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Protein

Forkhead box protein P4

Gene

FOXP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that represses lung-specific expression.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri307 – 33226C2H2-typeAdd
BLAST
DNA bindingi467 – 55993Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. embryonic foregut morphogenesis Source: Ensembl
  2. heart development Source: Ensembl
  3. lung secretory cell differentiation Source: Ensembl
  4. negative regulation of lung goblet cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P4
Alternative name(s):
Fork head-related protein-like A
Gene namesi
Name:FOXP4
Synonyms:FKHLA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20842. FOXP4.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Forkhead box protein P4PRO_0000091889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei660 – 6601PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IVH2.
PaxDbiQ8IVH2.
PRIDEiQ8IVH2.

PTM databases

PhosphoSiteiQ8IVH2.

Expressioni

Gene expression databases

BgeeiQ8IVH2.
CleanExiHS_FOXP4.
ExpressionAtlasiQ8IVH2. baseline and differential.
GenevestigatoriQ8IVH2.

Organism-specific databases

HPAiHPA007176.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By similarity).By similarity

Protein-protein interaction databases

BioGridi125474. 8 interactions.
DIPiDIP-59301N.
IntActiQ8IVH2. 3 interactions.
STRINGi9606.ENSP00000309823.

Structurei

3D structure databases

ProteinModelPortaliQ8IVH2.
SMRiQ8IVH2. Positions 312-370, 466-547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni349 – 37022Leucine-zipperAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 219155Gln-richAdd
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri307 – 33226C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ8IVH2.
KOiK09409.
OMAiDEHEYQK.
OrthoDBiEOG7M6D7G.
PhylomeDBiQ8IVH2.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA
60 70 80 90 100
DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ
110 120 130 140 150
VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ
160 170 180 190 200
EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ
210 220 230 240 250
GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL
260 270 280 290 300
DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS
310 320 330 340 350
HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ
360 370 380 390 400
QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA
410 420 430 440 450
ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI
460 470 480 490 500
SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM
510 520 530 540 550
FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK
560 570 580 590 600
MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL
610 620 630 640 650
LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP
660 670 680
GPPLGAPNPS ASGPPEDRDL EEELPGEELS
Length:680
Mass (Da):73,488
Last modified:March 1, 2003 - v1
Checksum:iA63826ED85B24752
GO
Isoform 2 (identifier: Q8IVH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-142: Missing.

Note: No experimental confirmation available.

Show »
Length:678
Mass (Da):73,247
Checksum:i987E8AB35DD70E40
GO
Isoform 3 (identifier: Q8IVH2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.
     384-395: Missing.

Note: No experimental confirmation available.

Show »
Length:667
Mass (Da):72,216
Checksum:i41ED0AF8996FE17F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti464 – 4641A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036219

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei141 – 1422Missing in isoform 2. 1 PublicationVSP_043034
Alternative sequencei220 – 2201Missing in isoform 3. 1 PublicationVSP_043465
Alternative sequencei384 – 39512Missing in isoform 3. 1 PublicationVSP_043466Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080747 mRNA. Translation: BAC53809.1.
AL139331 Genomic DNA. Translation: CAH72540.1.
AL139331 Genomic DNA. Translation: CAH72541.1.
AL139331 Genomic DNA. Translation: CAH72542.1.
CH471081 Genomic DNA. Translation: EAX04047.1.
CH471081 Genomic DNA. Translation: EAX04048.1.
CH471081 Genomic DNA. Translation: EAX04049.1.
BC013030 mRNA. Translation: AAH13030.2.
BC040962 mRNA. Translation: AAH40962.1.
BC052803 mRNA. Translation: AAH52803.1.
CCDSiCCDS34447.1. [Q8IVH2-1]
CCDS34448.1. [Q8IVH2-2]
CCDS4856.1. [Q8IVH2-3]
RefSeqiNP_001012426.1. NM_001012426.1. [Q8IVH2-1]
NP_001012427.1. NM_001012427.1. [Q8IVH2-2]
NP_612466.1. NM_138457.2. [Q8IVH2-3]
UniGeneiHs.131436.

Genome annotation databases

EnsembliENST00000307972; ENSP00000309823; ENSG00000137166. [Q8IVH2-1]
ENST00000373057; ENSP00000362148; ENSG00000137166. [Q8IVH2-2]
ENST00000373060; ENSP00000362151; ENSG00000137166. [Q8IVH2-1]
ENST00000373063; ENSP00000362154; ENSG00000137166. [Q8IVH2-3]
GeneIDi116113.
KEGGihsa:116113.
UCSCiuc003oql.3. human. [Q8IVH2-1]
uc003oqm.3. human. [Q8IVH2-2]
uc003oqn.3. human. [Q8IVH2-3]

Polymorphism databases

DMDMi46395887.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080747 mRNA. Translation: BAC53809.1.
AL139331 Genomic DNA. Translation: CAH72540.1.
AL139331 Genomic DNA. Translation: CAH72541.1.
AL139331 Genomic DNA. Translation: CAH72542.1.
CH471081 Genomic DNA. Translation: EAX04047.1.
CH471081 Genomic DNA. Translation: EAX04048.1.
CH471081 Genomic DNA. Translation: EAX04049.1.
BC013030 mRNA. Translation: AAH13030.2.
BC040962 mRNA. Translation: AAH40962.1.
BC052803 mRNA. Translation: AAH52803.1.
CCDSiCCDS34447.1. [Q8IVH2-1]
CCDS34448.1. [Q8IVH2-2]
CCDS4856.1. [Q8IVH2-3]
RefSeqiNP_001012426.1. NM_001012426.1. [Q8IVH2-1]
NP_001012427.1. NM_001012427.1. [Q8IVH2-2]
NP_612466.1. NM_138457.2. [Q8IVH2-3]
UniGeneiHs.131436.

3D structure databases

ProteinModelPortaliQ8IVH2.
SMRiQ8IVH2. Positions 312-370, 466-547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125474. 8 interactions.
DIPiDIP-59301N.
IntActiQ8IVH2. 3 interactions.
STRINGi9606.ENSP00000309823.

PTM databases

PhosphoSiteiQ8IVH2.

Polymorphism databases

DMDMi46395887.

Proteomic databases

MaxQBiQ8IVH2.
PaxDbiQ8IVH2.
PRIDEiQ8IVH2.

Protocols and materials databases

DNASUi116113.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307972; ENSP00000309823; ENSG00000137166. [Q8IVH2-1]
ENST00000373057; ENSP00000362148; ENSG00000137166. [Q8IVH2-2]
ENST00000373060; ENSP00000362151; ENSG00000137166. [Q8IVH2-1]
ENST00000373063; ENSP00000362154; ENSG00000137166. [Q8IVH2-3]
GeneIDi116113.
KEGGihsa:116113.
UCSCiuc003oql.3. human. [Q8IVH2-1]
uc003oqm.3. human. [Q8IVH2-2]
uc003oqn.3. human. [Q8IVH2-3]

Organism-specific databases

CTDi116113.
GeneCardsiGC06P041514.
HGNCiHGNC:20842. FOXP4.
HPAiHPA007176.
MIMi608924. gene.
neXtProtiNX_Q8IVH2.
PharmGKBiPA134943098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ8IVH2.
KOiK09409.
OMAiDEHEYQK.
OrthoDBiEOG7M6D7G.
PhylomeDBiQ8IVH2.
TreeFamiTF326978.

Miscellaneous databases

ChiTaRSiFOXP4. human.
GeneWikiiFOXP4.
GenomeRNAii116113.
NextBioi79765.
PROiQ8IVH2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IVH2.
CleanExiHS_FOXP4.
ExpressionAtlasiQ8IVH2. baseline and differential.
GenevestigatoriQ8IVH2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, mapping, and characterization of a novel human cDNA differentially expressed in the fundus of W/Wv mutant mice."
    Daigo Y., Takayama I., Fujino M.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Lung and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-464.

Entry informationi

Entry nameiFOXP4_HUMAN
AccessioniPrimary (citable) accession number: Q8IVH2
Secondary accession number(s): Q5W098
, Q7Z7F8, Q8IW55, Q96E19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.