ID NOSTN_HUMAN Reviewed; 506 AA. AC Q8IVI9; A8K2I9; B3KSF5; E7EPT9; Q27HG3; Q53S62; Q96CJ9; DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 11-JAN-2011, sequence version 2. DT 27-MAR-2024, entry version 178. DE RecName: Full=Nostrin {ECO:0000305}; DE AltName: Full=BM247 homolog; DE AltName: Full=Nitric oxide synthase traffic inducer; DE AltName: Full=Nitric oxide synthase trafficker; DE AltName: Full=eNOS-trafficking inducer; GN Name=NOSTRIN {ECO:0000312|HGNC:HGNC:20203}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION RP WITH NOS3, SUBCELLULAR LOCATION, FUNCTION, AND VARIANT GLU-473. RC TISSUE=Placenta; RX PubMed=12446846; DOI=10.1073/pnas.252345399; RA Zimmermann K., Opitz N., Dedio J., Renne C., Mueller-Esterl W., Oess S.; RT "NOSTRIN: a protein modulating nitric oxide release and subcellular RT distribution of endothelial nitric oxide synthase."; RL Proc. Natl. Acad. Sci. U.S.A. 99:17167-17172(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT GLU-473. RA Beese M., Kirsch T.; RT "Molecular characterization of an alternatively spliced variant of human RT NOSTRIN."; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT RP GLU-473. RC TISSUE=Colon, Placenta, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT RP GLU-473. RC TISSUE=Placenta, and Thyroid; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-304. RC TISSUE=Placenta; RA Li W.B., Gruber C., Jessee J., Polayes D.; RT "Full-length cDNA libraries and normalization."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [7] RP IDENTIFICATION. RX PubMed=11489260; DOI=10.1016/s0006-8993(01)02670-1; RA Kirsch T., Wellner M., Luft F.C., Haller H., Lippoldt A.; RT "Altered gene expression in cerebral capillaries of stroke-prone RT spontaneously hypertensive rats."; RL Brain Res. 910:106-115(2001). RN [8] RP TISSUE SPECIFICITY. RX PubMed=15847871; DOI=10.1016/j.ijgo.2004.12.041; RA Xiang W., Chen H., Xu X., Zhang M., Jiang R.; RT "Expression of endothelial nitric oxide synthase traffic inducer in the RT placentas of women with pre-eclampsia."; RL Int. J. Gynecol. Obstet. 89:103-107(2005). RN [9] RP SUBUNIT, INTERACTION WITH DNM2 AND WASL, SUBCELLULAR LOCATION, AND RP FUNCTION. RX PubMed=16234328; DOI=10.1242/jcs.02620; RA Icking A., Matt S., Opitz N., Wiesenthal A., Mueller-Esterl W., RA Schilling K.; RT "NOSTRIN functions as a homotrimeric adaptor protein facilitating RT internalization of eNOS."; RL J. Cell Sci. 118:5059-5069(2005). RN [10] RP SUBCELLULAR LOCATION. RX PubMed=16376344; DOI=10.1016/j.febslet.2005.11.078; RA Icking A., Schilling K., Wiesenthal A., Opitz N., Mueller-Esterl W.; RT "FCH/Cdc15 domain determines distinct subcellular localization of RT NOSTRIN."; RL FEBS Lett. 580:223-228(2006). RN [11] RP INTERACTION WITH CAV1, AND FUNCTION. RX PubMed=16807357; DOI=10.1091/mbc.e05-08-0709; RA Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., RA Mueller-Esterl W., Icking A.; RT "Translocation of endothelial nitric-oxide synthase involves a ternary RT complex with caveolin-1 and NOSTRIN."; RL Mol. Biol. Cell 17:3870-3880(2006). RN [12] RP SUBCELLULAR LOCATION (ISOFORM 3). RX PubMed=18980613; DOI=10.1111/j.1600-0854.2008.00850.x; RA Wiesenthal A., Hoffmeister M., Siddique M., Kovacevic I., Oess S., RA Muller-Esterl W., Siehoff-Icking A.; RT "NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional RT regulation."; RL Traffic 10:26-34(2009). RN [13] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [14] RP STRUCTURE BY NMR OF 439-506. RG RIKEN structural genomics initiative (RSGI); RT "Solution structure of the SH3 domain of human nostrin."; RL Submitted (OCT-2007) to the PDB data bank. CC -!- FUNCTION: Multivalent adapter protein which may decrease NOS3 activity CC by inducing its translocation away from the plasma membrane. CC {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16234328, CC ECO:0000269|PubMed:16807357}. CC -!- SUBUNIT: Homotrimer. Interacts with DAB2 (By similarity). Interacts CC with NOS3, DNM2, WASL and CAV1. Interacts (via SH3 domain) with DNM2; CC this interaction allows the recruitment of NOS3 to dynamin-positive CC structures (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q5I0D6, CC ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16234328, CC ECO:0000269|PubMed:16807357}. CC -!- INTERACTION: CC Q8IVI9; Q05193: DNM1; NbExp=3; IntAct=EBI-1391643, EBI-713135; CC Q8IVI9; P11362: FGFR1; NbExp=5; IntAct=EBI-1391643, EBI-1028277; CC Q8IVI9; P29474: NOS3; NbExp=9; IntAct=EBI-1391643, EBI-1391623; CC Q8IVI9; O08816: Wasl; Xeno; NbExp=3; IntAct=EBI-1391643, EBI-6142604; CC Q8IVI9-3; P43360: MAGEA6; NbExp=3; IntAct=EBI-12280006, EBI-1045155; CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane CC {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344}; Peripheral CC membrane protein {ECO:0000269|PubMed:12446846, CC ECO:0000269|PubMed:16376344}; Cytoplasmic side CC {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344}. Cytoplasmic CC vesicle {ECO:0000269|PubMed:12446846}. Cytoplasm, cytoskeleton CC {ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16376344}. CC Note=Enriched in selected actin structures (PubMed:16234328, CC PubMed:16376344). CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Nucleus CC {ECO:0000269|PubMed:18980613}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; Synonyms=NOSTRINalpha; CC IsoId=Q8IVI9-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8IVI9-2; Sequence=VSP_025885; CC Name=3; Synonyms=NOSTRINbeta; CC IsoId=Q8IVI9-3; Sequence=VSP_025884; CC Name=4; CC IsoId=Q8IVI9-4; Sequence=VSP_044995; CC -!- TISSUE SPECIFICITY: Expressed at highest levels in heart, kidney, CC placenta and lung, and at lowest levels in brain, thymus and spleen. CC Present in vascular endothelial cells and placenta. Over-expressed in CC placenta from women with pre-eclampsia (at protein level). CC {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:15847871}. CC -!- DOMAIN: The SH3 domain mediates interaction with NOS3, DNM2 and WASL. CC -!- DOMAIN: The F-BAR domain is necessary for membrane targeting. CC -!- MISCELLANEOUS: [Isoform 3]: May negatively regulate transcription of CC the NOSTRIN gene. {ECO:0000269|PubMed:18980613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ532842; CAD58724.1; -; mRNA. DR EMBL; DQ402497; ABD62889.1; -; mRNA. DR EMBL; AK002203; BAE46614.1; -; mRNA. DR EMBL; AK093444; BAG52717.1; -; mRNA. DR EMBL; AK290254; BAF82943.1; -; mRNA. DR EMBL; AC069137; AAY24097.1; -; Genomic_DNA. DR EMBL; AC009475; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC014189; AAH14189.1; -; mRNA. DR EMBL; BC093072; AAH93072.1; -; mRNA. DR EMBL; AL550371; -; NOT_ANNOTATED_CDS; mRNA. DR CCDS; CCDS42771.1; -. [Q8IVI9-1] DR CCDS; CCDS42772.1; -. [Q8IVI9-3] DR CCDS; CCDS54415.1; -. [Q8IVI9-4] DR CCDS; CCDS54416.1; -. [Q8IVI9-2] DR RefSeq; NP_001034813.2; NM_001039724.3. [Q8IVI9-1] DR RefSeq; NP_001165102.1; NM_001171631.1. [Q8IVI9-4] DR RefSeq; NP_001165103.1; NM_001171632.1. [Q8IVI9-2] DR RefSeq; NP_443178.2; NM_052946.3. [Q8IVI9-3] DR PDB; 2YUN; NMR; -; A=441-506. DR PDBsum; 2YUN; -. DR AlphaFoldDB; Q8IVI9; -. DR SMR; Q8IVI9; -. DR BioGRID; 125446; 11. DR CORUM; Q8IVI9; -. DR IntAct; Q8IVI9; 15. DR MINT; Q8IVI9; -. DR STRING; 9606.ENSP00000394051; -. DR iPTMnet; Q8IVI9; -. DR PhosphoSitePlus; Q8IVI9; -. DR BioMuta; NOSTRIN; -. DR DMDM; 317373401; -. DR EPD; Q8IVI9; -. DR jPOST; Q8IVI9; -. DR MassIVE; Q8IVI9; -. DR MaxQB; Q8IVI9; -. DR PeptideAtlas; Q8IVI9; -. DR ProteomicsDB; 17440; -. DR ProteomicsDB; 70712; -. [Q8IVI9-1] DR ProteomicsDB; 70713; -. [Q8IVI9-2] DR ProteomicsDB; 70714; -. [Q8IVI9-3] DR Pumba; Q8IVI9; -. DR ABCD; Q8IVI9; 6 sequenced antibodies. DR Antibodypedia; 47609; 224 antibodies from 27 providers. DR DNASU; 115677; -. DR Ensembl; ENST00000317647.12; ENSP00000318921.7; ENSG00000163072.16. [Q8IVI9-1] DR Ensembl; ENST00000397206.6; ENSP00000380390.2; ENSG00000163072.16. [Q8IVI9-3] DR Ensembl; ENST00000397209.6; ENSP00000380392.2; ENSG00000163072.16. [Q8IVI9-2] DR Ensembl; ENST00000444448.6; ENSP00000394051.2; ENSG00000163072.16. [Q8IVI9-4] DR Ensembl; ENST00000445023.6; ENSP00000404413.2; ENSG00000163072.16. [Q8IVI9-3] DR Ensembl; ENST00000458381.6; ENSP00000402140.2; ENSG00000163072.16. [Q8IVI9-4] DR GeneID; 115677; -. DR KEGG; hsa:115677; -. DR MANE-Select; ENST00000317647.12; ENSP00000318921.7; NM_001039724.4; NP_001034813.2. DR UCSC; uc002uef.4; human. [Q8IVI9-1] DR AGR; HGNC:20203; -. DR CTD; 115677; -. DR DisGeNET; 115677; -. DR GeneCards; NOSTRIN; -. DR HGNC; HGNC:20203; NOSTRIN. DR HPA; ENSG00000163072; Low tissue specificity. DR MIM; 607496; gene. DR neXtProt; NX_Q8IVI9; -. DR OpenTargets; ENSG00000163072; -. DR PharmGKB; PA134992787; -. DR VEuPathDB; HostDB:ENSG00000163072; -. DR GeneTree; ENSGT00510000048120; -. DR HOGENOM; CLU_027170_1_0_1; -. DR InParanoid; Q8IVI9; -. DR OMA; YSAWCHV; -. DR OrthoDB; 5400939at2759; -. DR PhylomeDB; Q8IVI9; -. DR PathwayCommons; Q8IVI9; -. DR Reactome; R-HSA-203641; NOSTRIN mediated eNOS trafficking. DR SignaLink; Q8IVI9; -. DR BioGRID-ORCS; 115677; 10 hits in 1157 CRISPR screens. DR ChiTaRS; NOSTRIN; human. DR EvolutionaryTrace; Q8IVI9; -. DR GenomeRNAi; 115677; -. DR Pharos; Q8IVI9; Tbio. DR PRO; PR:Q8IVI9; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q8IVI9; Protein. DR Bgee; ENSG00000163072; Expressed in right lung and 97 other cell types or tissues. DR ExpressionAtlas; Q8IVI9; baseline and differential. DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. DR GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0003677; F:DNA binding; IEA:Ensembl. DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central. DR GO; GO:0016477; P:cell migration; IBA:GO_Central. DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd11823; SH3_Nostrin; 1. DR Gene3D; 6.10.140.470; -; 1. DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR027267; AH/BAR_dom_sf. DR InterPro; IPR031160; F_BAR. DR InterPro; IPR001060; FCH_dom. DR InterPro; IPR011072; HR1_rho-bd. DR InterPro; IPR036274; HR1_rpt_sf. DR InterPro; IPR035656; Nostrin_SH3. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR23065:SF62; NOSTRIN, ISOFORM H; 1. DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1. DR Pfam; PF00611; FCH; 1. DR Pfam; PF14604; SH3_9; 1. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF103657; BAR/IMD domain-like; 1. DR SUPFAM; SSF46585; HR1 repeat; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS51741; F_BAR; 1. DR PROSITE; PS51860; REM_1; 1. DR PROSITE; PS50002; SH3; 1. DR Genevisible; Q8IVI9; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Coiled coil; Cytoplasm; KW Cytoplasmic vesicle; Cytoskeleton; Endocytosis; Membrane; Nucleus; KW Phosphoprotein; Reference proteome; SH3 domain. FT CHAIN 1..506 FT /note="Nostrin" FT /id="PRO_0000289089" FT DOMAIN 1..260 FT /note="F-BAR" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01077" FT DOMAIN 292..372 FT /note="REM-1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01207" FT DOMAIN 438..497 FT /note="SH3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192" FT COILED 160..222 FT /evidence="ECO:0000255" FT MOD_RES 114 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q5I0D6" FT MOD_RES 479 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q6WKZ7" FT VAR_SEQ 1..78 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_025884" FT VAR_SEQ 38..65 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|Ref.2" FT /id="VSP_025885" FT VAR_SEQ 209 FT /note="Y -> YQVTHSICLYAFWVKRAWGKCVSDLRYQDTFLPGNLPPLWFGYDIVK FT RLIMRLCSVCL (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044995" FT VARIANT 473 FT /note="G -> E (in dbSNP:rs479661)" FT /evidence="ECO:0000269|PubMed:12446846, FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334, FT ECO:0000269|Ref.2" FT /id="VAR_032569" FT CONFLICT 225 FT /note="N -> D (in Ref. 3; BAG52717)" FT /evidence="ECO:0000305" FT STRAND 441..447 FT /evidence="ECO:0007829|PDB:2YUN" FT STRAND 464..469 FT /evidence="ECO:0007829|PDB:2YUN" FT STRAND 472..474 FT /evidence="ECO:0007829|PDB:2YUN" FT STRAND 476..482 FT /evidence="ECO:0007829|PDB:2YUN" FT STRAND 484..487 FT /evidence="ECO:0007829|PDB:2YUN" FT STRAND 492..497 FT /evidence="ECO:0007829|PDB:2YUN" FT CONFLICT Q8IVI9-4:238 FT /note="T -> I (in Ref. 3; BAG52717)" FT /evidence="ECO:0000305" SQ SEQUENCE 506 AA; 57660 MW; DC9A6DF5B9C2AED0 CRC64; MRDPLTDCPY NKVYKNLKEF SQNGENFCKQ VTSVLQQRAN LEISYAKGLQ KLASKLSKAL QNTRKSCVSS AWAWASEGMK STADLHQKLG KAIELEAIKP TYQVLNVQEK KRKSLDNEVE KTANLVISNW NQQIKAKKKL MVSTKKHEAL FQLVESSKQS MTEKEKRKLL NKLTKSTEKL EKEDENYYQK NMAGYSTRLK WENTLENCYQ SILELEKERI QLLCNNLNQY SQHISLFGQT LTTCHTQIHC AISKIDIEKD IQAVMEETAI LSTENKSEFL LTDYFEEDPN SAMDKERRKS LLKPKLLRLQ RDIEKASKDK EGLERMLKTY SSTSSFSDAK SQKDTAALMD ENNLKLDLLE ANSYKLSSML AELEQRPQPS HPCSNSIFRW REKEHTHSYV KISRPFLMKR LENIVSKASS GGQSNPGSST PAPGAAQLSS RLCKALYSFQ ARQDDELNLE KGDIVIIHEK KEGGWWFGSL NGKKGHFPAA YVEELPSNAG NTATKA //