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Protein

Neuron navigator 2

Gene

NAV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2157 – 2164ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron navigator 2 (EC:3.6.4.12)
Alternative name(s):
Helicase APC down-regulated 1
Pore membrane and/or filament-interacting-like protein 2
Retinoic acid inducible in neuroblastoma 1
Steerin-2
Unc-53 homolog 2
Short name:
unc53H2
Gene namesi
Name:NAV2
Synonyms:HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15997. NAV2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi89797.
OpenTargetsiENSG00000166833.
PharmGKBiPA31452.

Polymorphism and mutation databases

BioMutaiNAV2.
DMDMi308153582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002671981 – 2488Neuron navigator 2Add BLAST2488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1480PhosphoserineCombined sources1
Modified residuei1484PhosphoserineCombined sources1
Modified residuei1488PhosphoserineCombined sources1
Modified residuei1977PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IVL1.
PaxDbiQ8IVL1.
PeptideAtlasiQ8IVL1.
PRIDEiQ8IVL1.

PTM databases

iPTMnetiQ8IVL1.
PhosphoSitePlusiQ8IVL1.

Expressioni

Tissue specificityi

Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.4 Publications

Developmental stagei

Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney.1 Publication

Inductioni

By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.2 Publications

Gene expression databases

BgeeiENSG00000166833.
ExpressionAtlasiQ8IVL1. baseline and differential.
GenevisibleiQ8IVL1. HS.

Organism-specific databases

HPAiHPA011755.
HPA011891.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAT2Q7Z6V53EBI-741200,EBI-2809203
CFAP58Q5T6553EBI-741200,EBI-10245749
ING4Q9UNL43EBI-741200,EBI-2866661
ING5Q8WYH84EBI-741200,EBI-488533
MORF4L1Q9UBU83EBI-741200,EBI-399246
PIAS2O759284EBI-741200,EBI-348555
RBM15Q96T373EBI-741200,EBI-2514922
RBM15BQ8NDT23EBI-741200,EBI-726721
RBM15BQ8NDT2-23EBI-741200,EBI-10269922

Protein-protein interaction databases

BioGridi124606. 12 interactors.
IntActiQ8IVL1. 10 interactors.
MINTiMINT-1455352.
STRINGi9606.ENSP00000379394.

Structurei

Secondary structure

12488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi90 – 101Combined sources12
Helixi111 – 114Combined sources4
Beta strandi115 – 118Combined sources4
Helixi119 – 128Combined sources10
Helixi145 – 159Combined sources15
Helixi169 – 174Combined sources6
Helixi177 – 191Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRNNMR-A90-197[»]
ProteinModelPortaliQ8IVL1.
SMRiQ8IVL1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IVL1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 192CHPROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili498 – 531Sequence analysisAdd BLAST34
Coiled coili743 – 771Sequence analysisAdd BLAST29
Coiled coili1686 – 1773Sequence analysisAdd BLAST88
Coiled coili1897 – 1964Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi192 – 255Gln-richAdd BLAST64
Compositional biasi324 – 328Poly-Pro5
Compositional biasi633 – 638Poly-Ser6
Compositional biasi1363 – 1683Ser-richAdd BLAST321
Compositional biasi1824 – 1829Poly-Lys6

Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGVF. Eukaryota.
ENOG410XRG8. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8IVL1.
KOiK19483.
PhylomeDBiQ8IVL1.
TreeFamiTF329881.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001715. CH-domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms may exist.
Isoform 1 (identifier: Q8IVL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT
60 70 80 90 100
TYPSQIPLKS QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA
110 120 130 140 150
KSGHKRLIRD LQQDVTDGVL LAQIIQVVAN EKIEDINGCP KNRSQMIENI
160 170 180 190 200
DACLNFLAAK GINIQGLSAE EIRNGNLKAI LGLFFSLSRY KQQQQQPQKQ
210 220 230 240 250
HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH QPAPHQQSKA
260 270 280 290 300
QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG
310 320 330 340 350
STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA
360 370 380 390 400
PASLESGSSS TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK
410 420 430 440 450
PPGPEAPRPT PEAMKPAPNN QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC
460 470 480 490 500
ERLETLPSFE ESEELEAASR MLTTVGPASS SPKIALKGIA QRTFSRALTN
510 520 530 540 550
KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK EEPKEDPSGA
560 570 580 590 600
AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP
610 620 630 640 650
SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT
660 670 680 690 700
TLNHSISSQT VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY
710 720 730 740 750
RSQTDTEGNV TAESSSTGVS VEPSHFTKTG QPALEELTGE DPEARRLRTV
760 770 780 790 800
KNIADLRQNL EETMSSLRGT QVTHSTLETT FDTNVTTEMS GRSILSLTGR
810 820 830 840 850
PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE SGRYVYSAPL
860 870 880 890 900
RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD
910 920 930 940 950
DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS
960 970 980 990 1000
SSVSSGISDT IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ
1010 1020 1030 1040 1050
VERNSLWSGD DVKKSDGGSD SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK
1060 1070 1080 1090 1100
NPVISQTGSW RRGMTAQVGI TMPRTKPSAP AGALKTPGTG KTDDAKVSEK
1110 1120 1130 1140 1150
GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA NSFGFKKQSG
1160 1170 1180 1190 1200
SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD
1210 1220 1230 1240 1250
GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV
1260 1270 1280 1290 1300
PKLREPSKTA LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV
1310 1320 1330 1340 1350
SSPAQTSLQP GAKYPDVASP TLRRLFGGKP TKQVPIATAE NMKNSVVISN
1360 1370 1380 1390 1400
PHATMTQQGN LDSPSGSGVL SSGSSSPLYS KNVDLNQSPL ASSPSSAHSA
1410 1420 1430 1440 1450
PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS LSSGGVPSHN
1460 1470 1480 1490 1500
SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ
1510 1520 1530 1540 1550
DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP
1560 1570 1580 1590 1600
FSSGSSVTSP SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD
1610 1620 1630 1640 1650
PYTDSRFRNS SMSLDEKSRT MSRSGSFRDG FEEESWEKSS VDNFVSRLHS
1660 1670 1680 1690 1700
SLHFSLPLFH HARYELVHGS SLSLVSSTSS VYSTPEEKCQ SEIRKLRREL
1710 1720 1730 1740 1750
DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM TAEQKDSELN
1760 1770 1780 1790 1800
ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS
1810 1820 1830 1840 1850
DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK
1860 1870 1880 1890 1900
SASSHSDIEE MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE
1910 1920 1930 1940 1950
AETVMQLRNE LRDKEMKLTD IRLEALSSAH QLDQLREAMN RMQSEIEKLK
1960 1970 1980 1990 2000
AENDRLKSES QGSGCSRAPS QVSISASPRQ SMGLSQHSLN LTESTSLDML
2010 2020 2030 2040 2050
LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI GCIGVSGKTK
2060 2070 2080 2090 2100
WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE
2110 2120 2130 2140 2150
LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH
2160 2170 2180 2190 2200
RRIILSGPSG TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL
2210 2220 2230 2240 2250
RQYLSNLADQ CNSENNAVDM PLVIILDNLH HVSSLGEIFN GLLNCKYHKC
2260 2270 2280 2290 2300
PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN HTEPVKGFLG RFLRRKLMET
2310 2320 2330 2340 2350
EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG PRLFLSCPID
2360 2370 2380 2390 2400
VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW
2410 2420 2430 2440 2450
AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM
2460 2470 2480
LMRLQEAANY SSPQSYDSDS NSNSHHDDIL DSSLESTL
Length:2,488
Mass (Da):268,167
Last modified:October 5, 2010 - v3
Checksum:i0AEDD1C1469A11A8
GO
Isoform 2 (identifier: Q8IVL1-2) [UniParc]FASTAAdd to basket
Also known as: RAINB1d

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.

Show »
Length:2,432
Mass (Da):261,750
Checksum:i1CEC21B583BB5B36
GO
Isoform 3 (identifier: Q8IVL1-3) [UniParc]FASTAAdd to basket
Also known as: HELAD1L

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:2,429
Mass (Da):261,408
Checksum:iFF906F1F4EB428B5
GO
Isoform 4 (identifier: Q8IVL1-4) [UniParc]FASTAAdd to basket
Also known as: HELAD1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPAILVASKM...GSVENGFDTQ → MESVSESSQQQKRKPVIHGLEDQKR
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:2,365
Mass (Da):254,978
Checksum:i000C16EB12682A2C
GO
Isoform 5 (identifier: Q8IVL1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-937: Missing.
     938-945: SLGLGDAD → MLWPRNLT
     1480-1501: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:1,493
Mass (Da):161,946
Checksum:i278DEF938E0D3DC2
GO
Isoform 6 (identifier: Q8IVL1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1578: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:874
Mass (Da):97,684
Checksum:iAEFA49541B2A2E94
GO
Isoform 7 (identifier: Q8IVL1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1896: Missing.

Show »
Length:592
Mass (Da):66,897
Checksum:i6B8F113F3C036820
GO
Isoform 8 (identifier: Q8IVL1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MLWPRNLT

Show »
Length:2,408
Mass (Da):259,971
Checksum:i635AC30132928AF6
GO
Isoform 9 (identifier: Q8IVL1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAGTSAASSWGGGK

Show »
Length:2,414
Mass (Da):260,208
Checksum:iFF6423A81066C65B
GO
Isoform 10 (identifier: Q8IVL1-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MSVMLWRWEQNNTTMKL

Show »
Length:2,417
Mass (Da):261,109
Checksum:iDFBF27444A625EB2
GO
Isoform 11 (identifier: Q8IVL1-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MESVSESSQQQKRKPVIHGLEDQKR

Show »
Length:2,425
Mass (Da):261,866
Checksum:i5C153BF3E2FA6698
GO
Isoform 12 (identifier: Q8IVL1-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MQECDSKFFLPSGSNSGFTLLSNQ

Show »
Length:2,424
Mass (Da):261,579
Checksum:iA902C8AFDA1FA86E
GO
Isoform 13 (identifier: Q8IVL1-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAIDLYCGLACLWGIHEPR

Show »
Length:2,419
Mass (Da):261,102
Checksum:i98CA63F4C60A1573
GO

Sequence cautioni

The sequence BAA92657 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB85038 differs from that shown. Reason: Frameshift at position 2074.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100A → T in BAC00854 (PubMed:12214280).Curated1
Sequence conflicti100A → T in CAD32471 (PubMed:15158073).Curated1
Sequence conflicti259S → P in AAL96479 (PubMed:11904404).Curated1
Sequence conflicti259S → P in AAL96480 (PubMed:11904404).Curated1
Sequence conflicti259S → P in BAA92657 (PubMed:10718198).Curated1
Sequence conflicti282P → S in CAD32471 (PubMed:15158073).Curated1
Sequence conflicti1046T → M in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti1173G → D in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti1845Missing in AAH16054 (PubMed:16554811).Curated1
Sequence conflicti1939M → V in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti2012E → G in BAA91965 (PubMed:14702039).Curated1
Sequence conflicti2053V → A in BAA91723 (PubMed:14702039).Curated1
Sequence conflicti2075L → V in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti2296K → E in BAA91965 (PubMed:14702039).Curated1
Sequence conflicti2299E → K in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti2395M → V in BAA91723 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029640109R → K.2 PublicationsCorresponds to variant rs6483617dbSNPEnsembl.1
Natural variantiVAR_029641491Q → H.Corresponds to variant rs16937251dbSNPEnsembl.1
Natural variantiVAR_0296421041E → D.1 PublicationCorresponds to variant rs3802799dbSNPEnsembl.1
Natural variantiVAR_0296431077P → A.6 PublicationsCorresponds to variant rs3802800dbSNPEnsembl.1
Natural variantiVAR_0322522374V → I.1 PublicationCorresponds to variant rs35891966dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0219241 – 1896Missing in isoform 7. 1 PublicationAdd BLAST1896
Alternative sequenceiVSP_0219251 – 1578Missing in isoform 6. 2 PublicationsAdd BLAST1578
Alternative sequenceiVSP_0219261 – 937Missing in isoform 5. 1 PublicationAdd BLAST937
Alternative sequenceiVSP_0219271 – 89MPAIL…GFDTQ → MESVSESSQQQKRKPVIHGL EDQKR in isoform 4. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0219281 – 88MPAIL…NGFDT → MSVMLWRWEQNNTTMKL in isoform 10. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219291 – 88MPAIL…NGFDT → MESVSESSQQQKRKPVIHGL EDQKR in isoform 11. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219301 – 88MPAIL…NGFDT → MQECDSKFFLPSGSNSGFTL LSNQ in isoform 12. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219311 – 88MPAIL…NGFDT → MAIDLYCGLACLWGIHEPR in isoform 13. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219321 – 88MPAIL…NGFDT → MLWPRNLT in isoform 8. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219331 – 88MPAIL…NGFDT → MAGTSAASSWGGGK in isoform 9. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_021934256 – 278Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_021935938 – 945SLGLGDAD → MLWPRNLT in isoform 5. 1 Publication8
Alternative sequenceiVSP_0219361480 – 1501Missing in isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0219371634 – 1666Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 5 PublicationsAdd BLAST33
Alternative sequenceiVSP_0219381832 – 1834Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 4 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466143 mRNA. Translation: AAL96479.1.
AF466144 mRNA. Translation: AAL96480.1.
AB063115 mRNA. Translation: BAC00853.1.
AB063116 mRNA. Translation: BAC00854.1.
AJ488102 mRNA. Translation: CAD32471.1.
AJ488203 mRNA. Translation: CAD32556.1.
AJ488204 mRNA. Translation: CAD32557.1.
AJ488205 mRNA. Translation: CAD32558.1.
AJ488206 mRNA. Translation: CAD32559.1.
AJ488207 mRNA. Translation: CAD32560.1.
AJ488208 mRNA. Translation: CAD32561.1.
AB037840 mRNA. Translation: BAA92657.3. Different initiation.
AK001495 mRNA. Translation: BAA91723.1.
AK001892 mRNA. Translation: BAA91965.1.
AK074287 mRNA. Translation: BAB85038.1. Frameshift.
AC009549 Genomic DNA. No translation available.
AC015684 Genomic DNA. No translation available.
AC023950 Genomic DNA. No translation available.
AC090662 Genomic DNA. No translation available.
AC111163 Genomic DNA. No translation available.
AC113193 Genomic DNA. No translation available.
BC016054 mRNA. Translation: AAH16054.1.
CCDSiCCDS44552.1. [Q8IVL1-5]
CCDS53612.1. [Q8IVL1-4]
CCDS58126.1. [Q8IVL1-1]
CCDS7850.1. [Q8IVL1-3]
CCDS7851.2. [Q8IVL1-2]
RefSeqiNP_001104488.1. NM_001111018.1. [Q8IVL1-4]
NP_001104489.1. NM_001111019.2. [Q8IVL1-5]
NP_001231892.1. NM_001244963.1. [Q8IVL1-1]
NP_660093.2. NM_145117.4. [Q8IVL1-3]
NP_892009.3. NM_182964.5. [Q8IVL1-2]
XP_006718431.1. XM_006718368.3. [Q8IVL1-5]
XP_011518754.1. XM_011520452.2. [Q8IVL1-4]
UniGeneiHs.502116.
Hs.639427.
Hs.639428.
Hs.64341.

Genome annotation databases

EnsembliENST00000349880; ENSP00000309577; ENSG00000166833. [Q8IVL1-3]
ENST00000360655; ENSP00000353871; ENSG00000166833. [Q8IVL1-4]
ENST00000396085; ENSP00000379394; ENSG00000166833. [Q8IVL1-2]
ENST00000396087; ENSP00000379396; ENSG00000166833. [Q8IVL1-1]
ENST00000533917; ENSP00000437316; ENSG00000166833. [Q8IVL1-5]
GeneIDi89797.
KEGGihsa:89797.
UCSCiuc001mpp.4. human. [Q8IVL1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466143 mRNA. Translation: AAL96479.1.
AF466144 mRNA. Translation: AAL96480.1.
AB063115 mRNA. Translation: BAC00853.1.
AB063116 mRNA. Translation: BAC00854.1.
AJ488102 mRNA. Translation: CAD32471.1.
AJ488203 mRNA. Translation: CAD32556.1.
AJ488204 mRNA. Translation: CAD32557.1.
AJ488205 mRNA. Translation: CAD32558.1.
AJ488206 mRNA. Translation: CAD32559.1.
AJ488207 mRNA. Translation: CAD32560.1.
AJ488208 mRNA. Translation: CAD32561.1.
AB037840 mRNA. Translation: BAA92657.3. Different initiation.
AK001495 mRNA. Translation: BAA91723.1.
AK001892 mRNA. Translation: BAA91965.1.
AK074287 mRNA. Translation: BAB85038.1. Frameshift.
AC009549 Genomic DNA. No translation available.
AC015684 Genomic DNA. No translation available.
AC023950 Genomic DNA. No translation available.
AC090662 Genomic DNA. No translation available.
AC111163 Genomic DNA. No translation available.
AC113193 Genomic DNA. No translation available.
BC016054 mRNA. Translation: AAH16054.1.
CCDSiCCDS44552.1. [Q8IVL1-5]
CCDS53612.1. [Q8IVL1-4]
CCDS58126.1. [Q8IVL1-1]
CCDS7850.1. [Q8IVL1-3]
CCDS7851.2. [Q8IVL1-2]
RefSeqiNP_001104488.1. NM_001111018.1. [Q8IVL1-4]
NP_001104489.1. NM_001111019.2. [Q8IVL1-5]
NP_001231892.1. NM_001244963.1. [Q8IVL1-1]
NP_660093.2. NM_145117.4. [Q8IVL1-3]
NP_892009.3. NM_182964.5. [Q8IVL1-2]
XP_006718431.1. XM_006718368.3. [Q8IVL1-5]
XP_011518754.1. XM_011520452.2. [Q8IVL1-4]
UniGeneiHs.502116.
Hs.639427.
Hs.639428.
Hs.64341.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRNNMR-A90-197[»]
ProteinModelPortaliQ8IVL1.
SMRiQ8IVL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124606. 12 interactors.
IntActiQ8IVL1. 10 interactors.
MINTiMINT-1455352.
STRINGi9606.ENSP00000379394.

PTM databases

iPTMnetiQ8IVL1.
PhosphoSitePlusiQ8IVL1.

Polymorphism and mutation databases

BioMutaiNAV2.
DMDMi308153582.

Proteomic databases

MaxQBiQ8IVL1.
PaxDbiQ8IVL1.
PeptideAtlasiQ8IVL1.
PRIDEiQ8IVL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349880; ENSP00000309577; ENSG00000166833. [Q8IVL1-3]
ENST00000360655; ENSP00000353871; ENSG00000166833. [Q8IVL1-4]
ENST00000396085; ENSP00000379394; ENSG00000166833. [Q8IVL1-2]
ENST00000396087; ENSP00000379396; ENSG00000166833. [Q8IVL1-1]
ENST00000533917; ENSP00000437316; ENSG00000166833. [Q8IVL1-5]
GeneIDi89797.
KEGGihsa:89797.
UCSCiuc001mpp.4. human. [Q8IVL1-1]

Organism-specific databases

CTDi89797.
DisGeNETi89797.
GeneCardsiNAV2.
HGNCiHGNC:15997. NAV2.
HPAiHPA011755.
HPA011891.
MIMi607026. gene.
neXtProtiNX_Q8IVL1.
OpenTargetsiENSG00000166833.
PharmGKBiPA31452.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVF. Eukaryota.
ENOG410XRG8. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8IVL1.
KOiK19483.
PhylomeDBiQ8IVL1.
TreeFamiTF329881.

Miscellaneous databases

ChiTaRSiNAV2. human.
EvolutionaryTraceiQ8IVL1.
GeneWikiiNAV2.
GenomeRNAii89797.
PROiQ8IVL1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166833.
ExpressionAtlasiQ8IVL1. baseline and differential.
GenevisibleiQ8IVL1. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001715. CH-domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAV2_HUMAN
AccessioniPrimary (citable) accession number: Q8IVL1
Secondary accession number(s): A6NEC1
, Q8IVK3, Q8IVK4, Q8IVK5, Q8IVK6, Q8IVK7, Q8IVK8, Q8NHC9, Q8NHD0, Q8TDE9, Q8TDF0, Q8TEB3, Q96B30, Q9NUZ6, Q9NVM7, Q9P2C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:15158073 experiments have been carried out in mouse.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.