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Q8IVN8 (SBSPO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatomedin-B and thrombospondin type-1 domain-containing protein
Alternative name(s):
RPE-spondin
Gene names
Name:SBSPON
Synonyms:C8orf84, RPESP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secretedextracellular spaceextracellular matrix Ref.5.

Tissue specificity

Detected in aorta extracellular matrix (at protein level). Ref.5

Sequence similarities

Belongs to the thrombospondin family.

Contains 1 SMB (somatomedin-B) domain.

Contains 1 TSP type-1 domain.

Sequence caution

The sequence AAH42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAK83466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAF85659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processimmune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpolysaccharide binding

Inferred from electronic annotation. Source: InterPro

scavenger receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 264244Somatomedin-B and thrombospondin type-1 domain-containing protein
PRO_0000332158

Regions

Domain24 – 7552SMB
Domain74 – 12754TSP type-1

Amino acid modifications

Glycosylation2271N-linked (GlcNAc...) Potential
Disulfide bond28 ↔ 52Alternate By similarity
Disulfide bond28 ↔ 36Alternate By similarity
Disulfide bond36 ↔ 70Alternate By similarity
Disulfide bond50 ↔ 63Alternate By similarity
Disulfide bond50 ↔ 52Alternate By similarity
Disulfide bond56 ↔ 62 By similarity
Disulfide bond63 ↔ 70Alternate By similarity

Natural variations

Natural variant581F → L. Ref.1
Corresponds to variant rs59331088 [ dbSNP | Ensembl ].
VAR_061914
Natural variant1861W → R. Ref.1 Ref.2
Corresponds to variant rs2291219 [ dbSNP | Ensembl ].
VAR_042961

Sequences

Sequence LengthMass (Da)Tools
Q8IVN8 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: 1A8406EC6BDC8A41

FASTA26429,610
        10         20         30         40         50         60 
MRTLWMALCA LSRLWPGAQA GCAEAGRCCP GRDPACFARG WRLDRVYGTC FCDQACRFTG 

        70         80         90        100        110        120 
DCCFDYDRAC PARPCFVGEW SPWSGCADQC KPTTRVRRRS VQQEPQNGGA PCPPLEERAG 

       130        140        150        160        170        180 
CLEYSTPQGQ DCGHTYVPAF ITTSAFNKER TRQATSPHWS THTEDAGYCM EFKTESLTPH 

       190        200        210        220        230        240 
CALENWPLTR WMQYLREGYT VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL HWQAIGNPRC 

       250        260 
QGTWKKVRRV DQCSCPAVHS FIFI 

« Hide

References

« Hide 'large scale' references
[1]"Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-58 AND ARG-186.
Tissue: Eye.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-186.
Tissue: Trachea.
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Proteomics characterization of extracellular space components in the human aorta."
Didangelos A., Yin X., Mandal K., Baumert M., Jahangiri M., Mayr M.
Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY040546 mRNA. Translation: AAK83466.1. Different initiation.
AK292970 mRNA. Translation: BAF85659.1. Different initiation.
AC022893 Genomic DNA. No translation available.
AC100823 Genomic DNA. No translation available.
BC042877 mRNA. Translation: AAH42877.1. Different initiation.
RefSeqNP_694957.3. NM_153225.3.
UniGeneHs.439040.

3D structure databases

ProteinModelPortalQ8IVN8.
SMRQ8IVN8. Positions 12-128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000297354.

Polymorphism databases

DMDM187611420.

Proteomic databases

PaxDbQ8IVN8.
PRIDEQ8IVN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297354; ENSP00000297354; ENSG00000164764.
GeneID157869.
KEGGhsa:157869.
UCSCuc003xzf.3. human.

Organism-specific databases

CTD157869.
GeneCardsGC08M073977.
H-InvDBHIX0020800.
HGNCHGNC:30362. SBSPON.
HPACAB034214.
CAB034332.
HPA029595.
neXtProtNX_Q8IVN8.
PharmGKBPA164717487.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG14004.
HOGENOMHOG000006768.
HOVERGENHBG108417.
InParanoidQ8IVN8.
OMADRVYGTC.
OrthoDBEOG76MK95.
PhylomeDBQ8IVN8.
TreeFamTF315634.

Gene expression databases

BgeeQ8IVN8.
GenevestigatorQ8IVN8.

Family and domain databases

InterProIPR001212. Somatomedin_B_dom.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
SMARTSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMSSF82895. SSF82895. 1 hit.
PROSITEPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi157869.
NextBio87571.
PROQ8IVN8.

Entry information

Entry nameSBSPO_HUMAN
AccessionPrimary (citable) accession number: Q8IVN8
Secondary accession number(s): A8KAA5, Q96J64
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM