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Protein

Somatomedin-B and thrombospondin type-1 domain-containing protein

Gene

SBSPON

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. polysaccharide binding Source: InterPro
  2. scavenger receptor activity Source: InterPro

GO - Biological processi

  1. immune response Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_264269. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatomedin-B and thrombospondin type-1 domain-containing protein
Alternative name(s):
RPE-spondin
Gene namesi
Name:SBSPON
Synonyms:C8orf84, RPESP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30362. SBSPON.

Subcellular locationi

  1. Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717487.

Polymorphism and mutation databases

BioMutaiSBSPON.
DMDMi187611420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 264244Somatomedin-B and thrombospondin type-1 domain-containing proteinPRO_0000332158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 52AlternatePROSITE-ProRule annotation
Disulfide bondi28 ↔ 36AlternatePROSITE-ProRule annotation
Disulfide bondi36 ↔ 70AlternatePROSITE-ProRule annotation
Disulfide bondi50 ↔ 63AlternatePROSITE-ProRule annotation
Disulfide bondi50 ↔ 52AlternatePROSITE-ProRule annotation
Disulfide bondi56 ↔ 62By similarity
Disulfide bondi63 ↔ 70AlternatePROSITE-ProRule annotation
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IVN8.
PRIDEiQ8IVN8.

Expressioni

Tissue specificityi

Detected in aorta extracellular matrix (at protein level).1 Publication

Gene expression databases

BgeeiQ8IVN8.
GenevestigatoriQ8IVN8.

Organism-specific databases

HPAiCAB034214.
CAB034332.
HPA029595.

Interactioni

Protein-protein interaction databases

BioGridi127630. 4 interactions.
STRINGi9606.ENSP00000297354.

Structurei

3D structure databases

ProteinModelPortaliQ8IVN8.
SMRiQ8IVN8. Positions 12-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 7552SMBPROSITE-ProRule annotationAdd
BLAST
Domaini74 – 12754TSP type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 1 SMB (somatomedin-B) domain.Curated
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG14004.
GeneTreeiENSGT00390000008325.
HOGENOMiHOG000006768.
HOVERGENiHBG108417.
InParanoidiQ8IVN8.
OMAiDRVYGTC.
OrthoDBiEOG76MK95.
PhylomeDBiQ8IVN8.
TreeFamiTF315634.

Family and domain databases

InterProiIPR001212. Somatomedin_B_dom.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IVN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLWMALCA LSRLWPGAQA GCAEAGRCCP GRDPACFARG WRLDRVYGTC
60 70 80 90 100
FCDQACRFTG DCCFDYDRAC PARPCFVGEW SPWSGCADQC KPTTRVRRRS
110 120 130 140 150
VQQEPQNGGA PCPPLEERAG CLEYSTPQGQ DCGHTYVPAF ITTSAFNKER
160 170 180 190 200
TRQATSPHWS THTEDAGYCM EFKTESLTPH CALENWPLTR WMQYLREGYT
210 220 230 240 250
VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL HWQAIGNPRC QGTWKKVRRV
260
DQCSCPAVHS FIFI
Length:264
Mass (Da):29,610
Last modified:April 29, 2008 - v2
Checksum:i1A8406EC6BDC8A41
GO

Sequence cautioni

The sequence AAH42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK83466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAF85659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581F → L.1 Publication
Corresponds to variant rs59331088 [ dbSNP | Ensembl ].
VAR_061914
Natural varianti186 – 1861W → R.2 Publications
Corresponds to variant rs2291219 [ dbSNP | Ensembl ].
VAR_042961

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040546 mRNA. Translation: AAK83466.1. Different initiation.
AK292970 mRNA. Translation: BAF85659.1. Different initiation.
AC022893 Genomic DNA. No translation available.
AC100823 Genomic DNA. No translation available.
BC042877 mRNA. Translation: AAH42877.1. Different initiation.
CCDSiCCDS43747.2.
RefSeqiNP_694957.3. NM_153225.3.
UniGeneiHs.439040.

Genome annotation databases

EnsembliENST00000297354; ENSP00000297354; ENSG00000164764.
GeneIDi157869.
KEGGihsa:157869.
UCSCiuc003xzf.3. human.

Polymorphism and mutation databases

BioMutaiSBSPON.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040546 mRNA. Translation: AAK83466.1. Different initiation.
AK292970 mRNA. Translation: BAF85659.1. Different initiation.
AC022893 Genomic DNA. No translation available.
AC100823 Genomic DNA. No translation available.
BC042877 mRNA. Translation: AAH42877.1. Different initiation.
CCDSiCCDS43747.2.
RefSeqiNP_694957.3. NM_153225.3.
UniGeneiHs.439040.

3D structure databases

ProteinModelPortaliQ8IVN8.
SMRiQ8IVN8. Positions 12-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127630. 4 interactions.
STRINGi9606.ENSP00000297354.

Polymorphism and mutation databases

BioMutaiSBSPON.
DMDMi187611420.

Proteomic databases

PaxDbiQ8IVN8.
PRIDEiQ8IVN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297354; ENSP00000297354; ENSG00000164764.
GeneIDi157869.
KEGGihsa:157869.
UCSCiuc003xzf.3. human.

Organism-specific databases

CTDi157869.
GeneCardsiGC08M073977.
H-InvDBHIX0020800.
HGNCiHGNC:30362. SBSPON.
HPAiCAB034214.
CAB034332.
HPA029595.
neXtProtiNX_Q8IVN8.
PharmGKBiPA164717487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG14004.
GeneTreeiENSGT00390000008325.
HOGENOMiHOG000006768.
HOVERGENiHBG108417.
InParanoidiQ8IVN8.
OMAiDRVYGTC.
OrthoDBiEOG76MK95.
PhylomeDBiQ8IVN8.
TreeFamiTF315634.

Enzyme and pathway databases

ReactomeiREACT_264269. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii157869.
NextBioi87571.
PROiQ8IVN8.

Gene expression databases

BgeeiQ8IVN8.
GenevestigatoriQ8IVN8.

Family and domain databases

InterProiIPR001212. Somatomedin_B_dom.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
    Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
    Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-58 AND ARG-186.
    Tissue: Eye.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-186.
    Tissue: Trachea.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Proteomics characterization of extracellular space components in the human aorta."
    Didangelos A., Yin X., Mandal K., Baumert M., Jahangiri M., Mayr M.
    Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSBSPO_HUMAN
AccessioniPrimary (citable) accession number: Q8IVN8
Secondary accession number(s): A8KAA5, Q96J64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 29, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.