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Protein

Prolyl 3-hydroxylase 2

Gene

LEPREL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Shows prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types II, IV and V.By similarity

Catalytic activityi

L-proline-[procollagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-proline-[procollagen] + succinate + CO2.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi580 – 5801Iron
Metal bindingi582 – 5821Iron
Metal bindingi652 – 6521Iron
Active sitei662 – 6621By similarity

GO - Molecular functioni

GO - Biological processi

  • collagen metabolic process Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • negative regulation of cell proliferation Source: UniProtKB
  • peptidyl-proline hydroxylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding, Vitamin C

Enzyme and pathway databases

BRENDAi1.14.11.7. 2681.
ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolyl 3-hydroxylase 2 (EC:1.14.11.7)
Alternative name(s):
Leprecan-like protein 1
Myxoid liposarcoma-associated protein 4
Gene namesi
Name:LEPREL1
Synonyms:MLAT4, P3H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19317. LEPREL1.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum lumen Source: Reactome
  • Golgi apparatus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Myopia, high, with cataract and vitreoretinal degeneration (MCVD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by severe myopia with variable expressivity of cataract and vitreoretinal degeneration. Some patients manifest lens subluxation, lens instability and retinal detachment.

See also OMIM:614292
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti508 – 5081G → V in MCVD; loss of function. 1 Publication
VAR_066637

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614292. phenotype.
Orphaneti98619. Rare isolated myopia.
PharmGKBiPA134922807.

Chemistry

DrugBankiDB00172. L-Proline.
DB00139. Succinic acid.
DB00126. Vitamin C.

Polymorphism and mutation databases

BioMutaiLEPREL1.
DMDMi74714365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 708684Prolyl 3-hydroxylase 2PRO_0000240356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IVL5.
PaxDbiQ8IVL5.
PRIDEiQ8IVL5.

PTM databases

PhosphoSiteiQ8IVL5.

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung, liver, skeletal muscle and kidney. Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells.1 Publication

Gene expression databases

BgeeiQ8IVL5.
CleanExiHS_LEPREL1.
ExpressionAtlasiQ8IVL5. baseline and differential.
GenevisibleiQ8IVL5. HS.

Organism-specific databases

HPAiHPA007890.
HPA013355.

Interactioni

Protein-protein interaction databases

BioGridi120510. 4 interactions.
IntActiQ8IVL5. 3 interactions.
STRINGi9606.ENSP00000316881.

Structurei

3D structure databases

ProteinModelPortaliQ8IVL5.
SMRiQ8IVL5. Positions 155-187, 310-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 7734TPR 1Add
BLAST
Repeati148 – 18134TPR 2Add
BLAST
Repeati210 – 24334TPR 3Add
BLAST
Repeati306 – 33934TPR 4Add
BLAST
Domaini557 – 671115Fe2OG dioxygenasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi705 – 7084Prevents secretion from ERPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi93 – 997Poly-Pro

Sequence similaritiesi

Belongs to the leprecan family.Curated
Contains 1 Fe2OG dioxygenase domain.PROSITE-ProRule annotation
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiNOG269251.
GeneTreeiENSGT00550000074573.
HOGENOMiHOG000231087.
HOVERGENiHBG053224.
InParanoidiQ8IVL5.
OMAiQGKHELN.
OrthoDBiEOG7BZVSS.
PhylomeDBiQ8IVL5.
TreeFamiTF320837.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
[Graphical view]
PfamiPF13640. 2OG-FeII_Oxy_3. 1 hit.
PF07719. TPR_2. 2 hits.
[Graphical view]
SMARTiSM00702. P4Hc. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51471. FE2OG_OXY. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRERIWAPPL LLLLPLLLPP PLWGGPPDSP RRELELEPGP LQPFDLLYAS
60 70 80 90 100
GAAAYYSGDY ERAVRDLEAA LRSHRRLREI RTRCARHCAA RHPLPPPPPG
110 120 130 140 150
EGPGAELPLF RSLLGRARCY RSCETQRLGG PASRHRVSED VRSDFQRRVP
160 170 180 190 200
YNYLQRAYIK LNQLEKAVEA AHTFFVANPE HMEMQQNIEN YRATAGVEAL
210 220 230 240 250
QLVDREAKPH MESYNAGVKH YEADDFEMAI RHFEQALREY FVEDTECRTL
260 270 280 290 300
CEGPQRFEEY EYLGYKAGLY EAIADHYMQV LVCQHECVRE LATRPGRLSP
310 320 330 340 350
IENFLPLHYD YLQFAYYRVG EYVKALECAK AYLLCHPDDE DVLDNVDYYE
360 370 380 390 400
SLLDDSIDPA SIEAREDLTM FVKRHKLESE LIKSAAEGLG FSYTEPNYWI
410 420 430 440 450
RYGGRQDENR VPSGVNVEGA EVHGFSMGKK LSPKIDRDLR EGGPLLYENI
460 470 480 490 500
TFVYNSEQLN GTQRVLLDNV LSEEQCRELH SVASGIMLVG DGYRGKTSPH
510 520 530 540 550
TPNEKFEGAT VLKALKSGYE GRVPLKSARL FYDISEKARR IVESYFMLNS
560 570 580 590 600
TLYFSYTHMV CRTALSGQQD RRNDLSHPIH ADNCLLDPEA NECWKEPPAY
610 620 630 640 650
TFRDYSALLY MNDDFEGGEF IFTEMDAKTV TASIKPKCGR MISFSSGGEN
660 670 680 690 700
PHGVKAVTKG KRCAVALWFT LDPLYRELER IQADEVIAIL DQEQQGKHEL

NINPKDEL
Length:708
Mass (Da):80,984
Last modified:March 1, 2003 - v1
Checksum:iB9E680C90D607291
GO
Isoform 2 (identifier: Q8IVL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):60,387
Checksum:iD3B80AE780F6D8DD
GO

Sequence cautioni

The sequence BAA91769.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti477 – 4771R → Q in BAG51712 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti508 – 5081G → V in MCVD; loss of function. 1 Publication
VAR_066637
Natural varianti613 – 6131D → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_036123

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 181181Missing in isoform 2. CuratedVSP_053814Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430351 mRNA. Translation: CAD23039.2.
AK001580 mRNA. Translation: BAA91769.1. Different initiation.
AK056447 mRNA. Translation: BAG51712.1.
AK125134 mRNA. Translation: BAG54151.1.
AC016966 Genomic DNA. No translation available.
AC063939 Genomic DNA. No translation available.
AC099660 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78109.1.
CH471052 Genomic DNA. Translation: EAW78110.1.
CH471052 Genomic DNA. Translation: EAW78111.1.
BC005029 mRNA. Translation: AAH05029.1.
CCDSiCCDS3294.1. [Q8IVL5-1]
CCDS46981.1. [Q8IVL5-2]
RefSeqiNP_001127890.1. NM_001134418.1. [Q8IVL5-2]
NP_060662.2. NM_018192.3. [Q8IVL5-1]
UniGeneiHs.374191.

Genome annotation databases

EnsembliENST00000319332; ENSP00000316881; ENSG00000090530. [Q8IVL5-1]
ENST00000427335; ENSP00000408947; ENSG00000090530. [Q8IVL5-2]
GeneIDi55214.
KEGGihsa:55214.
UCSCiuc003fsg.3. human. [Q8IVL5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430351 mRNA. Translation: CAD23039.2.
AK001580 mRNA. Translation: BAA91769.1. Different initiation.
AK056447 mRNA. Translation: BAG51712.1.
AK125134 mRNA. Translation: BAG54151.1.
AC016966 Genomic DNA. No translation available.
AC063939 Genomic DNA. No translation available.
AC099660 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78109.1.
CH471052 Genomic DNA. Translation: EAW78110.1.
CH471052 Genomic DNA. Translation: EAW78111.1.
BC005029 mRNA. Translation: AAH05029.1.
CCDSiCCDS3294.1. [Q8IVL5-1]
CCDS46981.1. [Q8IVL5-2]
RefSeqiNP_001127890.1. NM_001134418.1. [Q8IVL5-2]
NP_060662.2. NM_018192.3. [Q8IVL5-1]
UniGeneiHs.374191.

3D structure databases

ProteinModelPortaliQ8IVL5.
SMRiQ8IVL5. Positions 155-187, 310-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120510. 4 interactions.
IntActiQ8IVL5. 3 interactions.
STRINGi9606.ENSP00000316881.

Chemistry

DrugBankiDB00172. L-Proline.
DB00139. Succinic acid.
DB00126. Vitamin C.

PTM databases

PhosphoSiteiQ8IVL5.

Polymorphism and mutation databases

BioMutaiLEPREL1.
DMDMi74714365.

Proteomic databases

MaxQBiQ8IVL5.
PaxDbiQ8IVL5.
PRIDEiQ8IVL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319332; ENSP00000316881; ENSG00000090530. [Q8IVL5-1]
ENST00000427335; ENSP00000408947; ENSG00000090530. [Q8IVL5-2]
GeneIDi55214.
KEGGihsa:55214.
UCSCiuc003fsg.3. human. [Q8IVL5-1]

Organism-specific databases

CTDi55214.
GeneCardsiGC03M189674.
HGNCiHGNC:19317. LEPREL1.
HPAiHPA007890.
HPA013355.
MIMi610341. gene.
614292. phenotype.
neXtProtiNX_Q8IVL5.
Orphaneti98619. Rare isolated myopia.
PharmGKBiPA134922807.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG269251.
GeneTreeiENSGT00550000074573.
HOGENOMiHOG000231087.
HOVERGENiHBG053224.
InParanoidiQ8IVL5.
OMAiQGKHELN.
OrthoDBiEOG7BZVSS.
PhylomeDBiQ8IVL5.
TreeFamiTF320837.

Enzyme and pathway databases

BRENDAi1.14.11.7. 2681.
ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

ChiTaRSiLEPREL1. human.
GenomeRNAii55214.
NextBioi35469224.
PROiQ8IVL5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IVL5.
CleanExiHS_LEPREL1.
ExpressionAtlasiQ8IVL5. baseline and differential.
GenevisibleiQ8IVL5. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
[Graphical view]
PfamiPF13640. 2OG-FeII_Oxy_3. 1 hit.
PF07719. TPR_2. 2 hits.
[Graphical view]
SMARTiSM00702. P4Hc. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51471. FE2OG_OXY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas."
    Thelin-Jaernum S., Lassen C., Panagopoulos I., Mandahl N., Aaman P.
    Int. J. Cancer 83:30-33(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liposarcoma.
  2. "LEPREL1, a novel ER and Golgi resident member of the Leprecan family."
    Jaernum S., Kjellman C., Darabi A., Nilsson I., Edvardsen K., Aaman P.
    Biochem. Biophys. Res. Commun. 317:342-351(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, POSSIBLE FUNCTION.
    Tissue: Liposarcoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma and Tongue.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-708 (ISOFORM 1).
    Tissue: Lung.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-613.
  8. Cited for: VARIANT MCVD VAL-508, CHARACTERIZATION OF VARIANT MCVD VAL-508.

Entry informationi

Entry nameiP3H2_HUMAN
AccessioniPrimary (citable) accession number: Q8IVL5
Secondary accession number(s): B3KPK0
, B3KWI9, D3DNV8, Q9NVI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.