Q8IVL1 (NAV2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuron navigator 2
EC=3.6.4.12

Alternative name(s):
Helicase APC down-regulated 1
Pore membrane and/or filament-interacting-like protein 2
Retinoic acid inducible in neuroblastoma 1
Steerin-2
Unc-53 homolog 2
Short name=unc53H2

Gene names

Name:	NAV2
Synonyms:	HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2488 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. Ref.2 Ref.3
Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Nucleus Ref.2.
Tissue specificity	Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers. Ref.1 Ref.2 Ref.10 Ref.11
Developmental stage	Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney. Ref.1
Induction	By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas. Ref.1 Ref.2
Sequence similarities	Belongs to the Nav/unc-53 family. Contains 1 CH (calponin-homology) domain.
Caution	Ref.3 experiments have been carried out in mouse.
Sequence caution	The sequence BAA92657.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB85038.1 differs from that shown. Reason: Frameshift at position 2074.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glossopharyngeal nerve development Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara optic nerve development Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by baroreceptor feedback Inferred from electronic annotation. Source: Compara sensory perception of smell Inferred from electronic annotation. Source: Compara sensory perception of sound Inferred from electronic annotation. Source: Compara vagus nerve development Inferred from electronic annotation. Source: Compara
Cellular_component	interstitial matrix Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW helicase activity Inferred from electronic annotation. Source: UniProtKB-KW heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist.

Isoform 1 (identifier: Q8IVL1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IVL1-2)

Also known as: RAINB1d;

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.

Isoform 3 (identifier: Q8IVL1-3)

Also known as: HELAD1L;

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Isoform 4 (identifier: Q8IVL1-4)

Also known as: HELAD1S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPAILVASKM...GSVENGFDTQ → MESVSESSQQQKRKPVIHGLEDQKR
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Isoform 5 (identifier: Q8IVL1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-937: Missing.
     938-945: SLGLGDAD → MLWPRNLT
     1480-1501: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Isoform 6 (identifier: Q8IVL1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1578: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Isoform 7 (identifier: Q8IVL1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1896: Missing.

Isoform 8 (identifier: Q8IVL1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MLWPRNLT

Isoform 9 (identifier: Q8IVL1-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAGTSAASSWGGGK

Isoform 10 (identifier: Q8IVL1-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MSVMLWRWEQNNTTMKL

Isoform 11 (identifier: Q8IVL1-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MESVSESSQQQKRKPVIHGLEDQKR

Isoform 12 (identifier: Q8IVL1-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MQECDSKFFLPSGSNSGFTLLSNQ

Isoform 13 (identifier: Q8IVL1-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAIDLYCGLACLWGIHEPR

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2488

2488

Neuron navigator 2

PRO_0000267198

Regions

Domain

85 – 192

108

CH

Nucleotide binding

2157 – 2164

8

ATP Potential

Coiled coil

498 – 531

34

Potential

Coiled coil

743 – 771

29

Potential

Coiled coil

1686 – 1773

88

Potential

Coiled coil

1897 – 1964

68

Potential

Compositional bias

192 – 255

64

Gln-rich

Compositional bias

324 – 328

5

Poly-Pro

Compositional bias

633 – 638

6

Poly-Ser

Compositional bias

1363 – 1683

321

Ser-rich

Compositional bias

1824 – 1829

6

Poly-Lys

Amino acid modifications

Modified residue

1480

1

Phosphoserine Ref.13

Modified residue

1484

1

Phosphoserine Ref.13

Modified residue

1488

1

Phosphoserine Ref.13

Modified residue

1977

1

Phosphoserine Ref.12 Ref.13

Natural variations

Alternative sequence

1 – 1896

1896

Missing in isoform 7.

VSP_021924

Alternative sequence

1 – 1578

1578

Missing in isoform 6.

VSP_021925

Alternative sequence

1 – 937

937

Missing in isoform 5.

VSP_021926

Alternative sequence

1 – 89

89

MPAIL…GFDTQ → MESVSESSQQQKRKPVIHGL EDQKR in isoform 4.

VSP_021927

Alternative sequence

1 – 88

88

MPAIL…NGFDT → MSVMLWRWEQNNTTMKL in isoform 10.

VSP_021928

Alternative sequence

1 – 88

88

MPAIL…NGFDT → MESVSESSQQQKRKPVIHGL EDQKR in isoform 11.

VSP_021929

Alternative sequence

1 – 88

88

MPAIL…NGFDT → MQECDSKFFLPSGSNSGFTL LSNQ in isoform 12.

VSP_021930

Alternative sequence

1 – 88

88

MPAIL…NGFDT → MAIDLYCGLACLWGIHEPR in isoform 13.

VSP_021931

Alternative sequence

1 – 88

88

MPAIL…NGFDT → MLWPRNLT in isoform 8.

VSP_021932

Alternative sequence

1 – 88

88

MPAIL…NGFDT → MAGTSAASSWGGGK in isoform 9.

VSP_021933

Alternative sequence

256 – 278

23

Missing in isoform 2, isoform 3 and isoform 4.

VSP_021934

Alternative sequence

938 – 945

8

SLGLGDAD → MLWPRNLT in isoform 5.

VSP_021935

Alternative sequence

1480 – 1501

22

Missing in isoform 5.

VSP_021936

Alternative sequence

1634 – 1666

33

Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.

VSP_021937

Alternative sequence

1832 – 1834

3

Missing in isoform 3, isoform 4, isoform 5 and isoform 6.

VSP_021938

Natural variant

109

1

R → K. Ref.2 Ref.3
Corresponds to variant rs6483617 [ dbSNP | Ensembl ].

VAR_029640

Natural variant

491

1

Q → H.
Corresponds to variant rs16937251 [ dbSNP | Ensembl ].

VAR_029641

Natural variant

1041

1

E → D. Ref.7
Corresponds to variant rs3802799 [ dbSNP | Ensembl ].

VAR_029642

Natural variant

1077

1

P → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.7 Ref.9
Corresponds to variant rs3802800 [ dbSNP | Ensembl ].

VAR_029643

Natural variant

2374

1

V → I. Ref.7
Corresponds to variant rs35891966 [ dbSNP | Ensembl ].

VAR_032252

Experimental info

Sequence conflict

100

1

A → T in BAC00854. Ref.2

Sequence conflict

100

1

A → T in CAD32471. Ref.3

Sequence conflict

259

1

S → P in AAL96479. Ref.1

Sequence conflict

259

1

S → P in AAL96480. Ref.1

Sequence conflict

259

1

S → P in BAA92657. Ref.4

Sequence conflict

282

1

P → S in CAD32471. Ref.3

Sequence conflict

1046

1

T → M in BAB85038. Ref.7

Sequence conflict

1173

1

G → D in BAB85038. Ref.7

Sequence conflict

1845

1

Missing in AAH16054. Ref.8

Sequence conflict

1939

1

M → V in BAB85038. Ref.7

Sequence conflict

2012

1

E → G in BAA91965. Ref.7

Sequence conflict

2053

1

V → A in BAA91723. Ref.7

Sequence conflict

2075

1

L → V in BAB85038. Ref.7

Sequence conflict

2296

1

K → E in BAA91965. Ref.7

Sequence conflict

2299

1

E → K in BAB85038. Ref.7

Sequence conflict

2395

1

M → V in BAA91723. Ref.7

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

2488

Helix Strand Turn

Details...

Helix

90 – 101

12

Helix

111 – 114

4

Beta strand

115 – 118

4

Helix

119 – 128

10

Helix

145 – 159

15

Helix

169 – 174

6

Helix

177 – 191

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 0AEDD1C1469A11A8	FASTA	2,488	268,167
	10 20 30 40 50 60 MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT TYPSQIPLKS 70 80 90 100 110 120 QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA KSGHKRLIRD LQQDVTDGVL 130 140 150 160 170 180 LAQIIQVVAN EKIEDINGCP KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI 190 200 210 220 230 240 LGLFFSLSRY KQQQQQPQKQ HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH 250 260 270 280 290 300 QPAPHQQSKA QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG 310 320 330 340 350 360 STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA PASLESGSSS 370 380 390 400 410 420 TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK PPGPEAPRPT PEAMKPAPNN 430 440 450 460 470 480 QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC ERLETLPSFE ESEELEAASR MLTTVGPASS 490 500 510 520 530 540 SPKIALKGIA QRTFSRALTN KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK 550 560 570 580 590 600 EEPKEDPSGA AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP 610 620 630 640 650 660 SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT TLNHSISSQT 670 680 690 700 710 720 VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY RSQTDTEGNV TAESSSTGVS 730 740 750 760 770 780 VEPSHFTKTG QPALEELTGE DPEARRLRTV KNIADLRQNL EETMSSLRGT QVTHSTLETT 790 800 810 820 830 840 FDTNVTTEMS GRSILSLTGR PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE 850 860 870 880 890 900 SGRYVYSAPL RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD 910 920 930 940 950 960 DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS SSVSSGISDT 970 980 990 1000 1010 1020 IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ VERNSLWSGD DVKKSDGGSD 1030 1040 1050 1060 1070 1080 SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK NPVISQTGSW RRGMTAQVGI TMPRTKPSAP 1090 1100 1110 1120 1130 1140 AGALKTPGTG KTDDAKVSEK GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA 1150 1160 1170 1180 1190 1200 NSFGFKKQSG SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD 1210 1220 1230 1240 1250 1260 GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV PKLREPSKTA 1270 1280 1290 1300 1310 1320 LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV SSPAQTSLQP GAKYPDVASP 1330 1340 1350 1360 1370 1380 TLRRLFGGKP TKQVPIATAE NMKNSVVISN PHATMTQQGN LDSPSGSGVL SSGSSSPLYS 1390 1400 1410 1420 1430 1440 KNVDLNQSPL ASSPSSAHSA PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS 1450 1460 1470 1480 1490 1500 LSSGGVPSHN SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ 1510 1520 1530 1540 1550 1560 DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP FSSGSSVTSP 1570 1580 1590 1600 1610 1620 SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD PYTDSRFRNS SMSLDEKSRT 1630 1640 1650 1660 1670 1680 MSRSGSFRDG FEEESWEKSS VDNFVSRLHS SLHFSLPLFH HARYELVHGS SLSLVSSTSS 1690 1700 1710 1720 1730 1740 VYSTPEEKCQ SEIRKLRREL DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM 1750 1760 1770 1780 1790 1800 TAEQKDSELN ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS 1810 1820 1830 1840 1850 1860 DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK SASSHSDIEE 1870 1880 1890 1900 1910 1920 MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE AETVMQLRNE LRDKEMKLTD 1930 1940 1950 1960 1970 1980 IRLEALSSAH QLDQLREAMN RMQSEIEKLK AENDRLKSES QGSGCSRAPS QVSISASPRQ 1990 2000 2010 2020 2030 2040 SMGLSQHSLN LTESTSLDML LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI 2050 2060 2070 2080 2090 2100 GCIGVSGKTK WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE 2110 2120 2130 2140 2150 2160 LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH RRIILSGPSG 2170 2180 2190 2200 2210 2220 TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL RQYLSNLADQ CNSENNAVDM 2230 2240 2250 2260 2270 2280 PLVIILDNLH HVSSLGEIFN GLLNCKYHKC PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN 2290 2300 2310 2320 2330 2340 HTEPVKGFLG RFLRRKLMET EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG 2350 2360 2370 2380 2390 2400 PRLFLSCPID VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW 2410 2420 2430 2440 2450 2460 AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM LMRLQEAANY 2470 2480 SSPQSYDSDS NSNSHHDDIL DSSLESTL
	Isoform 2 (RAINB1d) [UniParc]. Checksum: 1CEC21B583BB5B36	FASTA	2,432	261,750
	10 20 30 40 50 60 MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT TYPSQIPLKS 70 80 90 100 110 120 QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA KSGHKRLIRD LQQDVTDGVL 130 140 150 160 170 180 LAQIIQVVAN EKIEDINGCP KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI 190 200 210 220 230 240 LGLFFSLSRY KQQQQQPQKQ HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH 250 260 270 280 290 300 QPAPHQQSKA QAEMQSRLPG PTARVSAAGS EAKTRGGSTT ANNRRSQSFN NYDKSKPVTS 310 320 330 340 350 360 PPPPPSSHEK EPLASSASSH PGMSDNAPAS LESGSSSTPT NCSTSSAIPQ PGAATKPWRS 370 380 390 400 410 420 KSLSVKHSAT VSMLSVKPPG PEAPRPTPEA MKPAPNNQKS MLEKLKLFNS KGGSKAGEGP 430 440 450 460 470 480 GSRDTSCERL ETLPSFEESE ELEAASRMLT TVGPASSSPK IALKGIAQRT FSRALTNKKS 490 500 510 520 530 540 SLKGNEKEKE KQQREKDKEK SKDLAKRASV TERLDLKEEP KEDPSGAAVP EMPKKSSKIA 550 560 570 580 590 600 SFIPKGGKLN SAKKEPMAPS HSGIPKPGMK SMPGKSPSAP APSKEGERSR SGKLSSGLPQ 610 620 630 640 650 660 QKPQLDGRHS SSSSSLASSE GKGPGGTTLN HSISSQTVSG SVGTTQTTGS NTVSVQLPQP 670 680 690 700 710 720 QQQYNHPNTA TVAPFLYRSQ TDTEGNVTAE SSSTGVSVEP SHFTKTGQPA LEELTGEDPE 730 740 750 760 770 780 ARRLRTVKNI ADLRQNLEET MSSLRGTQVT HSTLETTFDT NVTTEMSGRS ILSLTGRPTP 790 800 810 820 830 840 LSWRLGQSSP RLQAGDAPSM GNGYPPRANA SRFINTESGR YVYSAPLRRQ LASRGSSVCH 850 860 870 880 890 900 VDVSDKAGDE MDLEGISMDA PGYMSDGDVL SKNIRTDDIT SGYMTDGGLG LYTRRLNRLP 910 920 930 940 950 960 DGMAVVRETL QRNTSLGLGD ADSWDDSSSV SSGISDTIDN LSTDDINTSS SISSYANTPA 970 980 990 1000 1010 1020 SSRKNLDVQT DAEKHSQVER NSLWSGDDVK KSDGGSDSGI KMEPGSKWRR NPSDVSDESD 1030 1040 1050 1060 1070 1080 KSTSGKKNPV ISQTGSWRRG MTAQVGITMP RTKPSAPAGA LKTPGTGKTD DAKVSEKGRL 1090 1100 1110 1120 1130 1140 SPKASQVKRS PSDAGRSSGD ESKKPLPSSS RTPTANANSF GFKKQSGSAA GLAMITASGV 1150 1160 1170 1180 1190 1200 TVTSRSATLG KIPKSSALVS RSAGRKSSMD GAQNQDDGYL ALSSRTNLQY RSLPRPSKSN 1210 1220 1230 1240 1250 1260 SRNGAGNRSS TSSIDSNISS KSAGLPVPKL REPSKTALGS SLPGLVNQTD KEKGISSDNE 1270 1280 1290 1300 1310 1320 SVASCNSVKV NPAAQPVSSP AQTSLQPGAK YPDVASPTLR RLFGGKPTKQ VPIATAENMK 1330 1340 1350 1360 1370 1380 NSVVISNPHA TMTQQGNLDS PSGSGVLSSG SSSPLYSKNV DLNQSPLASS PSSAHSAPSN 1390 1400 1410 1420 1430 1440 SLTWGTNASS SSAVSKDGLG FQSVSSLHTS CESIDISLSS GGVPSHNSST GLIASSKDDS 1450 1460 1470 1480 1490 1500 LTPFVRTNSV KTTLSESPLS SPAASPKFCR STLPRKQDSD PHLDRNTLPK KGLRYTPTSQ 1510 1520 1530 1540 1550 1560 LRTQEDAKEW LRSHSAGGLQ DTAANSPFSS GSSVTSPSGT RFNFSQLASP TTVTQMSLSN 1570 1580 1590 1600 1610 1620 PTMLRTHSLS NADGQYDPYT DSRFRNSSMS LDEKSRTMSR SGSFRDGFEE VHGSSLSLVS 1630 1640 1650 1660 1670 1680 STSSVYSTPE EKCQSEIRKL RRELDASQEK VSALTTQLTA NAHLVAAFEQ SLGNMTIRLQ 1690 1700 1710 1720 1730 1740 SLTMTAEQKD SELNELRKTI ELLKKQNAAA QAAINGVINT PELNCKGNGT AQSADLRIRR 1750 1760 1770 1780 1790 1800 QHSSDSVSSI NSATSHSSVG SNIESDSKKK KRKNWVNELR SSFKQAFGKK KSPKSASSHS 1810 1820 1830 1840 1850 1860 DIEEMTDSSL PSSPKLPHNG STGSTPLLRN SHSNSLISEC MDSEAETVMQ LRNELRDKEM 1870 1880 1890 1900 1910 1920 KLTDIRLEAL SSAHQLDQLR EAMNRMQSEI EKLKAENDRL KSESQGSGCS RAPSQVSISA 1930 1940 1950 1960 1970 1980 SPRQSMGLSQ HSLNLTESTS LDMLLDDTGE CSARKEGGRH VKIVVSFQEE MKWKEDSRPH 1990 2000 2010 2020 2030 2040 LFLIGCIGVS GKTKWDVLDG VVRRLFKEYI IHVDPVSQLG LNSDSVLGYS IGEIKRSNTS 2050 2060 2070 2080 2090 2100 ETPELLPCGY LVGENTTISV TVKGLAENSL DSLVFESLIP KPILQRYVSL LIEHRRIILS 2110 2120 2130 2140 2150 2160 GPSGTGKTYL ANRLSEYIVL REGRELTDGV IATFNVDHKS SKELRQYLSN LADQCNSENN 2170 2180 2190 2200 2210 2220 AVDMPLVIIL DNLHHVSSLG EIFNGLLNCK YHKCPYIIGT MNQATSSTPN LQLHHNFRWV 2230 2240 2250 2260 2270 2280 LCANHTEPVK GFLGRFLRRK LMETEISGRV RNMELVKIID WIPKVWHHLN RFLEAHSSSD 2290 2300 2310 2320 2330 2340 VTIGPRLFLS CPIDVDGSRV WFTDLWNYSI IPYLLEAVRE GLQLYGRRAP WEDPAKWVMD 2350 2360 2370 2380 2390 2400 TYPWAASPQQ HEWPPLLQLR PEDVGFDGYS MPREGSTSKQ MPPSDAEGDP LMNMLMRLQE 2410 2420 2430 AANYSSPQSY DSDSNSNSHH DDILDSSLES TL
	Isoform 3 (HELAD1L) [UniParc]. Checksum: FF906F1F4EB428B5	FASTA	2,429	261,408
	10 20 30 40 50 60 MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT TYPSQIPLKS 70 80 90 100 110 120 QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA KSGHKRLIRD LQQDVTDGVL 130 140 150 160 170 180 LAQIIQVVAN EKIEDINGCP KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI 190 200 210 220 230 240 LGLFFSLSRY KQQQQQPQKQ HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH 250 260 270 280 290 300 QPAPHQQSKA QAEMQSRLPG PTARVSAAGS EAKTRGGSTT ANNRRSQSFN NYDKSKPVTS 310 320 330 340 350 360 PPPPPSSHEK EPLASSASSH PGMSDNAPAS LESGSSSTPT NCSTSSAIPQ PGAATKPWRS 370 380 390 400 410 420 KSLSVKHSAT VSMLSVKPPG PEAPRPTPEA MKPAPNNQKS MLEKLKLFNS KGGSKAGEGP 430 440 450 460 470 480 GSRDTSCERL ETLPSFEESE ELEAASRMLT TVGPASSSPK IALKGIAQRT FSRALTNKKS 490 500 510 520 530 540 SLKGNEKEKE KQQREKDKEK SKDLAKRASV TERLDLKEEP KEDPSGAAVP EMPKKSSKIA 550 560 570 580 590 600 SFIPKGGKLN SAKKEPMAPS HSGIPKPGMK SMPGKSPSAP APSKEGERSR SGKLSSGLPQ 610 620 630 640 650 660 QKPQLDGRHS SSSSSLASSE GKGPGGTTLN HSISSQTVSG SVGTTQTTGS NTVSVQLPQP 670 680 690 700 710 720 QQQYNHPNTA TVAPFLYRSQ TDTEGNVTAE SSSTGVSVEP SHFTKTGQPA LEELTGEDPE 730 740 750 760 770 780 ARRLRTVKNI ADLRQNLEET MSSLRGTQVT HSTLETTFDT NVTTEMSGRS ILSLTGRPTP 790 800 810 820 830 840 LSWRLGQSSP RLQAGDAPSM GNGYPPRANA SRFINTESGR YVYSAPLRRQ LASRGSSVCH 850 860 870 880 890 900 VDVSDKAGDE MDLEGISMDA PGYMSDGDVL SKNIRTDDIT SGYMTDGGLG LYTRRLNRLP 910 920 930 940 950 960 DGMAVVRETL QRNTSLGLGD ADSWDDSSSV SSGISDTIDN LSTDDINTSS SISSYANTPA 970 980 990 1000 1010 1020 SSRKNLDVQT DAEKHSQVER NSLWSGDDVK KSDGGSDSGI KMEPGSKWRR NPSDVSDESD 1030 1040 1050 1060 1070 1080 KSTSGKKNPV ISQTGSWRRG MTAQVGITMP RTKPSAPAGA LKTPGTGKTD DAKVSEKGRL 1090 1100 1110 1120 1130 1140 SPKASQVKRS PSDAGRSSGD ESKKPLPSSS RTPTANANSF GFKKQSGSAA GLAMITASGV 1150 1160 1170 1180 1190 1200 TVTSRSATLG KIPKSSALVS RSAGRKSSMD GAQNQDDGYL ALSSRTNLQY RSLPRPSKSN 1210 1220 1230 1240 1250 1260 SRNGAGNRSS TSSIDSNISS KSAGLPVPKL REPSKTALGS SLPGLVNQTD KEKGISSDNE 1270 1280 1290 1300 1310 1320 SVASCNSVKV NPAAQPVSSP AQTSLQPGAK YPDVASPTLR RLFGGKPTKQ VPIATAENMK 1330 1340 1350 1360 1370 1380 NSVVISNPHA TMTQQGNLDS PSGSGVLSSG SSSPLYSKNV DLNQSPLASS PSSAHSAPSN 1390 1400 1410 1420 1430 1440 SLTWGTNASS SSAVSKDGLG FQSVSSLHTS CESIDISLSS GGVPSHNSST GLIASSKDDS 1450 1460 1470 1480 1490 1500 LTPFVRTNSV KTTLSESPLS SPAASPKFCR STLPRKQDSD PHLDRNTLPK KGLRYTPTSQ 1510 1520 1530 1540 1550 1560 LRTQEDAKEW LRSHSAGGLQ DTAANSPFSS GSSVTSPSGT RFNFSQLASP TTVTQMSLSN 1570 1580 1590 1600 1610 1620 PTMLRTHSLS NADGQYDPYT DSRFRNSSMS LDEKSRTMSR SGSFRDGFEE VHGSSLSLVS 1630 1640 1650 1660 1670 1680 STSSVYSTPE EKCQSEIRKL RRELDASQEK VSALTTQLTA NAHLVAAFEQ SLGNMTIRLQ 1690 1700 1710 1720 1730 1740 SLTMTAEQKD SELNELRKTI ELLKKQNAAA QAAINGVINT PELNCKGNGT AQSADLRIRR 1750 1760 1770 1780 1790 1800 QHSSDSVSSI NSATSHSSVG SNIESDSKKK KRKNWLRSSF KQAFGKKKSP KSASSHSDIE 1810 1820 1830 1840 1850 1860 EMTDSSLPSS PKLPHNGSTG STPLLRNSHS NSLISECMDS EAETVMQLRN ELRDKEMKLT 1870 1880 1890 1900 1910 1920 DIRLEALSSA HQLDQLREAM NRMQSEIEKL KAENDRLKSE SQGSGCSRAP SQVSISASPR 1930 1940 1950 1960 1970 1980 QSMGLSQHSL NLTESTSLDM LLDDTGECSA RKEGGRHVKI VVSFQEEMKW KEDSRPHLFL 1990 2000 2010 2020 2030 2040 IGCIGVSGKT KWDVLDGVVR RLFKEYIIHV DPVSQLGLNS DSVLGYSIGE IKRSNTSETP 2050 2060 2070 2080 2090 2100 ELLPCGYLVG ENTTISVTVK GLAENSLDSL VFESLIPKPI LQRYVSLLIE HRRIILSGPS 2110 2120 2130 2140 2150 2160 GTGKTYLANR LSEYIVLREG RELTDGVIAT FNVDHKSSKE LRQYLSNLAD QCNSENNAVD 2170 2180 2190 2200 2210 2220 MPLVIILDNL HHVSSLGEIF NGLLNCKYHK CPYIIGTMNQ ATSSTPNLQL HHNFRWVLCA 2230 2240 2250 2260 2270 2280 NHTEPVKGFL GRFLRRKLME TEISGRVRNM ELVKIIDWIP KVWHHLNRFL EAHSSSDVTI 2290 2300 2310 2320 2330 2340 GPRLFLSCPI DVDGSRVWFT DLWNYSIIPY LLEAVREGLQ LYGRRAPWED PAKWVMDTYP 2350 2360 2370 2380 2390 2400 WAASPQQHEW PPLLQLRPED VGFDGYSMPR EGSTSKQMPP SDAEGDPLMN MLMRLQEAAN 2410 2420 YSSPQSYDSD SNSNSHHDDI LDSSLESTL
	Isoform 4 (HELAD1S) [UniParc]. Checksum: 000C16EB12682A2C	FASTA	2,365	254,978
	10 20 30 40 50 60 MESVSESSQQ QKRKPVIHGL EDQKRIYTDW ANHYLAKSGH KRLIRDLQQD VTDGVLLAQI 70 80 90 100 110 120 IQVVANEKIE DINGCPKNRS QMIENIDACL NFLAAKGINI QGLSAEEIRN GNLKAILGLF 130 140 150 160 170 180 FSLSRYKQQQ QQPQKQHLSS PLPPAVSQVA GAPSQCQAGT PQQQVPVTPQ APCQPHQPAP 190 200 210 220 230 240 HQQSKAQAEM QSRLPGPTAR VSAAGSEAKT RGGSTTANNR RSQSFNNYDK SKPVTSPPPP 250 260 270 280 290 300 PSSHEKEPLA SSASSHPGMS DNAPASLESG SSSTPTNCST SSAIPQPGAA TKPWRSKSLS 310 320 330 340 350 360 VKHSATVSML SVKPPGPEAP RPTPEAMKPA PNNQKSMLEK LKLFNSKGGS KAGEGPGSRD 370 380 390 400 410 420 TSCERLETLP SFEESEELEA ASRMLTTVGP ASSSPKIALK GIAQRTFSRA LTNKKSSLKG 430 440 450 460 470 480 NEKEKEKQQR EKDKEKSKDL AKRASVTERL DLKEEPKEDP SGAAVPEMPK KSSKIASFIP 490 500 510 520 530 540 KGGKLNSAKK EPMAPSHSGI PKPGMKSMPG KSPSAPAPSK EGERSRSGKL SSGLPQQKPQ 550 560 570 580 590 600 LDGRHSSSSS SLASSEGKGP GGTTLNHSIS SQTVSGSVGT TQTTGSNTVS VQLPQPQQQY 610 620 630 640 650 660 NHPNTATVAP FLYRSQTDTE GNVTAESSST GVSVEPSHFT KTGQPALEEL TGEDPEARRL 670 680 690 700 710 720 RTVKNIADLR QNLEETMSSL RGTQVTHSTL ETTFDTNVTT EMSGRSILSL TGRPTPLSWR 730 740 750 760 770 780 LGQSSPRLQA GDAPSMGNGY PPRANASRFI NTESGRYVYS APLRRQLASR GSSVCHVDVS 790 800 810 820 830 840 DKAGDEMDLE GISMDAPGYM SDGDVLSKNI RTDDITSGYM TDGGLGLYTR RLNRLPDGMA 850 860 870 880 890 900 VVRETLQRNT SLGLGDADSW DDSSSVSSGI SDTIDNLSTD DINTSSSISS YANTPASSRK 910 920 930 940 950 960 NLDVQTDAEK HSQVERNSLW SGDDVKKSDG GSDSGIKMEP GSKWRRNPSD VSDESDKSTS 970 980 990 1000 1010 1020 GKKNPVISQT GSWRRGMTAQ VGITMPRTKP SAPAGALKTP GTGKTDDAKV SEKGRLSPKA 1030 1040 1050 1060 1070 1080 SQVKRSPSDA GRSSGDESKK PLPSSSRTPT ANANSFGFKK QSGSAAGLAM ITASGVTVTS 1090 1100 1110 1120 1130 1140 RSATLGKIPK SSALVSRSAG RKSSMDGAQN QDDGYLALSS RTNLQYRSLP RPSKSNSRNG 1150 1160 1170 1180 1190 1200 AGNRSSTSSI DSNISSKSAG LPVPKLREPS KTALGSSLPG LVNQTDKEKG ISSDNESVAS 1210 1220 1230 1240 1250 1260 CNSVKVNPAA QPVSSPAQTS LQPGAKYPDV ASPTLRRLFG GKPTKQVPIA TAENMKNSVV 1270 1280 1290 1300 1310 1320 ISNPHATMTQ QGNLDSPSGS GVLSSGSSSP LYSKNVDLNQ SPLASSPSSA HSAPSNSLTW 1330 1340 1350 1360 1370 1380 GTNASSSSAV SKDGLGFQSV SSLHTSCESI DISLSSGGVP SHNSSTGLIA SSKDDSLTPF 1390 1400 1410 1420 1430 1440 VRTNSVKTTL SESPLSSPAA SPKFCRSTLP RKQDSDPHLD RNTLPKKGLR YTPTSQLRTQ 1450 1460 1470 1480 1490 1500 EDAKEWLRSH SAGGLQDTAA NSPFSSGSSV TSPSGTRFNF SQLASPTTVT QMSLSNPTML 1510 1520 1530 1540 1550 1560 RTHSLSNADG QYDPYTDSRF RNSSMSLDEK SRTMSRSGSF RDGFEEVHGS SLSLVSSTSS 1570 1580 1590 1600 1610 1620 VYSTPEEKCQ SEIRKLRREL DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM 1630 1640 1650 1660 1670 1680 TAEQKDSELN ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS 1690 1700 1710 1720 1730 1740 DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WLRSSFKQAF GKKKSPKSAS SHSDIEEMTD 1750 1760 1770 1780 1790 1800 SSLPSSPKLP HNGSTGSTPL LRNSHSNSLI SECMDSEAET VMQLRNELRD KEMKLTDIRL 1810 1820 1830 1840 1850 1860 EALSSAHQLD QLREAMNRMQ SEIEKLKAEN DRLKSESQGS GCSRAPSQVS ISASPRQSMG 1870 1880 1890 1900 1910 1920 LSQHSLNLTE STSLDMLLDD TGECSARKEG GRHVKIVVSF QEEMKWKEDS RPHLFLIGCI 1930 1940 1950 1960 1970 1980 GVSGKTKWDV LDGVVRRLFK EYIIHVDPVS QLGLNSDSVL GYSIGEIKRS NTSETPELLP 1990 2000 2010 2020 2030 2040 CGYLVGENTT ISVTVKGLAE NSLDSLVFES LIPKPILQRY VSLLIEHRRI ILSGPSGTGK 2050 2060 2070 2080 2090 2100 TYLANRLSEY IVLREGRELT DGVIATFNVD HKSSKELRQY LSNLADQCNS ENNAVDMPLV 2110 2120 2130 2140 2150 2160 IILDNLHHVS SLGEIFNGLL NCKYHKCPYI IGTMNQATSS TPNLQLHHNF RWVLCANHTE 2170 2180 2190 2200 2210 2220 PVKGFLGRFL RRKLMETEIS GRVRNMELVK IIDWIPKVWH HLNRFLEAHS SSDVTIGPRL 2230 2240 2250 2260 2270 2280 FLSCPIDVDG SRVWFTDLWN YSIIPYLLEA VREGLQLYGR RAPWEDPAKW VMDTYPWAAS 2290 2300 2310 2320 2330 2340 PQQHEWPPLL QLRPEDVGFD GYSMPREGST SKQMPPSDAE GDPLMNMLMR LQEAANYSSP 2350 2360 QSYDSDSNSN SHHDDILDSS LESTL
	Isoform 5 [UniParc]. Checksum: 278DEF938E0D3DC2	FASTA	1,493	161,946
	10 20 30 40 50 60 MLWPRNLTSW DDSSSVSSGI SDTIDNLSTD DINTSSSISS YANTPASSRK NLDVQTDAEK 70 80 90 100 110 120 HSQVERNSLW SGDDVKKSDG GSDSGIKMEP GSKWRRNPSD VSDESDKSTS GKKNPVISQT 130 140 150 160 170 180 GSWRRGMTAQ VGITMPRTKP SAPAGALKTP GTGKTDDAKV SEKGRLSPKA SQVKRSPSDA 190 200 210 220 230 240 GRSSGDESKK PLPSSSRTPT ANANSFGFKK QSGSAAGLAM ITASGVTVTS RSATLGKIPK 250 260 270 280 290 300 SSALVSRSAG RKSSMDGAQN QDDGYLALSS RTNLQYRSLP RPSKSNSRNG AGNRSSTSSI 310 320 330 340 350 360 DSNISSKSAG LPVPKLREPS KTALGSSLPG LVNQTDKEKG ISSDNESVAS CNSVKVNPAA 370 380 390 400 410 420 QPVSSPAQTS LQPGAKYPDV ASPTLRRLFG GKPTKQVPIA TAENMKNSVV ISNPHATMTQ 430 440 450 460 470 480 QGNLDSPSGS GVLSSGSSSP LYSKNVDLNQ SPLASSPSSA HSAPSNSLTW GTNASSSSAV 490 500 510 520 530 540 SKDGLGFQSV SSLHTSCESI DISLSSGGVP SHNSSTGLIA SSKDDSLTPF VRTNSVKTTL 550 560 570 580 590 600 SESDPHLDRN TLPKKGLRYT PTSQLRTQED AKEWLRSHSA GGLQDTAANS PFSSGSSVTS 610 620 630 640 650 660 PSGTRFNFSQ LASPTTVTQM SLSNPTMLRT HSLSNADGQY DPYTDSRFRN SSMSLDEKSR 670 680 690 700 710 720 TMSRSGSFRD GFEEVHGSSL SLVSSTSSVY STPEEKCQSE IRKLRRELDA SQEKVSALTT 730 740 750 760 770 780 QLTANAHLVA AFEQSLGNMT IRLQSLTMTA EQKDSELNEL RKTIELLKKQ NAAAQAAING 790 800 810 820 830 840 VINTPELNCK GNGTAQSADL RIRRQHSSDS VSSINSATSH SSVGSNIESD SKKKKRKNWL 850 860 870 880 890 900 RSSFKQAFGK KKSPKSASSH SDIEEMTDSS LPSSPKLPHN GSTGSTPLLR NSHSNSLISE 910 920 930 940 950 960 CMDSEAETVM QLRNELRDKE MKLTDIRLEA LSSAHQLDQL REAMNRMQSE IEKLKAENDR 970 980 990 1000 1010 1020 LKSESQGSGC SRAPSQVSIS ASPRQSMGLS QHSLNLTEST SLDMLLDDTG ECSARKEGGR 1030 1040 1050 1060 1070 1080 HVKIVVSFQE EMKWKEDSRP HLFLIGCIGV SGKTKWDVLD GVVRRLFKEY IIHVDPVSQL 1090 1100 1110 1120 1130 1140 GLNSDSVLGY SIGEIKRSNT SETPELLPCG YLVGENTTIS VTVKGLAENS LDSLVFESLI 1150 1160 1170 1180 1190 1200 PKPILQRYVS LLIEHRRIIL SGPSGTGKTY LANRLSEYIV LREGRELTDG VIATFNVDHK 1210 1220 1230 1240 1250 1260 SSKELRQYLS NLADQCNSEN NAVDMPLVII LDNLHHVSSL GEIFNGLLNC KYHKCPYIIG 1270 1280 1290 1300 1310 1320 TMNQATSSTP NLQLHHNFRW VLCANHTEPV KGFLGRFLRR KLMETEISGR VRNMELVKII 1330 1340 1350 1360 1370 1380 DWIPKVWHHL NRFLEAHSSS DVTIGPRLFL SCPIDVDGSR VWFTDLWNYS IIPYLLEAVR 1390 1400 1410 1420 1430 1440 EGLQLYGRRA PWEDPAKWVM DTYPWAASPQ QHEWPPLLQL RPEDVGFDGY SMPREGSTSK 1450 1460 1470 1480 1490 QMPPSDAEGD PLMNMLMRLQ EAANYSSPQS YDSDSNSNSH HDDILDSSLE STL
	Isoform 6 [UniParc]. Checksum: AEFA49541B2A2E94	FASTA	874	97,684
	10 20 30 40 50 60 MSLSNPTMLR THSLSNADGQ YDPYTDSRFR NSSMSLDEKS RTMSRSGSFR DGFEEVHGSS 70 80 90 100 110 120 LSLVSSTSSV YSTPEEKCQS EIRKLRRELD ASQEKVSALT TQLTANAHLV AAFEQSLGNM 130 140 150 160 170 180 TIRLQSLTMT AEQKDSELNE LRKTIELLKK QNAAAQAAIN GVINTPELNC KGNGTAQSAD 190 200 210 220 230 240 LRIRRQHSSD SVSSINSATS HSSVGSNIES DSKKKKRKNW LRSSFKQAFG KKKSPKSASS 250 260 270 280 290 300 HSDIEEMTDS SLPSSPKLPH NGSTGSTPLL RNSHSNSLIS ECMDSEAETV MQLRNELRDK 310 320 330 340 350 360 EMKLTDIRLE ALSSAHQLDQ LREAMNRMQS EIEKLKAEND RLKSESQGSG CSRAPSQVSI 370 380 390 400 410 420 SASPRQSMGL SQHSLNLTES TSLDMLLDDT GECSARKEGG RHVKIVVSFQ EEMKWKEDSR 430 440 450 460 470 480 PHLFLIGCIG VSGKTKWDVL DGVVRRLFKE YIIHVDPVSQ LGLNSDSVLG YSIGEIKRSN 490 500 510 520 530 540 TSETPELLPC GYLVGENTTI SVTVKGLAEN SLDSLVFESL IPKPILQRYV SLLIEHRRII 550 560 570 580 590 600 LSGPSGTGKT YLANRLSEYI VLREGRELTD GVIATFNVDH KSSKELRQYL SNLADQCNSE 610 620 630 640 650 660 NNAVDMPLVI ILDNLHHVSS LGEIFNGLLN CKYHKCPYII GTMNQATSST PNLQLHHNFR 670 680 690 700 710 720 WVLCANHTEP VKGFLGRFLR RKLMETEISG RVRNMELVKI IDWIPKVWHH LNRFLEAHSS 730 740 750 760 770 780 SDVTIGPRLF LSCPIDVDGS RVWFTDLWNY SIIPYLLEAV REGLQLYGRR APWEDPAKWV 790 800 810 820 830 840 MDTYPWAASP QQHEWPPLLQ LRPEDVGFDG YSMPREGSTS KQMPPSDAEG DPLMNMLMRL 850 860 870 QEAANYSSPQ SYDSDSNSNS HHDDILDSSL ESTL
	Isoform 7 [UniParc]. Checksum: 6B8F113F3C036820	FASTA	592	66,897
	10 20 30 40 50 60 MDSEAETVMQ LRNELRDKEM KLTDIRLEAL SSAHQLDQLR EAMNRMQSEI EKLKAENDRL 70 80 90 100 110 120 KSESQGSGCS RAPSQVSISA SPRQSMGLSQ HSLNLTESTS LDMLLDDTGE CSARKEGGRH 130 140 150 160 170 180 VKIVVSFQEE MKWKEDSRPH LFLIGCIGVS GKTKWDVLDG VVRRLFKEYI IHVDPVSQLG 190 200 210 220 230 240 LNSDSVLGYS IGEIKRSNTS ETPELLPCGY LVGENTTISV TVKGLAENSL DSLVFESLIP 250 260 270 280 290 300 KPILQRYVSL LIEHRRIILS GPSGTGKTYL ANRLSEYIVL REGRELTDGV IATFNVDHKS 310 320 330 340 350 360 SKELRQYLSN LADQCNSENN AVDMPLVIIL DNLHHVSSLG EIFNGLLNCK YHKCPYIIGT 370 380 390 400 410 420 MNQATSSTPN LQLHHNFRWV LCANHTEPVK GFLGRFLRRK LMETEISGRV RNMELVKIID 430 440 450 460 470 480 WIPKVWHHLN RFLEAHSSSD VTIGPRLFLS CPIDVDGSRV WFTDLWNYSI IPYLLEAVRE 490 500 510 520 530 540 GLQLYGRRAP WEDPAKWVMD TYPWAASPQQ HEWPPLLQLR PEDVGFDGYS MPREGSTSKQ 550 560 570 580 590 MPPSDAEGDP LMNMLMRLQE AANYSSPQSY DSDSNSNSHH DDILDSSLES TL
	Isoform 8 [UniParc]. Checksum: 635AC30132928AF6	FASTA	2,408	259,971
	10 20 30 40 50 60 MLWPRNLTQI YTDWANHYLA KSGHKRLIRD LQQDVTDGVL LAQIIQVVAN EKIEDINGCP 70 80 90 100 110 120 KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI LGLFFSLSRY KQQQQQPQKQ 130 140 150 160 170 180 HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH QPAPHQQSKA QAEMQSSASS 190 200 210 220 230 240 KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG STTANNRRSQ SFNNYDKSKP 250 260 270 280 290 300 VTSPPPPPSS HEKEPLASSA SSHPGMSDNA PASLESGSSS TPTNCSTSSA IPQPGAATKP 310 320 330 340 350 360 WRSKSLSVKH SATVSMLSVK PPGPEAPRPT PEAMKPAPNN QKSMLEKLKL FNSKGGSKAG 370 380 390 400 410 420 EGPGSRDTSC ERLETLPSFE ESEELEAASR MLTTVGPASS SPKIALKGIA QRTFSRALTN 430 440 450 460 470 480 KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK EEPKEDPSGA AVPEMPKKSS 490 500 510 520 530 540 KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP SAPAPSKEGE RSRSGKLSSG 550 560 570 580 590 600 LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT TLNHSISSQT VSGSVGTTQT TGSNTVSVQL 610 620 630 640 650 660 PQPQQQYNHP NTATVAPFLY RSQTDTEGNV TAESSSTGVS VEPSHFTKTG QPALEELTGE 670 680 690 700 710 720 DPEARRLRTV KNIADLRQNL EETMSSLRGT QVTHSTLETT FDTNVTTEMS GRSILSLTGR 730 740 750 760 770 780 PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE SGRYVYSAPL RRQLASRGSS 790 800 810 820 830 840 VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD DITSGYMTDG GLGLYTRRLN 850 860 870 880 890 900 RLPDGMAVVR ETLQRNTSLG LGDADSWDDS SSVSSGISDT IDNLSTDDIN TSSSISSYAN 910 920 930 940 950 960 TPASSRKNLD VQTDAEKHSQ VERNSLWSGD DVKKSDGGSD SGIKMEPGSK WRRNPSDVSD 970 980 990 1000 1010 1020 ESDKSTSGKK NPVISQTGSW RRGMTAQVGI TMPRTKPSAP AGALKTPGTG KTDDAKVSEK 1030 1040 1050 1060 1070 1080 GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA NSFGFKKQSG SAAGLAMITA 1090 1100 1110 1120 1130 1140 SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD GYLALSSRTN LQYRSLPRPS 1150 1160 1170 1180 1190 1200 KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV PKLREPSKTA LGSSLPGLVN QTDKEKGISS 1210 1220 1230 1240 1250 1260 DNESVASCNS VKVNPAAQPV SSPAQTSLQP GAKYPDVASP TLRRLFGGKP TKQVPIATAE 1270 1280 1290 1300 1310 1320 NMKNSVVISN PHATMTQQGN LDSPSGSGVL SSGSSSPLYS KNVDLNQSPL ASSPSSAHSA 1330 1340 1350 1360 1370 1380 PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS LSSGGVPSHN SSTGLIASSK 1390 1400 1410 1420 1430 1440 DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ DSDPHLDRNT LPKKGLRYTP 1450 1460 1470 1480 1490 1500 TSQLRTQEDA KEWLRSHSAG GLQDTAANSP FSSGSSVTSP SGTRFNFSQL ASPTTVTQMS 1510 1520 1530 1540 1550 1560 LSNPTMLRTH SLSNADGQYD PYTDSRFRNS SMSLDEKSRT MSRSGSFRDG FEEESWEKSS 1570 1580 1590 1600 1610 1620 VDNFVSRLHS SLHFSLPLFH HARYELVHGS SLSLVSSTSS VYSTPEEKCQ SEIRKLRREL 1630 1640 1650 1660 1670 1680 DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM TAEQKDSELN ELRKTIELLK 1690 1700 1710 1720 1730 1740 KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS DSVSSINSAT SHSSVGSNIE 1750 1760 1770 1780 1790 1800 SDSKKKKRKN WVNELRSSFK QAFGKKKSPK SASSHSDIEE MTDSSLPSSP KLPHNGSTGS 1810 1820 1830 1840 1850 1860 TPLLRNSHSN SLISECMDSE AETVMQLRNE LRDKEMKLTD IRLEALSSAH QLDQLREAMN 1870 1880 1890 1900 1910 1920 RMQSEIEKLK AENDRLKSES QGSGCSRAPS QVSISASPRQ SMGLSQHSLN LTESTSLDML 1930 1940 1950 1960 1970 1980 LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI GCIGVSGKTK WDVLDGVVRR 1990 2000 2010 2020 2030 2040 LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE LLPCGYLVGE NTTISVTVKG 2050 2060 2070 2080 2090 2100 LAENSLDSLV FESLIPKPIL QRYVSLLIEH RRIILSGPSG TGKTYLANRL SEYIVLREGR 2110 2120 2130 2140 2150 2160 ELTDGVIATF NVDHKSSKEL RQYLSNLADQ CNSENNAVDM PLVIILDNLH HVSSLGEIFN 2170 2180 2190 2200 2210 2220 GLLNCKYHKC PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN HTEPVKGFLG RFLRRKLMET 2230 2240 2250 2260 2270 2280 EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG PRLFLSCPID VDGSRVWFTD 2290 2300 2310 2320 2330 2340 LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW AASPQQHEWP PLLQLRPEDV 2350 2360 2370 2380 2390 2400 GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM LMRLQEAANY SSPQSYDSDS NSNSHHDDIL DSSLESTL
	Isoform 9 [UniParc]. Checksum: FF6423A81066C65B	FASTA	2,414	260,208
	10 20 30 40 50 60 MAGTSAASSW GGGKQIYTDW ANHYLAKSGH KRLIRDLQQD VTDGVLLAQI IQVVANEKIE 70 80 90 100 110 120 DINGCPKNRS QMIENIDACL NFLAAKGINI QGLSAEEIRN GNLKAILGLF FSLSRYKQQQ 130 140 150 160 170 180 QQPQKQHLSS PLPPAVSQVA GAPSQCQAGT PQQQVPVTPQ APCQPHQPAP HQQSKAQAEM 190 200 210 220 230 240 QSSASSKDSS QSKIIRFTLG QKKISRLPGP TARVSAAGSE AKTRGGSTTA NNRRSQSFNN 250 260 270 280 290 300 YDKSKPVTSP PPPPSSHEKE PLASSASSHP GMSDNAPASL ESGSSSTPTN CSTSSAIPQP 310 320 330 340 350 360 GAATKPWRSK SLSVKHSATV SMLSVKPPGP EAPRPTPEAM KPAPNNQKSM LEKLKLFNSK 370 380 390 400 410 420 GGSKAGEGPG SRDTSCERLE TLPSFEESEE LEAASRMLTT VGPASSSPKI ALKGIAQRTF 430 440 450 460 470 480 SRALTNKKSS LKGNEKEKEK QQREKDKEKS KDLAKRASVT ERLDLKEEPK EDPSGAAVPE 490 500 510 520 530 540 MPKKSSKIAS FIPKGGKLNS AKKEPMAPSH SGIPKPGMKS MPGKSPSAPA PSKEGERSRS 550 560 570 580 590 600 GKLSSGLPQQ KPQLDGRHSS SSSSLASSEG KGPGGTTLNH SISSQTVSGS VGTTQTTGSN 610 620 630 640 650 660 TVSVQLPQPQ QQYNHPNTAT VAPFLYRSQT DTEGNVTAES SSTGVSVEPS HFTKTGQPAL 670 680 690 700 710 720 EELTGEDPEA RRLRTVKNIA DLRQNLEETM SSLRGTQVTH STLETTFDTN VTTEMSGRSI 730 740 750 760 770 780 LSLTGRPTPL SWRLGQSSPR LQAGDAPSMG NGYPPRANAS RFINTESGRY VYSAPLRRQL 790 800 810 820 830 840 ASRGSSVCHV DVSDKAGDEM DLEGISMDAP GYMSDGDVLS KNIRTDDITS GYMTDGGLGL 850 860 870 880 890 900 YTRRLNRLPD GMAVVRETLQ RNTSLGLGDA DSWDDSSSVS SGISDTIDNL STDDINTSSS 910 920 930 940 950 960 ISSYANTPAS SRKNLDVQTD AEKHSQVERN SLWSGDDVKK SDGGSDSGIK MEPGSKWRRN 970 980 990 1000 1010 1020 PSDVSDESDK STSGKKNPVI SQTGSWRRGM TAQVGITMPR TKPSAPAGAL KTPGTGKTDD 1030 1040 1050 1060 1070 1080 AKVSEKGRLS PKASQVKRSP SDAGRSSGDE SKKPLPSSSR TPTANANSFG FKKQSGSAAG 1090 1100 1110 1120 1130 1140 LAMITASGVT VTSRSATLGK IPKSSALVSR SAGRKSSMDG AQNQDDGYLA LSSRTNLQYR 1150 1160 1170 1180 1190 1200 SLPRPSKSNS RNGAGNRSST SSIDSNISSK SAGLPVPKLR EPSKTALGSS LPGLVNQTDK 1210 1220 1230 1240 1250 1260 EKGISSDNES VASCNSVKVN PAAQPVSSPA QTSLQPGAKY PDVASPTLRR LFGGKPTKQV 1270 1280 1290 1300 1310 1320 PIATAENMKN SVVISNPHAT MTQQGNLDSP SGSGVLSSGS SSPLYSKNVD LNQSPLASSP 1330 1340 1350 1360 1370 1380 SSAHSAPSNS LTWGTNASSS SAVSKDGLGF QSVSSLHTSC ESIDISLSSG GVPSHNSSTG 1390 1400 1410 1420 1430 1440 LIASSKDDSL TPFVRTNSVK TTLSESPLSS PAASPKFCRS TLPRKQDSDP HLDRNTLPKK 1450 1460 1470 1480 1490 1500 GLRYTPTSQL RTQEDAKEWL RSHSAGGLQD TAANSPFSSG SSVTSPSGTR FNFSQLASPT 1510 1520 1530 1540 1550 1560 TVTQMSLSNP TMLRTHSLSN ADGQYDPYTD SRFRNSSMSL DEKSRTMSRS GSFRDGFEEE 1570 1580 1590 1600 1610 1620 SWEKSSVDNF VSRLHSSLHF SLPLFHHARY ELVHGSSLSL VSSTSSVYST PEEKCQSEIR 1630 1640 1650 1660 1670 1680 KLRRELDASQ EKVSALTTQL TANAHLVAAF EQSLGNMTIR LQSLTMTAEQ KDSELNELRK 1690 1700 1710 1720 1730 1740 TIELLKKQNA AAQAAINGVI NTPELNCKGN GTAQSADLRI RRQHSSDSVS SINSATSHSS 1750 1760 1770 1780 1790 1800 VGSNIESDSK KKKRKNWVNE LRSSFKQAFG KKKSPKSASS HSDIEEMTDS SLPSSPKLPH 1810 1820 1830 1840 1850 1860 NGSTGSTPLL RNSHSNSLIS ECMDSEAETV MQLRNELRDK EMKLTDIRLE ALSSAHQLDQ 1870 1880 1890 1900 1910 1920 LREAMNRMQS EIEKLKAEND RLKSESQGSG CSRAPSQVSI SASPRQSMGL SQHSLNLTES 1930 1940 1950 1960 1970 1980 TSLDMLLDDT GECSARKEGG RHVKIVVSFQ EEMKWKEDSR PHLFLIGCIG VSGKTKWDVL 1990 2000 2010 2020 2030 2040 DGVVRRLFKE YIIHVDPVSQ LGLNSDSVLG YSIGEIKRSN TSETPELLPC GYLVGENTTI 2050 2060 2070 2080 2090 2100 SVTVKGLAEN SLDSLVFESL IPKPILQRYV SLLIEHRRII LSGPSGTGKT YLANRLSEYI 2110 2120 2130 2140 2150 2160 VLREGRELTD GVIATFNVDH KSSKELRQYL SNLADQCNSE NNAVDMPLVI ILDNLHHVSS 2170 2180 2190 2200 2210 2220 LGEIFNGLLN CKYHKCPYII GTMNQATSST PNLQLHHNFR WVLCANHTEP VKGFLGRFLR 2230 2240 2250 2260 2270 2280 RKLMETEISG RVRNMELVKI IDWIPKVWHH LNRFLEAHSS SDVTIGPRLF LSCPIDVDGS 2290 2300 2310 2320 2330 2340 RVWFTDLWNY SIIPYLLEAV REGLQLYGRR APWEDPAKWV MDTYPWAASP QQHEWPPLLQ 2350 2360 2370 2380 2390 2400 LRPEDVGFDG YSMPREGSTS KQMPPSDAEG DPLMNMLMRL QEAANYSSPQ SYDSDSNSNS 2410 HHDDILDSSL ESTL
	Isoform 10 [UniParc]. Checksum: DFBF27444A625EB2	FASTA	2,417	261,109
	10 20 30 40 50 60 MSVMLWRWEQ NNTTMKLQIY TDWANHYLAK SGHKRLIRDL QQDVTDGVLL AQIIQVVANE 70 80 90 100 110 120 KIEDINGCPK NRSQMIENID ACLNFLAAKG INIQGLSAEE IRNGNLKAIL GLFFSLSRYK 130 140 150 160 170 180 QQQQQPQKQH LSSPLPPAVS QVAGAPSQCQ AGTPQQQVPV TPQAPCQPHQ PAPHQQSKAQ 190 200 210 220 230 240 AEMQSSASSK DSSQSKIIRF TLGQKKISRL PGPTARVSAA GSEAKTRGGS TTANNRRSQS 250 260 270 280 290 300 FNNYDKSKPV TSPPPPPSSH EKEPLASSAS SHPGMSDNAP ASLESGSSST PTNCSTSSAI 310 320 330 340 350 360 PQPGAATKPW RSKSLSVKHS ATVSMLSVKP PGPEAPRPTP EAMKPAPNNQ KSMLEKLKLF 370 380 390 400 410 420 NSKGGSKAGE GPGSRDTSCE RLETLPSFEE SEELEAASRM LTTVGPASSS PKIALKGIAQ 430 440 450 460 470 480 RTFSRALTNK KSSLKGNEKE KEKQQREKDK EKSKDLAKRA SVTERLDLKE EPKEDPSGAA 490 500 510 520 530 540 VPEMPKKSSK IASFIPKGGK LNSAKKEPMA PSHSGIPKPG MKSMPGKSPS APAPSKEGER 550 560 570 580 590 600 SRSGKLSSGL PQQKPQLDGR HSSSSSSLAS SEGKGPGGTT LNHSISSQTV SGSVGTTQTT 610 620 630 640 650 660 GSNTVSVQLP QPQQQYNHPN TATVAPFLYR SQTDTEGNVT AESSSTGVSV EPSHFTKTGQ 670 680 690 700 710 720 PALEELTGED PEARRLRTVK NIADLRQNLE ETMSSLRGTQ VTHSTLETTF DTNVTTEMSG 730 740 750 760 770 780 RSILSLTGRP TPLSWRLGQS SPRLQAGDAP SMGNGYPPRA NASRFINTES GRYVYSAPLR 790 800 810 820 830 840 RQLASRGSSV CHVDVSDKAG DEMDLEGISM DAPGYMSDGD VLSKNIRTDD ITSGYMTDGG 850 860 870 880 890 900 LGLYTRRLNR LPDGMAVVRE TLQRNTSLGL GDADSWDDSS SVSSGISDTI DNLSTDDINT 910 920 930 940 950 960 SSSISSYANT PASSRKNLDV QTDAEKHSQV ERNSLWSGDD VKKSDGGSDS GIKMEPGSKW 970 980 990 1000 1010 1020 RRNPSDVSDE SDKSTSGKKN PVISQTGSWR RGMTAQVGIT MPRTKPSAPA GALKTPGTGK 1030 1040 1050 1060 1070 1080 TDDAKVSEKG RLSPKASQVK RSPSDAGRSS GDESKKPLPS SSRTPTANAN SFGFKKQSGS 1090 1100 1110 1120 1130 1140 AAGLAMITAS GVTVTSRSAT LGKIPKSSAL VSRSAGRKSS MDGAQNQDDG YLALSSRTNL 1150 1160 1170 1180 1190 1200 QYRSLPRPSK SNSRNGAGNR SSTSSIDSNI SSKSAGLPVP KLREPSKTAL GSSLPGLVNQ 1210 1220 1230 1240 1250 1260 TDKEKGISSD NESVASCNSV KVNPAAQPVS SPAQTSLQPG AKYPDVASPT LRRLFGGKPT 1270 1280 1290 1300 1310 1320 KQVPIATAEN MKNSVVISNP HATMTQQGNL DSPSGSGVLS SGSSSPLYSK NVDLNQSPLA 1330 1340 1350 1360 1370 1380 SSPSSAHSAP SNSLTWGTNA SSSSAVSKDG LGFQSVSSLH TSCESIDISL SSGGVPSHNS 1390 1400 1410 1420 1430 1440 STGLIASSKD DSLTPFVRTN SVKTTLSESP LSSPAASPKF CRSTLPRKQD SDPHLDRNTL 1450 1460 1470 1480 1490 1500 PKKGLRYTPT SQLRTQEDAK EWLRSHSAGG LQDTAANSPF SSGSSVTSPS GTRFNFSQLA 1510 1520 1530 1540 1550 1560 SPTTVTQMSL SNPTMLRTHS LSNADGQYDP YTDSRFRNSS MSLDEKSRTM SRSGSFRDGF 1570 1580 1590 1600 1610 1620 EEESWEKSSV DNFVSRLHSS LHFSLPLFHH ARYELVHGSS LSLVSSTSSV YSTPEEKCQS 1630 1640 1650 1660 1670 1680 EIRKLRRELD ASQEKVSALT TQLTANAHLV AAFEQSLGNM TIRLQSLTMT AEQKDSELNE 1690 1700 1710 1720 1730 1740 LRKTIELLKK QNAAAQAAIN GVINTPELNC KGNGTAQSAD LRIRRQHSSD SVSSINSATS 1750 1760 1770 1780 1790 1800 HSSVGSNIES DSKKKKRKNW VNELRSSFKQ AFGKKKSPKS ASSHSDIEEM TDSSLPSSPK 1810 1820 1830 1840 1850 1860 LPHNGSTGST PLLRNSHSNS LISECMDSEA ETVMQLRNEL RDKEMKLTDI RLEALSSAHQ 1870 1880 1890 1900 1910 1920 LDQLREAMNR MQSEIEKLKA ENDRLKSESQ GSGCSRAPSQ VSISASPRQS MGLSQHSLNL 1930 1940 1950 1960 1970 1980 TESTSLDMLL DDTGECSARK EGGRHVKIVV SFQEEMKWKE DSRPHLFLIG CIGVSGKTKW 1990 2000 2010 2020 2030 2040 DVLDGVVRRL FKEYIIHVDP VSQLGLNSDS VLGYSIGEIK RSNTSETPEL LPCGYLVGEN 2050 2060 2070 2080 2090 2100 TTISVTVKGL AENSLDSLVF ESLIPKPILQ RYVSLLIEHR RIILSGPSGT GKTYLANRLS 2110 2120 2130 2140 2150 2160 EYIVLREGRE LTDGVIATFN VDHKSSKELR QYLSNLADQC NSENNAVDMP LVIILDNLHH 2170 2180 2190 2200 2210 2220 VSSLGEIFNG LLNCKYHKCP YIIGTMNQAT SSTPNLQLHH NFRWVLCANH TEPVKGFLGR 2230 2240 2250 2260 2270 2280 FLRRKLMETE ISGRVRNMEL VKIIDWIPKV WHHLNRFLEA HSSSDVTIGP RLFLSCPIDV 2290 2300 2310 2320 2330 2340 DGSRVWFTDL WNYSIIPYLL EAVREGLQLY GRRAPWEDPA KWVMDTYPWA ASPQQHEWPP 2350 2360 2370 2380 2390 2400 LLQLRPEDVG FDGYSMPREG STSKQMPPSD AEGDPLMNML MRLQEAANYS SPQSYDSDSN 2410 SNSHHDDILD SSLESTL
	Isoform 11 [UniParc]. Checksum: 5C153BF3E2FA6698	FASTA	2,425	261,866
	10 20 30 40 50 60 MESVSESSQQ QKRKPVIHGL EDQKRQIYTD WANHYLAKSG HKRLIRDLQQ DVTDGVLLAQ 70 80 90 100 110 120 IIQVVANEKI EDINGCPKNR SQMIENIDAC LNFLAAKGIN IQGLSAEEIR NGNLKAILGL 130 140 150 160 170 180 FFSLSRYKQQ QQQPQKQHLS SPLPPAVSQV AGAPSQCQAG TPQQQVPVTP QAPCQPHQPA 190 200 210 220 230 240 PHQQSKAQAE MQSSASSKDS SQSKIIRFTL GQKKISRLPG PTARVSAAGS EAKTRGGSTT 250 260 270 280 290 300 ANNRRSQSFN NYDKSKPVTS PPPPPSSHEK EPLASSASSH PGMSDNAPAS LESGSSSTPT 310 320 330 340 350 360 NCSTSSAIPQ PGAATKPWRS KSLSVKHSAT VSMLSVKPPG PEAPRPTPEA MKPAPNNQKS 370 380 390 400 410 420 MLEKLKLFNS KGGSKAGEGP GSRDTSCERL ETLPSFEESE ELEAASRMLT TVGPASSSPK 430 440 450 460 470 480 IALKGIAQRT FSRALTNKKS SLKGNEKEKE KQQREKDKEK SKDLAKRASV TERLDLKEEP 490 500 510 520 530 540 KEDPSGAAVP EMPKKSSKIA SFIPKGGKLN SAKKEPMAPS HSGIPKPGMK SMPGKSPSAP 550 560 570 580 590 600 APSKEGERSR SGKLSSGLPQ QKPQLDGRHS SSSSSLASSE GKGPGGTTLN HSISSQTVSG 610 620 630 640 650 660 SVGTTQTTGS NTVSVQLPQP QQQYNHPNTA TVAPFLYRSQ TDTEGNVTAE SSSTGVSVEP 670 680 690 700 710 720 SHFTKTGQPA LEELTGEDPE ARRLRTVKNI ADLRQNLEET MSSLRGTQVT HSTLETTFDT 730 740 750 760 770 780 NVTTEMSGRS ILSLTGRPTP LSWRLGQSSP RLQAGDAPSM GNGYPPRANA SRFINTESGR 790 800 810 820 830 840 YVYSAPLRRQ LASRGSSVCH VDVSDKAGDE MDLEGISMDA PGYMSDGDVL SKNIRTDDIT 850 860 870 880 890 900 SGYMTDGGLG LYTRRLNRLP DGMAVVRETL QRNTSLGLGD ADSWDDSSSV SSGISDTIDN 910 920 930 940 950 960 LSTDDINTSS SISSYANTPA SSRKNLDVQT DAEKHSQVER NSLWSGDDVK KSDGGSDSGI 970 980 990 1000 1010 1020 KMEPGSKWRR NPSDVSDESD KSTSGKKNPV ISQTGSWRRG MTAQVGITMP RTKPSAPAGA 1030 1040 1050 1060 1070 1080 LKTPGTGKTD DAKVSEKGRL SPKASQVKRS PSDAGRSSGD ESKKPLPSSS RTPTANANSF 1090 1100 1110 1120 1130 1140 GFKKQSGSAA GLAMITASGV TVTSRSATLG KIPKSSALVS RSAGRKSSMD GAQNQDDGYL 1150 1160 1170 1180 1190 1200 ALSSRTNLQY RSLPRPSKSN SRNGAGNRSS TSSIDSNISS KSAGLPVPKL REPSKTALGS 1210 1220 1230 1240 1250 1260 SLPGLVNQTD KEKGISSDNE SVASCNSVKV NPAAQPVSSP AQTSLQPGAK YPDVASPTLR 1270 1280 1290 1300 1310 1320 RLFGGKPTKQ VPIATAENMK NSVVISNPHA TMTQQGNLDS PSGSGVLSSG SSSPLYSKNV 1330 1340 1350 1360 1370 1380 DLNQSPLASS PSSAHSAPSN SLTWGTNASS SSAVSKDGLG FQSVSSLHTS CESIDISLSS 1390 1400 1410 1420 1430 1440 GGVPSHNSST GLIASSKDDS LTPFVRTNSV KTTLSESPLS SPAASPKFCR STLPRKQDSD 1450 1460 1470 1480 1490 1500 PHLDRNTLPK KGLRYTPTSQ LRTQEDAKEW LRSHSAGGLQ DTAANSPFSS GSSVTSPSGT 1510 1520 1530 1540 1550 1560 RFNFSQLASP TTVTQMSLSN PTMLRTHSLS NADGQYDPYT DSRFRNSSMS LDEKSRTMSR 1570 1580 1590 1600 1610 1620 SGSFRDGFEE ESWEKSSVDN FVSRLHSSLH FSLPLFHHAR YELVHGSSLS LVSSTSSVYS 1630 1640 1650 1660 1670 1680 TPEEKCQSEI RKLRRELDAS QEKVSALTTQ LTANAHLVAA FEQSLGNMTI RLQSLTMTAE 1690 1700 1710 1720 1730 1740 QKDSELNELR KTIELLKKQN AAAQAAINGV INTPELNCKG NGTAQSADLR IRRQHSSDSV 1750 1760 1770 1780 1790 1800 SSINSATSHS SVGSNIESDS KKKKRKNWVN ELRSSFKQAF GKKKSPKSAS SHSDIEEMTD 1810 1820 1830 1840 1850 1860 SSLPSSPKLP HNGSTGSTPL LRNSHSNSLI SECMDSEAET VMQLRNELRD KEMKLTDIRL 1870 1880 1890 1900 1910 1920 EALSSAHQLD QLREAMNRMQ SEIEKLKAEN DRLKSESQGS GCSRAPSQVS ISASPRQSMG 1930 1940 1950 1960 1970 1980 LSQHSLNLTE STSLDMLLDD TGECSARKEG GRHVKIVVSF QEEMKWKEDS RPHLFLIGCI 1990 2000 2010 2020 2030 2040 GVSGKTKWDV LDGVVRRLFK EYIIHVDPVS QLGLNSDSVL GYSIGEIKRS NTSETPELLP 2050 2060 2070 2080 2090 2100 CGYLVGENTT ISVTVKGLAE NSLDSLVFES LIPKPILQRY VSLLIEHRRI ILSGPSGTGK 2110 2120 2130 2140 2150 2160 TYLANRLSEY IVLREGRELT DGVIATFNVD HKSSKELRQY LSNLADQCNS ENNAVDMPLV 2170 2180 2190 2200 2210 2220 IILDNLHHVS SLGEIFNGLL NCKYHKCPYI IGTMNQATSS TPNLQLHHNF RWVLCANHTE 2230 2240 2250 2260 2270 2280 PVKGFLGRFL RRKLMETEIS GRVRNMELVK IIDWIPKVWH HLNRFLEAHS SSDVTIGPRL 2290 2300 2310 2320 2330 2340 FLSCPIDVDG SRVWFTDLWN YSIIPYLLEA VREGLQLYGR RAPWEDPAKW VMDTYPWAAS 2350 2360 2370 2380 2390 2400 PQQHEWPPLL QLRPEDVGFD GYSMPREGST SKQMPPSDAE GDPLMNMLMR LQEAANYSSP 2410 2420 QSYDSDSNSN SHHDDILDSS LESTL
	Isoform 12 [UniParc]. Checksum: A902C8AFDA1FA86E	FASTA	2,424	261,579
	10 20 30 40 50 60 MQECDSKFFL PSGSNSGFTL LSNQQIYTDW ANHYLAKSGH KRLIRDLQQD VTDGVLLAQI 70 80 90 100 110 120 IQVVANEKIE DINGCPKNRS QMIENIDACL NFLAAKGINI QGLSAEEIRN GNLKAILGLF 130 140 150 160 170 180 FSLSRYKQQQ QQPQKQHLSS PLPPAVSQVA GAPSQCQAGT PQQQVPVTPQ APCQPHQPAP 190 200 210 220 230 240 HQQSKAQAEM QSSASSKDSS QSKIIRFTLG QKKISRLPGP TARVSAAGSE AKTRGGSTTA 250 260 270 280 290 300 NNRRSQSFNN YDKSKPVTSP PPPPSSHEKE PLASSASSHP GMSDNAPASL ESGSSSTPTN 310 320 330 340 350 360 CSTSSAIPQP GAATKPWRSK SLSVKHSATV SMLSVKPPGP EAPRPTPEAM KPAPNNQKSM 370 380 390 400 410 420 LEKLKLFNSK GGSKAGEGPG SRDTSCERLE TLPSFEESEE LEAASRMLTT VGPASSSPKI 430 440 450 460 470 480 ALKGIAQRTF SRALTNKKSS LKGNEKEKEK QQREKDKEKS KDLAKRASVT ERLDLKEEPK 490 500 510 520 530 540 EDPSGAAVPE MPKKSSKIAS FIPKGGKLNS AKKEPMAPSH SGIPKPGMKS MPGKSPSAPA 550 560 570 580 590 600 PSKEGERSRS GKLSSGLPQQ KPQLDGRHSS SSSSLASSEG KGPGGTTLNH SISSQTVSGS 610 620 630 640 650 660 VGTTQTTGSN TVSVQLPQPQ QQYNHPNTAT VAPFLYRSQT DTEGNVTAES SSTGVSVEPS 670 680 690 700 710 720 HFTKTGQPAL EELTGEDPEA RRLRTVKNIA DLRQNLEETM SSLRGTQVTH STLETTFDTN 730 740 750 760 770 780 VTTEMSGRSI LSLTGRPTPL SWRLGQSSPR LQAGDAPSMG NGYPPRANAS RFINTESGRY 790 800 810 820 830 840 VYSAPLRRQL ASRGSSVCHV DVSDKAGDEM DLEGISMDAP GYMSDGDVLS KNIRTDDITS 850 860 870 880 890 900 GYMTDGGLGL YTRRLNRLPD GMAVVRETLQ RNTSLGLGDA DSWDDSSSVS SGISDTIDNL 910 920 930 940 950 960 STDDINTSSS ISSYANTPAS SRKNLDVQTD AEKHSQVERN SLWSGDDVKK SDGGSDSGIK 970 980 990 1000 1010 1020 MEPGSKWRRN PSDVSDESDK STSGKKNPVI SQTGSWRRGM TAQVGITMPR TKPSAPAGAL 1030 1040 1050 1060 1070 1080 KTPGTGKTDD AKVSEKGRLS PKASQVKRSP SDAGRSSGDE SKKPLPSSSR TPTANANSFG 1090 1100 1110 1120 1130 1140 FKKQSGSAAG LAMITASGVT VTSRSATLGK IPKSSALVSR SAGRKSSMDG AQNQDDGYLA 1150 1160 1170 1180 1190 1200 LSSRTNLQYR SLPRPSKSNS RNGAGNRSST SSIDSNISSK SAGLPVPKLR EPSKTALGSS 1210 1220 1230 1240 1250 1260 LPGLVNQTDK EKGISSDNES VASCNSVKVN PAAQPVSSPA QTSLQPGAKY PDVASPTLRR 1270 1280 1290 1300 1310 1320 LFGGKPTKQV PIATAENMKN SVVISNPHAT MTQQGNLDSP SGSGVLSSGS SSPLYSKNVD 1330 1340 1350 1360 1370 1380 LNQSPLASSP SSAHSAPSNS LTWGTNASSS SAVSKDGLGF QSVSSLHTSC ESIDISLSSG 1390 1400 1410 1420 1430 1440 GVPSHNSSTG LIASSKDDSL TPFVRTNSVK TTLSESPLSS PAASPKFCRS TLPRKQDSDP 1450 1460 1470 1480 1490 1500 HLDRNTLPKK GLRYTPTSQL RTQEDAKEWL RSHSAGGLQD TAANSPFSSG SSVTSPSGTR 1510 1520 1530 1540 1550 1560 FNFSQLASPT TVTQMSLSNP TMLRTHSLSN ADGQYDPYTD SRFRNSSMSL DEKSRTMSRS 1570 1580 1590 1600 1610 1620 GSFRDGFEEE SWEKSSVDNF VSRLHSSLHF SLPLFHHARY ELVHGSSLSL VSSTSSVYST 1630 1640 1650 1660 1670 1680 PEEKCQSEIR KLRRELDASQ EKVSALTTQL TANAHLVAAF EQSLGNMTIR LQSLTMTAEQ 1690 1700 1710 1720 1730 1740 KDSELNELRK TIELLKKQNA AAQAAINGVI NTPELNCKGN GTAQSADLRI RRQHSSDSVS 1750 1760 1770 1780 1790 1800 SINSATSHSS VGSNIESDSK KKKRKNWVNE LRSSFKQAFG KKKSPKSASS HSDIEEMTDS 1810 1820 1830 1840 1850 1860 SLPSSPKLPH NGSTGSTPLL RNSHSNSLIS ECMDSEAETV MQLRNELRDK EMKLTDIRLE 1870 1880 1890 1900 1910 1920 ALSSAHQLDQ LREAMNRMQS EIEKLKAEND RLKSESQGSG CSRAPSQVSI SASPRQSMGL 1930 1940 1950 1960 1970 1980 SQHSLNLTES TSLDMLLDDT GECSARKEGG RHVKIVVSFQ EEMKWKEDSR PHLFLIGCIG 1990 2000 2010 2020 2030 2040 VSGKTKWDVL DGVVRRLFKE YIIHVDPVSQ LGLNSDSVLG YSIGEIKRSN TSETPELLPC 2050 2060 2070 2080 2090 2100 GYLVGENTTI SVTVKGLAEN SLDSLVFESL IPKPILQRYV SLLIEHRRII LSGPSGTGKT 2110 2120 2130 2140 2150 2160 YLANRLSEYI VLREGRELTD GVIATFNVDH KSSKELRQYL SNLADQCNSE NNAVDMPLVI 2170 2180 2190 2200 2210 2220 ILDNLHHVSS LGEIFNGLLN CKYHKCPYII GTMNQATSST PNLQLHHNFR WVLCANHTEP 2230 2240 2250 2260 2270 2280 VKGFLGRFLR RKLMETEISG RVRNMELVKI IDWIPKVWHH LNRFLEAHSS SDVTIGPRLF 2290 2300 2310 2320 2330 2340 LSCPIDVDGS RVWFTDLWNY SIIPYLLEAV REGLQLYGRR APWEDPAKWV MDTYPWAASP 2350 2360 2370 2380 2390 2400 QQHEWPPLLQ LRPEDVGFDG YSMPREGSTS KQMPPSDAEG DPLMNMLMRL QEAANYSSPQ 2410 2420 SYDSDSNSNS HHDDILDSSL ESTL
	Isoform 13 [UniParc]. Checksum: 98CA63F4C60A1573	FASTA	2,419	261,102
	10 20 30 40 50 60 MAIDLYCGLA CLWGIHEPRQ IYTDWANHYL AKSGHKRLIR DLQQDVTDGV LLAQIIQVVA 70 80 90 100 110 120 NEKIEDINGC PKNRSQMIEN IDACLNFLAA KGINIQGLSA EEIRNGNLKA ILGLFFSLSR 130 140 150 160 170 180 YKQQQQQPQK QHLSSPLPPA VSQVAGAPSQ CQAGTPQQQV PVTPQAPCQP HQPAPHQQSK 190 200 210 220 230 240 AQAEMQSSAS SKDSSQSKII RFTLGQKKIS RLPGPTARVS AAGSEAKTRG GSTTANNRRS 250 260 270 280 290 300 QSFNNYDKSK PVTSPPPPPS SHEKEPLASS ASSHPGMSDN APASLESGSS STPTNCSTSS 310 320 330 340 350 360 AIPQPGAATK PWRSKSLSVK HSATVSMLSV KPPGPEAPRP TPEAMKPAPN NQKSMLEKLK 370 380 390 400 410 420 LFNSKGGSKA GEGPGSRDTS CERLETLPSF EESEELEAAS RMLTTVGPAS SSPKIALKGI 430 440 450 460 470 480 AQRTFSRALT NKKSSLKGNE KEKEKQQREK DKEKSKDLAK RASVTERLDL KEEPKEDPSG 490 500 510 520 530 540 AAVPEMPKKS SKIASFIPKG GKLNSAKKEP MAPSHSGIPK PGMKSMPGKS PSAPAPSKEG 550 560 570 580 590 600 ERSRSGKLSS GLPQQKPQLD GRHSSSSSSL ASSEGKGPGG TTLNHSISSQ TVSGSVGTTQ 610 620 630 640 650 660 TTGSNTVSVQ LPQPQQQYNH PNTATVAPFL YRSQTDTEGN VTAESSSTGV SVEPSHFTKT 670 680 690 700 710 720 GQPALEELTG EDPEARRLRT VKNIADLRQN LEETMSSLRG TQVTHSTLET TFDTNVTTEM 730 740 750 760 770 780 SGRSILSLTG RPTPLSWRLG QSSPRLQAGD APSMGNGYPP RANASRFINT ESGRYVYSAP 790 800 810 820 830 840 LRRQLASRGS SVCHVDVSDK AGDEMDLEGI SMDAPGYMSD GDVLSKNIRT DDITSGYMTD 850 860 870 880 890 900 GGLGLYTRRL NRLPDGMAVV RETLQRNTSL GLGDADSWDD SSSVSSGISD TIDNLSTDDI 910 920 930 940 950 960 NTSSSISSYA NTPASSRKNL DVQTDAEKHS QVERNSLWSG DDVKKSDGGS DSGIKMEPGS 970 980 990 1000 1010 1020 KWRRNPSDVS DESDKSTSGK KNPVISQTGS WRRGMTAQVG ITMPRTKPSA PAGALKTPGT 1030 1040 1050 1060 1070 1080 GKTDDAKVSE KGRLSPKASQ VKRSPSDAGR SSGDESKKPL PSSSRTPTAN ANSFGFKKQS 1090 1100 1110 1120 1130 1140 GSAAGLAMIT ASGVTVTSRS ATLGKIPKSS ALVSRSAGRK SSMDGAQNQD DGYLALSSRT 1150 1160 1170 1180 1190 1200 NLQYRSLPRP SKSNSRNGAG NRSSTSSIDS NISSKSAGLP VPKLREPSKT ALGSSLPGLV 1210 1220 1230 1240 1250 1260 NQTDKEKGIS SDNESVASCN SVKVNPAAQP VSSPAQTSLQ PGAKYPDVAS PTLRRLFGGK 1270 1280 1290 1300 1310 1320 PTKQVPIATA ENMKNSVVIS NPHATMTQQG NLDSPSGSGV LSSGSSSPLY SKNVDLNQSP 1330 1340 1350 1360 1370 1380 LASSPSSAHS APSNSLTWGT NASSSSAVSK DGLGFQSVSS LHTSCESIDI SLSSGGVPSH 1390 1400 1410 1420 1430 1440 NSSTGLIASS KDDSLTPFVR TNSVKTTLSE SPLSSPAASP KFCRSTLPRK QDSDPHLDRN 1450 1460 1470 1480 1490 1500 TLPKKGLRYT PTSQLRTQED AKEWLRSHSA GGLQDTAANS PFSSGSSVTS PSGTRFNFSQ 1510 1520 1530 1540 1550 1560 LASPTTVTQM SLSNPTMLRT HSLSNADGQY DPYTDSRFRN SSMSLDEKSR TMSRSGSFRD 1570 1580 1590 1600 1610 1620 GFEEESWEKS SVDNFVSRLH SSLHFSLPLF HHARYELVHG SSLSLVSSTS SVYSTPEEKC 1630 1640 1650 1660 1670 1680 QSEIRKLRRE LDASQEKVSA LTTQLTANAH LVAAFEQSLG NMTIRLQSLT MTAEQKDSEL 1690 1700 1710 1720 1730 1740 NELRKTIELL KKQNAAAQAA INGVINTPEL NCKGNGTAQS ADLRIRRQHS SDSVSSINSA 1750 1760 1770 1780 1790 1800 TSHSSVGSNI ESDSKKKKRK NWVNELRSSF KQAFGKKKSP KSASSHSDIE EMTDSSLPSS 1810 1820 1830 1840 1850 1860 PKLPHNGSTG STPLLRNSHS NSLISECMDS EAETVMQLRN ELRDKEMKLT DIRLEALSSA 1870 1880 1890 1900 1910 1920 HQLDQLREAM NRMQSEIEKL KAENDRLKSE SQGSGCSRAP SQVSISASPR QSMGLSQHSL 1930 1940 1950 1960 1970 1980 NLTESTSLDM LLDDTGECSA RKEGGRHVKI VVSFQEEMKW KEDSRPHLFL IGCIGVSGKT 1990 2000 2010 2020 2030 2040 KWDVLDGVVR RLFKEYIIHV DPVSQLGLNS DSVLGYSIGE IKRSNTSETP ELLPCGYLVG 2050 2060 2070 2080 2090 2100 ENTTISVTVK GLAENSLDSL VFESLIPKPI LQRYVSLLIE HRRIILSGPS GTGKTYLANR 2110 2120 2130 2140 2150 2160 LSEYIVLREG RELTDGVIAT FNVDHKSSKE LRQYLSNLAD QCNSENNAVD MPLVIILDNL 2170 2180 2190 2200 2210 2220 HHVSSLGEIF NGLLNCKYHK CPYIIGTMNQ ATSSTPNLQL HHNFRWVLCA NHTEPVKGFL 2230 2240 2250 2260 2270 2280 GRFLRRKLME TEISGRVRNM ELVKIIDWIP KVWHHLNRFL EAHSSSDVTI GPRLFLSCPI 2290 2300 2310 2320 2330 2340 DVDGSRVWFT DLWNYSIIPY LLEAVREGLQ LYGRRAPWED PAKWVMDTYP WAASPQQHEW 2350 2360 2370 2380 2390 2400 PPLLQLRPED VGFDGYSMPR EGSTSKQMPP SDAEGDPLMN MLMRLQEAAN YSSPQSYDSD 2410 SNSNSHHDDI LDSSLESTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos." Merrill R.A., Plum L.A., Kaiser M.E., Clagett-Dame M. Proc. Natl. Acad. Sci. U.S.A. 99:3422-3427(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), INDUCTION BY ATRA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-1077.
[2]	"Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas." Ishiguro H., Shimokawa T., Tsunoda T., Tanaka T., Fujii Y., Nakamura Y., Furukawa Y. Oncogene 21:6387-6394(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION, FUNCTION AS A HELICASE, INDUCTION, TISSUE SPECIFICITY, VARIANTS LYS-109 AND ALA-1077.
[3]	"Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53." Peeters P.J., Baker A., Goris I., Daneels G., Verhasselt P., Luyten W.H.M.L., Geysen J.J.G.H., Kass S.U., Moechars D.W.E. Brain Res. Dev. Brain Res. 150:89-101(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 8; 9; 10; 11; 12 AND 13), FUNCTION, VARIANTS LYS-109 AND ALA-1077.
[4]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-1077. Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[6]	Ohara O. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7), VARIANTS ASP-1041; ALA-1077 AND ILE-2374. Tissue: Placenta.
[8]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-1077. Tissue: Skin.
[10]	"Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms." Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O., Christiansen H., Poustka A. Gene 290:73-94(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[11]	"Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans." Maes T., Barcelo A., Buesa C. Genomics 80:21-30(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[12]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1977, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1480; SER-1484; SER-1488 AND SER-1977, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Solution structure of the CH domain from human neuron navigator 2." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2009) to the PDB data bank Cited for: STRUCTURE BY NMR OF 90-197.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF466143 mRNA. Translation: AAL96479.1.
AF466144 mRNA. Translation: AAL96480.1.
AB063115 mRNA. Translation: BAC00853.1.
AB063116 mRNA. Translation: BAC00854.1.
AJ488102 mRNA. Translation: CAD32471.1.
AJ488203 mRNA. Translation: CAD32556.1.
AJ488204 mRNA. Translation: CAD32557.1.
AJ488205 mRNA. Translation: CAD32558.1.
AJ488206 mRNA. Translation: CAD32559.1.
AJ488207 mRNA. Translation: CAD32560.1.
AJ488208 mRNA. Translation: CAD32561.1.
AB037840 mRNA. Translation: BAA92657.3. Different initiation.
AK001495 mRNA. Translation: BAA91723.1.
AK001892 mRNA. Translation: BAA91965.1.
AK074287 mRNA. Translation: BAB85038.1. Frameshift.
AC009549 Genomic DNA. No translation available.
AC015684 Genomic DNA. No translation available.
AC023950 Genomic DNA. No translation available.
AC090662 Genomic DNA. No translation available.
AC111163 Genomic DNA. No translation available.
AC113193 Genomic DNA. No translation available.
BC016054 mRNA. Translation: AAH16054.1.

IPI

IPI00152696.
IPI00217052.
IPI00815697.
IPI00815765.
IPI00815856.
IPI00816020.
IPI00816099.
IPI00816407.
IPI00816570.
IPI00816751.
IPI00816806.
IPI00872269.
IPI00879900.

RefSeq

NP_001104488.1. NM_001111018.1.
NP_001104489.1. NM_001111019.2.
NP_001231892.1. NM_001244963.1.
NP_660093.2. NM_145117.4.
NP_892009.3. NM_182964.5.

UniGene

Hs.502116.
Hs.639427.
Hs.639428.
Hs.64341.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YRN	NMR	-	A	90-197	[»]

ProteinModelPortal

Q8IVL1.

SMR

Q8IVL1. Positions 78-197, 2139-2244.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IVL1. 4 interactions.

MINT

MINT-1455352.

PTM databases

PhosphoSite

Q8IVL1.

Polymorphism databases

DMDM

308153582.

Proteomic databases

PaxDb

Q8IVL1.

PRIDE

Q8IVL1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000311043; ENSP00000312169; ENSG00000166833.
ENST00000349880; ENSP00000309577; ENSG00000166833.
ENST00000360655; ENSP00000353871; ENSG00000166833.
ENST00000396085; ENSP00000379394; ENSG00000166833.
ENST00000396087; ENSP00000379396; ENSG00000166833.
ENST00000527559; ENSP00000435395; ENSG00000166833.
ENST00000533917; ENSP00000437316; ENSG00000166833.
ENST00000540292; ENSP00000443489; ENSG00000166833.

GeneID

89797.

KEGG

hsa:89797.

UCSC

uc001mpp.3. human.
uc001mpr.4. human.
uc001mpu.3. human.
uc009yhx.3. human.
uc010rdm.2. human.

Organism-specific databases

CTD

89797.

GeneCards

GC11P019372.

HGNC

HGNC:15997. NAV2.

HPA

HPA011755.
HPA011891.

MIM

607026. gene.

neXtProt

NX_Q8IVL1.

PharmGKB

PA31452.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5069.

HOVERGEN

HBG058814.

OMA

DQCNSEN.

PhylomeDB

Q8IVL1.

Gene expression databases

ArrayExpress

Q8IVL1.

Bgee

Q8IVL1.

Genevestigator

Q8IVL1.

GermOnline

ENSG00000166833. Homo sapiens.

Family and domain databases

Gene3D

1.10.418.10. 1 hit.

InterPro

IPR003593. AAA+_ATPase.
IPR001715. CH-domain.
[Graphical view]

Pfam

PF00307. CH. 1 hit.
[Graphical view]

SMART

SM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view]

SUPFAM

SSF47576. Calponin-homology. 1 hit.

PROSITE

PS50021. CH. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NAV2. human.

EvolutionaryTrace

Q8IVL1.

GenomeRNAi

89797.

NextBio

76293.

SOURCE

Search...

Entry information

Entry name

NAV2_HUMAN

Accession

Primary (citable) accession number: Q8IVL1
Secondary accession number(s): A6NEC1 , Q8IVK3, Q8IVK4, Q8IVK5, Q8IVK6, Q8IVK7, Q8IVK8, Q8NHC9, Q8NHD0, Q8TDE9, Q8TDF0, Q8TEB3, Q96B30, Q9NUZ6, Q9NVM7, Q9P2C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 5, 2010
Last modified:	April 3, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.