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Protein

FUN14 domain-containing protein 1

Gene

FUNDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.1 Publication

GO - Biological processi

  • autophagy of mitochondrion Source: UniProtKB
  • macroautophagy Source: Reactome
  • response to hypoxia Source: UniProtKB
  • response to organonitrogen compound Source: Ensembl

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-HSA-8934903. Receptor Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
FUN14 domain-containing protein 1
Gene namesi
Name:FUNDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000069509.5.
HGNCiHGNC:28746. FUNDC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 74Mitochondrial intermembraneSequence analysis6
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 133CytoplasmicSequence analysisAdd BLAST38
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155Mitochondrial intermembraneSequence analysis1

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18Y → A: Impairs interaction with MAP1 LC3 family proteins. 1 Publication1
Mutagenesisi18Y → W: Abolishes phosphorylation by SRC. 1 Publication1
Mutagenesisi21L → A: Impairs interaction with MAP1 LC3 family proteins. 1 Publication1
Mutagenesisi32 – 33WW → AA: Does not affect interaction with MAP1 LC3 family proteins. 2

Organism-specific databases

OpenTargetsiENSG00000069509.
PharmGKBiPA134875965.

Polymorphism and mutation databases

BioMutaiFUNDC1.
DMDMi74750673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713451 – 155FUN14 domain-containing protein 1Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei18Phosphotyrosine; by SRC1 Publication1

Post-translational modificationi

Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IVP5.
MaxQBiQ8IVP5.
PaxDbiQ8IVP5.
PeptideAtlasiQ8IVP5.
PRIDEiQ8IVP5.

PTM databases

iPTMnetiQ8IVP5.
PhosphoSitePlusiQ8IVP5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000069509.
CleanExiHS_FUNDC1.
GenevisibleiQ8IVP5. HS.

Organism-specific databases

HPAiHPA038773.

Interactioni

Subunit structurei

Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126561. 18 interactors.
IntActiQ8IVP5. 15 interactors.
STRINGi9606.ENSP00000367284.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N9XNMR-B10-26[»]
5GMVX-ray2.25C/D16-23[»]
ProteinModelPortaliQ8IVP5.
SMRiQ8IVP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi18 – 21YXXL4

Domaini

The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.1 Publication

Sequence similaritiesi

Belongs to the FUN14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4099. Eukaryota.
ENOG41122V1. LUCA.
GeneTreeiENSGT00390000003926.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
InParanoidiQ8IVP5.
KOiK17986.
OMAiNHSGYVQ.
OrthoDBiEOG091G15SP.
PhylomeDBiQ8IVP5.
TreeFamiTF300280.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR007014. FUN14.
IPR029052. Metallo-depent_PP-like.
PfamiView protein in Pfam
PF04930. FUN14. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IVP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRNPPPQD YESDDDSYEV LDLTEYARRH QWWNRVFGHS SGPMVEKYSV
60 70 80 90 100
ATQIVMGGVT GWCAGFLFQK VGKLAATAVG GGFLLLQIAS HSGYVQIDWK
110 120 130 140 150
RVEKDVNKAK RQIKKRANKA APEINNLIEE ATEFIKQNIV ISSGFVGGFL

LGLAS
Length:155
Mass (Da):17,178
Last modified:March 1, 2003 - v1
Checksum:i4E9ABF640795F0A9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07463856M → V1 PublicationCorresponds to variant dbSNP:rs189499062Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136137, AL022163 Genomic DNA. Translation: CAI40461.1.
AL022163, AL136137 Genomic DNA. Translation: CAI42944.1.
BC035015 mRNA. Translation: AAH35015.1.
BC042813 mRNA. Translation: AAH42813.1.
CCDSiCCDS14263.1.
RefSeqiNP_776155.1. NM_173794.3.
UniGeneiHs.7549.

Genome annotation databases

EnsembliENST00000378045; ENSP00000367284; ENSG00000069509.
GeneIDi139341.
KEGGihsa:139341.
UCSCiuc004dgc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFUND1_HUMAN
AccessioniPrimary (citable) accession number: Q8IVP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families