Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 41 member 1

Gene

SLC41A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a magnesium transporter that is responsive to magnesium balance.1 Publication

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiREACT_20547. Metal ion SLC transporters.

Protein family/group databases

TCDBi1.A.26.2.1. the mg(2+) transporter-e (mgte) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 41 member 1
Gene namesi
Name:SLC41A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19429. SLC41A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence AnalysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889327.

Polymorphism and mutation databases

BioMutaiSLC41A1.
DMDMi152112285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Solute carrier family 41 member 1PRO_0000295111Add
BLAST

Proteomic databases

MaxQBiQ8IVJ1.
PaxDbiQ8IVJ1.
PRIDEiQ8IVJ1.

PTM databases

PhosphoSiteiQ8IVJ1.

Expressioni

Tissue specificityi

Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.1 Publication

Gene expression databases

BgeeiQ8IVJ1.
CleanExiHS_SLC41A1.
ExpressionAtlasiQ8IVJ1. baseline and differential.
GenevestigatoriQ8IVJ1.

Organism-specific databases

HPAiHPA015138.

Interactioni

Protein-protein interaction databases

BioGridi129036. 5 interactions.
STRINGi9606.ENSP00000356105.

Structurei

3D structure databases

ProteinModelPortaliQ8IVJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1824.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ8IVJ1.
KOiK15122.
OMAiDDWQYIY.
OrthoDBiEOG78SQJ1.
PhylomeDBiQ8IVJ1.
TreeFamiTF313647.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKPEPKDV HQLNGTGPSA SPCSSDGPGR EPLAGTSEFL GPDGAGVEVV
60 70 80 90 100
IESRANAKGV REEDALLENG SQSNESDDVS TDRGPAPPSP LKETSFSIGL
110 120 130 140 150
QVLFPFLLAG FGTVAAGMVL DIVQHWEVFQ KVTEVFILVP ALLGLKGNLE
160 170 180 190 200
MTLASRLSTA ANIGHMDTPK ELWRMITGNM ALIQVQATVV GFLASIAAVV
210 220 230 240 250
FGWIPDGHFS IPHAFLLCAS SVATAFIASL VLGMIMIGVI IGSRKIGINP
260 270 280 290 300
DNVATPIAAS LGDLITLALL SGISWGLYLE LNHWRYIYPL VCAFFVALLP
310 320 330 340 350
VWVVLARRSP ATREVLYSGW EPVIIAMAIS SVGGLILDKT VSDPNFAGMA
360 370 380 390 400
VFTPVINGVG GNLVAVQASR ISTFLHMNGM PGENSEQAPR RCPSPCTTFF
410 420 430 440 450
SPDVNSRSAR VLFLLVVPGH LVFLYTISCM QGGHTTLTLI FIIFYMTAAL
460 470 480 490 500
LQVLILLYIA DWMVHWMWGR GLDPDNFSIP YLTALGDLLG TGLLALSFHV
510
LWLIGDRDTD VGD
Length:513
Mass (Da):54,901
Last modified:July 10, 2007 - v2
Checksum:i2B6676F9C3AF6136
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → P in CAH56135 (PubMed:17974005).Curated
Sequence conflicti196 – 1961I → T in CAH56213 (PubMed:17974005).Curated
Sequence conflicti204 – 2041I → V in CAH56213 (PubMed:17974005).Curated
Sequence conflicti207 – 2071G → D in CAH56135 (PubMed:17974005).Curated
Sequence conflicti217 – 2171L → P in CAH56135 (PubMed:17974005).Curated
Sequence conflicti272 – 2754GISW → ASAG in CAD58404 (PubMed:12810078).Curated
Sequence conflicti365 – 3651A → T in CAE46028 (PubMed:17974005).Curated
Sequence conflicti416 – 4161V → A in CAD58404 (PubMed:12810078).Curated
Sequence conflicti464 – 4641V → A in CAH56135 (PubMed:17974005).Curated
Sequence conflicti511 – 5111V → A in CAH56135 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ514402 mRNA. Translation: CAD58404.1.
AL831974 mRNA. Translation: CAH56217.1.
AL832001 mRNA. Translation: CAH56211.1.
AL832362 mRNA. Translation: CAH56213.1.
BX641054 mRNA. Translation: CAE46028.1.
BX648979 mRNA. Translation: CAH56135.1.
CCDSiCCDS30988.1.
RefSeqiNP_776253.3. NM_173854.5.
XP_005245126.1. XM_005245069.1.
UniGeneiHs.20274.

Genome annotation databases

EnsembliENST00000367137; ENSP00000356105; ENSG00000133065.
GeneIDi254428.
KEGGihsa:254428.
UCSCiuc001hdh.1. human.

Polymorphism and mutation databases

BioMutaiSLC41A1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ514402 mRNA. Translation: CAD58404.1.
AL831974 mRNA. Translation: CAH56217.1.
AL832001 mRNA. Translation: CAH56211.1.
AL832362 mRNA. Translation: CAH56213.1.
BX641054 mRNA. Translation: CAE46028.1.
BX648979 mRNA. Translation: CAH56135.1.
CCDSiCCDS30988.1.
RefSeqiNP_776253.3. NM_173854.5.
XP_005245126.1. XM_005245069.1.
UniGeneiHs.20274.

3D structure databases

ProteinModelPortaliQ8IVJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129036. 5 interactions.
STRINGi9606.ENSP00000356105.

Protein family/group databases

TCDBi1.A.26.2.1. the mg(2+) transporter-e (mgte) family.

PTM databases

PhosphoSiteiQ8IVJ1.

Polymorphism and mutation databases

BioMutaiSLC41A1.
DMDMi152112285.

Proteomic databases

MaxQBiQ8IVJ1.
PaxDbiQ8IVJ1.
PRIDEiQ8IVJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367137; ENSP00000356105; ENSG00000133065.
GeneIDi254428.
KEGGihsa:254428.
UCSCiuc001hdh.1. human.

Organism-specific databases

CTDi254428.
GeneCardsiGC01M205758.
H-InvDBHIX0001523.
HGNCiHGNC:19429. SLC41A1.
HPAiHPA015138.
MIMi610801. gene.
neXtProtiNX_Q8IVJ1.
PharmGKBiPA134889327.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1824.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ8IVJ1.
KOiK15122.
OMAiDDWQYIY.
OrthoDBiEOG78SQJ1.
PhylomeDBiQ8IVJ1.
TreeFamiTF313647.

Enzyme and pathway databases

ReactomeiREACT_20547. Metal ion SLC transporters.

Miscellaneous databases

ChiTaRSiSLC41A1. human.
GenomeRNAii254428.
NextBioi92351.
PROiQ8IVJ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IVJ1.
CleanExiHS_SLC41A1.
ExpressionAtlasiQ8IVJ1. baseline and differential.
GenevestigatoriQ8IVJ1.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters."
    Wabakken T., Rian E., Kveine M., Aasheim H.-C.
    Biochem. Biophys. Res. Commun. 306:718-724(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrial tumor, Skeletal muscle and Testis.
  3. "Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters."
    Goytain A., Quamme G.A.
    Physiol. Genomics 21:337-342(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiS41A1_HUMAN
AccessioniPrimary (citable) accession number: Q8IVJ1
Secondary accession number(s): Q63HJ4
, Q658Z5, Q659A4, Q6MZK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 29, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.