Q8IVI9 (NOSTN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nostrin

Alternative name(s):
BM247 homolog
Nitric oxide synthase traffic inducer
Nitric oxide synthase trafficker
eNOS-trafficking inducer

Gene names

Name:

NOSTRIN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. Ref.1 Ref.9 Ref.11
Subunit structure	Homotrimer. Interacts with DAB2 By similarity. Interacts with NOS3, DNM2, WASL and CAV1. Ref.1 Ref.9 Ref.11
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm › cytoskeleton. Note: Enriched in selected actin structures. Ref.1 Ref.9 Ref.10
Tissue specificity	Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level). Ref.1 Ref.8
Domain	The SH3 domain mediates interaction with NOS3, DNM2 and WASL. The FCH domain is necessary for membrane targeting.
Sequence similarities	Contains 1 FCH domain. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cell membrane Cytoplasm Cytoplasmic vesicle Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW nitric oxide metabolic process Traceable author statement. Source: Reactome regulation of nitric-oxide synthase activity Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell endocytic vesicle membrane Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NOS3	P29474	7	EBI-1391643,EBI-1391623

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IVI9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IVI9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     38-65: Missing.

Isoform 3 (identifier: Q8IVI9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8IVI9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: Y → YQVTHSICLYAFWVKRAWGKCVSDLRYQDTFLPGNLPPLWFGYDIVKRLIMRLCSVCL

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 506

506

Nostrin

PRO_0000289089

Regions

Domain

1 – 66

66

FCH

Domain

438 – 497

60

SH3

Coiled coil

160 – 222

63

Potential

Amino acid modifications

Modified residue

479

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 78

78

Missing in isoform 3.

VSP_025884

Alternative sequence

38 – 65

28

Missing in isoform 2.

VSP_025885

Alternative sequence

209

1

Y → YQVTHSICLYAFWVKRAWGK CVSDLRYQDTFLPGNLPPLW FGYDIVKRLIMRLCSVCL in isoform 4.

VSP_044995

Natural variant

473

1

G → E. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs479661 [ dbSNP | Ensembl ].

VAR_032569

Experimental info

Sequence conflict

225

1

N → D in BAG52717. Ref.3

Isoform 4:

Sequence conflict

238

1

T → I in BAG52717. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

506

Helix Strand Turn

Details...

Beta strand

441 – 447

7

Beta strand

464 – 469

6

Beta strand

472 – 474

3

Beta strand

476 – 482

7

Beta strand

484 – 487

4

Beta strand

492 – 497

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: DC9A6DF5B9C2AED0	FASTA	506	57,660
	10 20 30 40 50 60 MRDPLTDCPY NKVYKNLKEF SQNGENFCKQ VTSVLQQRAN LEISYAKGLQ KLASKLSKAL 70 80 90 100 110 120 QNTRKSCVSS AWAWASEGMK STADLHQKLG KAIELEAIKP TYQVLNVQEK KRKSLDNEVE 130 140 150 160 170 180 KTANLVISNW NQQIKAKKKL MVSTKKHEAL FQLVESSKQS MTEKEKRKLL NKLTKSTEKL 190 200 210 220 230 240 EKEDENYYQK NMAGYSTRLK WENTLENCYQ SILELEKERI QLLCNNLNQY SQHISLFGQT 250 260 270 280 290 300 LTTCHTQIHC AISKIDIEKD IQAVMEETAI LSTENKSEFL LTDYFEEDPN SAMDKERRKS 310 320 330 340 350 360 LLKPKLLRLQ RDIEKASKDK EGLERMLKTY SSTSSFSDAK SQKDTAALMD ENNLKLDLLE 370 380 390 400 410 420 ANSYKLSSML AELEQRPQPS HPCSNSIFRW REKEHTHSYV KISRPFLMKR LENIVSKASS 430 440 450 460 470 480 GGQSNPGSST PAPGAAQLSS RLCKALYSFQ ARQDDELNLE KGDIVIIHEK KEGGWWFGSL 490 500 NGKKGHFPAA YVEELPSNAG NTATKA
	Isoform 2 [UniParc]. Checksum: E8E6E3B37569F432	FASTA	478	54,547
	10 20 30 40 50 60 MRDPLTDCPY NKVYKNLKEF SQNGENFCKQ VTSVLQQSCV SSAWAWASEG MKSTADLHQK 70 80 90 100 110 120 LGKAIELEAI KPTYQVLNVQ EKKRKSLDNE VEKTANLVIS NWNQQIKAKK KLMVSTKKHE 130 140 150 160 170 180 ALFQLVESSK QSMTEKEKRK LLNKLTKSTE KLEKEDENYY QKNMAGYSTR LKWENTLENC 190 200 210 220 230 240 YQSILELEKE RIQLLCNNLN QYSQHISLFG QTLTTCHTQI HCAISKIDIE KDIQAVMEET 250 260 270 280 290 300 AILSTENKSE FLLTDYFEED PNSAMDKERR KSLLKPKLLR LQRDIEKASK DKEGLERMLK 310 320 330 340 350 360 TYSSTSSFSD AKSQKDTAAL MDENNLKLDL LEANSYKLSS MLAELEQRPQ PSHPCSNSIF 370 380 390 400 410 420 RWREKEHTHS YVKISRPFLM KRLENIVSKA SSGGQSNPGS STPAPGAAQL SSRLCKALYS 430 440 450 460 470 FQARQDDELN LEKGDIVIIH EKKEGGWWFG SLNGKKGHFP AAYVEELPSN AGNTATKA
	Isoform 3 [UniParc]. Checksum: 8819706D71DAC60C	FASTA	428	48,876
	10 20 30 40 50 60 MKSTADLHQK LGKAIELEAI KPTYQVLNVQ EKKRKSLDNE VEKTANLVIS NWNQQIKAKK 70 80 90 100 110 120 KLMVSTKKHE ALFQLVESSK QSMTEKEKRK LLNKLTKSTE KLEKEDENYY QKNMAGYSTR 130 140 150 160 170 180 LKWENTLENC YQSILELEKE RIQLLCNNLN QYSQHISLFG QTLTTCHTQI HCAISKIDIE 190 200 210 220 230 240 KDIQAVMEET AILSTENKSE FLLTDYFEED PNSAMDKERR KSLLKPKLLR LQRDIEKASK 250 260 270 280 290 300 DKEGLERMLK TYSSTSSFSD AKSQKDTAAL MDENNLKLDL LEANSYKLSS MLAELEQRPQ 310 320 330 340 350 360 PSHPCSNSIF RWREKEHTHS YVKISRPFLM KRLENIVSKA SSGGQSNPGS STPAPGAAQL 370 380 390 400 410 420 SSRLCKALYS FQARQDDELN LEKGDIVIIH EKKEGGWWFG SLNGKKGHFP AAYVEELPSN AGNTATKA
	Isoform 4 [UniParc]. Checksum: 6FE667B285DD4D54	FASTA	563	64,364
	10 20 30 40 50 60 MRDPLTDCPY NKVYKNLKEF SQNGENFCKQ VTSVLQQRAN LEISYAKGLQ KLASKLSKAL 70 80 90 100 110 120 QNTRKSCVSS AWAWASEGMK STADLHQKLG KAIELEAIKP TYQVLNVQEK KRKSLDNEVE 130 140 150 160 170 180 KTANLVISNW NQQIKAKKKL MVSTKKHEAL FQLVESSKQS MTEKEKRKLL NKLTKSTEKL 190 200 210 220 230 240 EKEDENYYQK NMAGYSTRLK WENTLENCYQ VTHSICLYAF WVKRAWGKCV SDLRYQDTFL 250 260 270 280 290 300 PGNLPPLWFG YDIVKRLIMR LCSVCLQSIL ELEKERIQLL CNNLNQYSQH ISLFGQTLTT 310 320 330 340 350 360 CHTQIHCAIS KIDIEKDIQA VMEETAILST ENKSEFLLTD YFEEDPNSAM DKERRKSLLK 370 380 390 400 410 420 PKLLRLQRDI EKASKDKEGL ERMLKTYSST SSFSDAKSQK DTAALMDENN LKLDLLEANS 430 440 450 460 470 480 YKLSSMLAEL EQRPQPSHPC SNSIFRWREK EHTHSYVKIS RPFLMKRLEN IVSKASSGGQ 490 500 510 520 530 540 SNPGSSTPAP GAAQLSSRLC KALYSFQARQ DDELNLEKGD IVIIHEKKEG GWWFGSLNGK 550 560 KGHFPAAYVE ELPSNAGNTA TKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase." Zimmermann K., Opitz N., Dedio J., Renne C., Mueller-Esterl W., Oess S. Proc. Natl. Acad. Sci. U.S.A. 99:17167-17172(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH NOS3, SUBCELLULAR LOCATION, FUNCTION, VARIANT GLU-473. Tissue: Placenta.
[2]	"Molecular characterization of an alternatively spliced variant of human NOSTRIN." Beese M., Kirsch T. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLU-473.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT GLU-473. Tissue: Colon, Placenta and Testis.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLU-473. Tissue: Placenta and Thyroid.
[6]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-304. Tissue: Placenta.
[7]	"Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats." Kirsch T., Wellner M., Luft F.C., Haller H., Lippoldt A. Brain Res. 910:106-115(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	"Expression of endothelial nitric oxide synthase traffic inducer in the placentas of women with pre-eclampsia." Xiang W., Chen H., Xu X., Zhang M., Jiang R. Int. J. Gynecol. Obstet. 89:103-107(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS." Icking A., Matt S., Opitz N., Wiesenthal A., Mueller-Esterl W., Schilling K. J. Cell Sci. 118:5059-5069(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, INTERACTION WITH DNM2 AND WASL, SUBCELLULAR LOCATION, FUNCTION.
[10]	"FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN." Icking A., Schilling K., Wiesenthal A., Opitz N., Mueller-Esterl W. FEBS Lett. 580:223-228(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[11]	"Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN." Schilling K., Opitz N., Wiesenthal A., Oess S., Tikkanen R., Mueller-Esterl W., Icking A. Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CAV1, FUNCTION.
[12]	"Solution structure of the SH3 domain of human nostrin." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 439-506.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ532842 mRNA. Translation: CAD58724.1.
DQ402497 mRNA. Translation: ABD62889.1.
AK002203 mRNA. Translation: BAE46614.1.
AK093444 mRNA. Translation: BAG52717.1.
AK290254 mRNA. Translation: BAF82943.1.
AC069137 Genomic DNA. Translation: AAY24097.1.
AC009475 Genomic DNA. No translation available.
BC014189 mRNA. Translation: AAH14189.1.
BC093072 mRNA. Translation: AAH93072.1.
AL550371 mRNA. No translation available.

IPI

IPI00549783.
IPI00738288.
IPI00848266.
IPI00927526.

RefSeq

NP_001034813.2. NM_001039724.3.
NP_001165102.1. NM_001171631.1.
NP_001165103.1. NM_001171632.1.
NP_443178.2. NM_052946.3.

UniGene

Hs.189780.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YUN	NMR	-	A	441-506	[»]

ProteinModelPortal

Q8IVI9.

SMR

Q8IVI9. Positions 434-506.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IVI9. 5 interactions.

STRING

9606.ENSP00000318921.

PTM databases

PhosphoSite

Q8IVI9.

Polymorphism databases

DMDM

74728063.

Proteomic databases

PaxDb

Q8IVI9.

PRIDE

Q8IVI9.

Protocols and materials databases

DNASU

115677.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000317647; ENSP00000318921; ENSG00000163072.
ENST00000397206; ENSP00000380390; ENSG00000163072.
ENST00000397209; ENSP00000380392; ENSG00000163072.
ENST00000421711; ENSP00000401316; ENSG00000163072.
ENST00000444448; ENSP00000394051; ENSG00000163072.
ENST00000445023; ENSP00000404413; ENSG00000163072.
ENST00000458381; ENSP00000402140; ENSG00000163072.
ENST00000571377; ENSP00000460608; ENSG00000262773.
ENST00000574102; ENSP00000460765; ENSG00000262773.
ENST00000574750; ENSP00000458654; ENSG00000262773.
ENST00000574986; ENSP00000460968; ENSG00000262773.
ENST00000576231; ENSP00000461773; ENSG00000262773.

GeneID

115677.

KEGG

hsa:115677.

UCSC

uc002uef.3. human.
uc002ueg.3. human.
uc010fpu.3. human.

Organism-specific databases

CTD

115677.

GeneCards

GC02P169643.

HGNC

HGNC:20203. NOSTRIN.

HPA

HPA044384.

MIM

607496. gene.

neXtProt

NX_Q8IVI9.

PharmGKB

PA134992787.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG266189.

HOGENOM

HOG000113830.

HOVERGEN

HBG101730.

InParanoid

Q8IVI9.

OMA

KKHEALF.

OrthoDB

EOG469QV0.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

Q8IVI9.

Bgee

Q8IVI9.

CleanEx

HS_NOSTRIN.

Genevestigator

Q8IVI9.

Family and domain databases

InterPro

IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]

PRINTS

PR00452. SH3DOMAIN.

SMART

SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 1 hit.

PROSITE

PS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8IVI9.

GenomeRNAi

115677.

NextBio

79640.

SOURCE

Search...

Entry information

Entry name

NOSTN_HUMAN

Accession

Primary (citable) accession number: Q8IVI9
Secondary accession number(s): A8K2I9 , B3KSF5, E7EPT9, Q27HG3, Q53S62, Q96CJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	January 11, 2011
Last modified:	May 29, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.