Q8IVN8 (SBSPO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatomedin-B and thrombospondin type-1 domain-containing protein

Alternative name(s):
RPE-spondin

Gene names

Name:	SBSPON
Synonyms:	C8orf84, RPESP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted › extracellular space › extracellular matrix Ref.5.
Tissue specificity	Detected in aorta extracellular matrix (at protein level). Ref.5
Sequence similarities	Belongs to the thrombospondin family. Contains 1 SMB (somatomedin-B) domain. Contains 1 TSP type-1 domain.
Sequence caution	The sequence AAH42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAK83466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAF85659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	polysaccharide binding Inferred from electronic annotation. Source: InterPro scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 264	244	Somatomedin-B and thrombospondin type-1 domain-containing protein		PRO_0000332158
Regions
	Domain	24 – 75	52	SMB
	Domain	74 – 127	54	TSP type-1
Amino acid modifications
	Glycosylation	227	1	N-linked (GlcNAc...) Potential
	Disulfide bond	28 ↔ 52		Alternate By similarity
	Disulfide bond	28 ↔ 36		Alternate By similarity
	Disulfide bond	36 ↔ 70		Alternate By similarity
	Disulfide bond	50 ↔ 63		Alternate By similarity
	Disulfide bond	50 ↔ 52		Alternate By similarity
	Disulfide bond	56 ↔ 62		By similarity
	Disulfide bond	63 ↔ 70		Alternate By similarity
Natural variations
	Natural variant	58	1	F → L. Ref.1 Corresponds to variant rs59331088 [ dbSNP | Ensembl ].		VAR_061914
	Natural variant	186	1	W → R. Ref.1 Ref.2 Corresponds to variant rs2291219 [ dbSNP | Ensembl ].		VAR_042961

Sequences

	Sequence		Length	Mass (Da)
	Q8IVN8 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 1A8406EC6BDC8A41	FASTA	264	29,610
	10 20 30 40 50 60 MRTLWMALCA LSRLWPGAQA GCAEAGRCCP GRDPACFARG WRLDRVYGTC FCDQACRFTG 70 80 90 100 110 120 DCCFDYDRAC PARPCFVGEW SPWSGCADQC KPTTRVRRRS VQQEPQNGGA PCPPLEERAG 130 140 150 160 170 180 CLEYSTPQGQ DCGHTYVPAF ITTSAFNKER TRQATSPHWS THTEDAGYCM EFKTESLTPH 190 200 210 220 230 240 CALENWPLTR WMQYLREGYT VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL HWQAIGNPRC 250 260 QGTWKKVRRV DQCSCPAVHS FIFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants." Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K. Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-58 AND ARG-186. Tissue: Eye.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-186. Tissue: Trachea.
[3]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Proteomics characterization of extracellular space components in the human aorta." Didangelos A., Yin X., Mandal K., Baumert M., Jahangiri M., Mayr M. Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY040546 mRNA. Translation: AAK83466.1. Different initiation. AK292970 mRNA. Translation: BAF85659.1. Different initiation. AC022893 Genomic DNA. No translation available. AC100823 Genomic DNA. No translation available. BC042877 mRNA. Translation: AAH42877.1. Different initiation.
IPI	IPI00063877.
RefSeq	NP_694957.3. NM_153225.3.
UniGene	Hs.439040.
3D structure databases
ProteinModelPortal	Q8IVN8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000297354.
Polymorphism databases
DMDM	187611420.
Proteomic databases
PaxDb	Q8IVN8.
PRIDE	Q8IVN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297354; ENSP00000297354; ENSG00000164764.
GeneID	157869.
KEGG	hsa:157869.
UCSC	uc003xzf.3. human.
Organism-specific databases
CTD	157869.
GeneCards	GC08M073977.
H-InvDB	HIX0020800.
HGNC	HGNC:30362. SBSPON.
HPA	CAB034214. CAB034332. HPA029595.
neXtProt	NX_Q8IVN8.
PharmGKB	PA164717487.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG14004.
HOGENOM	HOG000006768.
HOVERGEN	HBG108417.
InParanoid	Q8IVN8.
OMA	DRVYGTC.
OrthoDB	EOG4SJ5F9.
Gene expression databases
Bgee	Q8IVN8.
Genevestigator	Q8IVN8.
Family and domain databases
InterPro	IPR001212. Somatomedin_B_dom. IPR000884. Thrombospondin_1_rpt. [Graphical view]
SMART	SM00209. TSP1. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS00524. SMB_1. 1 hit. PS50958. SMB_2. 1 hit. PS50092. TSP1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	157869.
NextBio	87571.

Entry information

Entry name

SBSPO_HUMAN

Accession

Primary (citable) accession number: Q8IVN8
Secondary accession number(s): A8KAA5, Q96J64

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.