Q8IVL8 (CBPO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carboxypeptidase O
Short name=CPO
EC=3.4.17.-

Gene names

Name:

CPO

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues By similarity. Ref.4
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the peptidase M14 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Hydrolase Metalloprotease Protease
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metallocarboxypeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 374	354	Carboxypeptidase O		PRO_0000252401
Sites
	Active site	288	1	Proton donor By similarity
	Active site	310	1	Nucleophile By similarity
	Metal binding	108	1	Zinc By similarity
	Metal binding	111	1	Zinc By similarity
	Metal binding	236	1	Zinc By similarity
Amino acid modifications
	Glycosylation	132	1	N-linked (GlcNAc...) Potential
	Glycosylation	174	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Glycosylation	251	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	85	1	M → I. Ref.3 Corresponds to variant rs13420911 [ dbSNP | Ensembl ].		VAR_027850
	Natural variant	134	1	S → R. Ref.3 Corresponds to variant rs11903403 [ dbSNP | Ensembl ].		VAR_027851
	Natural variant	273	1	K → N in a colorectal cancer sample; somatic mutation. Ref.5		VAR_036012

Sequences

	Sequence		Length	Mass (Da)
	Q8IVL8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 404C373BB841AAD2	FASTA	374	42,529
	10 20 30 40 50 60 MKPLLETLYL LGMLVPGGLG YDRSLAQHRQ EIVDKSVSPW SLETYSYNIY HPMGEIYEWM 70 80 90 100 110 120 REISEKYKEV VTQHFLGVTY ETHPMYYLKI SQPSGNPKKI IWMDCGIHAR EWIAPAFCQW 130 140 150 160 170 180 FVKEILQNHK DNSSIRKLLR NLDFYVLPVL NIDGYIYTWT TDRLWRKSRS PHNNGTCFGT 190 200 210 220 230 240 DLNRNFNASW CSIGASRNCQ DQTFCGTGPV SEPETKAVAS FIESKKDDIL CFLTMHSYGQ 250 260 270 280 290 300 LILTPYGYTK NKSSNHPEMI QVGQKAANAL KAKYGTNYRV GSSADILYAS SGSSRDWARD 310 320 330 340 350 360 IGIPFSYTFE LRDSGTYGFV LPEAQIQPTC EETMEAVLSV LDDVYAKHWH SDSAGRVTSA 370 TMLLGLLVSC MSLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new Zn-carboxypeptidase highly expressed in ovary." Obaya A.J., Lopez-Otin C. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-85 AND ARG-134.
[4]	"Identification and characterization of three members of the human metallocarboxypeptidase gene family." Wei S., Segura S., Vendrell J., Aviles F.X., Lanoue E., Day R., Feng Y., Fricker L.D. J. Biol. Chem. 277:14954-14964(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, PUTATIVE FUNCTION.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-273.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ422118 mRNA. Translation: CAD19478.1. AC019052 Genomic DNA. Translation: AAX93277.1. BC112076 mRNA. Translation: AAI12077.1. BC112078 mRNA. Translation: AAI12079.1. BK000189 mRNA. Translation: DAA00036.1.
IPI	IPI00220711.
RefSeq	NP_775100.1. NM_173077.2.
UniGene	Hs.684103.
3D structure databases
HSSP	HSSP built from PDB template 1Z5R based on UniProtKB P09955.
ProteinModelPortal	Q8IVL8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000272852.
Protein family/group databases
MEROPS	M14.021.
PTM databases
PhosphoSite	Q8IVL8.
Polymorphism databases
DMDM	74723635.
Proteomic databases
PaxDb	Q8IVL8.
PRIDE	Q8IVL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272852; ENSP00000272852; ENSG00000144410.
GeneID	130749.
KEGG	hsa:130749.
UCSC	uc002vby.2. human.
Organism-specific databases
CTD	130749.
GeneCards	GC02P207804.
HGNC	HGNC:21011. CPO.
HPA	HPA040533.
MIM	609563. gene.
neXtProt	NX_Q8IVL8.
PharmGKB	PA164741367.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2866.
HOGENOM	HOG000252967.
HOVERGEN	HBG050815.
InParanoid	Q8IVL8.
OMA	MYYLKIS.
OrthoDB	EOG4W6NW4.
PhylomeDB	Q8IVL8.
Gene expression databases
Bgee	Q8IVL8.
CleanEx	HS_CPO.
Genevestigator	Q8IVL8.
GermOnline	ENSG00000144410. Homo sapiens.
Family and domain databases
InterPro	IPR000834. Peptidase_M14. [Graphical view]
Pfam	PF00246. Peptidase_M14. 1 hit. [Graphical view]
PRINTS	PR00765. CRBOXYPTASEA.
SMART	SM00631. Zn_pept. 1 hit. [Graphical view]
PROSITE	PS00132. CARBOXYPEPT_ZN_1. 1 hit. PS00133. CARBOXYPEPT_ZN_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	130749.
NextBio	82806.
SOURCE	Search...

Entry information

Entry name

CBPO_HUMAN

Accession

Primary (citable) accession number: Q8IVL8
Secondary accession number(s): Q2M277, Q7RTW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.