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Q8IVM8

- S22A9_HUMAN

UniProt

Q8IVM8 - S22A9_HUMAN

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Protein

Solute carrier family 22 member 9

Gene

SLC22A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.1 Publication

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB
  2. short-chain fatty acid uptake transporter activity Source: UniProtKB
  3. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. hormone transport Source: UniProtKB
  2. short-chain fatty acid import Source: UniProtKB
  3. sodium-independent organic anion transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.19.18. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 9
Alternative name(s):
Organic anion transporter 7
Gene namesi
Name:SLC22A9
Synonyms:hOAT4, OAT7, UST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16261. SLC22A9.

Subcellular locationi

Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Enriched at the sinusoidal part of the plasma membrane.

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 22 member 9PRO_0000233715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IVM8.
PRIDEiQ8IVM8.

Expressioni

Tissue specificityi

Specifically expressed in liver by hepatocytes (at protein level).2 Publications

Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

BgeeiQ8IVM8.
CleanExiHS_SLC22A9.
ExpressionAtlasiQ8IVM8. baseline and differential.
GenevestigatoriQ8IVM8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000279178.

Structurei

3D structure databases

ProteinModelPortaliQ8IVM8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini37 – 143107ExtracellularSequence AnalysisAdd
BLAST
Topological domaini165 – 17713CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini199 – 2035ExtracellularSequence Analysis
Topological domaini225 – 2339CytoplasmicSequence Analysis
Topological domaini255 – 2595ExtracellularSequence Analysis
Topological domaini281 – 35070CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini370 – 3789ExtracellularSequence Analysis
Topological domaini400 – 4078CytoplasmicSequence Analysis
Topological domaini429 – 4368ExtracellularSequence Analysis
Topological domaini458 – 46912CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini491 – 4955ExtracellularSequence Analysis
Topological domaini517 – 55337CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei351 – 36919HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence AnalysisAdd
BLAST
Transmembranei437 – 45721HelicalSequence AnalysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence AnalysisAdd
BLAST
Transmembranei496 – 51621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238692.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ8IVM8.
KOiK08206.
OMAiLVCDSQS.
OrthoDBiEOG7J70FK.
PhylomeDBiQ8IVM8.
TreeFamiTF315847.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVM8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW
60 70 80 90 100
VHILDNDTVS DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH
110 120 130 140 150
LNGTFPNTSD ADMEPCVDGW VYDRISFSST IVTEWDLVCD SQSLTSVAKF
160 170 180 190 200
VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY LQVAIVGTCA ALAPTFLIYC
210 220 230 240 250
SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP SGIAFMTLAG
260 270 280 290 300
LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR
310 320 330 340 350
KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR
360 370 380 390 400
ISLLSFTRFA NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA
410 420 430 440 450
LKYMNRRASQ MLLMFLLAIC LLAIIFVPQE MQTLREVLAT LGLGASALAN
460 470 480 490 500
TLAFAHGNEV IPTIIRARAM GINATFANIA GALAPLMMIL SVYSPPLPWI
510 520 530 540 550
IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE PKQEDPRVEV

TQF
Length:553
Mass (Da):62,169
Last modified:March 1, 2003 - v1
Checksum:iFE0A1B725FCB7617
GO
Isoform 2 (identifier: Q8IVM8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-346: RFGRRFVLRW...SLCEMLHMPN → SSRVGNTQIP...RVCSVAHYQQ
     347-553: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:238
Mass (Da):26,523
Checksum:i490097B28CC4169E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti518 – 5181E → G in BAB83517. 1 PublicationCurated
Sequence conflicti535 – 5351Missing in BAB85030. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti393 – 3931A → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036403
Natural varianti487 – 4871M → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036404
Natural varianti521 – 5211N → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036405

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei169 – 346178RFGRR…LHMPN → SSRVGNTQIPGHGNYIGNVP FWYCIYDPGRPGFCHSRLAY PPAGGVCTILCDLSDLKLAA RVCSVAHYQQ in isoform 2. 1 PublicationVSP_036710Add
BLAST
Alternative sequencei347 – 553207Missing in isoform 2. 1 PublicationVSP_036711Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB074812 mRNA. Translation: BAF51552.1.
AJ295270 mRNA. Translation: CAC82910.1.
AB062418 mRNA. Translation: BAB83517.1.
AF440402 mRNA. Translation: AAP97316.1.
AK074246 mRNA. Translation: BAB85030.1.
AP001880 Genomic DNA. No translation available.
AP000484 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74146.1.
CH471076 Genomic DNA. Translation: EAW74148.1.
BC022379 mRNA. Translation: AAH22379.1.
BC126288 mRNA. Translation: AAI26289.1.
CCDSiCCDS8043.1. [Q8IVM8-1]
RefSeqiNP_543142.2. NM_080866.2. [Q8IVM8-1]
UniGeneiHs.502772.

Genome annotation databases

EnsembliENST00000279178; ENSP00000279178; ENSG00000149742. [Q8IVM8-1]
ENST00000536333; ENSP00000440206; ENSG00000149742. [Q8IVM8-2]
GeneIDi114571.
KEGGihsa:114571.
UCSCiuc001nww.3. human. [Q8IVM8-1]

Polymorphism databases

DMDMi74723638.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB074812 mRNA. Translation: BAF51552.1 .
AJ295270 mRNA. Translation: CAC82910.1 .
AB062418 mRNA. Translation: BAB83517.1 .
AF440402 mRNA. Translation: AAP97316.1 .
AK074246 mRNA. Translation: BAB85030.1 .
AP001880 Genomic DNA. No translation available.
AP000484 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74146.1 .
CH471076 Genomic DNA. Translation: EAW74148.1 .
BC022379 mRNA. Translation: AAH22379.1 .
BC126288 mRNA. Translation: AAI26289.1 .
CCDSi CCDS8043.1. [Q8IVM8-1 ]
RefSeqi NP_543142.2. NM_080866.2. [Q8IVM8-1 ]
UniGenei Hs.502772.

3D structure databases

ProteinModelPortali Q8IVM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000279178.

Chemistry

ChEMBLi CHEMBL2073721.

Protein family/group databases

TCDBi 2.A.1.19.18. the major facilitator superfamily (mfs).

Polymorphism databases

DMDMi 74723638.

Proteomic databases

PaxDbi Q8IVM8.
PRIDEi Q8IVM8.

Protocols and materials databases

DNASUi 114571.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000279178 ; ENSP00000279178 ; ENSG00000149742 . [Q8IVM8-1 ]
ENST00000536333 ; ENSP00000440206 ; ENSG00000149742 . [Q8IVM8-2 ]
GeneIDi 114571.
KEGGi hsa:114571.
UCSCi uc001nww.3. human. [Q8IVM8-1 ]

Organism-specific databases

CTDi 114571.
GeneCardsi GC11P063137.
HGNCi HGNC:16261. SLC22A9.
MIMi 607579. gene.
neXtProti NX_Q8IVM8.
PharmGKBi PA38102.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238692.
GeneTreei ENSGT00760000118852.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q8IVM8.
KOi K08206.
OMAi LVCDSQS.
OrthoDBi EOG7J70FK.
PhylomeDBi Q8IVM8.
TreeFami TF315847.

Miscellaneous databases

GeneWikii SLC22A9.
GenomeRNAii 114571.
NextBioi 79092.
PROi Q8IVM8.
SOURCEi Search...

Gene expression databases

Bgeei Q8IVM8.
CleanExi HS_SLC22A9.
ExpressionAtlasi Q8IVM8. baseline and differential.
Genevestigatori Q8IVM8.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate."
    Shin H.J., Anzai N., Enomoto A., He X., Kim do K., Endou H., Kanai Y.
    Hepatology 45:1046-1055(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Liver.
  2. "Putative integral membrane transport protein UST3H."
    Engel K., Gruendemann D., Schoemig E.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "Isolation of novel clone of amphiphilic solute facilitator family from human fetal liver."
    Takanaga H., Ohtsuki S., Hosoya K., Terasaki T.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal liver.
  4. Guo J.H., Yu L.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Liver.
  9. "Isolation of a family of organic anion transporters from human liver and kidney."
    Sun W., Wu R.R., van Poelje P.D., Erion M.D.
    Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  10. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-393; VAL-487 AND LYS-521.

Entry informationi

Entry nameiS22A9_HUMAN
AccessioniPrimary (citable) accession number: Q8IVM8
Secondary accession number(s): A0AVB7
, A4PB24, Q8TCC8, Q8TEC0, Q8WYN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3