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Protein

Palmitoyltransferase ZDHHC21

Gene

ZDHHC21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri90 – 14051DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • hair follicle development Source: Ensembl
  • peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  • protein palmitoylation Source: UniProtKB
  • regulation of nitric-oxide synthase activity Source: Reactome
  • sebaceous gland development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-203615. eNOS activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC21 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 21
Short name:
DHHC-21
Gene namesi
Name:ZDHHC21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:20750. ZDHHC21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919189.

Polymorphism and mutation databases

BioMutaiZDHHC21.
DMDMi37999848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Palmitoyltransferase ZDHHC21PRO_0000212908Add
BLAST

Proteomic databases

MaxQBiQ8IVQ6.
PaxDbiQ8IVQ6.
PRIDEiQ8IVQ6.

PTM databases

iPTMnetiQ8IVQ6.
PhosphoSiteiQ8IVQ6.
SwissPalmiQ8IVQ6.

Expressioni

Gene expression databases

BgeeiQ8IVQ6.
CleanExiHS_ZDHHC21.
GenevisibleiQ8IVQ6. HS.

Interactioni

Protein-protein interaction databases

BioGridi131055. 8 interactions.
IntActiQ8IVQ6. 2 interactions.
STRINGi9606.ENSP00000370303.

Structurei

3D structure databases

ProteinModelPortaliQ8IVQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri90 – 14051DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000013210.
HOVERGENiHBG055594.
InParanoidiQ8IVQ6.
KOiK18932.
OMAiYYYFQPL.
OrthoDBiEOG7966H2.
PhylomeDBiQ8IVQ6.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRIHFVVD PHGWCCMGLI VFVWLYNIVL IPKIVLFPHY EEGHIPGILI
60 70 80 90 100
IIFYGISIFC LVALVRASIT DPGRLPENPK IPHGEREFWE LCNKCNLMRP
110 120 130 140 150
KRSHHCSRCG HCVRRMDHHC PWINNCVGED NHWLFLQLCF YTELLTCYAL
160 170 180 190 200
MFSFCHYYYF LPLKKRNLDL FVFRHELAIM RLAAFMGITM LVGITGLFYT
210 220 230 240 250
QLIGIITDTT SIEKMSNCCE DISRPRKPWQ QTFSEVFGTR WKILWFIPFR
260
QRQPLRVPYH FANHV
Length:265
Mass (Da):31,385
Last modified:March 1, 2003 - v1
Checksum:i3C0978532B088F97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292960 mRNA. Translation: BAF85649.1.
AL390732 Genomic DNA. Translation: CAH73849.1.
CH471071 Genomic DNA. Translation: EAW58692.1.
CH471071 Genomic DNA. Translation: EAW58693.1.
BC042558 mRNA. Translation: AAH42558.1.
CCDSiCCDS6475.1.
RefSeqiNP_848661.1. NM_178566.4.
XP_006716823.1. XM_006716760.1.
UniGeneiHs.649522.
Hs.714266.

Genome annotation databases

EnsembliENST00000380916; ENSP00000370303; ENSG00000175893.
GeneIDi340481.
KEGGihsa:340481.
UCSCiuc003zlh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292960 mRNA. Translation: BAF85649.1.
AL390732 Genomic DNA. Translation: CAH73849.1.
CH471071 Genomic DNA. Translation: EAW58692.1.
CH471071 Genomic DNA. Translation: EAW58693.1.
BC042558 mRNA. Translation: AAH42558.1.
CCDSiCCDS6475.1.
RefSeqiNP_848661.1. NM_178566.4.
XP_006716823.1. XM_006716760.1.
UniGeneiHs.649522.
Hs.714266.

3D structure databases

ProteinModelPortaliQ8IVQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131055. 8 interactions.
IntActiQ8IVQ6. 2 interactions.
STRINGi9606.ENSP00000370303.

PTM databases

iPTMnetiQ8IVQ6.
PhosphoSiteiQ8IVQ6.
SwissPalmiQ8IVQ6.

Polymorphism and mutation databases

BioMutaiZDHHC21.
DMDMi37999848.

Proteomic databases

MaxQBiQ8IVQ6.
PaxDbiQ8IVQ6.
PRIDEiQ8IVQ6.

Protocols and materials databases

DNASUi340481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380916; ENSP00000370303; ENSG00000175893.
GeneIDi340481.
KEGGihsa:340481.
UCSCiuc003zlh.3. human.

Organism-specific databases

CTDi340481.
GeneCardsiZDHHC21.
HGNCiHGNC:20750. ZDHHC21.
MIMi614605. gene.
neXtProtiNX_Q8IVQ6.
PharmGKBiPA134919189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000013210.
HOVERGENiHBG055594.
InParanoidiQ8IVQ6.
KOiK18932.
OMAiYYYFQPL.
OrthoDBiEOG7966H2.
PhylomeDBiQ8IVQ6.
TreeFamiTF319798.

Enzyme and pathway databases

ReactomeiR-HSA-203615. eNOS activation.

Miscellaneous databases

ChiTaRSiZDHHC21. human.
GenomeRNAii340481.
PROiQ8IVQ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IVQ6.
CleanExiHS_ZDHHC21.
GenevisibleiQ8IVQ6. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."
    Pedram A., Razandi M., Deschenes R.J., Levin E.R.
    Mol. Biol. Cell 23:188-199(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZDH21_HUMAN
AccessioniPrimary (citable) accession number: Q8IVQ6
Secondary accession number(s): A8KA95, D3DRI7, Q5VWG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.