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Q8IVH2

- FOXP4_HUMAN

UniProt

Q8IVH2 - FOXP4_HUMAN

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Protein
Forkhead box protein P4
Gene
FOXP4, FKHLA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor that represses lung-specific expression By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri307 – 33226C2H2-type
Add
BLAST
DNA bindingi467 – 55993Fork-head
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. embryonic foregut morphogenesis Source: Ensembl
  2. heart development Source: Ensembl
  3. lung secretory cell differentiation Source: Ensembl
  4. negative regulation of lung goblet cell differentiation Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P4
Alternative name(s):
Fork head-related protein-like A
Gene namesi
Name:FOXP4
Synonyms:FKHLA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20842. FOXP4.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Forkhead box protein P4
PRO_0000091889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IVH2.
PaxDbiQ8IVH2.
PRIDEiQ8IVH2.

PTM databases

PhosphoSiteiQ8IVH2.

Expressioni

Gene expression databases

ArrayExpressiQ8IVH2.
BgeeiQ8IVH2.
CleanExiHS_FOXP4.
GenevestigatoriQ8IVH2.

Organism-specific databases

HPAiHPA007176.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding By similarity.

Protein-protein interaction databases

BioGridi125474. 7 interactions.
DIPiDIP-59301N.
IntActiQ8IVH2. 3 interactions.
STRINGi9606.ENSP00000309823.

Structurei

3D structure databases

ProteinModelPortaliQ8IVH2.
SMRiQ8IVH2. Positions 312-370, 466-547.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni349 – 37022Leucine-zipper
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 219155Gln-rich
Add
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression By similarity.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ8IVH2.
KOiK09409.
OMAiPQPKEAL.
OrthoDBiEOG7M6D7G.
PhylomeDBiQ8IVH2.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVH2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA    50
DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ 100
VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ 150
EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ 200
GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL 250
DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS 300
HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ 350
QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA 400
ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI 450
SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM 500
FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK 550
MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL 600
LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP 650
GPPLGAPNPS ASGPPEDRDL EEELPGEELS 680
Length:680
Mass (Da):73,488
Last modified:March 1, 2003 - v1
Checksum:iA63826ED85B24752
GO
Isoform 2 (identifier: Q8IVH2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-142: Missing.

Note: No experimental confirmation available.

Show »
Length:678
Mass (Da):73,247
Checksum:i987E8AB35DD70E40
GO
Isoform 3 (identifier: Q8IVH2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.
     384-395: Missing.

Note: No experimental confirmation available.

Show »
Length:667
Mass (Da):72,216
Checksum:i41ED0AF8996FE17F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti464 – 4641A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036219

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei141 – 1422Missing in isoform 2.
VSP_043034
Alternative sequencei220 – 2201Missing in isoform 3.
VSP_043465
Alternative sequencei384 – 39512Missing in isoform 3.
VSP_043466Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080747 mRNA. Translation: BAC53809.1.
AL139331 Genomic DNA. Translation: CAH72540.1.
AL139331 Genomic DNA. Translation: CAH72541.1.
AL139331 Genomic DNA. Translation: CAH72542.1.
CH471081 Genomic DNA. Translation: EAX04047.1.
CH471081 Genomic DNA. Translation: EAX04048.1.
CH471081 Genomic DNA. Translation: EAX04049.1.
BC013030 mRNA. Translation: AAH13030.2.
BC040962 mRNA. Translation: AAH40962.1.
BC052803 mRNA. Translation: AAH52803.1.
CCDSiCCDS34447.1. [Q8IVH2-1]
CCDS34448.1. [Q8IVH2-2]
CCDS4856.1. [Q8IVH2-3]
RefSeqiNP_001012426.1. NM_001012426.1. [Q8IVH2-1]
NP_001012427.1. NM_001012427.1. [Q8IVH2-2]
NP_612466.1. NM_138457.2. [Q8IVH2-3]
UniGeneiHs.131436.

Genome annotation databases

EnsembliENST00000307972; ENSP00000309823; ENSG00000137166. [Q8IVH2-1]
ENST00000373057; ENSP00000362148; ENSG00000137166. [Q8IVH2-2]
ENST00000373060; ENSP00000362151; ENSG00000137166. [Q8IVH2-1]
ENST00000373063; ENSP00000362154; ENSG00000137166. [Q8IVH2-3]
GeneIDi116113.
KEGGihsa:116113.
UCSCiuc003oql.3. human. [Q8IVH2-1]
uc003oqm.3. human. [Q8IVH2-2]
uc003oqn.3. human. [Q8IVH2-3]

Polymorphism databases

DMDMi46395887.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080747 mRNA. Translation: BAC53809.1 .
AL139331 Genomic DNA. Translation: CAH72540.1 .
AL139331 Genomic DNA. Translation: CAH72541.1 .
AL139331 Genomic DNA. Translation: CAH72542.1 .
CH471081 Genomic DNA. Translation: EAX04047.1 .
CH471081 Genomic DNA. Translation: EAX04048.1 .
CH471081 Genomic DNA. Translation: EAX04049.1 .
BC013030 mRNA. Translation: AAH13030.2 .
BC040962 mRNA. Translation: AAH40962.1 .
BC052803 mRNA. Translation: AAH52803.1 .
CCDSi CCDS34447.1. [Q8IVH2-1 ]
CCDS34448.1. [Q8IVH2-2 ]
CCDS4856.1. [Q8IVH2-3 ]
RefSeqi NP_001012426.1. NM_001012426.1. [Q8IVH2-1 ]
NP_001012427.1. NM_001012427.1. [Q8IVH2-2 ]
NP_612466.1. NM_138457.2. [Q8IVH2-3 ]
UniGenei Hs.131436.

3D structure databases

ProteinModelPortali Q8IVH2.
SMRi Q8IVH2. Positions 312-370, 466-547.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125474. 7 interactions.
DIPi DIP-59301N.
IntActi Q8IVH2. 3 interactions.
STRINGi 9606.ENSP00000309823.

PTM databases

PhosphoSitei Q8IVH2.

Polymorphism databases

DMDMi 46395887.

Proteomic databases

MaxQBi Q8IVH2.
PaxDbi Q8IVH2.
PRIDEi Q8IVH2.

Protocols and materials databases

DNASUi 116113.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307972 ; ENSP00000309823 ; ENSG00000137166 . [Q8IVH2-1 ]
ENST00000373057 ; ENSP00000362148 ; ENSG00000137166 . [Q8IVH2-2 ]
ENST00000373060 ; ENSP00000362151 ; ENSG00000137166 . [Q8IVH2-1 ]
ENST00000373063 ; ENSP00000362154 ; ENSG00000137166 . [Q8IVH2-3 ]
GeneIDi 116113.
KEGGi hsa:116113.
UCSCi uc003oql.3. human. [Q8IVH2-1 ]
uc003oqm.3. human. [Q8IVH2-2 ]
uc003oqn.3. human. [Q8IVH2-3 ]

Organism-specific databases

CTDi 116113.
GeneCardsi GC06P041514.
HGNCi HGNC:20842. FOXP4.
HPAi HPA007176.
MIMi 608924. gene.
neXtProti NX_Q8IVH2.
PharmGKBi PA134943098.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000092089.
HOVERGENi HBG051657.
InParanoidi Q8IVH2.
KOi K09409.
OMAi PQPKEAL.
OrthoDBi EOG7M6D7G.
PhylomeDBi Q8IVH2.
TreeFami TF326978.

Miscellaneous databases

ChiTaRSi FOXP4. human.
GeneWikii FOXP4.
GenomeRNAii 116113.
NextBioi 79765.
PROi Q8IVH2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IVH2.
Bgeei Q8IVH2.
CleanExi HS_FOXP4.
Genevestigatori Q8IVH2.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, mapping, and characterization of a novel human cDNA differentially expressed in the fundus of W/Wv mutant mice."
    Daigo Y., Takayama I., Fujino M.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Lung and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-464.

Entry informationi

Entry nameiFOXP4_HUMAN
AccessioniPrimary (citable) accession number: Q8IVH2
Secondary accession number(s): Q5W098
, Q7Z7F8, Q8IW55, Q96E19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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