Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 547

Gene

ZNF547

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Caution

The gene of ZNF547 share a non-coding exon with TRAPPC2P.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 547
Gene namesi
Name:ZNF547
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000152433.14
HGNCiHGNC:26432 ZNF547
neXtProtiNX_Q8IVP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152433
PharmGKBiPA134931565

Polymorphism and mutation databases

BioMutaiZNF547
DMDMi74762478

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476441 – 402Zinc finger protein 547Add BLAST402

Proteomic databases

EPDiQ8IVP9
MaxQBiQ8IVP9
PaxDbiQ8IVP9
PeptideAtlasiQ8IVP9
PRIDEiQ8IVP9

PTM databases

iPTMnetiQ8IVP9
PhosphoSitePlusiQ8IVP9

Expressioni

Gene expression databases

BgeeiENSG00000152433
CleanExiHS_ZNF547
ExpressionAtlasiQ8IVP9 baseline and differential
GenevisibleiQ8IVP9 HS

Organism-specific databases

HPAiHPA056001

Interactioni

Protein-protein interaction databases

IntActiQ8IVP9, 2 interactors
STRINGi9606.ENSP00000282282

Structurei

3D structure databases

ProteinModelPortaliQ8IVP9
SMRiQ8IVP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 82KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8IVP9
KOiK09228
OMAiLCKSHLV
OrthoDBiEOG091G02KC
PhylomeDBiQ8IVP9
TreeFamiTF337732

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVP9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEMNPAQGH VVFEDVAIYF SQEEWGHLDE AQRLLYRDVM LENLALLSSL
60 70 80 90 100
GCCHGAEDEE APLEPGVSVG VSQVMAPKPC LSTQNTQPCE TCSSLLKDIL
110 120 130 140 150
RLAEHDGTHP EQGLYTCPAH LHQHQKEQIR EKLSRGDGGR PTFVKNHRVH
160 170 180 190 200
MAGKTFLCSE CGKAFSHKHK LSDHQKIHTG ERTYKCSKCG ILFMERSTLN
210 220 230 240 250
RHQRTHTGER PYECNECGKA FLCKSHLVRH QTIHSGERPY ECSECGKLFM
260 270 280 290 300
WSSTLITHQR VHTGKRPYGC SECGKFFKCN SNLFRHYRIH TGKRSYGCSE
310 320 330 340 350
CGKFFMERST LSRHQRVHTG ERPYECNECG KFFSLKSVLI QHQRVHTGER
360 370 380 390 400
PYECSECGKA FLTKSHLICH QTVHTAAKQC SECGKFFRYN STLLRHQKVH

TG
Length:402
Mass (Da):45,956
Last modified:December 7, 2004 - v2
Checksum:i5085F3EBA203C411
GO
Isoform 2 (identifier: Q8IVP9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-353: HTGERPYE → YTEEESFQ
     354-402: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,482
Checksum:iDF5684181CEE888A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016347346 – 353HTGERPYE → YTEEESFQ in isoform 2. 1 Publication8
Alternative sequenceiVSP_016348354 – 402Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055662 mRNA Translation: BAB70979.1
AK291464 mRNA Translation: BAF84153.1
CH471135 Genomic DNA Translation: EAW72497.1
BC042681 mRNA Translation: AAH42681.2
CCDSiCCDS33131.1 [Q8IVP9-1]
RefSeqiNP_775902.2, NM_173631.3 [Q8IVP9-1]
UniGeneiHs.446620

Genome annotation databases

EnsembliENST00000282282; ENSP00000282282; ENSG00000152433 [Q8IVP9-1]
GeneIDi284306
KEGGihsa:284306
UCSCiuc002qol.4 human [Q8IVP9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN547_HUMAN
AccessioniPrimary (citable) accession number: Q8IVP9
Secondary accession number(s): A8K5Z9, Q96NC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health