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Protein

Forkhead box protein P4

Gene

FOXP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that represses lung-specific expression.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri307 – 332C2H2-typeAdd BLAST26
DNA bindingi467 – 559Fork-headPROSITE-ProRule annotationAdd BLAST93

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P4
Alternative name(s):
Fork head-related protein-like A
Gene namesi
Name:FOXP4
Synonyms:FKHLA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137166.14
HGNCiHGNC:20842 FOXP4
MIMi608924 gene
neXtProtiNX_Q8IVH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi116113
OpenTargetsiENSG00000137166
PharmGKBiPA134943098

Polymorphism and mutation databases

BioMutaiFOXP4
DMDMi46395887

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918891 – 680Forkhead box protein P4Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki246Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki378Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei554PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IVH2
MaxQBiQ8IVH2
PaxDbiQ8IVH2
PeptideAtlasiQ8IVH2
PRIDEiQ8IVH2

PTM databases

iPTMnetiQ8IVH2
PhosphoSitePlusiQ8IVH2

Expressioni

Gene expression databases

BgeeiENSG00000137166
CleanExiHS_FOXP4
ExpressionAtlasiQ8IVH2 baseline and differential
GenevisibleiQ8IVH2 HS

Organism-specific databases

HPAiHPA007176

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By similarity).By similarity

Protein-protein interaction databases

BioGridi125474, 16 interactors
DIPiDIP-59301N
IntActiQ8IVH2, 12 interactors
MINTiQ8IVH2
STRINGi9606.ENSP00000309823

Structurei

3D structure databases

ProteinModelPortaliQ8IVH2
SMRiQ8IVH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni349 – 370Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 219Gln-richAdd BLAST155

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri307 – 332C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00910000144016
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiQ8IVH2
KOiK09409
OMAiDEHEYQK
OrthoDBiEOG091G08HY
PhylomeDBiQ8IVH2
TreeFamiTF326978

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA
60 70 80 90 100
DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ
110 120 130 140 150
VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ
160 170 180 190 200
EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ
210 220 230 240 250
GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL
260 270 280 290 300
DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS
310 320 330 340 350
HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ
360 370 380 390 400
QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA
410 420 430 440 450
ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI
460 470 480 490 500
SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM
510 520 530 540 550
FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK
560 570 580 590 600
MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL
610 620 630 640 650
LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP
660 670 680
GPPLGAPNPS ASGPPEDRDL EEELPGEELS
Length:680
Mass (Da):73,488
Last modified:March 1, 2003 - v1
Checksum:iA63826ED85B24752
GO
Isoform 2 (identifier: Q8IVH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-142: Missing.

Note: No experimental confirmation available.
Show »
Length:678
Mass (Da):73,247
Checksum:i987E8AB35DD70E40
GO
Isoform 3 (identifier: Q8IVH2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.
     384-395: Missing.

Note: No experimental confirmation available.
Show »
Length:667
Mass (Da):72,216
Checksum:i41ED0AF8996FE17F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036219464A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs867245225Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043034141 – 142Missing in isoform 2. 1 Publication2
Alternative sequenceiVSP_043465220Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_043466384 – 395Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080747 mRNA Translation: BAC53809.1
AL139331 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04047.1
CH471081 Genomic DNA Translation: EAX04048.1
CH471081 Genomic DNA Translation: EAX04049.1
BC013030 mRNA Translation: AAH13030.2
BC040962 mRNA Translation: AAH40962.1
BC052803 mRNA Translation: AAH52803.1
CCDSiCCDS34447.1 [Q8IVH2-1]
CCDS34448.1 [Q8IVH2-2]
CCDS4856.1 [Q8IVH2-3]
RefSeqiNP_001012426.1, NM_001012426.1 [Q8IVH2-1]
NP_001012427.1, NM_001012427.1 [Q8IVH2-2]
NP_612466.1, NM_138457.2 [Q8IVH2-3]
UniGeneiHs.131436

Genome annotation databases

EnsembliENST00000307972; ENSP00000309823; ENSG00000137166 [Q8IVH2-1]
ENST00000373057; ENSP00000362148; ENSG00000137166 [Q8IVH2-2]
ENST00000373060; ENSP00000362151; ENSG00000137166 [Q8IVH2-1]
ENST00000373063; ENSP00000362154; ENSG00000137166 [Q8IVH2-3]
GeneIDi116113
KEGGihsa:116113
UCSCiuc003oql.4 human [Q8IVH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXP4_HUMAN
AccessioniPrimary (citable) accession number: Q8IVH2
Secondary accession number(s): Q5W098
, Q7Z7F8, Q8IW55, Q96E19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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