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Protein

Zinc finger protein 547

Gene

ZNF547

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 547
Gene namesi
Name:ZNF547
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26432. ZNF547.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931565.

Polymorphism and mutation databases

BioMutaiZNF547.
DMDMi74762478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Zinc finger protein 547PRO_0000047644Add
BLAST

Proteomic databases

PaxDbiQ8IVP9.
PeptideAtlasiQ8IVP9.
PRIDEiQ8IVP9.

PTM databases

iPTMnetiQ8IVP9.
PhosphoSiteiQ8IVP9.

Expressioni

Gene expression databases

BgeeiQ8IVP9.
CleanExiHS_ZNF547.
ExpressionAtlasiQ8IVP9. baseline and differential.
GenevisibleiQ8IVP9. HS.

Organism-specific databases

HPAiHPA056001.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000282282.

Structurei

3D structure databases

ProteinModelPortaliQ8IVP9.
SMRiQ8IVP9. Positions 83-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8272KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IVP9.
KOiK09228.
OMAiLCKSHLV.
PhylomeDBiQ8IVP9.
TreeFamiTF337732.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVP9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEMNPAQGH VVFEDVAIYF SQEEWGHLDE AQRLLYRDVM LENLALLSSL
60 70 80 90 100
GCCHGAEDEE APLEPGVSVG VSQVMAPKPC LSTQNTQPCE TCSSLLKDIL
110 120 130 140 150
RLAEHDGTHP EQGLYTCPAH LHQHQKEQIR EKLSRGDGGR PTFVKNHRVH
160 170 180 190 200
MAGKTFLCSE CGKAFSHKHK LSDHQKIHTG ERTYKCSKCG ILFMERSTLN
210 220 230 240 250
RHQRTHTGER PYECNECGKA FLCKSHLVRH QTIHSGERPY ECSECGKLFM
260 270 280 290 300
WSSTLITHQR VHTGKRPYGC SECGKFFKCN SNLFRHYRIH TGKRSYGCSE
310 320 330 340 350
CGKFFMERST LSRHQRVHTG ERPYECNECG KFFSLKSVLI QHQRVHTGER
360 370 380 390 400
PYECSECGKA FLTKSHLICH QTVHTAAKQC SECGKFFRYN STLLRHQKVH

TG
Length:402
Mass (Da):45,956
Last modified:December 7, 2004 - v2
Checksum:i5085F3EBA203C411
GO
Isoform 2 (identifier: Q8IVP9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-353: HTGERPYE → YTEEESFQ
     354-402: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,482
Checksum:iDF5684181CEE888A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei346 – 3538HTGERPYE → YTEEESFQ in isoform 2. 1 PublicationVSP_016347
Alternative sequencei354 – 40249Missing in isoform 2. 1 PublicationVSP_016348Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055662 mRNA. Translation: BAB70979.1.
AK291464 mRNA. Translation: BAF84153.1.
CH471135 Genomic DNA. Translation: EAW72497.1.
BC042681 mRNA. Translation: AAH42681.2.
CCDSiCCDS33131.1. [Q8IVP9-1]
RefSeqiNP_775902.2. NM_173631.3. [Q8IVP9-1]
UniGeneiHs.446620.

Genome annotation databases

EnsembliENST00000282282; ENSP00000282282; ENSG00000152433. [Q8IVP9-1]
GeneIDi284306.
KEGGihsa:284306.
UCSCiuc002qol.4. human. [Q8IVP9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055662 mRNA. Translation: BAB70979.1.
AK291464 mRNA. Translation: BAF84153.1.
CH471135 Genomic DNA. Translation: EAW72497.1.
BC042681 mRNA. Translation: AAH42681.2.
CCDSiCCDS33131.1. [Q8IVP9-1]
RefSeqiNP_775902.2. NM_173631.3. [Q8IVP9-1]
UniGeneiHs.446620.

3D structure databases

ProteinModelPortaliQ8IVP9.
SMRiQ8IVP9. Positions 83-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000282282.

PTM databases

iPTMnetiQ8IVP9.
PhosphoSiteiQ8IVP9.

Polymorphism and mutation databases

BioMutaiZNF547.
DMDMi74762478.

Proteomic databases

PaxDbiQ8IVP9.
PeptideAtlasiQ8IVP9.
PRIDEiQ8IVP9.

Protocols and materials databases

DNASUi284306.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282282; ENSP00000282282; ENSG00000152433. [Q8IVP9-1]
GeneIDi284306.
KEGGihsa:284306.
UCSCiuc002qol.4. human. [Q8IVP9-1]

Organism-specific databases

CTDi284306.
GeneCardsiZNF547.
HGNCiHGNC:26432. ZNF547.
HPAiHPA056001.
neXtProtiNX_Q8IVP9.
PharmGKBiPA134931565.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IVP9.
KOiK09228.
OMAiLCKSHLV.
PhylomeDBiQ8IVP9.
TreeFamiTF337732.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii284306.
PROiQ8IVP9.

Gene expression databases

BgeeiQ8IVP9.
CleanExiHS_ZNF547.
ExpressionAtlasiQ8IVP9. baseline and differential.
GenevisibleiQ8IVP9. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Neuroblastoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiZN547_HUMAN
AccessioniPrimary (citable) accession number: Q8IVP9
Secondary accession number(s): A8K5Z9, Q96NC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The gene of ZNF547 share a non-coding exon with TRAPPC2P.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.