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Q8IVL1

- NAV2_HUMAN

UniProt

Q8IVL1 - NAV2_HUMAN

Protein

Neuron navigator 2

Gene

NAV2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.2 Publications

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi2157 – 21648ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. heparin binding Source: Ensembl

    GO - Biological processi

    1. glossopharyngeal nerve development Source: Ensembl
    2. locomotory behavior Source: Ensembl
    3. optic nerve development Source: Ensembl
    4. regulation of systemic arterial blood pressure by baroreceptor feedback Source: Ensembl
    5. sensory perception of smell Source: Ensembl
    6. sensory perception of sound Source: Ensembl
    7. vagus nerve development Source: Ensembl

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuron navigator 2 (EC:3.6.4.12)
    Alternative name(s):
    Helicase APC down-regulated 1
    Pore membrane and/or filament-interacting-like protein 2
    Retinoic acid inducible in neuroblastoma 1
    Steerin-2
    Unc-53 homolog 2
    Short name:
    unc53H2
    Gene namesi
    Name:NAV2
    Synonyms:HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15997. NAV2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. interstitial matrix Source: Ensembl
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31452.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24882488Neuron navigator 2PRO_0000267198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1480 – 14801Phosphoserine1 Publication
    Modified residuei1484 – 14841Phosphoserine1 Publication
    Modified residuei1488 – 14881Phosphoserine1 Publication
    Modified residuei1977 – 19771Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IVL1.
    PaxDbiQ8IVL1.
    PRIDEiQ8IVL1.

    PTM databases

    PhosphoSiteiQ8IVL1.

    Expressioni

    Tissue specificityi

    Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.4 Publications

    Developmental stagei

    Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney.1 Publication

    Inductioni

    By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.2 Publications

    Gene expression databases

    ArrayExpressiQ8IVL1.
    BgeeiQ8IVL1.
    GenevestigatoriQ8IVL1.

    Organism-specific databases

    HPAiHPA011755.
    HPA011891.

    Interactioni

    Protein-protein interaction databases

    BioGridi124606. 4 interactions.
    IntActiQ8IVL1. 4 interactions.
    MINTiMINT-1455352.

    Structurei

    Secondary structure

    1
    2488
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi90 – 10112
    Helixi111 – 1144
    Beta strandi115 – 1184
    Helixi119 – 12810
    Helixi145 – 15915
    Helixi169 – 1746
    Helixi177 – 19115

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YRNNMR-A90-197[»]
    ProteinModelPortaliQ8IVL1.
    SMRiQ8IVL1. Positions 78-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8IVL1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 192108CHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili498 – 53134Sequence AnalysisAdd
    BLAST
    Coiled coili743 – 77129Sequence AnalysisAdd
    BLAST
    Coiled coili1686 – 177388Sequence AnalysisAdd
    BLAST
    Coiled coili1897 – 196468Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi192 – 25564Gln-richAdd
    BLAST
    Compositional biasi324 – 3285Poly-Pro
    Compositional biasi633 – 6386Poly-Ser
    Compositional biasi1363 – 1683321Ser-richAdd
    BLAST
    Compositional biasi1824 – 18296Poly-Lys

    Sequence similaritiesi

    Belongs to the Nav/unc-53 family.Curated
    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5069.
    HOVERGENiHBG058814.
    OMAiERNSLWS.
    OrthoDBiEOG7GBFW1.
    PhylomeDBiQ8IVL1.
    TreeFamiTF329881.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR001715. CH-domain.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00307. CH. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00033. CH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEiPS50021. CH. 1 hit.
    [Graphical view]

    Sequences (13)i

    Sequence statusi: Complete.

    This entry describes 13 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms may exist.

    Isoform 1 (identifier: Q8IVL1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT     50
    TYPSQIPLKS QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA 100
    KSGHKRLIRD LQQDVTDGVL LAQIIQVVAN EKIEDINGCP KNRSQMIENI 150
    DACLNFLAAK GINIQGLSAE EIRNGNLKAI LGLFFSLSRY KQQQQQPQKQ 200
    HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH QPAPHQQSKA 250
    QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG 300
    STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA 350
    PASLESGSSS TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK 400
    PPGPEAPRPT PEAMKPAPNN QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC 450
    ERLETLPSFE ESEELEAASR MLTTVGPASS SPKIALKGIA QRTFSRALTN 500
    KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK EEPKEDPSGA 550
    AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP 600
    SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT 650
    TLNHSISSQT VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY 700
    RSQTDTEGNV TAESSSTGVS VEPSHFTKTG QPALEELTGE DPEARRLRTV 750
    KNIADLRQNL EETMSSLRGT QVTHSTLETT FDTNVTTEMS GRSILSLTGR 800
    PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE SGRYVYSAPL 850
    RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD 900
    DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS 950
    SSVSSGISDT IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ 1000
    VERNSLWSGD DVKKSDGGSD SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK 1050
    NPVISQTGSW RRGMTAQVGI TMPRTKPSAP AGALKTPGTG KTDDAKVSEK 1100
    GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA NSFGFKKQSG 1150
    SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD 1200
    GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV 1250
    PKLREPSKTA LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV 1300
    SSPAQTSLQP GAKYPDVASP TLRRLFGGKP TKQVPIATAE NMKNSVVISN 1350
    PHATMTQQGN LDSPSGSGVL SSGSSSPLYS KNVDLNQSPL ASSPSSAHSA 1400
    PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS LSSGGVPSHN 1450
    SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ 1500
    DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP 1550
    FSSGSSVTSP SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD 1600
    PYTDSRFRNS SMSLDEKSRT MSRSGSFRDG FEEESWEKSS VDNFVSRLHS 1650
    SLHFSLPLFH HARYELVHGS SLSLVSSTSS VYSTPEEKCQ SEIRKLRREL 1700
    DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM TAEQKDSELN 1750
    ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS 1800
    DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK 1850
    SASSHSDIEE MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE 1900
    AETVMQLRNE LRDKEMKLTD IRLEALSSAH QLDQLREAMN RMQSEIEKLK 1950
    AENDRLKSES QGSGCSRAPS QVSISASPRQ SMGLSQHSLN LTESTSLDML 2000
    LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI GCIGVSGKTK 2050
    WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE 2100
    LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH 2150
    RRIILSGPSG TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL 2200
    RQYLSNLADQ CNSENNAVDM PLVIILDNLH HVSSLGEIFN GLLNCKYHKC 2250
    PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN HTEPVKGFLG RFLRRKLMET 2300
    EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG PRLFLSCPID 2350
    VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW 2400
    AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM 2450
    LMRLQEAANY SSPQSYDSDS NSNSHHDDIL DSSLESTL 2488
    Length:2,488
    Mass (Da):268,167
    Last modified:October 5, 2010 - v3
    Checksum:i0AEDD1C1469A11A8
    GO
    Isoform 2 (identifier: Q8IVL1-2) [UniParc]FASTAAdd to Basket

    Also known as: RAINB1d

    The sequence of this isoform differs from the canonical sequence as follows:
         256-278: Missing.
         1634-1666: Missing.

    Show »
    Length:2,432
    Mass (Da):261,750
    Checksum:i1CEC21B583BB5B36
    GO
    Isoform 3 (identifier: Q8IVL1-3) [UniParc]FASTAAdd to Basket

    Also known as: HELAD1L

    The sequence of this isoform differs from the canonical sequence as follows:
         256-278: Missing.
         1634-1666: Missing.
         1832-1834: Missing.

    Show »
    Length:2,429
    Mass (Da):261,408
    Checksum:iFF906F1F4EB428B5
    GO
    Isoform 4 (identifier: Q8IVL1-4) [UniParc]FASTAAdd to Basket

    Also known as: HELAD1S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-89: MPAILVASKM...GSVENGFDTQ → MESVSESSQQQKRKPVIHGLEDQKR
         256-278: Missing.
         1634-1666: Missing.
         1832-1834: Missing.

    Show »
    Length:2,365
    Mass (Da):254,978
    Checksum:i000C16EB12682A2C
    GO
    Isoform 5 (identifier: Q8IVL1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-937: Missing.
         938-945: SLGLGDAD → MLWPRNLT
         1480-1501: Missing.
         1634-1666: Missing.
         1832-1834: Missing.

    Show »
    Length:1,493
    Mass (Da):161,946
    Checksum:i278DEF938E0D3DC2
    GO
    Isoform 6 (identifier: Q8IVL1-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1578: Missing.
         1634-1666: Missing.
         1832-1834: Missing.

    Show »
    Length:874
    Mass (Da):97,684
    Checksum:iAEFA49541B2A2E94
    GO
    Isoform 7 (identifier: Q8IVL1-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1896: Missing.

    Show »
    Length:592
    Mass (Da):66,897
    Checksum:i6B8F113F3C036820
    GO
    Isoform 8 (identifier: Q8IVL1-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: MPAILVASKM...SGSVENGFDT → MLWPRNLT

    Show »
    Length:2,408
    Mass (Da):259,971
    Checksum:i635AC30132928AF6
    GO
    Isoform 9 (identifier: Q8IVL1-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: MPAILVASKM...SGSVENGFDT → MAGTSAASSWGGGK

    Show »
    Length:2,414
    Mass (Da):260,208
    Checksum:iFF6423A81066C65B
    GO
    Isoform 10 (identifier: Q8IVL1-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: MPAILVASKM...SGSVENGFDT → MSVMLWRWEQNNTTMKL

    Show »
    Length:2,417
    Mass (Da):261,109
    Checksum:iDFBF27444A625EB2
    GO
    Isoform 11 (identifier: Q8IVL1-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: MPAILVASKM...SGSVENGFDT → MESVSESSQQQKRKPVIHGLEDQKR

    Show »
    Length:2,425
    Mass (Da):261,866
    Checksum:i5C153BF3E2FA6698
    GO
    Isoform 12 (identifier: Q8IVL1-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: MPAILVASKM...SGSVENGFDT → MQECDSKFFLPSGSNSGFTLLSNQ

    Show »
    Length:2,424
    Mass (Da):261,579
    Checksum:iA902C8AFDA1FA86E
    GO
    Isoform 13 (identifier: Q8IVL1-13) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: MPAILVASKM...SGSVENGFDT → MAIDLYCGLACLWGIHEPR

    Show »
    Length:2,419
    Mass (Da):261,102
    Checksum:i98CA63F4C60A1573
    GO

    Sequence cautioni

    The sequence BAB85038.1 differs from that shown. Reason: Frameshift at position 2074.
    The sequence BAA92657.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001A → T in BAC00854. (PubMed:12214280)Curated
    Sequence conflicti100 – 1001A → T in CAD32471. (PubMed:15158073)Curated
    Sequence conflicti259 – 2591S → P in AAL96479. (PubMed:11904404)Curated
    Sequence conflicti259 – 2591S → P in AAL96480. (PubMed:11904404)Curated
    Sequence conflicti259 – 2591S → P in BAA92657. (PubMed:10718198)Curated
    Sequence conflicti282 – 2821P → S in CAD32471. (PubMed:15158073)Curated
    Sequence conflicti1046 – 10461T → M in BAB85038. (PubMed:14702039)Curated
    Sequence conflicti1173 – 11731G → D in BAB85038. (PubMed:14702039)Curated
    Sequence conflicti1845 – 18451Missing in AAH16054. (PubMed:16554811)Curated
    Sequence conflicti1939 – 19391M → V in BAB85038. (PubMed:14702039)Curated
    Sequence conflicti2012 – 20121E → G in BAA91965. (PubMed:14702039)Curated
    Sequence conflicti2053 – 20531V → A in BAA91723. (PubMed:14702039)Curated
    Sequence conflicti2075 – 20751L → V in BAB85038. (PubMed:14702039)Curated
    Sequence conflicti2296 – 22961K → E in BAA91965. (PubMed:14702039)Curated
    Sequence conflicti2299 – 22991E → K in BAB85038. (PubMed:14702039)Curated
    Sequence conflicti2395 – 23951M → V in BAA91723. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091R → K.2 Publications
    Corresponds to variant rs6483617 [ dbSNP | Ensembl ].
    VAR_029640
    Natural varianti491 – 4911Q → H.
    Corresponds to variant rs16937251 [ dbSNP | Ensembl ].
    VAR_029641
    Natural varianti1041 – 10411E → D.1 Publication
    Corresponds to variant rs3802799 [ dbSNP | Ensembl ].
    VAR_029642
    Natural varianti1077 – 10771P → A.6 Publications
    Corresponds to variant rs3802800 [ dbSNP | Ensembl ].
    VAR_029643
    Natural varianti2374 – 23741V → I.1 Publication
    Corresponds to variant rs35891966 [ dbSNP | Ensembl ].
    VAR_032252

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 18961896Missing in isoform 7. 1 PublicationVSP_021924Add
    BLAST
    Alternative sequencei1 – 15781578Missing in isoform 6. 2 PublicationsVSP_021925Add
    BLAST
    Alternative sequencei1 – 937937Missing in isoform 5. 1 PublicationVSP_021926Add
    BLAST
    Alternative sequencei1 – 8989MPAIL…GFDTQ → MESVSESSQQQKRKPVIHGL EDQKR in isoform 4. 1 PublicationVSP_021927Add
    BLAST
    Alternative sequencei1 – 8888MPAIL…NGFDT → MSVMLWRWEQNNTTMKL in isoform 10. 1 PublicationVSP_021928Add
    BLAST
    Alternative sequencei1 – 8888MPAIL…NGFDT → MESVSESSQQQKRKPVIHGL EDQKR in isoform 11. 1 PublicationVSP_021929Add
    BLAST
    Alternative sequencei1 – 8888MPAIL…NGFDT → MQECDSKFFLPSGSNSGFTL LSNQ in isoform 12. 1 PublicationVSP_021930Add
    BLAST
    Alternative sequencei1 – 8888MPAIL…NGFDT → MAIDLYCGLACLWGIHEPR in isoform 13. 1 PublicationVSP_021931Add
    BLAST
    Alternative sequencei1 – 8888MPAIL…NGFDT → MLWPRNLT in isoform 8. 1 PublicationVSP_021932Add
    BLAST
    Alternative sequencei1 – 8888MPAIL…NGFDT → MAGTSAASSWGGGK in isoform 9. 1 PublicationVSP_021933Add
    BLAST
    Alternative sequencei256 – 27823Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_021934Add
    BLAST
    Alternative sequencei938 – 9458SLGLGDAD → MLWPRNLT in isoform 5. 1 PublicationVSP_021935
    Alternative sequencei1480 – 150122Missing in isoform 5. 1 PublicationVSP_021936Add
    BLAST
    Alternative sequencei1634 – 166633Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 5 PublicationsVSP_021937Add
    BLAST
    Alternative sequencei1832 – 18343Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 4 PublicationsVSP_021938

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF466143 mRNA. Translation: AAL96479.1.
    AF466144 mRNA. Translation: AAL96480.1.
    AB063115 mRNA. Translation: BAC00853.1.
    AB063116 mRNA. Translation: BAC00854.1.
    AJ488102 mRNA. Translation: CAD32471.1.
    AJ488203 mRNA. Translation: CAD32556.1.
    AJ488204 mRNA. Translation: CAD32557.1.
    AJ488205 mRNA. Translation: CAD32558.1.
    AJ488206 mRNA. Translation: CAD32559.1.
    AJ488207 mRNA. Translation: CAD32560.1.
    AJ488208 mRNA. Translation: CAD32561.1.
    AB037840 mRNA. Translation: BAA92657.3. Different initiation.
    AK001495 mRNA. Translation: BAA91723.1.
    AK001892 mRNA. Translation: BAA91965.1.
    AK074287 mRNA. Translation: BAB85038.1. Frameshift.
    AC009549 Genomic DNA. No translation available.
    AC015684 Genomic DNA. No translation available.
    AC023950 Genomic DNA. No translation available.
    AC090662 Genomic DNA. No translation available.
    AC111163 Genomic DNA. No translation available.
    AC113193 Genomic DNA. No translation available.
    BC016054 mRNA. Translation: AAH16054.1.
    CCDSiCCDS44552.1. [Q8IVL1-5]
    CCDS53612.1. [Q8IVL1-4]
    CCDS58126.1. [Q8IVL1-1]
    CCDS7850.1. [Q8IVL1-3]
    CCDS7851.2. [Q8IVL1-2]
    RefSeqiNP_001104488.1. NM_001111018.1. [Q8IVL1-4]
    NP_001104489.1. NM_001111019.2. [Q8IVL1-5]
    NP_001231892.1. NM_001244963.1. [Q8IVL1-1]
    NP_660093.2. NM_145117.4. [Q8IVL1-3]
    NP_892009.3. NM_182964.5. [Q8IVL1-2]
    XP_006718431.1. XM_006718368.1. [Q8IVL1-5]
    UniGeneiHs.502116.
    Hs.639427.
    Hs.639428.
    Hs.64341.

    Genome annotation databases

    EnsembliENST00000349880; ENSP00000309577; ENSG00000166833. [Q8IVL1-3]
    ENST00000360655; ENSP00000353871; ENSG00000166833. [Q8IVL1-4]
    ENST00000396085; ENSP00000379394; ENSG00000166833. [Q8IVL1-2]
    ENST00000396087; ENSP00000379396; ENSG00000166833. [Q8IVL1-1]
    ENST00000527559; ENSP00000435395; ENSG00000166833. [Q8IVL1-10]
    ENST00000533917; ENSP00000437316; ENSG00000166833. [Q8IVL1-5]
    ENST00000540292; ENSP00000443489; ENSG00000166833. [Q8IVL1-13]
    GeneIDi89797.
    KEGGihsa:89797.
    UCSCiuc001mpp.3. human. [Q8IVL1-4]
    uc001mpr.4. human. [Q8IVL1-2]
    uc001mpu.3. human. [Q8IVL1-6]
    uc009yhx.4. human. [Q8IVL1-5]
    uc010rdm.2. human. [Q8IVL1-1]

    Polymorphism databases

    DMDMi308153582.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF466143 mRNA. Translation: AAL96479.1 .
    AF466144 mRNA. Translation: AAL96480.1 .
    AB063115 mRNA. Translation: BAC00853.1 .
    AB063116 mRNA. Translation: BAC00854.1 .
    AJ488102 mRNA. Translation: CAD32471.1 .
    AJ488203 mRNA. Translation: CAD32556.1 .
    AJ488204 mRNA. Translation: CAD32557.1 .
    AJ488205 mRNA. Translation: CAD32558.1 .
    AJ488206 mRNA. Translation: CAD32559.1 .
    AJ488207 mRNA. Translation: CAD32560.1 .
    AJ488208 mRNA. Translation: CAD32561.1 .
    AB037840 mRNA. Translation: BAA92657.3 . Different initiation.
    AK001495 mRNA. Translation: BAA91723.1 .
    AK001892 mRNA. Translation: BAA91965.1 .
    AK074287 mRNA. Translation: BAB85038.1 . Frameshift.
    AC009549 Genomic DNA. No translation available.
    AC015684 Genomic DNA. No translation available.
    AC023950 Genomic DNA. No translation available.
    AC090662 Genomic DNA. No translation available.
    AC111163 Genomic DNA. No translation available.
    AC113193 Genomic DNA. No translation available.
    BC016054 mRNA. Translation: AAH16054.1 .
    CCDSi CCDS44552.1. [Q8IVL1-5 ]
    CCDS53612.1. [Q8IVL1-4 ]
    CCDS58126.1. [Q8IVL1-1 ]
    CCDS7850.1. [Q8IVL1-3 ]
    CCDS7851.2. [Q8IVL1-2 ]
    RefSeqi NP_001104488.1. NM_001111018.1. [Q8IVL1-4 ]
    NP_001104489.1. NM_001111019.2. [Q8IVL1-5 ]
    NP_001231892.1. NM_001244963.1. [Q8IVL1-1 ]
    NP_660093.2. NM_145117.4. [Q8IVL1-3 ]
    NP_892009.3. NM_182964.5. [Q8IVL1-2 ]
    XP_006718431.1. XM_006718368.1. [Q8IVL1-5 ]
    UniGenei Hs.502116.
    Hs.639427.
    Hs.639428.
    Hs.64341.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YRN NMR - A 90-197 [» ]
    ProteinModelPortali Q8IVL1.
    SMRi Q8IVL1. Positions 78-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124606. 4 interactions.
    IntActi Q8IVL1. 4 interactions.
    MINTi MINT-1455352.

    PTM databases

    PhosphoSitei Q8IVL1.

    Polymorphism databases

    DMDMi 308153582.

    Proteomic databases

    MaxQBi Q8IVL1.
    PaxDbi Q8IVL1.
    PRIDEi Q8IVL1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349880 ; ENSP00000309577 ; ENSG00000166833 . [Q8IVL1-3 ]
    ENST00000360655 ; ENSP00000353871 ; ENSG00000166833 . [Q8IVL1-4 ]
    ENST00000396085 ; ENSP00000379394 ; ENSG00000166833 . [Q8IVL1-2 ]
    ENST00000396087 ; ENSP00000379396 ; ENSG00000166833 . [Q8IVL1-1 ]
    ENST00000527559 ; ENSP00000435395 ; ENSG00000166833 . [Q8IVL1-10 ]
    ENST00000533917 ; ENSP00000437316 ; ENSG00000166833 . [Q8IVL1-5 ]
    ENST00000540292 ; ENSP00000443489 ; ENSG00000166833 . [Q8IVL1-13 ]
    GeneIDi 89797.
    KEGGi hsa:89797.
    UCSCi uc001mpp.3. human. [Q8IVL1-4 ]
    uc001mpr.4. human. [Q8IVL1-2 ]
    uc001mpu.3. human. [Q8IVL1-6 ]
    uc009yhx.4. human. [Q8IVL1-5 ]
    uc010rdm.2. human. [Q8IVL1-1 ]

    Organism-specific databases

    CTDi 89797.
    GeneCardsi GC11P019372.
    HGNCi HGNC:15997. NAV2.
    HPAi HPA011755.
    HPA011891.
    MIMi 607026. gene.
    neXtProti NX_Q8IVL1.
    PharmGKBi PA31452.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5069.
    HOVERGENi HBG058814.
    OMAi ERNSLWS.
    OrthoDBi EOG7GBFW1.
    PhylomeDBi Q8IVL1.
    TreeFami TF329881.

    Miscellaneous databases

    ChiTaRSi NAV2. human.
    EvolutionaryTracei Q8IVL1.
    GeneWikii NAV2.
    GenomeRNAii 89797.
    NextBioi 76293.
    PROi Q8IVL1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVL1.
    Bgeei Q8IVL1.
    Genevestigatori Q8IVL1.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR001715. CH-domain.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00307. CH. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00033. CH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEi PS50021. CH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos."
      Merrill R.A., Plum L.A., Kaiser M.E., Clagett-Dame M.
      Proc. Natl. Acad. Sci. U.S.A. 99:3422-3427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), INDUCTION BY ATRA, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-1077.
    2. "Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas."
      Ishiguro H., Shimokawa T., Tsunoda T., Tanaka T., Fujii Y., Nakamura Y., Furukawa Y.
      Oncogene 21:6387-6394(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION, FUNCTION AS A HELICASE, INDUCTION, TISSUE SPECIFICITY, VARIANTS LYS-109 AND ALA-1077.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 8; 9; 10; 11; 12 AND 13), FUNCTION, VARIANTS LYS-109 AND ALA-1077.
    4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-1077.
      Tissue: Brain.
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    6. Ohara O.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7), VARIANTS ASP-1041; ALA-1077 AND ILE-2374.
      Tissue: Placenta.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-1077.
      Tissue: Skin.
    10. "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms."
      Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O., Christiansen H., Poustka A.
      Gene 290:73-94(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    11. "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans."
      Maes T., Barcelo A., Buesa C.
      Genomics 80:21-30(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1480; SER-1484; SER-1488 AND SER-1977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Solution structure of the CH domain from human neuron navigator 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 90-197.

    Entry informationi

    Entry nameiNAV2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVL1
    Secondary accession number(s): A6NEC1
    , Q8IVK3, Q8IVK4, Q8IVK5, Q8IVK6, Q8IVK7, Q8IVK8, Q8NHC9, Q8NHD0, Q8TDE9, Q8TDF0, Q8TEB3, Q96B30, Q9NUZ6, Q9NVM7, Q9P2C8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    PubMed:15158073 experiments have been carried out in mouse.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3