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Q8IVM8 (S22A9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 9
Alternative name(s):
Organic anion transporter 4
Gene names
Name:SLC22A9
Synonyms:OAT4, UST3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Detected in liver. Ref.8

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IVM8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IVM8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     169-346: RFGRRFVLRW...SLCEMLHMPN → SSRVGNTQIP...RVCSVAHYQQ
     347-553: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Solute carrier family 22 member 9
PRO_0000233715

Regions

Topological domain1 – 1515Cytoplasmic Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 143107Extracellular Potential
Transmembrane144 – 16421Helical; Potential
Topological domain165 – 17713Cytoplasmic Potential
Transmembrane178 – 19821Helical; Potential
Topological domain199 – 2035Extracellular Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 2339Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 2595Extracellular Potential
Transmembrane260 – 28021Helical; Potential
Topological domain281 – 35070Cytoplasmic Potential
Transmembrane351 – 36919Helical; Potential
Topological domain370 – 3789Extracellular Potential
Transmembrane379 – 39921Helical; Potential
Topological domain400 – 4078Cytoplasmic Potential
Transmembrane408 – 42821Helical; Potential
Topological domain429 – 4368Extracellular Potential
Transmembrane437 – 45721Helical; Potential
Topological domain458 – 46912Cytoplasmic Potential
Transmembrane470 – 49021Helical; Potential
Topological domain491 – 4955Extracellular Potential
Transmembrane496 – 51621Helical; Potential
Topological domain517 – 55337Cytoplasmic Potential

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence169 – 346178RFGRR…LHMPN → SSRVGNTQIPGHGNYIGNVP FWYCIYDPGRPGFCHSRLAY PPAGGVCTILCDLSDLKLAA RVCSVAHYQQ in isoform 2.
VSP_036710
Alternative sequence347 – 553207Missing in isoform 2.
VSP_036711
Natural variant3931A → V in a breast cancer sample; somatic mutation. Ref.9
VAR_036403
Natural variant4871M → V in a breast cancer sample; somatic mutation. Ref.9
VAR_036404
Natural variant5211N → K in a colorectal cancer sample; somatic mutation. Ref.9
VAR_036405

Experimental info

Sequence conflict5181E → G in BAB83517. Ref.2
Sequence conflict5351Missing in BAB85030. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: FE0A1B725FCB7617

FASTA55362,169
        10         20         30         40         50         60 
MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW VHILDNDTVS 

        70         80         90        100        110        120 
DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH LNGTFPNTSD ADMEPCVDGW 

       130        140        150        160        170        180 
VYDRISFSST IVTEWDLVCD SQSLTSVAKF VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY 

       190        200        210        220        230        240 
LQVAIVGTCA ALAPTFLIYC SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP 

       250        260        270        280        290        300 
SGIAFMTLAG LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR 

       310        320        330        340        350        360 
KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR ISLLSFTRFA 

       370        380        390        400        410        420 
NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA LKYMNRRASQ MLLMFLLAIC 

       430        440        450        460        470        480 
LLAIIFVPQE MQTLREVLAT LGLGASALAN TLAFAHGNEV IPTIIRARAM GINATFANIA 

       490        500        510        520        530        540 
GALAPLMMIL SVYSPPLPWI IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE 

       550 
PKQEDPRVEV TQF 

« Hide

Isoform 2 [UniParc].

Checksum: 490097B28CC4169E
Show »

FASTA23826,523

References

« Hide 'large scale' references
[1]"Putative integral membrane transport protein UST3H."
Engel K., Gruendemann D., Schoemig E.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Kidney.
[2]"Isolation of novel clone of amphiphilic solute facilitator family from human fetal liver."
Takanaga H., Ohtsuki S., Hosoya K., Terasaki T.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal liver.
[3]Guo J.H., Yu L.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hepatoma.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Liver.
[8]"Isolation of a family of organic anion transporters from human liver and kidney."
Sun W., Wu R.R., van Poelje P.D., Erion M.D.
Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[9]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-393; VAL-487 AND LYS-521.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ295270 mRNA. Translation: CAC82910.1.
AB062418 mRNA. Translation: BAB83517.1.
AF440402 mRNA. Translation: AAP97316.1.
AK074246 mRNA. Translation: BAB85030.1.
AP001880 Genomic DNA. No translation available.
AP000484 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74148.1.
BC022379 mRNA. Translation: AAH22379.1.
BC126288 mRNA. Translation: AAI26289.1.
CCDSCCDS8043.1. [Q8IVM8-1]
RefSeqNP_543142.2. NM_080866.2. [Q8IVM8-1]
UniGeneHs.502772.

3D structure databases

ProteinModelPortalQ8IVM8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000279178.

Chemistry

ChEMBLCHEMBL2073721.

Protein family/group databases

TCDB2.A.1.19.18. the major facilitator superfamily (mfs).

Polymorphism databases

DMDM74723638.

Proteomic databases

PaxDbQ8IVM8.
PRIDEQ8IVM8.

Protocols and materials databases

DNASU114571.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000279178; ENSP00000279178; ENSG00000149742. [Q8IVM8-1]
ENST00000310969; ENSP00000311527; ENSG00000149742. [Q8IVM8-2]
ENST00000536333; ENSP00000440206; ENSG00000149742. [Q8IVM8-2]
GeneID114571.
KEGGhsa:114571.
UCSCuc001nww.3. human. [Q8IVM8-1]

Organism-specific databases

CTD114571.
GeneCardsGC11P063137.
HGNCHGNC:16261. SLC22A9.
MIM607579. gene.
neXtProtNX_Q8IVM8.
PharmGKBPA38102.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238692.
HOGENOMHOG000234569.
HOVERGENHBG108433.
InParanoidQ8IVM8.
KOK08206.
OMALVCDSQS.
OrthoDBEOG7J70FK.
PhylomeDBQ8IVM8.
TreeFamTF315847.

Gene expression databases

ArrayExpressQ8IVM8.
BgeeQ8IVM8.
CleanExHS_SLC22A9.
GenevestigatorQ8IVM8.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC22A9.
GenomeRNAi114571.
NextBio79092.
PROQ8IVM8.
SOURCESearch...

Entry information

Entry nameS22A9_HUMAN
AccessionPrimary (citable) accession number: Q8IVM8
Secondary accession number(s): A0AVB7 expand/collapse secondary AC list , Q8TCC8, Q8TEC0, Q8WYN7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM