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Q8IVL1

- NAV2_HUMAN

UniProt

Q8IVL1 - NAV2_HUMAN

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Protein
Neuron navigator 2
Gene
NAV2, HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2157 – 21648ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. heparin binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. glossopharyngeal nerve development Source: Ensembl
  2. locomotory behavior Source: Ensembl
  3. optic nerve development Source: Ensembl
  4. regulation of systemic arterial blood pressure by baroreceptor feedback Source: Ensembl
  5. sensory perception of smell Source: Ensembl
  6. sensory perception of sound Source: Ensembl
  7. vagus nerve development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron navigator 2 (EC:3.6.4.12)
Alternative name(s):
Helicase APC down-regulated 1
Pore membrane and/or filament-interacting-like protein 2
Retinoic acid inducible in neuroblastoma 1
Steerin-2
Unc-53 homolog 2
Short name:
unc53H2
Gene namesi
Name:NAV2
Synonyms:HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15997. NAV2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. interstitial matrix Source: Ensembl
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24882488Neuron navigator 2
PRO_0000267198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1480 – 14801Phosphoserine1 Publication
Modified residuei1484 – 14841Phosphoserine1 Publication
Modified residuei1488 – 14881Phosphoserine1 Publication
Modified residuei1977 – 19771Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IVL1.
PaxDbiQ8IVL1.
PRIDEiQ8IVL1.

PTM databases

PhosphoSiteiQ8IVL1.

Expressioni

Tissue specificityi

Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.4 Publications

Developmental stagei

Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney.1 Publication

Inductioni

By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.2 Publications

Gene expression databases

ArrayExpressiQ8IVL1.
BgeeiQ8IVL1.
GenevestigatoriQ8IVL1.

Organism-specific databases

HPAiHPA011755.
HPA011891.

Interactioni

Protein-protein interaction databases

BioGridi124606. 4 interactions.
IntActiQ8IVL1. 4 interactions.
MINTiMINT-1455352.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi90 – 10112
Helixi111 – 1144
Beta strandi115 – 1184
Helixi119 – 12810
Helixi145 – 15915
Helixi169 – 1746
Helixi177 – 19115

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YRNNMR-A90-197[»]
ProteinModelPortaliQ8IVL1.
SMRiQ8IVL1. Positions 78-197.

Miscellaneous databases

EvolutionaryTraceiQ8IVL1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 192108CH
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili498 – 53134 Reviewed prediction
Add
BLAST
Coiled coili743 – 77129 Reviewed prediction
Add
BLAST
Coiled coili1686 – 177388 Reviewed prediction
Add
BLAST
Coiled coili1897 – 196468 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi192 – 25564Gln-rich
Add
BLAST
Compositional biasi324 – 3285Poly-Pro
Compositional biasi633 – 6386Poly-Ser
Compositional biasi1363 – 1683321Ser-rich
Add
BLAST
Compositional biasi1824 – 18296Poly-Lys

Sequence similaritiesi

Belongs to the Nav/unc-53 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5069.
HOVERGENiHBG058814.
OMAiERNSLWS.
OrthoDBiEOG7GBFW1.
PhylomeDBiQ8IVL1.
TreeFamiTF329881.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001715. CH-domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. Align

Note: Additional isoforms may exist.

Isoform 1 (identifier: Q8IVL1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT     50
TYPSQIPLKS QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA 100
KSGHKRLIRD LQQDVTDGVL LAQIIQVVAN EKIEDINGCP KNRSQMIENI 150
DACLNFLAAK GINIQGLSAE EIRNGNLKAI LGLFFSLSRY KQQQQQPQKQ 200
HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH QPAPHQQSKA 250
QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG 300
STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA 350
PASLESGSSS TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK 400
PPGPEAPRPT PEAMKPAPNN QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC 450
ERLETLPSFE ESEELEAASR MLTTVGPASS SPKIALKGIA QRTFSRALTN 500
KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK EEPKEDPSGA 550
AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP 600
SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT 650
TLNHSISSQT VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY 700
RSQTDTEGNV TAESSSTGVS VEPSHFTKTG QPALEELTGE DPEARRLRTV 750
KNIADLRQNL EETMSSLRGT QVTHSTLETT FDTNVTTEMS GRSILSLTGR 800
PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE SGRYVYSAPL 850
RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD 900
DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS 950
SSVSSGISDT IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ 1000
VERNSLWSGD DVKKSDGGSD SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK 1050
NPVISQTGSW RRGMTAQVGI TMPRTKPSAP AGALKTPGTG KTDDAKVSEK 1100
GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA NSFGFKKQSG 1150
SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD 1200
GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV 1250
PKLREPSKTA LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV 1300
SSPAQTSLQP GAKYPDVASP TLRRLFGGKP TKQVPIATAE NMKNSVVISN 1350
PHATMTQQGN LDSPSGSGVL SSGSSSPLYS KNVDLNQSPL ASSPSSAHSA 1400
PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS LSSGGVPSHN 1450
SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ 1500
DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP 1550
FSSGSSVTSP SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD 1600
PYTDSRFRNS SMSLDEKSRT MSRSGSFRDG FEEESWEKSS VDNFVSRLHS 1650
SLHFSLPLFH HARYELVHGS SLSLVSSTSS VYSTPEEKCQ SEIRKLRREL 1700
DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM TAEQKDSELN 1750
ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS 1800
DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK 1850
SASSHSDIEE MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE 1900
AETVMQLRNE LRDKEMKLTD IRLEALSSAH QLDQLREAMN RMQSEIEKLK 1950
AENDRLKSES QGSGCSRAPS QVSISASPRQ SMGLSQHSLN LTESTSLDML 2000
LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI GCIGVSGKTK 2050
WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE 2100
LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH 2150
RRIILSGPSG TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL 2200
RQYLSNLADQ CNSENNAVDM PLVIILDNLH HVSSLGEIFN GLLNCKYHKC 2250
PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN HTEPVKGFLG RFLRRKLMET 2300
EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG PRLFLSCPID 2350
VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW 2400
AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM 2450
LMRLQEAANY SSPQSYDSDS NSNSHHDDIL DSSLESTL 2488
Length:2,488
Mass (Da):268,167
Last modified:October 5, 2010 - v3
Checksum:i0AEDD1C1469A11A8
GO
Isoform 2 (identifier: Q8IVL1-2) [UniParc]FASTAAdd to Basket

Also known as: RAINB1d

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.

Show »
Length:2,432
Mass (Da):261,750
Checksum:i1CEC21B583BB5B36
GO
Isoform 3 (identifier: Q8IVL1-3) [UniParc]FASTAAdd to Basket

Also known as: HELAD1L

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:2,429
Mass (Da):261,408
Checksum:iFF906F1F4EB428B5
GO
Isoform 4 (identifier: Q8IVL1-4) [UniParc]FASTAAdd to Basket

Also known as: HELAD1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPAILVASKM...GSVENGFDTQ → MESVSESSQQQKRKPVIHGLEDQKR
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:2,365
Mass (Da):254,978
Checksum:i000C16EB12682A2C
GO
Isoform 5 (identifier: Q8IVL1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-937: Missing.
     938-945: SLGLGDAD → MLWPRNLT
     1480-1501: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:1,493
Mass (Da):161,946
Checksum:i278DEF938E0D3DC2
GO
Isoform 6 (identifier: Q8IVL1-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1578: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:874
Mass (Da):97,684
Checksum:iAEFA49541B2A2E94
GO
Isoform 7 (identifier: Q8IVL1-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1896: Missing.

Show »
Length:592
Mass (Da):66,897
Checksum:i6B8F113F3C036820
GO
Isoform 8 (identifier: Q8IVL1-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MLWPRNLT

Show »
Length:2,408
Mass (Da):259,971
Checksum:i635AC30132928AF6
GO
Isoform 9 (identifier: Q8IVL1-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAGTSAASSWGGGK

Show »
Length:2,414
Mass (Da):260,208
Checksum:iFF6423A81066C65B
GO
Isoform 10 (identifier: Q8IVL1-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MSVMLWRWEQNNTTMKL

Show »
Length:2,417
Mass (Da):261,109
Checksum:iDFBF27444A625EB2
GO
Isoform 11 (identifier: Q8IVL1-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MESVSESSQQQKRKPVIHGLEDQKR

Show »
Length:2,425
Mass (Da):261,866
Checksum:i5C153BF3E2FA6698
GO
Isoform 12 (identifier: Q8IVL1-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MQECDSKFFLPSGSNSGFTLLSNQ

Show »
Length:2,424
Mass (Da):261,579
Checksum:iA902C8AFDA1FA86E
GO
Isoform 13 (identifier: Q8IVL1-13) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAIDLYCGLACLWGIHEPR

Show »
Length:2,419
Mass (Da):261,102
Checksum:i98CA63F4C60A1573
GO

Sequence cautioni

The sequence BAB85038.1 differs from that shown. Reason: Frameshift at position 2074.
The sequence BAA92657.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091R → K.2 Publications
Corresponds to variant rs6483617 [ dbSNP | Ensembl ].
VAR_029640
Natural varianti491 – 4911Q → H.
Corresponds to variant rs16937251 [ dbSNP | Ensembl ].
VAR_029641
Natural varianti1041 – 10411E → D.1 Publication
Corresponds to variant rs3802799 [ dbSNP | Ensembl ].
VAR_029642
Natural varianti1077 – 10771P → A.6 Publications
Corresponds to variant rs3802800 [ dbSNP | Ensembl ].
VAR_029643
Natural varianti2374 – 23741V → I.1 Publication
Corresponds to variant rs35891966 [ dbSNP | Ensembl ].
VAR_032252

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18961896Missing in isoform 7.
VSP_021924Add
BLAST
Alternative sequencei1 – 15781578Missing in isoform 6.
VSP_021925Add
BLAST
Alternative sequencei1 – 937937Missing in isoform 5.
VSP_021926Add
BLAST
Alternative sequencei1 – 8989MPAIL…GFDTQ → MESVSESSQQQKRKPVIHGL EDQKR in isoform 4.
VSP_021927Add
BLAST
Alternative sequencei1 – 8888MPAIL…NGFDT → MSVMLWRWEQNNTTMKL in isoform 10.
VSP_021928Add
BLAST
Alternative sequencei1 – 8888MPAIL…NGFDT → MESVSESSQQQKRKPVIHGL EDQKR in isoform 11.
VSP_021929Add
BLAST
Alternative sequencei1 – 8888MPAIL…NGFDT → MQECDSKFFLPSGSNSGFTL LSNQ in isoform 12.
VSP_021930Add
BLAST
Alternative sequencei1 – 8888MPAIL…NGFDT → MAIDLYCGLACLWGIHEPR in isoform 13.
VSP_021931Add
BLAST
Alternative sequencei1 – 8888MPAIL…NGFDT → MLWPRNLT in isoform 8.
VSP_021932Add
BLAST
Alternative sequencei1 – 8888MPAIL…NGFDT → MAGTSAASSWGGGK in isoform 9.
VSP_021933Add
BLAST
Alternative sequencei256 – 27823Missing in isoform 2, isoform 3 and isoform 4.
VSP_021934Add
BLAST
Alternative sequencei938 – 9458SLGLGDAD → MLWPRNLT in isoform 5.
VSP_021935
Alternative sequencei1480 – 150122Missing in isoform 5.
VSP_021936Add
BLAST
Alternative sequencei1634 – 166633Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.
VSP_021937Add
BLAST
Alternative sequencei1832 – 18343Missing in isoform 3, isoform 4, isoform 5 and isoform 6.
VSP_021938

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001A → T in BAC00854. 1 Publication
Sequence conflicti100 – 1001A → T in CAD32471. 1 Publication
Sequence conflicti259 – 2591S → P in AAL96479. 1 Publication
Sequence conflicti259 – 2591S → P in AAL96480. 1 Publication
Sequence conflicti259 – 2591S → P in BAA92657. 1 Publication
Sequence conflicti282 – 2821P → S in CAD32471. 1 Publication
Sequence conflicti1046 – 10461T → M in BAB85038. 1 Publication
Sequence conflicti1173 – 11731G → D in BAB85038. 1 Publication
Sequence conflicti1845 – 18451Missing in AAH16054. 1 Publication
Sequence conflicti1939 – 19391M → V in BAB85038. 1 Publication
Sequence conflicti2012 – 20121E → G in BAA91965. 1 Publication
Sequence conflicti2053 – 20531V → A in BAA91723. 1 Publication
Sequence conflicti2075 – 20751L → V in BAB85038. 1 Publication
Sequence conflicti2296 – 22961K → E in BAA91965. 1 Publication
Sequence conflicti2299 – 22991E → K in BAB85038. 1 Publication
Sequence conflicti2395 – 23951M → V in BAA91723. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF466143 mRNA. Translation: AAL96479.1.
AF466144 mRNA. Translation: AAL96480.1.
AB063115 mRNA. Translation: BAC00853.1.
AB063116 mRNA. Translation: BAC00854.1.
AJ488102 mRNA. Translation: CAD32471.1.
AJ488203 mRNA. Translation: CAD32556.1.
AJ488204 mRNA. Translation: CAD32557.1.
AJ488205 mRNA. Translation: CAD32558.1.
AJ488206 mRNA. Translation: CAD32559.1.
AJ488207 mRNA. Translation: CAD32560.1.
AJ488208 mRNA. Translation: CAD32561.1.
AB037840 mRNA. Translation: BAA92657.3. Different initiation.
AK001495 mRNA. Translation: BAA91723.1.
AK001892 mRNA. Translation: BAA91965.1.
AK074287 mRNA. Translation: BAB85038.1. Frameshift.
AC009549 Genomic DNA. No translation available.
AC015684 Genomic DNA. No translation available.
AC023950 Genomic DNA. No translation available.
AC090662 Genomic DNA. No translation available.
AC111163 Genomic DNA. No translation available.
AC113193 Genomic DNA. No translation available.
BC016054 mRNA. Translation: AAH16054.1.
CCDSiCCDS44552.1. [Q8IVL1-5]
CCDS53612.1. [Q8IVL1-4]
CCDS58126.1. [Q8IVL1-1]
CCDS7850.1. [Q8IVL1-3]
CCDS7851.2. [Q8IVL1-2]
RefSeqiNP_001104488.1. NM_001111018.1. [Q8IVL1-4]
NP_001104489.1. NM_001111019.2. [Q8IVL1-5]
NP_001231892.1. NM_001244963.1. [Q8IVL1-1]
NP_660093.2. NM_145117.4. [Q8IVL1-3]
NP_892009.3. NM_182964.5. [Q8IVL1-2]
XP_006718431.1. XM_006718368.1. [Q8IVL1-5]
UniGeneiHs.502116.
Hs.639427.
Hs.639428.
Hs.64341.

Genome annotation databases

EnsembliENST00000311043; ENSP00000312169; ENSG00000166833. [Q8IVL1-5]
ENST00000349880; ENSP00000309577; ENSG00000166833. [Q8IVL1-3]
ENST00000360655; ENSP00000353871; ENSG00000166833. [Q8IVL1-4]
ENST00000396085; ENSP00000379394; ENSG00000166833. [Q8IVL1-2]
ENST00000396087; ENSP00000379396; ENSG00000166833. [Q8IVL1-1]
ENST00000527559; ENSP00000435395; ENSG00000166833. [Q8IVL1-10]
ENST00000533917; ENSP00000437316; ENSG00000166833. [Q8IVL1-5]
ENST00000540292; ENSP00000443489; ENSG00000166833. [Q8IVL1-13]
GeneIDi89797.
KEGGihsa:89797.
UCSCiuc001mpp.3. human. [Q8IVL1-4]
uc001mpr.4. human. [Q8IVL1-2]
uc001mpu.3. human. [Q8IVL1-6]
uc009yhx.4. human. [Q8IVL1-5]
uc010rdm.2. human. [Q8IVL1-1]

Polymorphism databases

DMDMi308153582.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF466143 mRNA. Translation: AAL96479.1 .
AF466144 mRNA. Translation: AAL96480.1 .
AB063115 mRNA. Translation: BAC00853.1 .
AB063116 mRNA. Translation: BAC00854.1 .
AJ488102 mRNA. Translation: CAD32471.1 .
AJ488203 mRNA. Translation: CAD32556.1 .
AJ488204 mRNA. Translation: CAD32557.1 .
AJ488205 mRNA. Translation: CAD32558.1 .
AJ488206 mRNA. Translation: CAD32559.1 .
AJ488207 mRNA. Translation: CAD32560.1 .
AJ488208 mRNA. Translation: CAD32561.1 .
AB037840 mRNA. Translation: BAA92657.3 . Different initiation.
AK001495 mRNA. Translation: BAA91723.1 .
AK001892 mRNA. Translation: BAA91965.1 .
AK074287 mRNA. Translation: BAB85038.1 . Frameshift.
AC009549 Genomic DNA. No translation available.
AC015684 Genomic DNA. No translation available.
AC023950 Genomic DNA. No translation available.
AC090662 Genomic DNA. No translation available.
AC111163 Genomic DNA. No translation available.
AC113193 Genomic DNA. No translation available.
BC016054 mRNA. Translation: AAH16054.1 .
CCDSi CCDS44552.1. [Q8IVL1-5 ]
CCDS53612.1. [Q8IVL1-4 ]
CCDS58126.1. [Q8IVL1-1 ]
CCDS7850.1. [Q8IVL1-3 ]
CCDS7851.2. [Q8IVL1-2 ]
RefSeqi NP_001104488.1. NM_001111018.1. [Q8IVL1-4 ]
NP_001104489.1. NM_001111019.2. [Q8IVL1-5 ]
NP_001231892.1. NM_001244963.1. [Q8IVL1-1 ]
NP_660093.2. NM_145117.4. [Q8IVL1-3 ]
NP_892009.3. NM_182964.5. [Q8IVL1-2 ]
XP_006718431.1. XM_006718368.1. [Q8IVL1-5 ]
UniGenei Hs.502116.
Hs.639427.
Hs.639428.
Hs.64341.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YRN NMR - A 90-197 [» ]
ProteinModelPortali Q8IVL1.
SMRi Q8IVL1. Positions 78-197.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124606. 4 interactions.
IntActi Q8IVL1. 4 interactions.
MINTi MINT-1455352.

PTM databases

PhosphoSitei Q8IVL1.

Polymorphism databases

DMDMi 308153582.

Proteomic databases

MaxQBi Q8IVL1.
PaxDbi Q8IVL1.
PRIDEi Q8IVL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311043 ; ENSP00000312169 ; ENSG00000166833 . [Q8IVL1-5 ]
ENST00000349880 ; ENSP00000309577 ; ENSG00000166833 . [Q8IVL1-3 ]
ENST00000360655 ; ENSP00000353871 ; ENSG00000166833 . [Q8IVL1-4 ]
ENST00000396085 ; ENSP00000379394 ; ENSG00000166833 . [Q8IVL1-2 ]
ENST00000396087 ; ENSP00000379396 ; ENSG00000166833 . [Q8IVL1-1 ]
ENST00000527559 ; ENSP00000435395 ; ENSG00000166833 . [Q8IVL1-10 ]
ENST00000533917 ; ENSP00000437316 ; ENSG00000166833 . [Q8IVL1-5 ]
ENST00000540292 ; ENSP00000443489 ; ENSG00000166833 . [Q8IVL1-13 ]
GeneIDi 89797.
KEGGi hsa:89797.
UCSCi uc001mpp.3. human. [Q8IVL1-4 ]
uc001mpr.4. human. [Q8IVL1-2 ]
uc001mpu.3. human. [Q8IVL1-6 ]
uc009yhx.4. human. [Q8IVL1-5 ]
uc010rdm.2. human. [Q8IVL1-1 ]

Organism-specific databases

CTDi 89797.
GeneCardsi GC11P019372.
HGNCi HGNC:15997. NAV2.
HPAi HPA011755.
HPA011891.
MIMi 607026. gene.
neXtProti NX_Q8IVL1.
PharmGKBi PA31452.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5069.
HOVERGENi HBG058814.
OMAi ERNSLWS.
OrthoDBi EOG7GBFW1.
PhylomeDBi Q8IVL1.
TreeFami TF329881.

Miscellaneous databases

ChiTaRSi NAV2. human.
EvolutionaryTracei Q8IVL1.
GeneWikii NAV2.
GenomeRNAii 89797.
NextBioi 76293.
PROi Q8IVL1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IVL1.
Bgeei Q8IVL1.
Genevestigatori Q8IVL1.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR001715. CH-domain.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEi PS50021. CH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos."
    Merrill R.A., Plum L.A., Kaiser M.E., Clagett-Dame M.
    Proc. Natl. Acad. Sci. U.S.A. 99:3422-3427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), INDUCTION BY ATRA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-1077.
  2. "Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas."
    Ishiguro H., Shimokawa T., Tsunoda T., Tanaka T., Fujii Y., Nakamura Y., Furukawa Y.
    Oncogene 21:6387-6394(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION, FUNCTION AS A HELICASE, INDUCTION, TISSUE SPECIFICITY, VARIANTS LYS-109 AND ALA-1077.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 8; 9; 10; 11; 12 AND 13), FUNCTION, VARIANTS LYS-109 AND ALA-1077.
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-1077.
    Tissue: Brain.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. Ohara O.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7), VARIANTS ASP-1041; ALA-1077 AND ILE-2374.
    Tissue: Placenta.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-1077.
    Tissue: Skin.
  10. "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms."
    Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O., Christiansen H., Poustka A.
    Gene 290:73-94(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  11. "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans."
    Maes T., Barcelo A., Buesa C.
    Genomics 80:21-30(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1480; SER-1484; SER-1488 AND SER-1977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Solution structure of the CH domain from human neuron navigator 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 90-197.

Entry informationi

Entry nameiNAV2_HUMAN
AccessioniPrimary (citable) accession number: Q8IVL1
Secondary accession number(s): A6NEC1
, Q8IVK3, Q8IVK4, Q8IVK5, Q8IVK6, Q8IVK7, Q8IVK8, Q8NHC9, Q8NHD0, Q8TDE9, Q8TDF0, Q8TEB3, Q96B30, Q9NUZ6, Q9NVM7, Q9P2C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

1 Publication experiments have been carried out in mouse.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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