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Q8IVJ1

- S41A1_HUMAN

UniProt

Q8IVJ1 - S41A1_HUMAN

Protein

Solute carrier family 41 member 1

Gene

SLC41A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Acts as a magnesium transporter that is responsive to magnesium balance.1 Publication

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    ReactomeiREACT_20547. Metal ion SLC transporters.

    Protein family/group databases

    TCDBi1.A.26.2.1. the mg(2+) transporter-e (mgte) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 41 member 1
    Gene namesi
    Name:SLC41A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19429. SLC41A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134889327.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Solute carrier family 41 member 1PRO_0000295111Add
    BLAST

    Proteomic databases

    MaxQBiQ8IVJ1.
    PaxDbiQ8IVJ1.
    PRIDEiQ8IVJ1.

    PTM databases

    PhosphoSiteiQ8IVJ1.

    Expressioni

    Tissue specificityi

    Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ8IVJ1.
    BgeeiQ8IVJ1.
    CleanExiHS_SLC41A1.
    GenevestigatoriQ8IVJ1.

    Organism-specific databases

    HPAiHPA015138.

    Interactioni

    Protein-protein interaction databases

    BioGridi129036. 2 interactions.
    STRINGi9606.ENSP00000356105.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IVJ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC41A transporter family.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1824.
    HOGENOMiHOG000007017.
    HOVERGENiHBG057187.
    InParanoidiQ8IVJ1.
    KOiK15122.
    OMAiDDWQYIY.
    OrthoDBiEOG78SQJ1.
    PhylomeDBiQ8IVJ1.
    TreeFamiTF313647.

    Family and domain databases

    Gene3Di1.10.357.20. 2 hits.
    InterProiIPR006667. SLC41_membr_dom.
    [Graphical view]
    PfamiPF01769. MgtE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IVJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKPEPKDV HQLNGTGPSA SPCSSDGPGR EPLAGTSEFL GPDGAGVEVV    50
    IESRANAKGV REEDALLENG SQSNESDDVS TDRGPAPPSP LKETSFSIGL 100
    QVLFPFLLAG FGTVAAGMVL DIVQHWEVFQ KVTEVFILVP ALLGLKGNLE 150
    MTLASRLSTA ANIGHMDTPK ELWRMITGNM ALIQVQATVV GFLASIAAVV 200
    FGWIPDGHFS IPHAFLLCAS SVATAFIASL VLGMIMIGVI IGSRKIGINP 250
    DNVATPIAAS LGDLITLALL SGISWGLYLE LNHWRYIYPL VCAFFVALLP 300
    VWVVLARRSP ATREVLYSGW EPVIIAMAIS SVGGLILDKT VSDPNFAGMA 350
    VFTPVINGVG GNLVAVQASR ISTFLHMNGM PGENSEQAPR RCPSPCTTFF 400
    SPDVNSRSAR VLFLLVVPGH LVFLYTISCM QGGHTTLTLI FIIFYMTAAL 450
    LQVLILLYIA DWMVHWMWGR GLDPDNFSIP YLTALGDLLG TGLLALSFHV 500
    LWLIGDRDTD VGD 513
    Length:513
    Mass (Da):54,901
    Last modified:July 10, 2007 - v2
    Checksum:i2B6676F9C3AF6136
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31S → P in CAH56135. (PubMed:17974005)Curated
    Sequence conflicti196 – 1961I → T in CAH56213. (PubMed:17974005)Curated
    Sequence conflicti204 – 2041I → V in CAH56213. (PubMed:17974005)Curated
    Sequence conflicti207 – 2071G → D in CAH56135. (PubMed:17974005)Curated
    Sequence conflicti217 – 2171L → P in CAH56135. (PubMed:17974005)Curated
    Sequence conflicti272 – 2754GISW → ASAG in CAD58404. (PubMed:12810078)Curated
    Sequence conflicti365 – 3651A → T in CAE46028. (PubMed:17974005)Curated
    Sequence conflicti416 – 4161V → A in CAD58404. (PubMed:12810078)Curated
    Sequence conflicti464 – 4641V → A in CAH56135. (PubMed:17974005)Curated
    Sequence conflicti511 – 5111V → A in CAH56135. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ514402 mRNA. Translation: CAD58404.1.
    AL831974 mRNA. Translation: CAH56217.1.
    AL832001 mRNA. Translation: CAH56211.1.
    AL832362 mRNA. Translation: CAH56213.1.
    BX641054 mRNA. Translation: CAE46028.1.
    BX648979 mRNA. Translation: CAH56135.1.
    CCDSiCCDS30988.1.
    RefSeqiNP_776253.3. NM_173854.4.
    XP_005245126.1. XM_005245069.1.
    UniGeneiHs.20274.

    Genome annotation databases

    EnsembliENST00000367137; ENSP00000356105; ENSG00000133065.
    GeneIDi254428.
    KEGGihsa:254428.
    UCSCiuc001hdh.1. human.

    Polymorphism databases

    DMDMi152112285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ514402 mRNA. Translation: CAD58404.1 .
    AL831974 mRNA. Translation: CAH56217.1 .
    AL832001 mRNA. Translation: CAH56211.1 .
    AL832362 mRNA. Translation: CAH56213.1 .
    BX641054 mRNA. Translation: CAE46028.1 .
    BX648979 mRNA. Translation: CAH56135.1 .
    CCDSi CCDS30988.1.
    RefSeqi NP_776253.3. NM_173854.4.
    XP_005245126.1. XM_005245069.1.
    UniGenei Hs.20274.

    3D structure databases

    ProteinModelPortali Q8IVJ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129036. 2 interactions.
    STRINGi 9606.ENSP00000356105.

    Protein family/group databases

    TCDBi 1.A.26.2.1. the mg(2+) transporter-e (mgte) family.

    PTM databases

    PhosphoSitei Q8IVJ1.

    Polymorphism databases

    DMDMi 152112285.

    Proteomic databases

    MaxQBi Q8IVJ1.
    PaxDbi Q8IVJ1.
    PRIDEi Q8IVJ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367137 ; ENSP00000356105 ; ENSG00000133065 .
    GeneIDi 254428.
    KEGGi hsa:254428.
    UCSCi uc001hdh.1. human.

    Organism-specific databases

    CTDi 254428.
    GeneCardsi GC01M205758.
    H-InvDB HIX0001523.
    HGNCi HGNC:19429. SLC41A1.
    HPAi HPA015138.
    MIMi 610801. gene.
    neXtProti NX_Q8IVJ1.
    PharmGKBi PA134889327.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1824.
    HOGENOMi HOG000007017.
    HOVERGENi HBG057187.
    InParanoidi Q8IVJ1.
    KOi K15122.
    OMAi DDWQYIY.
    OrthoDBi EOG78SQJ1.
    PhylomeDBi Q8IVJ1.
    TreeFami TF313647.

    Enzyme and pathway databases

    Reactomei REACT_20547. Metal ion SLC transporters.

    Miscellaneous databases

    GenomeRNAii 254428.
    NextBioi 92351.
    PROi Q8IVJ1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVJ1.
    Bgeei Q8IVJ1.
    CleanExi HS_SLC41A1.
    Genevestigatori Q8IVJ1.

    Family and domain databases

    Gene3Di 1.10.357.20. 2 hits.
    InterProi IPR006667. SLC41_membr_dom.
    [Graphical view ]
    Pfami PF01769. MgtE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters."
      Wabakken T., Rian E., Kveine M., Aasheim H.-C.
      Biochem. Biophys. Res. Commun. 306:718-724(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Endometrial tumor, Skeletal muscle and Testis.
    3. "Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters."
      Goytain A., Quamme G.A.
      Physiol. Genomics 21:337-342(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiS41A1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVJ1
    Secondary accession number(s): Q63HJ4
    , Q658Z5, Q659A4, Q6MZK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3