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Q8IVN8

- SBSPO_HUMAN

UniProt

Q8IVN8 - SBSPO_HUMAN

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Protein

Somatomedin-B and thrombospondin type-1 domain-containing protein

Gene
SBSPON, C8orf84, RPESP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. polysaccharide binding Source: InterPro
  2. scavenger receptor activity Source: InterPro

GO - Biological processi

  1. immune response Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatomedin-B and thrombospondin type-1 domain-containing protein
Alternative name(s):
RPE-spondin
Gene namesi
Name:SBSPON
Synonyms:C8orf84, RPESP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:30362. SBSPON.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 264244Somatomedin-B and thrombospondin type-1 domain-containing proteinPRO_0000332158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 52Alternate By similarity
Disulfide bondi28 ↔ 36Alternate By similarity
Disulfide bondi36 ↔ 70Alternate By similarity
Disulfide bondi50 ↔ 63Alternate By similarity
Disulfide bondi50 ↔ 52Alternate By similarity
Disulfide bondi56 ↔ 62 By similarity
Disulfide bondi63 ↔ 70Alternate By similarity
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IVN8.
PRIDEiQ8IVN8.

Expressioni

Tissue specificityi

Detected in aorta extracellular matrix (at protein level).1 Publication

Gene expression databases

BgeeiQ8IVN8.
GenevestigatoriQ8IVN8.

Organism-specific databases

HPAiCAB034214.
CAB034332.
HPA029595.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297354.

Structurei

3D structure databases

ProteinModelPortaliQ8IVN8.
SMRiQ8IVN8. Positions 12-128.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 7552SMBAdd
BLAST
Domaini74 – 12754TSP type-1Add
BLAST

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 1 TSP type-1 domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG14004.
HOGENOMiHOG000006768.
HOVERGENiHBG108417.
InParanoidiQ8IVN8.
OMAiDRVYGTC.
OrthoDBiEOG76MK95.
PhylomeDBiQ8IVN8.
TreeFamiTF315634.

Family and domain databases

InterProiIPR001212. Somatomedin_B_dom.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IVN8-1 [UniParc]FASTAAdd to Basket

« Hide

MRTLWMALCA LSRLWPGAQA GCAEAGRCCP GRDPACFARG WRLDRVYGTC    50
FCDQACRFTG DCCFDYDRAC PARPCFVGEW SPWSGCADQC KPTTRVRRRS 100
VQQEPQNGGA PCPPLEERAG CLEYSTPQGQ DCGHTYVPAF ITTSAFNKER 150
TRQATSPHWS THTEDAGYCM EFKTESLTPH CALENWPLTR WMQYLREGYT 200
VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL HWQAIGNPRC QGTWKKVRRV 250
DQCSCPAVHS FIFI 264
Length:264
Mass (Da):29,610
Last modified:April 29, 2008 - v2
Checksum:i1A8406EC6BDC8A41
GO

Sequence cautioni

The sequence AAH42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAK83466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAF85659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581F → L.1 Publication
Corresponds to variant rs59331088 [ dbSNP | Ensembl ].
VAR_061914
Natural varianti186 – 1861W → R.2 Publications
Corresponds to variant rs2291219 [ dbSNP | Ensembl ].
VAR_042961

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY040546 mRNA. Translation: AAK83466.1. Different initiation.
AK292970 mRNA. Translation: BAF85659.1. Different initiation.
AC022893 Genomic DNA. No translation available.
AC100823 Genomic DNA. No translation available.
BC042877 mRNA. Translation: AAH42877.1. Different initiation.
CCDSiCCDS43747.2.
RefSeqiNP_694957.3. NM_153225.3.
UniGeneiHs.439040.

Genome annotation databases

EnsembliENST00000297354; ENSP00000297354; ENSG00000164764.
GeneIDi157869.
KEGGihsa:157869.
UCSCiuc003xzf.3. human.

Polymorphism databases

DMDMi187611420.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY040546 mRNA. Translation: AAK83466.1 . Different initiation.
AK292970 mRNA. Translation: BAF85659.1 . Different initiation.
AC022893 Genomic DNA. No translation available.
AC100823 Genomic DNA. No translation available.
BC042877 mRNA. Translation: AAH42877.1 . Different initiation.
CCDSi CCDS43747.2.
RefSeqi NP_694957.3. NM_153225.3.
UniGenei Hs.439040.

3D structure databases

ProteinModelPortali Q8IVN8.
SMRi Q8IVN8. Positions 12-128.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000297354.

Polymorphism databases

DMDMi 187611420.

Proteomic databases

PaxDbi Q8IVN8.
PRIDEi Q8IVN8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297354 ; ENSP00000297354 ; ENSG00000164764 .
GeneIDi 157869.
KEGGi hsa:157869.
UCSCi uc003xzf.3. human.

Organism-specific databases

CTDi 157869.
GeneCardsi GC08M073977.
H-InvDB HIX0020800.
HGNCi HGNC:30362. SBSPON.
HPAi CAB034214.
CAB034332.
HPA029595.
neXtProti NX_Q8IVN8.
PharmGKBi PA164717487.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG14004.
HOGENOMi HOG000006768.
HOVERGENi HBG108417.
InParanoidi Q8IVN8.
OMAi DRVYGTC.
OrthoDBi EOG76MK95.
PhylomeDBi Q8IVN8.
TreeFami TF315634.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii 157869.
NextBioi 87571.
PROi Q8IVN8.

Gene expression databases

Bgeei Q8IVN8.
Genevestigatori Q8IVN8.

Family and domain databases

InterProi IPR001212. Somatomedin_B_dom.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
SMARTi SM00209. TSP1. 1 hit.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 1 hit.
PROSITEi PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
    Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
    Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-58 AND ARG-186.
    Tissue: Eye.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-186.
    Tissue: Trachea.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Proteomics characterization of extracellular space components in the human aorta."
    Didangelos A., Yin X., Mandal K., Baumert M., Jahangiri M., Mayr M.
    Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSBSPO_HUMAN
AccessioniPrimary (citable) accession number: Q8IVN8
Secondary accession number(s): A8KAA5, Q96J64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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