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Protein

Immunoglobulin superfamily DCC subclass member 3

Gene

IGDCC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily DCC subclass member 3
Alternative name(s):
Putative neuronal cell adhesion molecule
Gene namesi
Name:IGDCC3
Synonyms:PUNC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:9700. IGDCC3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 640605ExtracellularSequence analysisAdd
BLAST
Transmembranei641 – 66121HelicalSequence analysisAdd
BLAST
Topological domaini662 – 814153CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720881.

Polymorphism and mutation databases

BioMutaiIGDCC3.
DMDMi296434537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 814779Immunoglobulin superfamily DCC subclass member 3PRO_0000014920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 117PROSITE-ProRule annotation
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi160 ↔ 209PROSITE-ProRule annotation
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi259 ↔ 307PROSITE-ProRule annotation
Disulfide bondi351 ↔ 400PROSITE-ProRule annotation
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence analysis
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence analysis
Glycosylationi604 – 6041N-linked (GlcNAc...)Sequence analysis
Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8IVU1.
PaxDbiQ8IVU1.
PeptideAtlasiQ8IVU1.
PRIDEiQ8IVU1.

PTM databases

iPTMnetiQ8IVU1.
PhosphoSiteiQ8IVU1.

Expressioni

Gene expression databases

BgeeiQ8IVU1.
ExpressionAtlasiQ8IVU1. baseline and differential.
GenevisibleiQ8IVU1. HS.

Organism-specific databases

HPAiHPA015246.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332773.

Structurei

3D structure databases

ProteinModelPortaliQ8IVU1.
SMRiQ8IVU1. Positions 42-643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 139104Ig-like C2-type 1Add
BLAST
Domaini140 – 22081Ig-like C2-type 2Add
BLAST
Domaini238 – 32184Ig-like C2-type 3Add
BLAST
Domaini329 – 41688Ig-like C2-type 4Add
BLAST
Domaini426 – 52095Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini523 – 61896Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi783 – 7864Poly-Pro

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
KOG4222. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000113008.
InParanoidiQ8IVU1.
OMAiTPPVRIT.
OrthoDBiEOG776SP5.
PhylomeDBiQ8IVU1.
TreeFamiTF321506.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IVU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQRAASPR RPPAPLWPRL LLPLLLLLLP APSEGLGHSA ELAFAVEPSD
60 70 80 90 100
DVAVPGQPIV LDCRVEGTPP VRITWRKNGV ELPESTHSTL LANGSLMIRH
110 120 130 140 150
FRLEPGGSPS DEGDYECVAQ NRFGLVVSRK ARIQAATMSD FHVHPQATVG
160 170 180 190 200
EEGGVARFQC QIHGLPKPLI TWEKNRVPID TDNERYTLLP KGVLQITGLR
210 220 230 240 250
AEDGGIFHCV ASNIASIRIS HGARLTVSGS GSGAYKEPAI LVGPENLTLT
260 270 280 290 300
VHQTAVLECV ATGNPRPIVS WSRLDGRPIG VEGIQVLGTG NLIISDVTVQ
310 320 330 340 350
HSGVYVCAAN RPGTRVRRTA QGRLVVQAPA EFVQHPQSIS RPAGTTAMFT
360 370 380 390 400
CQAQGEPPPH VTWLKNGQVL GPGGHVRLKN NNSTLTISGI GPEDEAIYQC
410 420 430 440 450
VAENSAGSSQ ASARLTVLWA EGLPGPPRNV RAVSVSSTEV RVSWSEPLAN
460 470 480 490 500
TKEIIGYVLH IRKAADPPEL EYQEAVSKST FQHLVSDLEP STAYSFYIKA
510 520 530 540 550
YTPRGASSAS VPTLASTLGE APAPPPLSVR VLGSSSLQLL WEPWPRLAQH
560 570 580 590 600
EGGFKLFYRP ASKTSFTGPI LLPGTVSSYN LSQLDPTAVY EVKLLAYNQH
610 620 630 640 650
GDGNATVRFV SLRGASERTA LSPPCDCRKE EAANQTSTTG IVIGIHIGVT
660 670 680 690 700
CIIFCVLFLL FGQRGRVLLC KDVENQLSPP QGPRSQRDPG ILALNGARRG
710 720 730 740 750
QRGQLGRDEK RVDMKELEQL FPPASAAGQP DPRPTQDPAA PAPCEETQLS
760 770 780 790 800
VLPLQGCGLM EGKTTEAKTT EATAPCAGLA AAPPPPDGGP GLLSEGQASR
810
PAAARVTQPA HSEQ
Length:814
Mass (Da):86,724
Last modified:May 18, 2010 - v2
Checksum:i7081B88569F77C68
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti598 – 5981N → S in AAD13399 (PubMed:9922388).Curated
Sequence conflicti650 – 6501T → A in AAD13399 (PubMed:9922388).Curated
Sequence conflicti654 – 6541F → L in AAD13399 (PubMed:9922388).Curated
Sequence conflicti729 – 7291Q → R in AAD13399 (PubMed:9922388).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti751 – 7511V → L.2 Publications
Corresponds to variant rs12907128 [ dbSNP | Ensembl ].
VAR_060356

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105129 Genomic DNA. No translation available.
BC042054 mRNA. Translation: AAH42054.1.
BC067107 mRNA. Translation: AAH67107.1.
AF063936 mRNA. Translation: AAD13399.1.
CCDSiCCDS10205.1.
RefSeqiNP_004875.2. NM_004884.3.
UniGeneiHs.128292.

Genome annotation databases

EnsembliENST00000327987; ENSP00000332773; ENSG00000174498.
GeneIDi9543.
KEGGihsa:9543.
UCSCiuc002aos.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105129 Genomic DNA. No translation available.
BC042054 mRNA. Translation: AAH42054.1.
BC067107 mRNA. Translation: AAH67107.1.
AF063936 mRNA. Translation: AAD13399.1.
CCDSiCCDS10205.1.
RefSeqiNP_004875.2. NM_004884.3.
UniGeneiHs.128292.

3D structure databases

ProteinModelPortaliQ8IVU1.
SMRiQ8IVU1. Positions 42-643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332773.

PTM databases

iPTMnetiQ8IVU1.
PhosphoSiteiQ8IVU1.

Polymorphism and mutation databases

BioMutaiIGDCC3.
DMDMi296434537.

Proteomic databases

EPDiQ8IVU1.
PaxDbiQ8IVU1.
PeptideAtlasiQ8IVU1.
PRIDEiQ8IVU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327987; ENSP00000332773; ENSG00000174498.
GeneIDi9543.
KEGGihsa:9543.
UCSCiuc002aos.2. human.

Organism-specific databases

CTDi9543.
GeneCardsiIGDCC3.
HGNCiHGNC:9700. IGDCC3.
HPAiHPA015246.
MIMi604184. gene.
neXtProtiNX_Q8IVU1.
PharmGKBiPA164720881.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
KOG4222. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000113008.
InParanoidiQ8IVU1.
OMAiTPPVRIT.
OrthoDBiEOG776SP5.
PhylomeDBiQ8IVU1.
TreeFamiTF321506.

Miscellaneous databases

ChiTaRSiIGDCC3. human.
GenomeRNAii9543.
PROiQ8IVU1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IVU1.
ExpressionAtlasiQ8IVU1. baseline and differential.
GenevisibleiQ8IVU1. HS.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-751.
    Tissue: Eye and Ovary.
  3. "Genomic structure and chromosomal localization of the mouse gene Punc."
    Salbaum J.M.
    Mamm. Genome 10:107-111(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 507-814, VARIANT LEU-751.
    Tissue: Placenta.

Entry informationi

Entry nameiIGDC3_HUMAN
AccessioniPrimary (citable) accession number: Q8IVU1
Secondary accession number(s): O95215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.