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Q8IVK1

- GLCM1_HUMAN

UniProt

Q8IVK1 - GLCM1_HUMAN

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Protein

Putative glycosylation-dependent cell adhesion molecule 1

Gene

GLYCAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

GO - Biological processi

  1. regulation of immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycosylation-dependent cell adhesion molecule 1
Short name:
GlyCAM-1
Gene namesi
Name:GLYCAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:18023. GLYCAM1.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 4729Putative glycosylation-dependent cell adhesion molecule 1PRO_0000342397Add
BLAST

Expressioni

Tissue specificityi

Expressed in cells harvested from milk of lactating women. Not found in other tissues.1 Publication

Gene expression databases

GenevestigatoriQ8IVK1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000406480.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP3/GlyCAM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000170742.
InParanoidiQ8IVK1.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVK1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40 
MKFFMVLLPA SLASTSLAIL DVESGLLPQL SVLLSNRLRG KTCQTGP
Length:47
Mass (Da):5,018
Last modified:March 1, 2003 - v1
Checksum:i2753AB9F16B3BF13
GO
Isoform 2 (identifier: Q8IVK1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-46: Missing.

Show »
Length:33
Mass (Da):3,489
Checksum:i06AFF0F0FD858966
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei33 – 4614Missing in isoform 2. 1 PublicationVSP_034444Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ489589 mRNA. Translation: CAD34030.1.
AJ489590 mRNA. Translation: CAD34031.1.
AJ489591 mRNA. Translation: CAD34032.1.
AJ489592 mRNA. Translation: CAD34033.1.
AJ489593 mRNA. Translation: CAD34034.1.
UniGeneiHs.483519.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ489589 mRNA. Translation: CAD34030.1 .
AJ489590 mRNA. Translation: CAD34031.1 .
AJ489591 mRNA. Translation: CAD34032.1 .
AJ489592 mRNA. Translation: CAD34033.1 .
AJ489593 mRNA. Translation: CAD34034.1 .
UniGenei Hs.483519.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000406480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC12M055001.
HGNCi HGNC:18023. GLYCAM1.
neXtProti NX_Q8IVK1.
PharmGKBi PA24384.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000170742.
InParanoidi Q8IVK1.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Gene expression databases

Genevestigatori Q8IVK1.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Human GlyCAM-1 mRNA is expressed in the mammary gland as splicing variants and encodes various aberrant truncated proteins."
    Rasmussen L.K., Johnsen L.B., Petersen T.E., Sorensen E.S.
    Immunol. Lett. 83:73-75(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Mammary gland.

Entry informationi

Entry nameiGLCM1_HUMAN
AccessioniPrimary (citable) accession number: Q8IVK1
Secondary accession number(s): Q8IUA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Encodes aberrant truncated proteins.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3