Q8IVH2 (FOXP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein P4

Alternative name(s):
Fork head-related protein-like A

Gene names

Name:	FOXP4
Synonyms:	FKHLA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional repressor that represses lung-specific expression By similarity.
Subunit structure	Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding By similarity.
Subcellular location	Nucleus Potential.
Domain	The leucine-zipper is required for dimerization and transcriptional repression By similarity.
Sequence similarities	Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryonic foregut morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome heart development Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome tissue development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome chromatin binding Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome protein heterodimerization activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein homodimerization activity Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IVH2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IVH2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     141-142: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8IVH2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.
     384-395: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 680	680	Forkhead box protein P4		PRO_0000091889
Regions
	Zinc finger	307 – 332	26	C2H2-type
	DNA binding	467 – 559	93	Fork-head
	Region	349 – 370	22	Leucine-zipper
	Compositional bias	65 – 219	155	Gln-rich
Amino acid modifications
	Modified residue	92	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	141 – 142	2	Missing in isoform 2.		VSP_043034
	Alternative sequence	220	1	Missing in isoform 3.		VSP_043465
	Alternative sequence	384 – 395	12	Missing in isoform 3.		VSP_043466
	Natural variant	464	1	A → T in a breast cancer sample; somatic mutation. Ref.7		VAR_036219

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A63826ED85B24752	FASTA	680	73,488
	10 20 30 40 50 60 MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE 70 80 90 100 110 120 LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ 130 140 150 160 170 180 ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ 190 200 210 220 230 240 QQLLQMQQLQ QQHLLNLQRQ GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP 250 260 270 280 290 300 AEDSVKQEGL DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS 310 320 330 340 350 360 HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ QLEIQLAKES 370 380 390 400 410 420 ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA ADSFPDGLVH PPTSAAAPVT 430 440 450 460 470 480 PLRPPGLGSA SLHGGGPARR RSSDKFCSPI SSELAQNHEF YKNADVRPPF TYASLIRQAI 490 500 510 520 530 540 LETPDRQLTL NEIYNWFTRM FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE 550 560 570 580 590 600 REYQKRRPPK MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL 610 620 630 640 650 660 LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP GPPLGAPNPS 670 680 ASGPPEDRDL EEELPGEELS
	Isoform 2 [UniParc]. Checksum: 987E8AB35DD70E40	FASTA	678	73,247
	10 20 30 40 50 60 MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE 70 80 90 100 110 120 LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ 130 140 150 160 170 180 ILSPPQLQAL LQQQQALMLQ QEYYKKQQEQ LHLQLLTQQQ AGKPQPKEAL GNKQLAFQQQ 190 200 210 220 230 240 LLQMQQLQQQ HLLNLQRQGL VSLQPNQASG PLQTLPQAAV CPTDLPQLWK GEGAPGQPAE 250 260 270 280 290 300 DSVKQEGLDL TGTAATATSF AAPPKVSPPL SHHTLPNGQP TVLTSRRDSS SHEETPGSHP 310 320 330 340 350 360 LYGHGECKWP GCETLCEDLG QFIKHLNTEH ALDDRSTAQC RVQMQVVQQL EIQLAKESER 370 380 390 400 410 420 LQAMMAHLHM RPSEPKPFSQ PLNPVPGSSS FSKVTVSAAD SFPDGLVHPP TSAAAPVTPL 430 440 450 460 470 480 RPPGLGSASL HGGGPARRRS SDKFCSPISS ELAQNHEFYK NADVRPPFTY ASLIRQAILE 490 500 510 520 530 540 TPDRQLTLNE IYNWFTRMFA YFRRNTATWK NAVRHNLSLH KCFVRVENVK GAVWTVDERE 550 560 570 580 590 600 YQKRRPPKMT GSPTLVKNMI SGLSYGALNA SYQAALAESS FPLLNSPGML NPGSASSLLP 610 620 630 640 650 660 LSHDDVGAPV EPLPSNGSSS PPRLSPPQYS HQVQVKEEPA EAEEDRQPGP PLGAPNPSAS 670 GPPEDRDLEE ELPGEELS
	Isoform 3 [UniParc]. Checksum: 41ED0AF8996FE17F	FASTA	667	72,216
	10 20 30 40 50 60 MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE 70 80 90 100 110 120 LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ 130 140 150 160 170 180 ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ 190 200 210 220 230 240 QQLLQMQQLQ QQHLLNLQRQ GLVSLQPNQA SGPLQTLPQA VCPTDLPQLW KGEGAPGQPA 250 260 270 280 290 300 EDSVKQEGLD LTGTAATATS FAAPPKVSPP LSHHTLPNGQ PTVLTSRRDS SSHEETPGSH 310 320 330 340 350 360 PLYGHGECKW PGCETLCEDL GQFIKHLNTE HALDDRSTAQ CRVQMQVVQQ LEIQLAKESE 370 380 390 400 410 420 RLQAMMAHLH MRPSEPKPFS QPVTVSAADS FPDGLVHPPT SAAAPVTPLR PPGLGSASLH 430 440 450 460 470 480 GGGPARRRSS DKFCSPISSE LAQNHEFYKN ADVRPPFTYA SLIRQAILET PDRQLTLNEI 490 500 510 520 530 540 YNWFTRMFAY FRRNTATWKN AVRHNLSLHK CFVRVENVKG AVWTVDEREY QKRRPPKMTG 550 560 570 580 590 600 SPTLVKNMIS GLSYGALNAS YQAALAESSF PLLNSPGMLN PGSASSLLPL SHDDVGAPVE 610 620 630 640 650 660 PLPSNGSSSP PRLSPPQYSH QVQVKEEPAE AEEDRQPGPP LGAPNPSASG PPEDRDLEEE LPGEELS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, mapping, and characterization of a novel human cDNA differentially expressed in the fundus of W/Wv mutant mice." Daigo Y., Takayama I., Fujino M.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Lung and Skin.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-464.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB080747 mRNA. Translation: BAC53809.1. AL139331 Genomic DNA. Translation: CAH72540.1. AL139331 Genomic DNA. Translation: CAH72541.1. AL139331 Genomic DNA. Translation: CAH72542.1. CH471081 Genomic DNA. Translation: EAX04047.1. CH471081 Genomic DNA. Translation: EAX04048.1. CH471081 Genomic DNA. Translation: EAX04049.1. BC013030 mRNA. Translation: AAH13030.2. BC040962 mRNA. Translation: AAH40962.1. BC052803 mRNA. Translation: AAH52803.1.
IPI	IPI00395554. IPI00554470. IPI00554643.
RefSeq	NP_001012426.1. NM_001012426.1. NP_001012427.1. NM_001012427.1. NP_612466.1. NM_138457.2.
UniGene	Hs.131436.
3D structure databases
ProteinModelPortal	Q8IVH2.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59301N.
IntAct	Q8IVH2. 3 interactions.
STRING	9606.ENSP00000309823.
PTM databases
PhosphoSite	Q8IVH2.
Polymorphism databases
DMDM	46395887.
Proteomic databases
PaxDb	Q8IVH2.
PRIDE	Q8IVH2.
Protocols and materials databases
DNASU	116113.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307972; ENSP00000309823; ENSG00000137166. ENST00000373057; ENSP00000362148; ENSG00000137166. ENST00000373060; ENSP00000362151; ENSG00000137166. ENST00000373063; ENSP00000362154; ENSG00000137166.
GeneID	116113.
KEGG	hsa:116113.
UCSC	uc003oql.3. human.
Organism-specific databases
CTD	116113.
GeneCards	GC06P041514.
HGNC	HGNC:20842. FOXP4.
HPA	HPA007176.
MIM	608924. gene.
neXtProt	NX_Q8IVH2.
PharmGKB	PA134943098.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000092089.
HOVERGEN	HBG051657.
InParanoid	Q8IVH2.
KO	K09409.
OMA	PQPKEAL.
Gene expression databases
ArrayExpress	Q8IVH2.
Bgee	Q8IVH2.
CleanEx	HS_FOXP4.
Genevestigator	Q8IVH2.
GermOnline	ENSG00000137166. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. False negative. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOXP4. human.
GenomeRNAi	116113.
NextBio	79765.
SOURCE	Search...

Entry information

Entry name

FOXP4_HUMAN

Accession

Primary (citable) accession number: Q8IVH2
Secondary accession number(s): Q5W098 , Q7Z7F8, Q8IW55, Q96E19

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.