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Q8IVK1

- GLCM1_HUMAN

UniProt

Q8IVK1 - GLCM1_HUMAN

Protein

Putative glycosylation-dependent cell adhesion molecule 1

Gene

GLYCAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Functioni

    GO - Biological processi

    1. regulation of immune response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glycosylation-dependent cell adhesion molecule 1
    Short name:
    GlyCAM-1
    Gene namesi
    Name:GLYCAM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:18023. GLYCAM1.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24384.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 4729Putative glycosylation-dependent cell adhesion molecule 1PRO_0000342397Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in cells harvested from milk of lactating women. Not found in other tissues.1 Publication

    Gene expression databases

    GenevestigatoriQ8IVK1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000406480.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP3/GlyCAM-1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000170742.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IVK1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKFFMVLLPA SLASTSLAIL DVESGLLPQL SVLLSNRLRG KTCQTGP      47
    Length:47
    Mass (Da):5,018
    Last modified:March 1, 2003 - v1
    Checksum:i2753AB9F16B3BF13
    GO
    Isoform 2 (identifier: Q8IVK1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-46: Missing.

    Show »
    Length:33
    Mass (Da):3,489
    Checksum:i06AFF0F0FD858966
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei33 – 4614Missing in isoform 2. 1 PublicationVSP_034444Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ489589 mRNA. Translation: CAD34030.1.
    AJ489590 mRNA. Translation: CAD34031.1.
    AJ489591 mRNA. Translation: CAD34032.1.
    AJ489592 mRNA. Translation: CAD34033.1.
    AJ489593 mRNA. Translation: CAD34034.1.
    UniGeneiHs.483519.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ489589 mRNA. Translation: CAD34030.1 .
    AJ489590 mRNA. Translation: CAD34031.1 .
    AJ489591 mRNA. Translation: CAD34032.1 .
    AJ489592 mRNA. Translation: CAD34033.1 .
    AJ489593 mRNA. Translation: CAD34034.1 .
    UniGenei Hs.483519.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000406480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC12M055001.
    HGNCi HGNC:18023. GLYCAM1.
    neXtProti NX_Q8IVK1.
    PharmGKBi PA24384.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000170742.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Gene expression databases

    Genevestigatori Q8IVK1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Human GlyCAM-1 mRNA is expressed in the mammary gland as splicing variants and encodes various aberrant truncated proteins."
      Rasmussen L.K., Johnsen L.B., Petersen T.E., Sorensen E.S.
      Immunol. Lett. 83:73-75(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiGLCM1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVK1
    Secondary accession number(s): Q8IUA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. Encodes aberrant truncated proteins.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3