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Q8IVM8

- S22A9_HUMAN

UniProt

Q8IVM8 - S22A9_HUMAN

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Protein
Solute carrier family 22 member 9
Gene
SLC22A9, OAT4, UST3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.19.18. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 9
Alternative name(s):
Organic anion transporter 4
Gene namesi
Name:SLC22A9
Synonyms:OAT4, UST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16261. SLC22A9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Topological domaini37 – 143107Extracellular Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Topological domaini165 – 17713Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei178 – 19821Helical; Reviewed prediction
Add
BLAST
Topological domaini199 – 2035Extracellular Reviewed prediction
Transmembranei204 – 22421Helical; Reviewed prediction
Add
BLAST
Topological domaini225 – 2339Cytoplasmic Reviewed prediction
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Topological domaini255 – 2595Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Reviewed prediction
Add
BLAST
Topological domaini281 – 35070Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei351 – 36919Helical; Reviewed prediction
Add
BLAST
Topological domaini370 – 3789Extracellular Reviewed prediction
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Topological domaini400 – 4078Cytoplasmic Reviewed prediction
Transmembranei408 – 42821Helical; Reviewed prediction
Add
BLAST
Topological domaini429 – 4368Extracellular Reviewed prediction
Transmembranei437 – 45721Helical; Reviewed prediction
Add
BLAST
Topological domaini458 – 46912Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei470 – 49021Helical; Reviewed prediction
Add
BLAST
Topological domaini491 – 4955Extracellular Reviewed prediction
Transmembranei496 – 51621Helical; Reviewed prediction
Add
BLAST
Topological domaini517 – 55337Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 22 member 9
PRO_0000233715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IVM8.
PRIDEiQ8IVM8.

Expressioni

Tissue specificityi

Detected in liver.1 Publication

Gene expression databases

ArrayExpressiQ8IVM8.
BgeeiQ8IVM8.
CleanExiHS_SLC22A9.
GenevestigatoriQ8IVM8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000279178.

Structurei

3D structure databases

ProteinModelPortaliQ8IVM8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238692.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ8IVM8.
KOiK08206.
OMAiLVCDSQS.
OrthoDBiEOG7J70FK.
PhylomeDBiQ8IVM8.
TreeFamiTF315847.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVM8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW    50
VHILDNDTVS DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH 100
LNGTFPNTSD ADMEPCVDGW VYDRISFSST IVTEWDLVCD SQSLTSVAKF 150
VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY LQVAIVGTCA ALAPTFLIYC 200
SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP SGIAFMTLAG 250
LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR 300
KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR 350
ISLLSFTRFA NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA 400
LKYMNRRASQ MLLMFLLAIC LLAIIFVPQE MQTLREVLAT LGLGASALAN 450
TLAFAHGNEV IPTIIRARAM GINATFANIA GALAPLMMIL SVYSPPLPWI 500
IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE PKQEDPRVEV 550
TQF 553
Length:553
Mass (Da):62,169
Last modified:March 1, 2003 - v1
Checksum:iFE0A1B725FCB7617
GO
Isoform 2 (identifier: Q8IVM8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-346: RFGRRFVLRW...SLCEMLHMPN → SSRVGNTQIP...RVCSVAHYQQ
     347-553: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:238
Mass (Da):26,523
Checksum:i490097B28CC4169E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti393 – 3931A → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036403
Natural varianti487 – 4871M → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036404
Natural varianti521 – 5211N → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036405

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei169 – 346178RFGRR…LHMPN → SSRVGNTQIPGHGNYIGNVP FWYCIYDPGRPGFCHSRLAY PPAGGVCTILCDLSDLKLAA RVCSVAHYQQ in isoform 2.
VSP_036710Add
BLAST
Alternative sequencei347 – 553207Missing in isoform 2.
VSP_036711Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti518 – 5181E → G in BAB83517. 1 Publication
Sequence conflicti535 – 5351Missing in BAB85030. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ295270 mRNA. Translation: CAC82910.1.
AB062418 mRNA. Translation: BAB83517.1.
AF440402 mRNA. Translation: AAP97316.1.
AK074246 mRNA. Translation: BAB85030.1.
AP001880 Genomic DNA. No translation available.
AP000484 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74148.1.
BC022379 mRNA. Translation: AAH22379.1.
BC126288 mRNA. Translation: AAI26289.1.
CCDSiCCDS8043.1. [Q8IVM8-1]
RefSeqiNP_543142.2. NM_080866.2. [Q8IVM8-1]
UniGeneiHs.502772.

Genome annotation databases

EnsembliENST00000279178; ENSP00000279178; ENSG00000149742. [Q8IVM8-1]
ENST00000310969; ENSP00000311527; ENSG00000149742. [Q8IVM8-2]
ENST00000536333; ENSP00000440206; ENSG00000149742. [Q8IVM8-2]
GeneIDi114571.
KEGGihsa:114571.
UCSCiuc001nww.3. human. [Q8IVM8-1]

Polymorphism databases

DMDMi74723638.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ295270 mRNA. Translation: CAC82910.1 .
AB062418 mRNA. Translation: BAB83517.1 .
AF440402 mRNA. Translation: AAP97316.1 .
AK074246 mRNA. Translation: BAB85030.1 .
AP001880 Genomic DNA. No translation available.
AP000484 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74148.1 .
BC022379 mRNA. Translation: AAH22379.1 .
BC126288 mRNA. Translation: AAI26289.1 .
CCDSi CCDS8043.1. [Q8IVM8-1 ]
RefSeqi NP_543142.2. NM_080866.2. [Q8IVM8-1 ]
UniGenei Hs.502772.

3D structure databases

ProteinModelPortali Q8IVM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000279178.

Chemistry

ChEMBLi CHEMBL2073721.

Protein family/group databases

TCDBi 2.A.1.19.18. the major facilitator superfamily (mfs).

Polymorphism databases

DMDMi 74723638.

Proteomic databases

PaxDbi Q8IVM8.
PRIDEi Q8IVM8.

Protocols and materials databases

DNASUi 114571.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000279178 ; ENSP00000279178 ; ENSG00000149742 . [Q8IVM8-1 ]
ENST00000310969 ; ENSP00000311527 ; ENSG00000149742 . [Q8IVM8-2 ]
ENST00000536333 ; ENSP00000440206 ; ENSG00000149742 . [Q8IVM8-2 ]
GeneIDi 114571.
KEGGi hsa:114571.
UCSCi uc001nww.3. human. [Q8IVM8-1 ]

Organism-specific databases

CTDi 114571.
GeneCardsi GC11P063137.
HGNCi HGNC:16261. SLC22A9.
MIMi 607579. gene.
neXtProti NX_Q8IVM8.
PharmGKBi PA38102.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238692.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q8IVM8.
KOi K08206.
OMAi LVCDSQS.
OrthoDBi EOG7J70FK.
PhylomeDBi Q8IVM8.
TreeFami TF315847.

Miscellaneous databases

GeneWikii SLC22A9.
GenomeRNAii 114571.
NextBioi 79092.
PROi Q8IVM8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IVM8.
Bgeei Q8IVM8.
CleanExi HS_SLC22A9.
Genevestigatori Q8IVM8.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Putative integral membrane transport protein UST3H."
    Engel K., Gruendemann D., Schoemig E.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "Isolation of novel clone of amphiphilic solute facilitator family from human fetal liver."
    Takanaga H., Ohtsuki S., Hosoya K., Terasaki T.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal liver.
  3. Guo J.H., Yu L.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Liver.
  8. "Isolation of a family of organic anion transporters from human liver and kidney."
    Sun W., Wu R.R., van Poelje P.D., Erion M.D.
    Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-393; VAL-487 AND LYS-521.

Entry informationi

Entry nameiS22A9_HUMAN
AccessioniPrimary (citable) accession number: Q8IVM8
Secondary accession number(s): A0AVB7
, Q8TCC8, Q8TEC0, Q8WYN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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