##gff-version 3 Q8IVG9 UniProtKB Chain 1 24 . . . ID=PRO_0000044146;Note=Humanin Q8IVG9 UniProtKB Region 1 12 . . . Note=Sufficient to interact with BID and BIM and to suppress BID and BIM activity;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15661735,ECO:0000269|PubMed:15661737;Dbxref=PMID:15661735,PMID:15661737 Q8IVG9 UniProtKB Region 3 19 . . . Note=Sufficient for neuroprotective activity Q8IVG9 UniProtKB Region 5 12 . . . Note=Sufficient to interact with MPP8;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23532874;Dbxref=PMID:23532874 Q8IVG9 UniProtKB Region 9 11 . . . Note=Required for secretion;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12860203;Dbxref=PMID:12860203 Q8IVG9 UniProtKB Region 19 20 . . . Note=Required for secretion;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12860203;Dbxref=PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 1 6 . . . Note=No effect on binding to BAX. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12732850;Dbxref=PMID:12732850 Q8IVG9 UniProtKB Mutagenesis 1 3 . . . Note=Abolishes neuroprotective activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11717357;Dbxref=PMID:11717357 Q8IVG9 UniProtKB Mutagenesis 1 2 . . . Note=No effect on neuroprotective activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11717357;Dbxref=PMID:11717357 Q8IVG9 UniProtKB Mutagenesis 3 3 . . . Note=Abolishes neuroprotective activity. P->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12860203;Dbxref=PMID:11717357,PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 4 6 . . . Note=Potentiates neuroprotective activity. RGF->AGA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11717357;Dbxref=PMID:11717357 Q8IVG9 UniProtKB Mutagenesis 6 6 . . . Note=Abolishes binding to IGFBP3 and increases insulin sensitivity. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14561895,ECO:0000269|PubMed:19623253;Dbxref=PMID:14561895,PMID:19623253 Q8IVG9 UniProtKB Mutagenesis 7 7 . . . Note=Abolishes neuroprotective activity and dimerization. No effect on insulin sensitivity. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12787071,ECO:0000269|PubMed:12860203,ECO:0000269|PubMed:19623253;Dbxref=PMID:12787071,PMID:12860203,PMID:19623253 Q8IVG9 UniProtKB Mutagenesis 8 8 . . . Note=Abolishes neuroprotective activity. Formation of short irregularly shaped fibers with BAX with fibers showing non-uniform diameters. Formation of thin irregularly kinked fibers with BID. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12732850,ECO:0000269|PubMed:12860203,ECO:0000269|PubMed:31690630,ECO:0000269|PubMed:33106313;Dbxref=PMID:11717357,PMID:12732850,PMID:12860203,PMID:31690630,PMID:33106313 Q8IVG9 UniProtKB Mutagenesis 8 8 . . . Note=Abolishes neuroprotective activity. C->D%2CE%2CF%2CG%2CI%2CL%2CM%2CN%2CQ%2CS%2CT%2CV%2CW%2CY;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12732850;Dbxref=PMID:11717357,PMID:12732850 Q8IVG9 UniProtKB Mutagenesis 8 8 . . . Note=Significantly reduces neuroprotective activity. C->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12732850;Dbxref=PMID:11717357,PMID:12732850 Q8IVG9 UniProtKB Mutagenesis 8 8 . . . Note=No effect on neuroprotective activity. C->K%2CR;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12732850;Dbxref=PMID:11717357,PMID:12732850 Q8IVG9 UniProtKB Mutagenesis 8 8 . . . Note=Abolishes neuroprotective activity and interaction with BAX and BID. Abolishes BID-induced caspase activation and mitochondrial release of SMAC. Greatly reduced interaction with BIM. Abolishes BIM-induced caspase activation and apoptosis. C->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12732850,ECO:0000269|PubMed:15661735,ECO:0000269|PubMed:15661737;Dbxref=PMID:11717357,PMID:12732850,PMID:15661735,PMID:15661737 Q8IVG9 UniProtKB Mutagenesis 9 9 . . . Note=Abolishes neuroprotective activity and dimerization. L->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12732850,ECO:0000269|PubMed:12860203;Dbxref=PMID:11717357,PMID:12732850,PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 9 9 . . . Note=Abolishes binding to BAX. Abolishes secretion. L->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11371646,ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12732850,ECO:0000269|PubMed:12860203;Dbxref=PMID:11371646,PMID:11717357,PMID:12732850,PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 10 10 . . . Note=Abolishes secretion. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12860203;Dbxref=PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 10 10 . . . Note=Abolishes secretion. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12860203;Dbxref=PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 11 11 . . . Note=Abolishes secretion. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12860203;Dbxref=PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 12 12 . . . Note=Abolishes neuroprotective activity. L->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12860203;Dbxref=PMID:11717357,PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 13 13 . . . Note=Abolishes neuroprotective activity. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12860203;Dbxref=PMID:11717357,PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 14 14 . . . Note=Abolishes neuroprotective activity. S->A%2CR%2CW%2CE%2CP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12787071,ECO:0000269|PubMed:12860203;Dbxref=PMID:11717357,PMID:12787071,PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 14 14 . . . Note=Potentiates neuroprotective activity. Increased inhibition of amyloid-beta protein 40 fibril formation. Reduced levels of amyloid-beta 42 protein. Affects fiber formation with BAX with fewer fibers running in parallel. Affects fiber formation with BID with formation of shorter fibers. No effect on binding to BID or on BID-induced caspase activation and mitochondrial release of SMAC. Does not affect interaction with FPR2 or FPR3. S->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:15465011,ECO:0000269|PubMed:15661737,ECO:0000269|PubMed:27349871,ECO:0000269|PubMed:28282805,ECO:0000269|PubMed:31690630,ECO:0000269|PubMed:33106313;Dbxref=PMID:11717357,PMID:15465011,PMID:15661737,PMID:27349871,PMID:28282805,PMID:31690630,PMID:33106313 Q8IVG9 UniProtKB Mutagenesis 19 24 . . . Note=Abolishes neuroprotective activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11717357;Dbxref=PMID:11717357 Q8IVG9 UniProtKB Mutagenesis 19 19 . . . Note=Abolishes neuroprotective activity. P->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11717357,ECO:0000269|PubMed:12860203;Dbxref=PMID:11717357,PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 19 19 . . . Note=Abolishes secretion. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12860203;Dbxref=PMID:12860203 Q8IVG9 UniProtKB Mutagenesis 20 24 . . . Note=No effect on neuroprotective activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11717357;Dbxref=PMID:11717357 Q8IVG9 UniProtKB Mutagenesis 20 20 . . . Note=Abolishes secretion. V->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12860203;Dbxref=PMID:12860203 Q8IVG9 UniProtKB Beta strand 5 10 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7WVX Q8IVG9 UniProtKB Beta strand 14 17 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2GD3 Q8IVG9 UniProtKB Beta strand 18 21 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1Y32