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Protein

Palmitoyltransferase ZDHHC21

Gene

ZDHHC21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • hair follicle development Source: Ensembl
  • peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  • protein palmitoylation Source: UniProtKB
  • regulation of nitric-oxide synthase activity Source: Reactome
  • sebaceous gland development Source: Ensembl

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-203615 eNOS activation

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC21 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 21
Short name:
DHHC-21
Gene namesi
Name:ZDHHC21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000175893.11
HGNCiHGNC:20750 ZDHHC21
MIMi614605 gene
neXtProtiNX_Q8IVQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175893
PharmGKBiPA134919189

Polymorphism and mutation databases

BioMutaiZDHHC21
DMDMi37999848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129081 – 265Palmitoyltransferase ZDHHC21Add BLAST265

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ8IVQ6
MaxQBiQ8IVQ6
PaxDbiQ8IVQ6
PeptideAtlasiQ8IVQ6
PRIDEiQ8IVQ6

PTM databases

iPTMnetiQ8IVQ6
PhosphoSitePlusiQ8IVQ6
SwissPalmiQ8IVQ6

Expressioni

Gene expression databases

BgeeiENSG00000175893
CleanExiHS_ZDHHC21
GenevisibleiQ8IVQ6 HS

Organism-specific databases

HPAiHPA065254

Interactioni

Protein-protein interaction databases

BioGridi131055, 9 interactors
IntActiQ8IVQ6, 3 interactors
MINTiQ8IVQ6
STRINGi9606.ENSP00000370303

Structurei

3D structure databases

ProteinModelPortaliQ8IVQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 140DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000013210
HOVERGENiHBG055594
InParanoidiQ8IVQ6
KOiK18932
OMAiCNMMRPK
OrthoDBiEOG091G0DM3
PhylomeDBiQ8IVQ6
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IVQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRIHFVVD PHGWCCMGLI VFVWLYNIVL IPKIVLFPHY EEGHIPGILI
60 70 80 90 100
IIFYGISIFC LVALVRASIT DPGRLPENPK IPHGEREFWE LCNKCNLMRP
110 120 130 140 150
KRSHHCSRCG HCVRRMDHHC PWINNCVGED NHWLFLQLCF YTELLTCYAL
160 170 180 190 200
MFSFCHYYYF LPLKKRNLDL FVFRHELAIM RLAAFMGITM LVGITGLFYT
210 220 230 240 250
QLIGIITDTT SIEKMSNCCE DISRPRKPWQ QTFSEVFGTR WKILWFIPFR
260
QRQPLRVPYH FANHV
Length:265
Mass (Da):31,385
Last modified:March 1, 2003 - v1
Checksum:i3C0978532B088F97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292960 mRNA Translation: BAF85649.1
AL390732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58692.1
CH471071 Genomic DNA Translation: EAW58693.1
BC042558 mRNA Translation: AAH42558.1
CCDSiCCDS6475.1
RefSeqiNP_848661.1, NM_178566.4
XP_016870171.1, XM_017014682.1
XP_016870172.1, XM_017014683.1
XP_016870173.1, XM_017014684.1
XP_016870174.1, XM_017014685.1
XP_016870175.1, XM_017014686.1
XP_016870176.1, XM_017014687.1
XP_016870177.1, XM_017014688.1
XP_016870178.1, XM_017014689.1
XP_016870179.1, XM_017014690.1
UniGeneiHs.649522
Hs.714266

Genome annotation databases

EnsembliENST00000380916; ENSP00000370303; ENSG00000175893
GeneIDi340481
KEGGihsa:340481
UCSCiuc003zlh.3 human

Similar proteinsi

Entry informationi

Entry nameiZDH21_HUMAN
AccessioniPrimary (citable) accession number: Q8IVQ6
Secondary accession number(s): A8KA95, D3DRI7, Q5VWG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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