Q8IVK1 (GLCM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glycosylation-dependent cell adhesion molecule 1
Short name=GlyCAM-1

Gene names

Name:

GLYCAM1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	47 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Tissue specificity	Expressed in cells harvested from milk of lactating women. Not found in other tissues. Ref.1
Sequence similarities	Belongs to the PP3/GlyCAM-1 family.
Caution	Could be the product of a pseudogene. Encodes aberrant truncated proteins.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of immune response Traceable author statement. Source: Reactome
Cellular_component	plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IVK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IVK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     33-46: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 47	29	Putative glycosylation-dependent cell adhesion molecule 1		PRO_0000342397
Natural variations
	Alternative sequence	33 – 46	14	Missing in isoform 2.		VSP_034444

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2753AB9F16B3BF13	FASTA	47	5,018
	10 20 30 40 MKFFMVLLPA SLASTSLAIL DVESGLLPQL SVLLSNRLRG KTCQTGP
	Isoform 2 [UniParc]. Checksum: 06AFF0F0FD858966	FASTA	33	3,489
	10 20 30 MKFFMVLLPA SLASTSLAIL DVESGLLPQL SVP

References

[1]	"Human GlyCAM-1 mRNA is expressed in the mammary gland as splicing variants and encodes various aberrant truncated proteins." Rasmussen L.K., Johnsen L.B., Petersen T.E., Sorensen E.S. Immunol. Lett. 83:73-75(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ489589 mRNA. Translation: CAD34030.1. AJ489590 mRNA. Translation: CAD34031.1. AJ489591 mRNA. Translation: CAD34032.1. AJ489592 mRNA. Translation: CAD34033.1. AJ489593 mRNA. Translation: CAD34034.1.
IPI	IPI00383418. IPI00896388.
UniGene	Hs.483519.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000406480.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC12M055001.
HGNC	HGNC:18023. GLYCAM1.
neXtProt	NX_Q8IVK1.
PharmGKB	PA24384.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000170742.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	Q8IVK1.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

GLCM1_HUMAN

Accession

Primary (citable) accession number: Q8IVK1
Secondary accession number(s): Q8IUA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.