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Protein

Probable E3 ubiquitin-protein ligase HERC6

Gene

HERC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei985Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC6 (EC:2.3.2.26)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 6
HECT-type E3 ubiquitin transferase HERC6
Gene namesi
Name:HERC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26072. HERC6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55008.
OpenTargetsiENSG00000138642.
PharmGKBiPA134894313.

Polymorphism and mutation databases

BioMutaiHERC6.
DMDMi74750679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782191 – 1022Probable E3 ubiquitin-protein ligase HERC6Add BLAST1022

Proteomic databases

EPDiQ8IVU3.
MaxQBiQ8IVU3.
PaxDbiQ8IVU3.
PeptideAtlasiQ8IVU3.
PRIDEiQ8IVU3.

PTM databases

iPTMnetiQ8IVU3.
PhosphoSitePlusiQ8IVU3.

Expressioni

Tissue specificityi

Detected in brain, heart, placenta and testis.1 Publication

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000138642.
ExpressionAtlasiQ8IVU3. baseline and differential.
GenevisibleiQ8IVU3. HS.

Organism-specific databases

HPAiHPA035846.

Interactioni

Protein-protein interaction databases

BioGridi120340. 9 interactors.
IntActiQ8IVU3. 1 interactor.
STRINGi9606.ENSP00000264346.

Structurei

3D structure databases

ProteinModelPortaliQ8IVU3.
SMRiQ8IVU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 92RCC1 1Add BLAST52
Repeati93 – 145RCC1 2Add BLAST53
Repeati147 – 198RCC1 3Add BLAST52
Repeati200 – 253RCC1 4Add BLAST54
Repeati254 – 304RCC1 5Add BLAST51
Domaini693 – 1017HECTPROSITE-ProRule annotationAdd BLAST325

Sequence similaritiesi

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
Contains 5 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOVERGENiHBG050878.
InParanoidiQ8IVU3.
OMAiHIFAGTY.
OrthoDBiEOG091G028I.
PhylomeDBiQ8IVU3.
TreeFamiTF315189.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.130.10.30. 1 hit.
InterProiIPR000569. HECT_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS00626. RCC1_2. 3 hits.
PS50012. RCC1_3. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN
60 70 80 90 100
SRGQLGRRGA QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG
110 120 130 140 150
AGSEGQLGIG EFKEISFTPK KIMTLNDIKI IQVSCGHYHS LALSKDSQVF
160 170 180 190 200
SWGKNSHGQL GLGKEFPSQA SPQRVRSLEG IPLAQVAAGG AHSFALSLCG
210 220 230 240 250
TSFGWGSNSA GQLALSGRNV PVQSNKPLSV GALKNLGVVY ISCGDAHTAV
260 270 280 290 300
LTQDGKVFTF GDNRSGQLGY SPTPEKRGPQ LVERIDGLVS QIDCGSYHTL
310 320 330 340 350
AYVHTTGQVV SFGHGPSDTS KPTHPEALTE NFDISCLISA EDFVDVQVKH
360 370 380 390 400
IFAGTYANFV TTHQDTSSTR APGKTLPEIS RISQSMAEKW IAVKRRSTEH
410 420 430 440 450
EMAKSEIRMI FSSPACLTAS FLKKRGTGET TSIDVDLEMA RDTFKKLTKK
460 470 480 490 500
EWISSMITTC LEDDLLRALP CHSPHQEALS VFLLLPECPV MHDSKNWKNL
510 520 530 540 550
VVPFAKAVCE MSKQSLQVLK KCWAFLQESS LNPLIQMLKA AIISQLLHQT
560 570 580 590 600
KTEQDHCNVK ALLGMMKELH KVNKANCRLP ENTFNINELS NLLNFYIDRG
610 620 630 640 650
RQLFRDNHLI PAETPSPVIF SDFPFIFNSL SKIKLLQADS HIKMQMSEKK
660 670 680 690 700
AYMLMHETIL QKKDEFPPSP RFILRVRRSR LVKDALRQLS QAEATDFCKV
710 720 730 740 750
LVVEFINEIC PESGGVSSEF FHCMFEEMTK PEYGMFMYPE MGSCMWFPAK
760 770 780 790 800
PKPEKKRYFL FGMLCGLSLF NLNVANLPFP LALYKKLLDQ KPSLEDLKEL
810 820 830 840 850
SPRLGKSLQE VLDDAADDIG DALCIRFSIH WDQNDVDLIP NGISIPVDQT
860 870 880 890 900
NKRDYVSKYI DYIFNVSVKA VYEEFQRGFY RVCEKEILRH FYPEELMTAI
910 920 930 940 950
IGNTDYDWKQ FEQNSKYEQG YQKSHPTIQL FWKAFHKLTL DEKKKFLFFL
960 970 980 990 1000
TGRDRLHARG IQKMEIVFRC PETFSERDHP TSITCHNILS LPKYSTMERM
1010 1020
EEALQVAINN NRGFVSPMLT QS
Note: Major transcript.
Length:1,022
Mass (Da):115,126
Last modified:July 5, 2005 - v2
Checksum:i713646243F269AD9
GO
Isoform 2 (identifier: Q8IVU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-645: Missing.

Note: Minor transcript.
Show »
Length:986
Mass (Da):111,084
Checksum:iE0E3B207DBBEE50C
GO
Isoform 3 (identifier: Q8IVU3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: SYHTLAYVHTT → RNSKHGFMTFF
     307-1022: Missing.

Note: Minor transcript.
Show »
Length:306
Mass (Da):32,717
Checksum:i9E8044CA333B16F5
GO

Sequence cautioni

The sequence BAA91303 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03879 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46056 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46151 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti742G → C in BAA91303 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051725123M → T.Corresponds to variant rs7677237dbSNPEnsembl.1
Natural variantiVAR_051726199C → R.Corresponds to variant rs12510688dbSNPEnsembl.1
Natural variantiVAR_051727343F → L.Corresponds to variant rs17014118dbSNPEnsembl.1
Natural variantiVAR_051728614T → I.Corresponds to variant rs6532068dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023183296 – 306SYHTLAYVHTT → RNSKHGFMTFF in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023184307 – 1022Missing in isoform 3. 1 PublicationAdd BLAST716
Alternative sequenceiVSP_023185610 – 645Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336798 mRNA. Translation: AAQ14893.1.
AY653201 mRNA. Translation: AAV66895.1.
AK000644 mRNA. Translation: BAA91303.1. Different initiation.
AK092403 mRNA. Translation: BAC03879.1. Different initiation.
AK295832 mRNA. Translation: BAG58647.1.
BC035775 mRNA. Translation: AAH35775.2.
BC042047 mRNA. Translation: AAH42047.2.
AL833664 mRNA. Translation: CAI46151.1. Different initiation.
BX647121 mRNA. Translation: CAI46056.1. Different initiation.
CCDSiCCDS47098.1. [Q8IVU3-1]
CCDS54777.1. [Q8IVU3-2]
RefSeqiNP_001158608.1. NM_001165136.1.
NP_060382.3. NM_017912.3. [Q8IVU3-1]
UniGeneiHs.529317.

Genome annotation databases

EnsembliENST00000264346; ENSP00000264346; ENSG00000138642. [Q8IVU3-1]
ENST00000380265; ENSP00000369617; ENSG00000138642. [Q8IVU3-2]
GeneIDi55008.
KEGGihsa:55008.
UCSCiuc011cdi.3. human. [Q8IVU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336798 mRNA. Translation: AAQ14893.1.
AY653201 mRNA. Translation: AAV66895.1.
AK000644 mRNA. Translation: BAA91303.1. Different initiation.
AK092403 mRNA. Translation: BAC03879.1. Different initiation.
AK295832 mRNA. Translation: BAG58647.1.
BC035775 mRNA. Translation: AAH35775.2.
BC042047 mRNA. Translation: AAH42047.2.
AL833664 mRNA. Translation: CAI46151.1. Different initiation.
BX647121 mRNA. Translation: CAI46056.1. Different initiation.
CCDSiCCDS47098.1. [Q8IVU3-1]
CCDS54777.1. [Q8IVU3-2]
RefSeqiNP_001158608.1. NM_001165136.1.
NP_060382.3. NM_017912.3. [Q8IVU3-1]
UniGeneiHs.529317.

3D structure databases

ProteinModelPortaliQ8IVU3.
SMRiQ8IVU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120340. 9 interactors.
IntActiQ8IVU3. 1 interactor.
STRINGi9606.ENSP00000264346.

PTM databases

iPTMnetiQ8IVU3.
PhosphoSitePlusiQ8IVU3.

Polymorphism and mutation databases

BioMutaiHERC6.
DMDMi74750679.

Proteomic databases

EPDiQ8IVU3.
MaxQBiQ8IVU3.
PaxDbiQ8IVU3.
PeptideAtlasiQ8IVU3.
PRIDEiQ8IVU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264346; ENSP00000264346; ENSG00000138642. [Q8IVU3-1]
ENST00000380265; ENSP00000369617; ENSG00000138642. [Q8IVU3-2]
GeneIDi55008.
KEGGihsa:55008.
UCSCiuc011cdi.3. human. [Q8IVU3-1]

Organism-specific databases

CTDi55008.
DisGeNETi55008.
GeneCardsiHERC6.
HGNCiHGNC:26072. HERC6.
HPAiHPA035846.
MIMi609249. gene.
neXtProtiNX_Q8IVU3.
OpenTargetsiENSG00000138642.
PharmGKBiPA134894313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOVERGENiHBG050878.
InParanoidiQ8IVU3.
OMAiHIFAGTY.
OrthoDBiEOG091G028I.
PhylomeDBiQ8IVU3.
TreeFamiTF315189.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii55008.
PROiQ8IVU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138642.
ExpressionAtlasiQ8IVU3. baseline and differential.
GenevisibleiQ8IVU3. HS.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.130.10.30. 1 hit.
InterProiIPR000569. HECT_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS00626. RCC1_2. 3 hits.
PS50012. RCC1_3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHERC6_HUMAN
AccessioniPrimary (citable) accession number: Q8IVU3
Secondary accession number(s): B4DIY5
, Q5GC90, Q5GRH3, Q5HYM6, Q5JPB6, Q6PIF4, Q8NAN3, Q9NWS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.