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Protein

FUN14 domain-containing protein 1

Gene

FUNDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.1 Publication

GO - Biological processi

  • mitophagy Source: UniProtKB
  • response to hypoxia Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
FUN14 domain-containing protein 1
Gene namesi
Name:FUNDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28746. FUNDC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Topological domaini69 – 746Mitochondrial intermembraneSequence analysis
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST
Topological domaini96 – 13338CytoplasmicSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 1551Mitochondrial intermembraneSequence analysis

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: UniProtKB
  • mitochondrial outer membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi18 – 181Y → A: Impairs interaction with MAP1 LC3 family proteins. 1 Publication
Mutagenesisi18 – 181Y → W: Abolishes phosphorylation by SRC. 1 Publication
Mutagenesisi21 – 211L → A: Impairs interaction with MAP1 LC3 family proteins. 1 Publication
Mutagenesisi32 – 332WW → AA: Does not affect interaction with MAP1 LC3 family proteins.

Organism-specific databases

PharmGKBiPA134875965.

Polymorphism and mutation databases

BioMutaiFUNDC1.
DMDMi74750673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155FUN14 domain-containing protein 1PRO_0000271345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei18 – 181Phosphotyrosine; by SRC1 Publication

Post-translational modificationi

Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IVP5.
MaxQBiQ8IVP5.
PaxDbiQ8IVP5.
PeptideAtlasiQ8IVP5.
PRIDEiQ8IVP5.

PTM databases

iPTMnetiQ8IVP5.
PhosphoSiteiQ8IVP5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000069509.
CleanExiHS_FUNDC1.
GenevisibleiQ8IVP5. HS.

Organism-specific databases

HPAiHPA038773.

Interactioni

Subunit structurei

Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2P565453EBI-3059266,EBI-741533
EHHADHQ084263EBI-3059266,EBI-2339219
GABARAPL2P605203EBI-3059266,EBI-720116
MAP1LC3AQ9H4924EBI-3059266,EBI-720768
MAP1LC3BQ9GZQ88EBI-3059266,EBI-373144
MTERF3Q96E293EBI-3059266,EBI-7825321
SENP2Q9HC623EBI-3059266,EBI-714881
SH3GLB1Q9Y3713EBI-3059266,EBI-2623095
SLC25A46Q96AG33EBI-3059266,EBI-10281975
SNX1Q135963EBI-3059266,EBI-2822329
TUFMP494113EBI-3059266,EBI-359097
Ulk1O704053EBI-3059266,EBI-8390771From a different organism.
YES1P079473EBI-3059266,EBI-515331

Protein-protein interaction databases

BioGridi126561. 15 interactions.
IntActiQ8IVP5. 15 interactions.
STRINGi9606.ENSP00000367284.

Structurei

3D structure databases

ProteinModelPortaliQ8IVP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi18 – 214YXXL

Domaini

The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.1 Publication

Sequence similaritiesi

Belongs to the FUN14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4099. Eukaryota.
ENOG41122V1. LUCA.
GeneTreeiENSGT00390000003926.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
InParanoidiQ8IVP5.
KOiK17986.
OMAiNHSGYVQ.
OrthoDBiEOG091G15SP.
PhylomeDBiQ8IVP5.
TreeFamiTF300280.

Family and domain databases

InterProiIPR007014. FUN14.
[Graphical view]
PfamiPF04930. FUN14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRNPPPQD YESDDDSYEV LDLTEYARRH QWWNRVFGHS SGPMVEKYSV
60 70 80 90 100
ATQIVMGGVT GWCAGFLFQK VGKLAATAVG GGFLLLQIAS HSGYVQIDWK
110 120 130 140 150
RVEKDVNKAK RQIKKRANKA APEINNLIEE ATEFIKQNIV ISSGFVGGFL

LGLAS
Length:155
Mass (Da):17,178
Last modified:March 1, 2003 - v1
Checksum:i4E9ABF640795F0A9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561M → V.1 Publication
Corresponds to variant rs189499062 [ dbSNP | Ensembl ].
VAR_074638

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136137, AL022163 Genomic DNA. Translation: CAI40461.1.
AL022163, AL136137 Genomic DNA. Translation: CAI42944.1.
BC035015 mRNA. Translation: AAH35015.1.
BC042813 mRNA. Translation: AAH42813.1.
CCDSiCCDS14263.1.
RefSeqiNP_776155.1. NM_173794.3.
UniGeneiHs.7549.

Genome annotation databases

EnsembliENST00000378045; ENSP00000367284; ENSG00000069509.
GeneIDi139341.
KEGGihsa:139341.
UCSCiuc004dgc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136137, AL022163 Genomic DNA. Translation: CAI40461.1.
AL022163, AL136137 Genomic DNA. Translation: CAI42944.1.
BC035015 mRNA. Translation: AAH35015.1.
BC042813 mRNA. Translation: AAH42813.1.
CCDSiCCDS14263.1.
RefSeqiNP_776155.1. NM_173794.3.
UniGeneiHs.7549.

3D structure databases

ProteinModelPortaliQ8IVP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126561. 15 interactions.
IntActiQ8IVP5. 15 interactions.
STRINGi9606.ENSP00000367284.

PTM databases

iPTMnetiQ8IVP5.
PhosphoSiteiQ8IVP5.

Polymorphism and mutation databases

BioMutaiFUNDC1.
DMDMi74750673.

Proteomic databases

EPDiQ8IVP5.
MaxQBiQ8IVP5.
PaxDbiQ8IVP5.
PeptideAtlasiQ8IVP5.
PRIDEiQ8IVP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378045; ENSP00000367284; ENSG00000069509.
GeneIDi139341.
KEGGihsa:139341.
UCSCiuc004dgc.4. human.

Organism-specific databases

CTDi139341.
GeneCardsiFUNDC1.
HGNCiHGNC:28746. FUNDC1.
HPAiHPA038773.
MIMi300871. gene.
neXtProtiNX_Q8IVP5.
PharmGKBiPA134875965.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4099. Eukaryota.
ENOG41122V1. LUCA.
GeneTreeiENSGT00390000003926.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
InParanoidiQ8IVP5.
KOiK17986.
OMAiNHSGYVQ.
OrthoDBiEOG091G15SP.
PhylomeDBiQ8IVP5.
TreeFamiTF300280.

Miscellaneous databases

GeneWikiiFUNDC1.
GenomeRNAii139341.
PROiQ8IVP5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069509.
CleanExiHS_FUNDC1.
GenevisibleiQ8IVP5. HS.

Family and domain databases

InterProiIPR007014. FUN14.
[Graphical view]
PfamiPF04930. FUN14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUND1_HUMAN
AccessioniPrimary (citable) accession number: Q8IVP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.