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Q8IVK1 (GLCM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative glycosylation-dependent cell adhesion molecule 1

Short name=GlyCAM-1
Gene names
Name:GLYCAM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length47 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceUncertain

General annotation (Comments)

Tissue specificity

Expressed in cells harvested from milk of lactating women. Not found in other tissues. Ref.1

Sequence similarities

Belongs to the PP3/GlyCAM-1 family.

Caution

Could be the product of a pseudogene. Encodes aberrant truncated proteins.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of immune response

Traceable author statement. Source: Reactome

   Cellular_componentplasma membrane

Traceable author statement. Source: Reactome

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IVK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IVK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     33-46: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 4729Putative glycosylation-dependent cell adhesion molecule 1
PRO_0000342397

Natural variations

Alternative sequence33 – 4614Missing in isoform 2.
VSP_034444

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2753AB9F16B3BF13

FASTA475,018
        10         20         30         40 
MKFFMVLLPA SLASTSLAIL DVESGLLPQL SVLLSNRLRG KTCQTGP 

« Hide

Isoform 2 [UniParc].

Checksum: 06AFF0F0FD858966
Show »

FASTA333,489

References

[1]"Human GlyCAM-1 mRNA is expressed in the mammary gland as splicing variants and encodes various aberrant truncated proteins."
Rasmussen L.K., Johnsen L.B., Petersen T.E., Sorensen E.S.
Immunol. Lett. 83:73-75(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ489589 mRNA. Translation: CAD34030.1.
AJ489590 mRNA. Translation: CAD34031.1.
AJ489591 mRNA. Translation: CAD34032.1.
AJ489592 mRNA. Translation: CAD34033.1.
AJ489593 mRNA. Translation: CAD34034.1.
UniGeneHs.483519.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000406480.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC12M055001.
HGNCHGNC:18023. GLYCAM1.
neXtProtNX_Q8IVK1.
PharmGKBPA24384.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000170742.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorQ8IVK1.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameGLCM1_HUMAN
AccessionPrimary (citable) accession number: Q8IVK1
Secondary accession number(s): Q8IUA8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: January 22, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM