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Q8IVH2

- FOXP4_HUMAN

UniProt

Q8IVH2 - FOXP4_HUMAN

Protein

Forkhead box protein P4

Gene

FOXP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that represses lung-specific expression.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri307 – 33226C2H2-typeAdd
    BLAST
    DNA bindingi467 – 55993Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. embryonic foregut morphogenesis Source: Ensembl
    2. heart development Source: Ensembl
    3. lung secretory cell differentiation Source: Ensembl
    4. negative regulation of lung goblet cell differentiation Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein P4
    Alternative name(s):
    Fork head-related protein-like A
    Gene namesi
    Name:FOXP4
    Synonyms:FKHLA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20842. FOXP4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134943098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 680680Forkhead box protein P4PRO_0000091889Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei92 – 921Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IVH2.
    PaxDbiQ8IVH2.
    PRIDEiQ8IVH2.

    PTM databases

    PhosphoSiteiQ8IVH2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IVH2.
    BgeeiQ8IVH2.
    CleanExiHS_FOXP4.
    GenevestigatoriQ8IVH2.

    Organism-specific databases

    HPAiHPA007176.

    Interactioni

    Subunit structurei

    Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125474. 7 interactions.
    DIPiDIP-59301N.
    IntActiQ8IVH2. 3 interactions.
    STRINGi9606.ENSP00000309823.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IVH2.
    SMRiQ8IVH2. Positions 312-370, 466-547.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni349 – 37022Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi65 – 219155Gln-richAdd
    BLAST

    Domaini

    The leucine-zipper is required for dimerization and transcriptional repression.By similarity

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Curated
    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri307 – 33226C2H2-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000092089.
    HOVERGENiHBG051657.
    InParanoidiQ8IVH2.
    KOiK09409.
    OMAiPQPKEAL.
    OrthoDBiEOG7M6D7G.
    PhylomeDBiQ8IVH2.
    TreeFamiTF326978.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IVH2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA    50
    DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ 100
    VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ 150
    EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ 200
    GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL 250
    DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS 300
    HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ 350
    QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA 400
    ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI 450
    SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM 500
    FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK 550
    MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL 600
    LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP 650
    GPPLGAPNPS ASGPPEDRDL EEELPGEELS 680
    Length:680
    Mass (Da):73,488
    Last modified:March 1, 2003 - v1
    Checksum:iA63826ED85B24752
    GO
    Isoform 2 (identifier: Q8IVH2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         141-142: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:678
    Mass (Da):73,247
    Checksum:i987E8AB35DD70E40
    GO
    Isoform 3 (identifier: Q8IVH2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-220: Missing.
         384-395: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:667
    Mass (Da):72,216
    Checksum:i41ED0AF8996FE17F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti464 – 4641A → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036219

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei141 – 1422Missing in isoform 2. 1 PublicationVSP_043034
    Alternative sequencei220 – 2201Missing in isoform 3. 1 PublicationVSP_043465
    Alternative sequencei384 – 39512Missing in isoform 3. 1 PublicationVSP_043466Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080747 mRNA. Translation: BAC53809.1.
    AL139331 Genomic DNA. Translation: CAH72540.1.
    AL139331 Genomic DNA. Translation: CAH72541.1.
    AL139331 Genomic DNA. Translation: CAH72542.1.
    CH471081 Genomic DNA. Translation: EAX04047.1.
    CH471081 Genomic DNA. Translation: EAX04048.1.
    CH471081 Genomic DNA. Translation: EAX04049.1.
    BC013030 mRNA. Translation: AAH13030.2.
    BC040962 mRNA. Translation: AAH40962.1.
    BC052803 mRNA. Translation: AAH52803.1.
    CCDSiCCDS34447.1. [Q8IVH2-1]
    CCDS34448.1. [Q8IVH2-2]
    CCDS4856.1. [Q8IVH2-3]
    RefSeqiNP_001012426.1. NM_001012426.1. [Q8IVH2-1]
    NP_001012427.1. NM_001012427.1. [Q8IVH2-2]
    NP_612466.1. NM_138457.2. [Q8IVH2-3]
    UniGeneiHs.131436.

    Genome annotation databases

    EnsembliENST00000307972; ENSP00000309823; ENSG00000137166. [Q8IVH2-1]
    ENST00000373057; ENSP00000362148; ENSG00000137166. [Q8IVH2-2]
    ENST00000373060; ENSP00000362151; ENSG00000137166. [Q8IVH2-1]
    ENST00000373063; ENSP00000362154; ENSG00000137166. [Q8IVH2-3]
    GeneIDi116113.
    KEGGihsa:116113.
    UCSCiuc003oql.3. human. [Q8IVH2-1]
    uc003oqm.3. human. [Q8IVH2-2]
    uc003oqn.3. human. [Q8IVH2-3]

    Polymorphism databases

    DMDMi46395887.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080747 mRNA. Translation: BAC53809.1 .
    AL139331 Genomic DNA. Translation: CAH72540.1 .
    AL139331 Genomic DNA. Translation: CAH72541.1 .
    AL139331 Genomic DNA. Translation: CAH72542.1 .
    CH471081 Genomic DNA. Translation: EAX04047.1 .
    CH471081 Genomic DNA. Translation: EAX04048.1 .
    CH471081 Genomic DNA. Translation: EAX04049.1 .
    BC013030 mRNA. Translation: AAH13030.2 .
    BC040962 mRNA. Translation: AAH40962.1 .
    BC052803 mRNA. Translation: AAH52803.1 .
    CCDSi CCDS34447.1. [Q8IVH2-1 ]
    CCDS34448.1. [Q8IVH2-2 ]
    CCDS4856.1. [Q8IVH2-3 ]
    RefSeqi NP_001012426.1. NM_001012426.1. [Q8IVH2-1 ]
    NP_001012427.1. NM_001012427.1. [Q8IVH2-2 ]
    NP_612466.1. NM_138457.2. [Q8IVH2-3 ]
    UniGenei Hs.131436.

    3D structure databases

    ProteinModelPortali Q8IVH2.
    SMRi Q8IVH2. Positions 312-370, 466-547.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125474. 7 interactions.
    DIPi DIP-59301N.
    IntActi Q8IVH2. 3 interactions.
    STRINGi 9606.ENSP00000309823.

    PTM databases

    PhosphoSitei Q8IVH2.

    Polymorphism databases

    DMDMi 46395887.

    Proteomic databases

    MaxQBi Q8IVH2.
    PaxDbi Q8IVH2.
    PRIDEi Q8IVH2.

    Protocols and materials databases

    DNASUi 116113.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307972 ; ENSP00000309823 ; ENSG00000137166 . [Q8IVH2-1 ]
    ENST00000373057 ; ENSP00000362148 ; ENSG00000137166 . [Q8IVH2-2 ]
    ENST00000373060 ; ENSP00000362151 ; ENSG00000137166 . [Q8IVH2-1 ]
    ENST00000373063 ; ENSP00000362154 ; ENSG00000137166 . [Q8IVH2-3 ]
    GeneIDi 116113.
    KEGGi hsa:116113.
    UCSCi uc003oql.3. human. [Q8IVH2-1 ]
    uc003oqm.3. human. [Q8IVH2-2 ]
    uc003oqn.3. human. [Q8IVH2-3 ]

    Organism-specific databases

    CTDi 116113.
    GeneCardsi GC06P041514.
    HGNCi HGNC:20842. FOXP4.
    HPAi HPA007176.
    MIMi 608924. gene.
    neXtProti NX_Q8IVH2.
    PharmGKBi PA134943098.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000092089.
    HOVERGENi HBG051657.
    InParanoidi Q8IVH2.
    KOi K09409.
    OMAi PQPKEAL.
    OrthoDBi EOG7M6D7G.
    PhylomeDBi Q8IVH2.
    TreeFami TF326978.

    Miscellaneous databases

    ChiTaRSi FOXP4. human.
    GeneWikii FOXP4.
    GenomeRNAii 116113.
    NextBioi 79765.
    PROi Q8IVH2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVH2.
    Bgeei Q8IVH2.
    CleanExi HS_FOXP4.
    Genevestigatori Q8IVH2.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, mapping, and characterization of a novel human cDNA differentially expressed in the fundus of W/Wv mutant mice."
      Daigo Y., Takayama I., Fujino M.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Lung and Skin.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-464.

    Entry informationi

    Entry nameiFOXP4_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVH2
    Secondary accession number(s): Q5W098
    , Q7Z7F8, Q8IW55, Q96E19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3