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Protein

Solute carrier family 22 member 9

Gene

SLC22A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.1 Publication

GO - Molecular functioni

  • anion:anion antiporter activity Source: UniProtKB
  • inorganic anion exchanger activity Source: GO_Central
  • short-chain fatty acid uptake transporter activity Source: UniProtKB
  • sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • hormone transport Source: UniProtKB
  • short-chain fatty acid import Source: UniProtKB
  • sodium-independent organic anion transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.19.18. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 9
Alternative name(s):
Organic anion transporter 7
Gene namesi
Name:SLC22A9
Synonyms:hOAT4, OAT7, UST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:16261. SLC22A9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 143ExtracellularSequence analysisAdd BLAST107
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 177CytoplasmicSequence analysisAdd BLAST13
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 203ExtracellularSequence analysis5
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 233CytoplasmicSequence analysis9
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 259ExtracellularSequence analysis5
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 350CytoplasmicSequence analysisAdd BLAST70
Transmembranei351 – 369HelicalSequence analysisAdd BLAST19
Topological domaini370 – 378ExtracellularSequence analysis9
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 407CytoplasmicSequence analysis8
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Topological domaini429 – 436ExtracellularSequence analysis8
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 469CytoplasmicSequence analysisAdd BLAST12
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 495ExtracellularSequence analysis5
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 553CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • basolateral plasma membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114571.
OpenTargetsiENSG00000149742.
PharmGKBiPA38102.

Chemistry databases

ChEMBLiCHEMBL2073721.

Polymorphism and mutation databases

BioMutaiSLC22A9.
DMDMi74723638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337151 – 553Solute carrier family 22 member 9Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IVM8.
PeptideAtlasiQ8IVM8.
PRIDEiQ8IVM8.

PTM databases

PhosphoSitePlusiQ8IVM8.

Expressioni

Tissue specificityi

Specifically expressed in liver by hepatocytes (at protein level).2 Publications

Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000149742.
CleanExiHS_SLC22A9.
GenevisibleiQ8IVM8. HS.

Interactioni

Protein-protein interaction databases

BioGridi125322. 65 interactors.
STRINGi9606.ENSP00000279178.

Structurei

3D structure databases

ProteinModelPortaliQ8IVM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ8IVM8.
KOiK08206.
OMAiCKRISLL.
OrthoDBiEOG091G04GS.
PhylomeDBiQ8IVM8.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW
60 70 80 90 100
VHILDNDTVS DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH
110 120 130 140 150
LNGTFPNTSD ADMEPCVDGW VYDRISFSST IVTEWDLVCD SQSLTSVAKF
160 170 180 190 200
VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY LQVAIVGTCA ALAPTFLIYC
210 220 230 240 250
SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP SGIAFMTLAG
260 270 280 290 300
LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR
310 320 330 340 350
KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR
360 370 380 390 400
ISLLSFTRFA NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA
410 420 430 440 450
LKYMNRRASQ MLLMFLLAIC LLAIIFVPQE MQTLREVLAT LGLGASALAN
460 470 480 490 500
TLAFAHGNEV IPTIIRARAM GINATFANIA GALAPLMMIL SVYSPPLPWI
510 520 530 540 550
IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE PKQEDPRVEV

TQF
Length:553
Mass (Da):62,169
Last modified:March 1, 2003 - v1
Checksum:iFE0A1B725FCB7617
GO
Isoform 2 (identifier: Q8IVM8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-346: RFGRRFVLRW...SLCEMLHMPN → SSRVGNTQIP...RVCSVAHYQQ
     347-553: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:238
Mass (Da):26,523
Checksum:i490097B28CC4169E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti518E → G in BAB83517 (Ref. 3) Curated1
Sequence conflicti535Missing in BAB85030 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036403393A → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036404487M → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036405521N → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs770073076dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036710169 – 346RFGRR…LHMPN → SSRVGNTQIPGHGNYIGNVP FWYCIYDPGRPGFCHSRLAY PPAGGVCTILCDLSDLKLAA RVCSVAHYQQ in isoform 2. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_036711347 – 553Missing in isoform 2. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074812 mRNA. Translation: BAF51552.1.
AJ295270 mRNA. Translation: CAC82910.1.
AB062418 mRNA. Translation: BAB83517.1.
AF440402 mRNA. Translation: AAP97316.1.
AK074246 mRNA. Translation: BAB85030.1.
AP001880 Genomic DNA. No translation available.
AP000484 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74146.1.
CH471076 Genomic DNA. Translation: EAW74148.1.
BC022379 mRNA. Translation: AAH22379.1.
BC126288 mRNA. Translation: AAI26289.1.
CCDSiCCDS8043.1. [Q8IVM8-1]
RefSeqiNP_543142.2. NM_080866.2. [Q8IVM8-1]
UniGeneiHs.502772.

Genome annotation databases

EnsembliENST00000279178; ENSP00000279178; ENSG00000149742. [Q8IVM8-1]
ENST00000536333; ENSP00000440206; ENSG00000149742. [Q8IVM8-2]
GeneIDi114571.
KEGGihsa:114571.
UCSCiuc001nww.4. human. [Q8IVM8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074812 mRNA. Translation: BAF51552.1.
AJ295270 mRNA. Translation: CAC82910.1.
AB062418 mRNA. Translation: BAB83517.1.
AF440402 mRNA. Translation: AAP97316.1.
AK074246 mRNA. Translation: BAB85030.1.
AP001880 Genomic DNA. No translation available.
AP000484 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74146.1.
CH471076 Genomic DNA. Translation: EAW74148.1.
BC022379 mRNA. Translation: AAH22379.1.
BC126288 mRNA. Translation: AAI26289.1.
CCDSiCCDS8043.1. [Q8IVM8-1]
RefSeqiNP_543142.2. NM_080866.2. [Q8IVM8-1]
UniGeneiHs.502772.

3D structure databases

ProteinModelPortaliQ8IVM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125322. 65 interactors.
STRINGi9606.ENSP00000279178.

Chemistry databases

ChEMBLiCHEMBL2073721.

Protein family/group databases

TCDBi2.A.1.19.18. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitePlusiQ8IVM8.

Polymorphism and mutation databases

BioMutaiSLC22A9.
DMDMi74723638.

Proteomic databases

PaxDbiQ8IVM8.
PeptideAtlasiQ8IVM8.
PRIDEiQ8IVM8.

Protocols and materials databases

DNASUi114571.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279178; ENSP00000279178; ENSG00000149742. [Q8IVM8-1]
ENST00000536333; ENSP00000440206; ENSG00000149742. [Q8IVM8-2]
GeneIDi114571.
KEGGihsa:114571.
UCSCiuc001nww.4. human. [Q8IVM8-1]

Organism-specific databases

CTDi114571.
DisGeNETi114571.
GeneCardsiSLC22A9.
HGNCiHGNC:16261. SLC22A9.
MIMi607579. gene.
neXtProtiNX_Q8IVM8.
OpenTargetsiENSG00000149742.
PharmGKBiPA38102.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ8IVM8.
KOiK08206.
OMAiCKRISLL.
OrthoDBiEOG091G04GS.
PhylomeDBiQ8IVM8.
TreeFamiTF315847.

Miscellaneous databases

GeneWikiiSLC22A9.
GenomeRNAii114571.
PROiQ8IVM8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149742.
CleanExiHS_SLC22A9.
GenevisibleiQ8IVM8. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22A9_HUMAN
AccessioniPrimary (citable) accession number: Q8IVM8
Secondary accession number(s): A0AVB7
, A4PB24, Q8TCC8, Q8TEC0, Q8WYN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.