQ8IVU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 92RCC1 1Add BLAST52
Repeati93 – 145RCC1 2Add BLAST53
Repeati147 – 198RCC1 3Add BLAST52
Repeati200 – 253RCC1 4Add BLAST54
Repeati254 – 304RCC1 5Add BLAST51
Domaini693 – 1017HECTPROSITE-ProRule annotationAdd BLAST325

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0941 Eukaryota
COG5021 LUCA
COG5184 LUCA
GeneTreeiENSGT00910000144004
HOVERGENiHBG050878
InParanoidiQ8IVU3
KOiK22372
OMAiHIFAGTY
OrthoDBiEOG091G028I
PhylomeDBiQ8IVU3
TreeFamiTF315189

Family and domain databases

CDDicd00078 HECTc, 1 hit
Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00632 HECT, 1 hit
PF00415 RCC1, 5 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS00626 RCC1_2, 3 hits
PS50012 RCC1_3, 5 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN
60 70 80 90 100
SRGQLGRRGA QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG
110 120 130 140 150
AGSEGQLGIG EFKEISFTPK KIMTLNDIKI IQVSCGHYHS LALSKDSQVF
160 170 180 190 200
SWGKNSHGQL GLGKEFPSQA SPQRVRSLEG IPLAQVAAGG AHSFALSLCG
210 220 230 240 250
TSFGWGSNSA GQLALSGRNV PVQSNKPLSV GALKNLGVVY ISCGDAHTAV
260 270 280 290 300
LTQDGKVFTF GDNRSGQLGY SPTPEKRGPQ LVERIDGLVS QIDCGSYHTL
310 320 330 340 350
AYVHTTGQVV SFGHGPSDTS KPTHPEALTE NFDISCLISA EDFVDVQVKH
360 370 380 390 400
IFAGTYANFV TTHQDTSSTR APGKTLPEIS RISQSMAEKW IAVKRRSTEH
410 420 430 440 450
EMAKSEIRMI FSSPACLTAS FLKKRGTGET TSIDVDLEMA RDTFKKLTKK
460 470 480 490 500
EWISSMITTC LEDDLLRALP CHSPHQEALS VFLLLPECPV MHDSKNWKNL
510 520 530 540 550
VVPFAKAVCE MSKQSLQVLK KCWAFLQESS LNPLIQMLKA AIISQLLHQT
560 570 580 590 600
KTEQDHCNVK ALLGMMKELH KVNKANCRLP ENTFNINELS NLLNFYIDRG
610 620 630 640 650
RQLFRDNHLI PAETPSPVIF SDFPFIFNSL SKIKLLQADS HIKMQMSEKK
660 670 680 690 700
AYMLMHETIL QKKDEFPPSP RFILRVRRSR LVKDALRQLS QAEATDFCKV
710 720 730 740 750
LVVEFINEIC PESGGVSSEF FHCMFEEMTK PEYGMFMYPE MGSCMWFPAK
760 770 780 790 800
PKPEKKRYFL FGMLCGLSLF NLNVANLPFP LALYKKLLDQ KPSLEDLKEL
810 820 830 840 850
SPRLGKSLQE VLDDAADDIG DALCIRFSIH WDQNDVDLIP NGISIPVDQT
860 870 880 890 900
NKRDYVSKYI DYIFNVSVKA VYEEFQRGFY RVCEKEILRH FYPEELMTAI
910 920 930 940 950
IGNTDYDWKQ FEQNSKYEQG YQKSHPTIQL FWKAFHKLTL DEKKKFLFFL
960 970 980 990 1000
TGRDRLHARG IQKMEIVFRC PETFSERDHP TSITCHNILS LPKYSTMERM
1010 1020
EEALQVAINN NRGFVSPMLT QS
Note: Major transcript.
Length:1,022
Mass (Da):115,126
Last modified:July 5, 2005 - v2
Checksum:i713646243F269AD9
GO
Isoform 2 (identifier: Q8IVU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-645: Missing.

Note: Minor transcript.
Show »
Length:986
Mass (Da):111,084
Checksum:iE0E3B207DBBEE50C
GO
Isoform 3 (identifier: Q8IVU3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: SYHTLAYVHTT → RNSKHGFMTFF
     307-1022: Missing.

Note: Minor transcript.
Show »
Length:306
Mass (Da):32,717
Checksum:i9E8044CA333B16F5
GO

Sequence cautioni

The sequence BAA91303 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03879 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46056 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46151 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti742G → C in BAA91303 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051725123M → T. Corresponds to variant dbSNP:rs7677237Ensembl.1
Natural variantiVAR_051726199C → R. Corresponds to variant dbSNP:rs12510688Ensembl.1
Natural variantiVAR_051727343F → L. Corresponds to variant dbSNP:rs17014118Ensembl.1
Natural variantiVAR_051728614T → I. Corresponds to variant dbSNP:rs6532068Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023183296 – 306SYHTLAYVHTT → RNSKHGFMTFF in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023184307 – 1022Missing in isoform 3. 1 PublicationAdd BLAST716
Alternative sequenceiVSP_023185610 – 645Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336798 mRNA Translation: AAQ14893.1
AY653201 mRNA Translation: AAV66895.1
AK000644 mRNA Translation: BAA91303.1 Different initiation.
AK092403 mRNA Translation: BAC03879.1 Different initiation.
AK295832 mRNA Translation: BAG58647.1
BC035775 mRNA Translation: AAH35775.2
BC042047 mRNA Translation: AAH42047.2
AL833664 mRNA Translation: CAI46151.1 Different initiation.
BX647121 mRNA Translation: CAI46056.1 Different initiation.
CCDSiCCDS47098.1 [Q8IVU3-1]
CCDS54777.1 [Q8IVU3-2]
RefSeqiNP_001158608.1, NM_001165136.1
NP_060382.3, NM_017912.3 [Q8IVU3-1]
UniGeneiHs.529317

Genome annotation databases

EnsembliENST00000264346; ENSP00000264346; ENSG00000138642 [Q8IVU3-1]
ENST00000380265; ENSP00000369617; ENSG00000138642 [Q8IVU3-2]
GeneIDi55008
KEGGihsa:55008
UCSCiuc011cdi.3 human [Q8IVU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHERC6_HUMAN
AccessioniPrimary (citable) accession number: Q8IVU3
Secondary accession number(s): B4DIY5
, Q5GC90, Q5GRH3, Q5HYM6, Q5JPB6, Q6PIF4, Q8NAN3, Q9NWS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health