Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 41 member 1

Gene

SLC41A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a magnesium transporter that is responsive to magnesium balance.1 Publication

GO - Molecular functioni

  • divalent inorganic cation transmembrane transporter activity Source: ParkinsonsUK-UCL
  • magnesium:sodium antiporter activity Source: ParkinsonsUK-UCL
  • magnesium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
  • substrate-specific transporter activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • cellular magnesium ion homeostasis Source: ParkinsonsUK-UCL
  • cellular response to magnesium ion Source: ParkinsonsUK-UCL
  • divalent metal ion transport Source: ParkinsonsUK-UCL
  • magnesium ion transmembrane transport Source: ParkinsonsUK-UCL
  • magnesium ion transport Source: ParkinsonsUK-UCL
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-HSA-425410. Metal ion SLC transporters.

Protein family/group databases

TCDBi1.A.26.2.1. the mg(2+) transporter-e (mgte) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 41 member 1
Gene namesi
Name:SLC41A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19429. SLC41A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • basolateral plasma membrane Source: ParkinsonsUK-UCL
  • cell Source: ParkinsonsUK-UCL
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: ParkinsonsUK-UCL
  • protein complex Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi254428.
OpenTargetsiENSG00000133065.
PharmGKBiPA134889327.

Polymorphism and mutation databases

BioMutaiSLC41A1.
DMDMi152112285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951111 – 513Solute carrier family 41 member 1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IVJ1.
MaxQBiQ8IVJ1.
PaxDbiQ8IVJ1.
PeptideAtlasiQ8IVJ1.
PRIDEiQ8IVJ1.

PTM databases

iPTMnetiQ8IVJ1.
PhosphoSitePlusiQ8IVJ1.
SwissPalmiQ8IVJ1.

Expressioni

Tissue specificityi

Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.1 Publication

Gene expression databases

BgeeiENSG00000133065.
CleanExiHS_SLC41A1.
ExpressionAtlasiQ8IVJ1. baseline and differential.
GenevisibleiQ8IVJ1. HS.

Organism-specific databases

HPAiHPA015138.

Interactioni

Protein-protein interaction databases

BioGridi129036. 4 interactors.
IntActiQ8IVJ1. 1 interactor.
STRINGi9606.ENSP00000356105.

Structurei

3D structure databases

ProteinModelPortaliQ8IVJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3788. Eukaryota.
ENOG410XSTG. LUCA.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ8IVJ1.
KOiK15122.
OMAiDDWQYIY.
OrthoDBiEOG091G08MB.
PhylomeDBiQ8IVJ1.
TreeFamiTF313647.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKPEPKDV HQLNGTGPSA SPCSSDGPGR EPLAGTSEFL GPDGAGVEVV
60 70 80 90 100
IESRANAKGV REEDALLENG SQSNESDDVS TDRGPAPPSP LKETSFSIGL
110 120 130 140 150
QVLFPFLLAG FGTVAAGMVL DIVQHWEVFQ KVTEVFILVP ALLGLKGNLE
160 170 180 190 200
MTLASRLSTA ANIGHMDTPK ELWRMITGNM ALIQVQATVV GFLASIAAVV
210 220 230 240 250
FGWIPDGHFS IPHAFLLCAS SVATAFIASL VLGMIMIGVI IGSRKIGINP
260 270 280 290 300
DNVATPIAAS LGDLITLALL SGISWGLYLE LNHWRYIYPL VCAFFVALLP
310 320 330 340 350
VWVVLARRSP ATREVLYSGW EPVIIAMAIS SVGGLILDKT VSDPNFAGMA
360 370 380 390 400
VFTPVINGVG GNLVAVQASR ISTFLHMNGM PGENSEQAPR RCPSPCTTFF
410 420 430 440 450
SPDVNSRSAR VLFLLVVPGH LVFLYTISCM QGGHTTLTLI FIIFYMTAAL
460 470 480 490 500
LQVLILLYIA DWMVHWMWGR GLDPDNFSIP YLTALGDLLG TGLLALSFHV
510
LWLIGDRDTD VGD
Length:513
Mass (Da):54,901
Last modified:July 10, 2007 - v2
Checksum:i2B6676F9C3AF6136
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → P in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti196I → T in CAH56213 (PubMed:17974005).Curated1
Sequence conflicti204I → V in CAH56213 (PubMed:17974005).Curated1
Sequence conflicti207G → D in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti217L → P in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti272 – 275GISW → ASAG in CAD58404 (PubMed:12810078).Curated4
Sequence conflicti365A → T in CAE46028 (PubMed:17974005).Curated1
Sequence conflicti416V → A in CAD58404 (PubMed:12810078).Curated1
Sequence conflicti464V → A in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti511V → A in CAH56135 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ514402 mRNA. Translation: CAD58404.1.
AL831974 mRNA. Translation: CAH56217.1.
AL832001 mRNA. Translation: CAH56211.1.
AL832362 mRNA. Translation: CAH56213.1.
BX641054 mRNA. Translation: CAE46028.1.
BX648979 mRNA. Translation: CAH56135.1.
CCDSiCCDS30988.1.
RefSeqiNP_776253.3. NM_173854.5.
XP_005245126.1. XM_005245069.2.
UniGeneiHs.20274.

Genome annotation databases

EnsembliENST00000367137; ENSP00000356105; ENSG00000133065.
GeneIDi254428.
KEGGihsa:254428.
UCSCiuc001hdh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ514402 mRNA. Translation: CAD58404.1.
AL831974 mRNA. Translation: CAH56217.1.
AL832001 mRNA. Translation: CAH56211.1.
AL832362 mRNA. Translation: CAH56213.1.
BX641054 mRNA. Translation: CAE46028.1.
BX648979 mRNA. Translation: CAH56135.1.
CCDSiCCDS30988.1.
RefSeqiNP_776253.3. NM_173854.5.
XP_005245126.1. XM_005245069.2.
UniGeneiHs.20274.

3D structure databases

ProteinModelPortaliQ8IVJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129036. 4 interactors.
IntActiQ8IVJ1. 1 interactor.
STRINGi9606.ENSP00000356105.

Protein family/group databases

TCDBi1.A.26.2.1. the mg(2+) transporter-e (mgte) family.

PTM databases

iPTMnetiQ8IVJ1.
PhosphoSitePlusiQ8IVJ1.
SwissPalmiQ8IVJ1.

Polymorphism and mutation databases

BioMutaiSLC41A1.
DMDMi152112285.

Proteomic databases

EPDiQ8IVJ1.
MaxQBiQ8IVJ1.
PaxDbiQ8IVJ1.
PeptideAtlasiQ8IVJ1.
PRIDEiQ8IVJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367137; ENSP00000356105; ENSG00000133065.
GeneIDi254428.
KEGGihsa:254428.
UCSCiuc001hdh.2. human.

Organism-specific databases

CTDi254428.
DisGeNETi254428.
GeneCardsiSLC41A1.
H-InvDBHIX0001523.
HGNCiHGNC:19429. SLC41A1.
HPAiHPA015138.
MIMi610801. gene.
neXtProtiNX_Q8IVJ1.
OpenTargetsiENSG00000133065.
PharmGKBiPA134889327.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3788. Eukaryota.
ENOG410XSTG. LUCA.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ8IVJ1.
KOiK15122.
OMAiDDWQYIY.
OrthoDBiEOG091G08MB.
PhylomeDBiQ8IVJ1.
TreeFamiTF313647.

Enzyme and pathway databases

ReactomeiR-HSA-425410. Metal ion SLC transporters.

Miscellaneous databases

ChiTaRSiSLC41A1. human.
GenomeRNAii254428.
PROiQ8IVJ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133065.
CleanExiHS_SLC41A1.
ExpressionAtlasiQ8IVJ1. baseline and differential.
GenevisibleiQ8IVJ1. HS.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS41A1_HUMAN
AccessioniPrimary (citable) accession number: Q8IVJ1
Secondary accession number(s): Q63HJ4
, Q658Z5, Q659A4, Q6MZK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.