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Q8IVM8

- S22A9_HUMAN

UniProt

Q8IVM8 - S22A9_HUMAN

Protein

Solute carrier family 22 member 9

Gene

SLC22A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.1 Publication

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: UniProtKB
    2. short-chain fatty acid uptake transporter activity Source: UniProtKB
    3. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. hormone transport Source: UniProtKB
    2. short-chain fatty acid import Source: UniProtKB
    3. sodium-independent organic anion transport Source: UniProtKB

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.1.19.18. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 9
    Alternative name(s):
    Organic anion transporter 7
    Gene namesi
    Name:SLC22A9
    Synonyms:hOAT4, OAT7, UST3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16261. SLC22A9.

    Subcellular locationi

    Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Enriched at the sinusoidal part of the plasma membrane.

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Solute carrier family 22 member 9PRO_0000233715Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8IVM8.
    PRIDEiQ8IVM8.

    Expressioni

    Tissue specificityi

    Specifically expressed in liver by hepatocytes (at protein level).2 Publications

    Developmental stagei

    Expressed in fetal liver.1 Publication

    Gene expression databases

    ArrayExpressiQ8IVM8.
    BgeeiQ8IVM8.
    CleanExiHS_SLC22A9.
    GenevestigatoriQ8IVM8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000279178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IVM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 143107ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini165 – 17713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini199 – 2035ExtracellularSequence Analysis
    Topological domaini225 – 2339CytoplasmicSequence Analysis
    Topological domaini255 – 2595ExtracellularSequence Analysis
    Topological domaini281 – 35070CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini370 – 3789ExtracellularSequence Analysis
    Topological domaini400 – 4078CytoplasmicSequence Analysis
    Topological domaini429 – 4368ExtracellularSequence Analysis
    Topological domaini458 – 46912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini491 – 4955ExtracellularSequence Analysis
    Topological domaini517 – 55337CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 36919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei496 – 51621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238692.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ8IVM8.
    KOiK08206.
    OMAiLVCDSQS.
    OrthoDBiEOG7J70FK.
    PhylomeDBiQ8IVM8.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IVM8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW    50
    VHILDNDTVS DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH 100
    LNGTFPNTSD ADMEPCVDGW VYDRISFSST IVTEWDLVCD SQSLTSVAKF 150
    VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY LQVAIVGTCA ALAPTFLIYC 200
    SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP SGIAFMTLAG 250
    LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR 300
    KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR 350
    ISLLSFTRFA NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA 400
    LKYMNRRASQ MLLMFLLAIC LLAIIFVPQE MQTLREVLAT LGLGASALAN 450
    TLAFAHGNEV IPTIIRARAM GINATFANIA GALAPLMMIL SVYSPPLPWI 500
    IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE PKQEDPRVEV 550
    TQF 553
    Length:553
    Mass (Da):62,169
    Last modified:March 1, 2003 - v1
    Checksum:iFE0A1B725FCB7617
    GO
    Isoform 2 (identifier: Q8IVM8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         169-346: RFGRRFVLRW...SLCEMLHMPN → SSRVGNTQIP...RVCSVAHYQQ
         347-553: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:238
    Mass (Da):26,523
    Checksum:i490097B28CC4169E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti518 – 5181E → G in BAB83517. 1 PublicationCurated
    Sequence conflicti535 – 5351Missing in BAB85030. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti393 – 3931A → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036403
    Natural varianti487 – 4871M → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036404
    Natural varianti521 – 5211N → K in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036405

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei169 – 346178RFGRR…LHMPN → SSRVGNTQIPGHGNYIGNVP FWYCIYDPGRPGFCHSRLAY PPAGGVCTILCDLSDLKLAA RVCSVAHYQQ in isoform 2. 1 PublicationVSP_036710Add
    BLAST
    Alternative sequencei347 – 553207Missing in isoform 2. 1 PublicationVSP_036711Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB074812 mRNA. Translation: BAF51552.1.
    AJ295270 mRNA. Translation: CAC82910.1.
    AB062418 mRNA. Translation: BAB83517.1.
    AF440402 mRNA. Translation: AAP97316.1.
    AK074246 mRNA. Translation: BAB85030.1.
    AP001880 Genomic DNA. No translation available.
    AP000484 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74146.1.
    CH471076 Genomic DNA. Translation: EAW74148.1.
    BC022379 mRNA. Translation: AAH22379.1.
    BC126288 mRNA. Translation: AAI26289.1.
    CCDSiCCDS8043.1. [Q8IVM8-1]
    RefSeqiNP_543142.2. NM_080866.2. [Q8IVM8-1]
    UniGeneiHs.502772.

    Genome annotation databases

    EnsembliENST00000279178; ENSP00000279178; ENSG00000149742. [Q8IVM8-1]
    ENST00000536333; ENSP00000440206; ENSG00000149742. [Q8IVM8-2]
    GeneIDi114571.
    KEGGihsa:114571.
    UCSCiuc001nww.3. human. [Q8IVM8-1]

    Polymorphism databases

    DMDMi74723638.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB074812 mRNA. Translation: BAF51552.1 .
    AJ295270 mRNA. Translation: CAC82910.1 .
    AB062418 mRNA. Translation: BAB83517.1 .
    AF440402 mRNA. Translation: AAP97316.1 .
    AK074246 mRNA. Translation: BAB85030.1 .
    AP001880 Genomic DNA. No translation available.
    AP000484 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74146.1 .
    CH471076 Genomic DNA. Translation: EAW74148.1 .
    BC022379 mRNA. Translation: AAH22379.1 .
    BC126288 mRNA. Translation: AAI26289.1 .
    CCDSi CCDS8043.1. [Q8IVM8-1 ]
    RefSeqi NP_543142.2. NM_080866.2. [Q8IVM8-1 ]
    UniGenei Hs.502772.

    3D structure databases

    ProteinModelPortali Q8IVM8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000279178.

    Chemistry

    ChEMBLi CHEMBL2073721.

    Protein family/group databases

    TCDBi 2.A.1.19.18. the major facilitator superfamily (mfs).

    Polymorphism databases

    DMDMi 74723638.

    Proteomic databases

    PaxDbi Q8IVM8.
    PRIDEi Q8IVM8.

    Protocols and materials databases

    DNASUi 114571.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279178 ; ENSP00000279178 ; ENSG00000149742 . [Q8IVM8-1 ]
    ENST00000536333 ; ENSP00000440206 ; ENSG00000149742 . [Q8IVM8-2 ]
    GeneIDi 114571.
    KEGGi hsa:114571.
    UCSCi uc001nww.3. human. [Q8IVM8-1 ]

    Organism-specific databases

    CTDi 114571.
    GeneCardsi GC11P063137.
    HGNCi HGNC:16261. SLC22A9.
    MIMi 607579. gene.
    neXtProti NX_Q8IVM8.
    PharmGKBi PA38102.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238692.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q8IVM8.
    KOi K08206.
    OMAi LVCDSQS.
    OrthoDBi EOG7J70FK.
    PhylomeDBi Q8IVM8.
    TreeFami TF315847.

    Miscellaneous databases

    GeneWikii SLC22A9.
    GenomeRNAii 114571.
    NextBioi 79092.
    PROi Q8IVM8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVM8.
    Bgeei Q8IVM8.
    CleanExi HS_SLC22A9.
    Genevestigatori Q8IVM8.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate."
      Shin H.J., Anzai N., Enomoto A., He X., Kim do K., Endou H., Kanai Y.
      Hepatology 45:1046-1055(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Liver.
    2. "Putative integral membrane transport protein UST3H."
      Engel K., Gruendemann D., Schoemig E.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "Isolation of novel clone of amphiphilic solute facilitator family from human fetal liver."
      Takanaga H., Ohtsuki S., Hosoya K., Terasaki T.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal liver.
    4. Guo J.H., Yu L.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hepatoma.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Liver.
    9. "Isolation of a family of organic anion transporters from human liver and kidney."
      Sun W., Wu R.R., van Poelje P.D., Erion M.D.
      Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    10. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-393; VAL-487 AND LYS-521.

    Entry informationi

    Entry nameiS22A9_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVM8
    Secondary accession number(s): A0AVB7
    , A4PB24, Q8TCC8, Q8TEC0, Q8WYN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3