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Q8IVJ1 (S41A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 41 member 1
Gene names
Name:SLC41A1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a magnesium transporter that is responsive to magnesium balance. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen. Ref.1

Sequence similarities

Belongs to the SLC41A transporter family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandMagnesium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncation transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Solute carrier family 41 member 1
PRO_0000295111

Regions

Transmembrane102 – 12221Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane286 – 30621Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane346 – 36621Helical; Potential
Transmembrane411 – 43121Helical; Potential
Transmembrane439 – 45921Helical; Potential
Transmembrane484 – 50421Helical; Potential

Experimental info

Sequence conflict31S → P in CAH56135. Ref.2
Sequence conflict1961I → T in CAH56213. Ref.2
Sequence conflict2041I → V in CAH56213. Ref.2
Sequence conflict2071G → D in CAH56135. Ref.2
Sequence conflict2171L → P in CAH56135. Ref.2
Sequence conflict272 – 2754GISW → ASAG in CAD58404. Ref.1
Sequence conflict3651A → T in CAE46028. Ref.2
Sequence conflict4161V → A in CAD58404. Ref.1
Sequence conflict4641V → A in CAH56135. Ref.2
Sequence conflict5111V → A in CAH56135. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8IVJ1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 2B6676F9C3AF6136

FASTA51354,901
        10         20         30         40         50         60 
MSSKPEPKDV HQLNGTGPSA SPCSSDGPGR EPLAGTSEFL GPDGAGVEVV IESRANAKGV 

        70         80         90        100        110        120 
REEDALLENG SQSNESDDVS TDRGPAPPSP LKETSFSIGL QVLFPFLLAG FGTVAAGMVL 

       130        140        150        160        170        180 
DIVQHWEVFQ KVTEVFILVP ALLGLKGNLE MTLASRLSTA ANIGHMDTPK ELWRMITGNM 

       190        200        210        220        230        240 
ALIQVQATVV GFLASIAAVV FGWIPDGHFS IPHAFLLCAS SVATAFIASL VLGMIMIGVI 

       250        260        270        280        290        300 
IGSRKIGINP DNVATPIAAS LGDLITLALL SGISWGLYLE LNHWRYIYPL VCAFFVALLP 

       310        320        330        340        350        360 
VWVVLARRSP ATREVLYSGW EPVIIAMAIS SVGGLILDKT VSDPNFAGMA VFTPVINGVG 

       370        380        390        400        410        420 
GNLVAVQASR ISTFLHMNGM PGENSEQAPR RCPSPCTTFF SPDVNSRSAR VLFLLVVPGH 

       430        440        450        460        470        480 
LVFLYTISCM QGGHTTLTLI FIIFYMTAAL LQVLILLYIA DWMVHWMWGR GLDPDNFSIP 

       490        500        510 
YLTALGDLLG TGLLALSFHV LWLIGDRDTD VGD 

« Hide

References

« Hide 'large scale' references
[1]"The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters."
Wabakken T., Rian E., Kveine M., Aasheim H.-C.
Biochem. Biophys. Res. Commun. 306:718-724(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Endometrial tumor, Skeletal muscle and Testis.
[3]"Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters."
Goytain A., Quamme G.A.
Physiol. Genomics 21:337-342(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ514402 mRNA. Translation: CAD58404.1.
AL831974 mRNA. Translation: CAH56217.1.
AL832001 mRNA. Translation: CAH56211.1.
AL832362 mRNA. Translation: CAH56213.1.
BX641054 mRNA. Translation: CAE46028.1.
BX648979 mRNA. Translation: CAH56135.1.
RefSeqNP_776253.3. NM_173854.4.
XP_005245126.1. XM_005245069.1.
UniGeneHs.20274.

3D structure databases

ProteinModelPortalQ8IVJ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129036. 2 interactions.
STRING9606.ENSP00000356105.

Protein family/group databases

TCDB1.A.26.2.1. the mg(2+) transporter-e (mgte) family.

PTM databases

PhosphoSiteQ8IVJ1.

Polymorphism databases

DMDM152112285.

Proteomic databases

PaxDbQ8IVJ1.
PRIDEQ8IVJ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367137; ENSP00000356105; ENSG00000133065.
GeneID254428.
KEGGhsa:254428.
UCSCuc001hdh.1. human.

Organism-specific databases

CTD254428.
GeneCardsGC01M205758.
H-InvDBHIX0001523.
HGNCHGNC:19429. SLC41A1.
HPAHPA015138.
MIM610801. gene.
neXtProtNX_Q8IVJ1.
PharmGKBPA134889327.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1824.
HOGENOMHOG000007017.
HOVERGENHBG057187.
InParanoidQ8IVJ1.
KOK15122.
OMADDWQYIY.
OrthoDBEOG78SQJ1.
PhylomeDBQ8IVJ1.
TreeFamTF313647.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ8IVJ1.
BgeeQ8IVJ1.
CleanExHS_SLC41A1.
GenevestigatorQ8IVJ1.

Family and domain databases

Gene3D1.10.357.20. 2 hits.
InterProIPR006667. SLC41_membr_dom.
[Graphical view]
PfamPF01769. MgtE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi254428.
NextBio92351.
PROQ8IVJ1.
SOURCESearch...

Entry information

Entry nameS41A1_HUMAN
AccessionPrimary (citable) accession number: Q8IVJ1
Secondary accession number(s): Q63HJ4 expand/collapse secondary AC list , Q658Z5, Q659A4, Q6MZK2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM