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Q8IVL1 (NAV2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuron navigator 2

EC=3.6.4.12
Alternative name(s):
Helicase APC down-regulated 1
Pore membrane and/or filament-interacting-like protein 2
Retinoic acid inducible in neuroblastoma 1
Steerin-2
Unc-53 homolog 2
Short name=unc53H2
Gene names
Name:NAV2
Synonyms:HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2488 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. Ref.2 Ref.3

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Nucleus Ref.2.

Tissue specificity

Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers. Ref.1 Ref.2 Ref.10 Ref.11

Developmental stage

Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney. Ref.1

Induction

By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas. Ref.1 Ref.2

Sequence similarities

Belongs to the Nav/unc-53 family.

Contains 1 CH (calponin-homology) domain.

Caution

Ref.3 experiments have been carried out in mouse.

Sequence caution

The sequence BAA92657.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB85038.1 differs from that shown. Reason: Frameshift at position 2074.

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist.
Isoform 1 (identifier: Q8IVL1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IVL1-2)

Also known as: RAINB1d;

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.
Isoform 3 (identifier: Q8IVL1-3)

Also known as: HELAD1L;

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.
Isoform 4 (identifier: Q8IVL1-4)

Also known as: HELAD1S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPAILVASKM...GSVENGFDTQ → MESVSESSQQQKRKPVIHGLEDQKR
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.
Isoform 5 (identifier: Q8IVL1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-937: Missing.
     938-945: SLGLGDAD → MLWPRNLT
     1480-1501: Missing.
     1634-1666: Missing.
     1832-1834: Missing.
Isoform 6 (identifier: Q8IVL1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1578: Missing.
     1634-1666: Missing.
     1832-1834: Missing.
Isoform 7 (identifier: Q8IVL1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1896: Missing.
Isoform 8 (identifier: Q8IVL1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MLWPRNLT
Isoform 9 (identifier: Q8IVL1-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAGTSAASSWGGGK
Isoform 10 (identifier: Q8IVL1-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MSVMLWRWEQNNTTMKL
Isoform 11 (identifier: Q8IVL1-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MESVSESSQQQKRKPVIHGLEDQKR
Isoform 12 (identifier: Q8IVL1-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MQECDSKFFLPSGSNSGFTLLSNQ
Isoform 13 (identifier: Q8IVL1-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAIDLYCGLACLWGIHEPR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24882488Neuron navigator 2
PRO_0000267198

Regions

Domain85 – 192108CH
Nucleotide binding2157 – 21648ATP Potential
Coiled coil498 – 53134 Potential
Coiled coil743 – 77129 Potential
Coiled coil1686 – 177388 Potential
Coiled coil1897 – 196468 Potential
Compositional bias192 – 25564Gln-rich
Compositional bias324 – 3285Poly-Pro
Compositional bias633 – 6386Poly-Ser
Compositional bias1363 – 1683321Ser-rich
Compositional bias1824 – 18296Poly-Lys

Amino acid modifications

Modified residue14801Phosphoserine Ref.13
Modified residue14841Phosphoserine Ref.13
Modified residue14881Phosphoserine Ref.13
Modified residue19771Phosphoserine Ref.12 Ref.13

Natural variations

Alternative sequence1 – 18961896Missing in isoform 7.
VSP_021924
Alternative sequence1 – 15781578Missing in isoform 6.
VSP_021925
Alternative sequence1 – 937937Missing in isoform 5.
VSP_021926
Alternative sequence1 – 8989MPAIL…GFDTQ → MESVSESSQQQKRKPVIHGL EDQKR in isoform 4.
VSP_021927
Alternative sequence1 – 8888MPAIL…NGFDT → MSVMLWRWEQNNTTMKL in isoform 10.
VSP_021928
Alternative sequence1 – 8888MPAIL…NGFDT → MESVSESSQQQKRKPVIHGL EDQKR in isoform 11.
VSP_021929
Alternative sequence1 – 8888MPAIL…NGFDT → MQECDSKFFLPSGSNSGFTL LSNQ in isoform 12.
VSP_021930
Alternative sequence1 – 8888MPAIL…NGFDT → MAIDLYCGLACLWGIHEPR in isoform 13.
VSP_021931
Alternative sequence1 – 8888MPAIL…NGFDT → MLWPRNLT in isoform 8.
VSP_021932
Alternative sequence1 – 8888MPAIL…NGFDT → MAGTSAASSWGGGK in isoform 9.
VSP_021933
Alternative sequence256 – 27823Missing in isoform 2, isoform 3 and isoform 4.
VSP_021934
Alternative sequence938 – 9458SLGLGDAD → MLWPRNLT in isoform 5.
VSP_021935
Alternative sequence1480 – 150122Missing in isoform 5.
VSP_021936
Alternative sequence1634 – 166633Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.
VSP_021937
Alternative sequence1832 – 18343Missing in isoform 3, isoform 4, isoform 5 and isoform 6.
VSP_021938
Natural variant1091R → K. Ref.2 Ref.3
Corresponds to variant rs6483617 [ dbSNP | Ensembl ].
VAR_029640
Natural variant4911Q → H.
Corresponds to variant rs16937251 [ dbSNP | Ensembl ].
VAR_029641
Natural variant10411E → D. Ref.7
Corresponds to variant rs3802799 [ dbSNP | Ensembl ].
VAR_029642
Natural variant10771P → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.7 Ref.9
Corresponds to variant rs3802800 [ dbSNP | Ensembl ].
VAR_029643
Natural variant23741V → I. Ref.7
Corresponds to variant rs35891966 [ dbSNP | Ensembl ].
VAR_032252

Experimental info

Sequence conflict1001A → T in BAC00854. Ref.2
Sequence conflict1001A → T in CAD32471. Ref.3
Sequence conflict2591S → P in AAL96479. Ref.1
Sequence conflict2591S → P in AAL96480. Ref.1
Sequence conflict2591S → P in BAA92657. Ref.4
Sequence conflict2821P → S in CAD32471. Ref.3
Sequence conflict10461T → M in BAB85038. Ref.7
Sequence conflict11731G → D in BAB85038. Ref.7
Sequence conflict18451Missing in AAH16054. Ref.8
Sequence conflict19391M → V in BAB85038. Ref.7
Sequence conflict20121E → G in BAA91965. Ref.7
Sequence conflict20531V → A in BAA91723. Ref.7
Sequence conflict20751L → V in BAB85038. Ref.7
Sequence conflict22961K → E in BAA91965. Ref.7
Sequence conflict22991E → K in BAB85038. Ref.7
Sequence conflict23951M → V in BAA91723. Ref.7

Secondary structure

............. 2488
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 0AEDD1C1469A11A8

FASTA2,488268,167
        10         20         30         40         50         60 
MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT TYPSQIPLKS 

        70         80         90        100        110        120 
QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA KSGHKRLIRD LQQDVTDGVL 

       130        140        150        160        170        180 
LAQIIQVVAN EKIEDINGCP KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI 

       190        200        210        220        230        240 
LGLFFSLSRY KQQQQQPQKQ HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH 

       250        260        270        280        290        300 
QPAPHQQSKA QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG 

       310        320        330        340        350        360 
STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA PASLESGSSS 

       370        380        390        400        410        420 
TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK PPGPEAPRPT PEAMKPAPNN 

       430        440        450        460        470        480 
QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC ERLETLPSFE ESEELEAASR MLTTVGPASS 

       490        500        510        520        530        540 
SPKIALKGIA QRTFSRALTN KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK 

       550        560        570        580        590        600 
EEPKEDPSGA AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP 

       610        620        630        640        650        660 
SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT TLNHSISSQT 

       670        680        690        700        710        720 
VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY RSQTDTEGNV TAESSSTGVS 

       730        740        750        760        770        780 
VEPSHFTKTG QPALEELTGE DPEARRLRTV KNIADLRQNL EETMSSLRGT QVTHSTLETT 

       790        800        810        820        830        840 
FDTNVTTEMS GRSILSLTGR PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE 

       850        860        870        880        890        900 
SGRYVYSAPL RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD 

       910        920        930        940        950        960 
DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS SSVSSGISDT 

       970        980        990       1000       1010       1020 
IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ VERNSLWSGD DVKKSDGGSD 

      1030       1040       1050       1060       1070       1080 
SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK NPVISQTGSW RRGMTAQVGI TMPRTKPSAP 

      1090       1100       1110       1120       1130       1140 
AGALKTPGTG KTDDAKVSEK GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA 

      1150       1160       1170       1180       1190       1200 
NSFGFKKQSG SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD 

      1210       1220       1230       1240       1250       1260 
GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV PKLREPSKTA 

      1270       1280       1290       1300       1310       1320 
LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV SSPAQTSLQP GAKYPDVASP 

      1330       1340       1350       1360       1370       1380 
TLRRLFGGKP TKQVPIATAE NMKNSVVISN PHATMTQQGN LDSPSGSGVL SSGSSSPLYS 

      1390       1400       1410       1420       1430       1440 
KNVDLNQSPL ASSPSSAHSA PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS 

      1450       1460       1470       1480       1490       1500 
LSSGGVPSHN SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ 

      1510       1520       1530       1540       1550       1560 
DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP FSSGSSVTSP 

      1570       1580       1590       1600       1610       1620 
SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD PYTDSRFRNS SMSLDEKSRT 

      1630       1640       1650       1660       1670       1680 
MSRSGSFRDG FEEESWEKSS VDNFVSRLHS SLHFSLPLFH HARYELVHGS SLSLVSSTSS 

      1690       1700       1710       1720       1730       1740 
VYSTPEEKCQ SEIRKLRREL DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM 

      1750       1760       1770       1780       1790       1800 
TAEQKDSELN ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS 

      1810       1820       1830       1840       1850       1860 
DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK SASSHSDIEE 

      1870       1880       1890       1900       1910       1920 
MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE AETVMQLRNE LRDKEMKLTD 

      1930       1940       1950       1960       1970       1980 
IRLEALSSAH QLDQLREAMN RMQSEIEKLK AENDRLKSES QGSGCSRAPS QVSISASPRQ 

      1990       2000       2010       2020       2030       2040 
SMGLSQHSLN LTESTSLDML LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI 

      2050       2060       2070       2080       2090       2100 
GCIGVSGKTK WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE 

      2110       2120       2130       2140       2150       2160 
LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH RRIILSGPSG 

      2170       2180       2190       2200       2210       2220 
TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL RQYLSNLADQ CNSENNAVDM 

      2230       2240       2250       2260       2270       2280 
PLVIILDNLH HVSSLGEIFN GLLNCKYHKC PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN 

      2290       2300       2310       2320       2330       2340 
HTEPVKGFLG RFLRRKLMET EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG 

      2350       2360       2370       2380       2390       2400 
PRLFLSCPID VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW 

      2410       2420       2430       2440       2450       2460 
AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM LMRLQEAANY 

      2470       2480 
SSPQSYDSDS NSNSHHDDIL DSSLESTL 

« Hide

Isoform 2 (RAINB1d) [UniParc].

Checksum: 1CEC21B583BB5B36
Show »

FASTA2,432261,750
Isoform 3 (HELAD1L) [UniParc].

Checksum: FF906F1F4EB428B5
Show »

FASTA2,429261,408
Isoform 4 (HELAD1S) [UniParc].

Checksum: 000C16EB12682A2C
Show »

FASTA2,365254,978
Isoform 5 [UniParc].

Checksum: 278DEF938E0D3DC2
Show »

FASTA1,493161,946
Isoform 6 [UniParc].

Checksum: AEFA49541B2A2E94
Show »

FASTA87497,684
Isoform 7 [UniParc].

Checksum: 6B8F113F3C036820
Show »

FASTA59266,897
Isoform 8 [UniParc].

Checksum: 635AC30132928AF6
Show »

FASTA2,408259,971
Isoform 9 [UniParc].

Checksum: FF6423A81066C65B
Show »

FASTA2,414260,208
Isoform 10 [UniParc].

Checksum: DFBF27444A625EB2
Show »

FASTA2,417261,109
Isoform 11 [UniParc].

Checksum: 5C153BF3E2FA6698
Show »

FASTA2,425261,866
Isoform 12 [UniParc].

Checksum: A902C8AFDA1FA86E
Show »

FASTA2,424261,579
Isoform 13 [UniParc].

Checksum: 98CA63F4C60A1573
Show »

FASTA2,419261,102

References

« Hide 'large scale' references
[1]"A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos."
Merrill R.A., Plum L.A., Kaiser M.E., Clagett-Dame M.
Proc. Natl. Acad. Sci. U.S.A. 99:3422-3427(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), INDUCTION BY ATRA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-1077.
[2]"Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas."
Ishiguro H., Shimokawa T., Tsunoda T., Tanaka T., Fujii Y., Nakamura Y., Furukawa Y.
Oncogene 21:6387-6394(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION, FUNCTION AS A HELICASE, INDUCTION, TISSUE SPECIFICITY, VARIANTS LYS-109 AND ALA-1077.
[3]"Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53."
Peeters P.J., Baker A., Goris I., Daneels G., Verhasselt P., Luyten W.H.M.L., Geysen J.J.G.H., Kass S.U., Moechars D.W.E.
Brain Res. Dev. Brain Res. 150:89-101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 8; 9; 10; 11; 12 AND 13), FUNCTION, VARIANTS LYS-109 AND ALA-1077.
[4]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-1077.
Tissue: Brain.
[5]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[6]Ohara O.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7), VARIANTS ASP-1041; ALA-1077 AND ILE-2374.
Tissue: Placenta.
[8]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-1077.
Tissue: Skin.
[10]"Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms."
Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O., Christiansen H., Poustka A.
Gene 290:73-94(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[11]"Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans."
Maes T., Barcelo A., Buesa C.
Genomics 80:21-30(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[12]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1480; SER-1484; SER-1488 AND SER-1977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"Solution structure of the CH domain from human neuron navigator 2."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2009) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 90-197.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF466143 mRNA. Translation: AAL96479.1.
AF466144 mRNA. Translation: AAL96480.1.
AB063115 mRNA. Translation: BAC00853.1.
AB063116 mRNA. Translation: BAC00854.1.
AJ488102 mRNA. Translation: CAD32471.1.
AJ488203 mRNA. Translation: CAD32556.1.
AJ488204 mRNA. Translation: CAD32557.1.
AJ488205 mRNA. Translation: CAD32558.1.
AJ488206 mRNA. Translation: CAD32559.1.
AJ488207 mRNA. Translation: CAD32560.1.
AJ488208 mRNA. Translation: CAD32561.1.
AB037840 mRNA. Translation: BAA92657.3. Different initiation.
AK001495 mRNA. Translation: BAA91723.1.
AK001892 mRNA. Translation: BAA91965.1.
AK074287 mRNA. Translation: BAB85038.1. Frameshift.
AC009549 Genomic DNA. No translation available.
AC015684 Genomic DNA. No translation available.
AC023950 Genomic DNA. No translation available.
AC090662 Genomic DNA. No translation available.
AC111163 Genomic DNA. No translation available.
AC113193 Genomic DNA. No translation available.
BC016054 mRNA. Translation: AAH16054.1.
CCDSCCDS44552.1. [Q8IVL1-5]
CCDS53612.1. [Q8IVL1-4]
CCDS58126.1. [Q8IVL1-1]
CCDS7850.1. [Q8IVL1-3]
CCDS7851.2. [Q8IVL1-2]
RefSeqNP_001104488.1. NM_001111018.1. [Q8IVL1-4]
NP_001104489.1. NM_001111019.2. [Q8IVL1-5]
NP_001231892.1. NM_001244963.1. [Q8IVL1-1]
NP_660093.2. NM_145117.4. [Q8IVL1-3]
NP_892009.3. NM_182964.5. [Q8IVL1-2]
XP_006718431.1. XM_006718368.1. [Q8IVL1-5]
UniGeneHs.502116.
Hs.639427.
Hs.639428.
Hs.64341.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YRNNMR-A90-197[»]
ProteinModelPortalQ8IVL1.
SMRQ8IVL1. Positions 78-197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124606. 4 interactions.
IntActQ8IVL1. 4 interactions.
MINTMINT-1455352.

PTM databases

PhosphoSiteQ8IVL1.

Polymorphism databases

DMDM308153582.

Proteomic databases

MaxQBQ8IVL1.
PaxDbQ8IVL1.
PRIDEQ8IVL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311043; ENSP00000312169; ENSG00000166833. [Q8IVL1-5]
ENST00000349880; ENSP00000309577; ENSG00000166833. [Q8IVL1-3]
ENST00000360655; ENSP00000353871; ENSG00000166833. [Q8IVL1-4]
ENST00000396085; ENSP00000379394; ENSG00000166833. [Q8IVL1-2]
ENST00000396087; ENSP00000379396; ENSG00000166833. [Q8IVL1-1]
ENST00000527559; ENSP00000435395; ENSG00000166833. [Q8IVL1-10]
ENST00000533917; ENSP00000437316; ENSG00000166833. [Q8IVL1-5]
ENST00000540292; ENSP00000443489; ENSG00000166833. [Q8IVL1-13]
GeneID89797.
KEGGhsa:89797.
UCSCuc001mpp.3. human. [Q8IVL1-4]
uc001mpr.4. human. [Q8IVL1-2]
uc001mpu.3. human. [Q8IVL1-6]
uc009yhx.4. human. [Q8IVL1-5]
uc010rdm.2. human. [Q8IVL1-1]

Organism-specific databases

CTD89797.
GeneCardsGC11P019372.
HGNCHGNC:15997. NAV2.
HPAHPA011755.
HPA011891.
MIM607026. gene.
neXtProtNX_Q8IVL1.
PharmGKBPA31452.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5069.
HOVERGENHBG058814.
OMAERNSLWS.
OrthoDBEOG7GBFW1.
PhylomeDBQ8IVL1.
TreeFamTF329881.

Gene expression databases

ArrayExpressQ8IVL1.
BgeeQ8IVL1.
GenevestigatorQ8IVL1.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR001715. CH-domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00307. CH. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEPS50021. CH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNAV2. human.
EvolutionaryTraceQ8IVL1.
GeneWikiNAV2.
GenomeRNAi89797.
NextBio76293.
PROQ8IVL1.
SOURCESearch...

Entry information

Entry nameNAV2_HUMAN
AccessionPrimary (citable) accession number: Q8IVL1
Secondary accession number(s): A6NEC1 expand/collapse secondary AC list , Q8IVK3, Q8IVK4, Q8IVK5, Q8IVK6, Q8IVK7, Q8IVK8, Q8NHC9, Q8NHD0, Q8TDE9, Q8TDF0, Q8TEB3, Q96B30, Q9NUZ6, Q9NVM7, Q9P2C8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM