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Q8IVN8

- SBSPO_HUMAN

UniProt

Q8IVN8 - SBSPO_HUMAN

Protein

Somatomedin-B and thrombospondin type-1 domain-containing protein

Gene

SBSPON

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. polysaccharide binding Source: InterPro
    2. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. immune response Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatomedin-B and thrombospondin type-1 domain-containing protein
    Alternative name(s):
    RPE-spondin
    Gene namesi
    Name:SBSPON
    Synonyms:C8orf84, RPESP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:30362. SBSPON.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix 1 Publication

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164717487.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 264244Somatomedin-B and thrombospondin type-1 domain-containing proteinPRO_0000332158Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 52AlternatePROSITE-ProRule annotation
    Disulfide bondi28 ↔ 36AlternatePROSITE-ProRule annotation
    Disulfide bondi36 ↔ 70AlternatePROSITE-ProRule annotation
    Disulfide bondi50 ↔ 63AlternatePROSITE-ProRule annotation
    Disulfide bondi50 ↔ 52AlternatePROSITE-ProRule annotation
    Disulfide bondi56 ↔ 62By similarity
    Disulfide bondi63 ↔ 70AlternatePROSITE-ProRule annotation
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IVN8.
    PRIDEiQ8IVN8.

    Expressioni

    Tissue specificityi

    Detected in aorta extracellular matrix (at protein level).1 Publication

    Gene expression databases

    BgeeiQ8IVN8.
    GenevestigatoriQ8IVN8.

    Organism-specific databases

    HPAiCAB034214.
    CAB034332.
    HPA029595.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000297354.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IVN8.
    SMRiQ8IVN8. Positions 12-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 7552SMBPROSITE-ProRule annotationAdd
    BLAST
    Domaini74 – 12754TSP type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 1 SMB (somatomedin-B) domain.Curated
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG14004.
    HOGENOMiHOG000006768.
    HOVERGENiHBG108417.
    InParanoidiQ8IVN8.
    OMAiDRVYGTC.
    OrthoDBiEOG76MK95.
    PhylomeDBiQ8IVN8.
    TreeFamiTF315634.

    Family and domain databases

    InterProiIPR001212. Somatomedin_B_dom.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    SMARTiSM00209. TSP1. 1 hit.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 1 hit.
    PROSITEiPS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS50092. TSP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IVN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLWMALCA LSRLWPGAQA GCAEAGRCCP GRDPACFARG WRLDRVYGTC    50
    FCDQACRFTG DCCFDYDRAC PARPCFVGEW SPWSGCADQC KPTTRVRRRS 100
    VQQEPQNGGA PCPPLEERAG CLEYSTPQGQ DCGHTYVPAF ITTSAFNKER 150
    TRQATSPHWS THTEDAGYCM EFKTESLTPH CALENWPLTR WMQYLREGYT 200
    VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL HWQAIGNPRC QGTWKKVRRV 250
    DQCSCPAVHS FIFI 264
    Length:264
    Mass (Da):29,610
    Last modified:April 29, 2008 - v2
    Checksum:i1A8406EC6BDC8A41
    GO

    Sequence cautioni

    The sequence AAH42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAK83466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAF85659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581F → L.1 Publication
    Corresponds to variant rs59331088 [ dbSNP | Ensembl ].
    VAR_061914
    Natural varianti186 – 1861W → R.2 Publications
    Corresponds to variant rs2291219 [ dbSNP | Ensembl ].
    VAR_042961

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040546 mRNA. Translation: AAK83466.1. Different initiation.
    AK292970 mRNA. Translation: BAF85659.1. Different initiation.
    AC022893 Genomic DNA. No translation available.
    AC100823 Genomic DNA. No translation available.
    BC042877 mRNA. Translation: AAH42877.1. Different initiation.
    CCDSiCCDS43747.2.
    RefSeqiNP_694957.3. NM_153225.3.
    UniGeneiHs.439040.

    Genome annotation databases

    EnsembliENST00000297354; ENSP00000297354; ENSG00000164764.
    GeneIDi157869.
    KEGGihsa:157869.
    UCSCiuc003xzf.3. human.

    Polymorphism databases

    DMDMi187611420.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040546 mRNA. Translation: AAK83466.1 . Different initiation.
    AK292970 mRNA. Translation: BAF85659.1 . Different initiation.
    AC022893 Genomic DNA. No translation available.
    AC100823 Genomic DNA. No translation available.
    BC042877 mRNA. Translation: AAH42877.1 . Different initiation.
    CCDSi CCDS43747.2.
    RefSeqi NP_694957.3. NM_153225.3.
    UniGenei Hs.439040.

    3D structure databases

    ProteinModelPortali Q8IVN8.
    SMRi Q8IVN8. Positions 12-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000297354.

    Polymorphism databases

    DMDMi 187611420.

    Proteomic databases

    PaxDbi Q8IVN8.
    PRIDEi Q8IVN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297354 ; ENSP00000297354 ; ENSG00000164764 .
    GeneIDi 157869.
    KEGGi hsa:157869.
    UCSCi uc003xzf.3. human.

    Organism-specific databases

    CTDi 157869.
    GeneCardsi GC08M073977.
    H-InvDB HIX0020800.
    HGNCi HGNC:30362. SBSPON.
    HPAi CAB034214.
    CAB034332.
    HPA029595.
    neXtProti NX_Q8IVN8.
    PharmGKBi PA164717487.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG14004.
    HOGENOMi HOG000006768.
    HOVERGENi HBG108417.
    InParanoidi Q8IVN8.
    OMAi DRVYGTC.
    OrthoDBi EOG76MK95.
    PhylomeDBi Q8IVN8.
    TreeFami TF315634.

    Enzyme and pathway databases

    Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

    Miscellaneous databases

    GenomeRNAii 157869.
    NextBioi 87571.
    PROi Q8IVN8.

    Gene expression databases

    Bgeei Q8IVN8.
    Genevestigatori Q8IVN8.

    Family and domain databases

    InterProi IPR001212. Somatomedin_B_dom.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    SMARTi SM00209. TSP1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 1 hit.
    PROSITEi PS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS50092. TSP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
      Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
      Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-58 AND ARG-186.
      Tissue: Eye.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-186.
      Tissue: Trachea.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Proteomics characterization of extracellular space components in the human aorta."
      Didangelos A., Yin X., Mandal K., Baumert M., Jahangiri M., Mayr M.
      Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSBSPO_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVN8
    Secondary accession number(s): A8KAA5, Q96J64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3