ID   DYH10_HUMAN             Reviewed;        4471 AA.
AC   Q8IVF4; C9JMF5; O95495; Q6ZUC9; Q6ZUP6; Q8N761;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 4.
DT   27-MAR-2024, entry version 154.
DE   RecName: Full=Dynein axonemal heavy chain 10;
DE   AltName: Full=Axonemal beta dynein heavy chain 10;
DE   AltName: Full=Ciliary dynein heavy chain 10;
GN   Name=DNAH10; Synonyms=KIAA2017;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-4471 (ISOFORM 2), NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 1487-2134 AND 2926-3760 (ISOFORM 1), AND
RP   VARIANT VAL-480.
RC   TISSUE=Brain, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1421-4471 (ISOFORM 1).
RC   TISSUE=Brain;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "The nucleotide sequence of a long cDNA clone isolated from human.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1836-1936 (ISOFORM 1).
RC   TISSUE=Nasal polyp;
RX   PubMed=11175280; DOI=10.1038/sj.ejhg.5200555;
RA   Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Zeigler A., Bouvagnet P.;
RT   "Identification, tissue specific expression, and chromosomal localisation
RT   of several human dynein heavy chain genes.";
RL   Eur. J. Hum. Genet. 8:923-932(2000).
RN   [5]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of multiple
RT   enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
RN   [6]
RP   INVOLVEMENT IN SPGF56, FUNCTION, AND VARIANTS SPGF56 GLN-1888; MET-2534;
RP   CYS-3963 AND ARG-4280.
RX   PubMed=34237282; DOI=10.1016/j.ajhg.2021.06.010;
RA   Tu C., Cong J., Zhang Q., He X., Zheng R., Yang X., Gao Y., Wu H., Lv M.,
RA   Gu Y., Lu S., Liu C., Tian S., Meng L., Wang W., Tan C., Nie H., Li D.,
RA   Zhang H., Gong F., Hu L., Lu G., Xu W., Lin G., Zhang F., Cao Y., Tan Y.Q.;
RT   "Bi-allelic mutations of DNAH10 cause primary male infertility with
RT   asthenoteratozoospermia in humans and mice.";
RL   Am. J. Hum. Genet. 108:1466-1477(2021).
CC   -!- FUNCTION: Force generating protein of respiratory cilia. Produces force
CC       towards the minus ends of microtubules. Dynein has ATPase activity; the
CC       force-producing power stroke is thought to occur on release of ADP.
CC       Involved in sperm motility; implicated in sperm flagellar assembly
CC       (PubMed:34237282). Probable inner arm dynein heavy chain. {ECO:0000250,
CC       ECO:0000269|PubMed:34237282}.
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8IVF4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IVF4-2; Sequence=VSP_033518, VSP_033519;
CC   -!- TISSUE SPECIFICITY: Expressed primarily in trachea and testis, 2
CC       tissues containing axonemal structures. Also expressed in brain but not
CC       in adult heart.
CC   -!- DOMAIN: Dynein heavy chains probably consist of an N-terminal stem
CC       (which binds cargo and interacts with other dynein components), and the
CC       head or motor domain. The motor contains six tandemly-linked AAA
CC       domains in the head, which form a ring. A stalk-like structure (formed
CC       by two of the coiled coil domains) protrudes between AAA 4 and AAA 5
CC       and terminates in a microtubule-binding site. A seventh domain may also
CC       contribute to this ring; it is not clear whether the N-terminus or the
CC       C-terminus forms this extra domain. There are four well-conserved and
CC       two non-conserved ATPase sites, one per AAA domain. Probably only one
CC       of these (within AAA 1) actually hydrolyzes ATP, the others may serve a
CC       regulatory function (By similarity). {ECO:0000250}.
CC   -!- DISEASE: Spermatogenic failure 56 (SPGF56) [MIM:619515]: An autosomal
CC       recessive male infertility disorder characterized by severely reduced
CC       sperm motility, due to multiple morphologic abnormalities of the
CC       flagella. {ECO:0000269|PubMed:34237282}. Note=The disease is caused by
CC       variants affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04579.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC86296.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC079315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC117503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK095581; BAC04579.1; ALT_INIT; mRNA.
DR   EMBL; AK125475; BAC86173.1; -; mRNA.
DR   EMBL; AK125796; BAC86296.1; ALT_INIT; mRNA.
DR   EMBL; AB095937; BAC23113.2; -; mRNA.
DR   EMBL; AJ132089; CAA10562.1; -; mRNA.
DR   CCDS; CCDS9255.2; -. [Q8IVF4-1]
DR   RefSeq; NP_997320.2; NM_207437.3. [Q8IVF4-1]
DR   SMR; Q8IVF4; -.
DR   BioGRID; 128201; 24.
DR   IntAct; Q8IVF4; 12.
DR   STRING; 9606.ENSP00000489675; -.
DR   GlyCosmos; Q8IVF4; 2 sites, 2 glycans.
DR   GlyGen; Q8IVF4; 2 sites, 2 O-linked glycans (1 site).
DR   iPTMnet; Q8IVF4; -.
DR   PhosphoSitePlus; Q8IVF4; -.
DR   BioMuta; DNAH10; -.
DR   DMDM; 296439473; -.
DR   EPD; Q8IVF4; -.
DR   jPOST; Q8IVF4; -.
DR   MassIVE; Q8IVF4; -.
DR   MaxQB; Q8IVF4; -.
DR   PaxDb; 9606-ENSP00000386770; -.
DR   PeptideAtlas; Q8IVF4; -.
DR   ProteomicsDB; 70691; -. [Q8IVF4-1]
DR   ProteomicsDB; 70692; -. [Q8IVF4-2]
DR   Antibodypedia; 52600; 31 antibodies from 8 providers.
DR   DNASU; 196385; -.
DR   Ensembl; ENST00000638045.1; ENSP00000489675.1; ENSG00000197653.16. [Q8IVF4-1]
DR   GeneID; 196385; -.
DR   KEGG; hsa:196385; -.
DR   UCSC; uc001uft.5; human. [Q8IVF4-1]
DR   AGR; HGNC:2941; -.
DR   CTD; 196385; -.
DR   DisGeNET; 196385; -.
DR   GeneCards; DNAH10; -.
DR   HGNC; HGNC:2941; DNAH10.
DR   HPA; ENSG00000197653; Tissue enhanced (fallopian tube, testis).
DR   MalaCards; DNAH10; -.
DR   MIM; 605884; gene.
DR   MIM; 619515; phenotype.
DR   neXtProt; NX_Q8IVF4; -.
DR   OpenTargets; ENSG00000197653; -.
DR   Orphanet; 137893; Male infertility due to large-headed multiflagellar polyploid spermatozoa.
DR   Orphanet; 399805; Male infertility with azoospermia or oligozoospermia due to single gene mutation.
DR   PharmGKB; PA27395; -.
DR   VEuPathDB; HostDB:ENSG00000197653; -.
DR   eggNOG; KOG3595; Eukaryota.
DR   GeneTree; ENSGT00940000154642; -.
DR   HOGENOM; CLU_000038_9_1_1; -.
DR   InParanoid; Q8IVF4; -.
DR   OrthoDB; 166463at2759; -.
DR   PhylomeDB; Q8IVF4; -.
DR   TreeFam; TF316836; -.
DR   PathwayCommons; Q8IVF4; -.
DR   SignaLink; Q8IVF4; -.
DR   SIGNOR; Q8IVF4; -.
DR   BioGRID-ORCS; 196385; 26 hits in 1147 CRISPR screens.
DR   ChiTaRS; DNAH10; human.
DR   GenomeRNAi; 196385; -.
DR   Pharos; Q8IVF4; Tbio.
DR   PRO; PR:Q8IVF4; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8IVF4; Protein.
DR   Bgee; ENSG00000197653; Expressed in right uterine tube and 99 other cell types or tissues.
DR   ExpressionAtlas; Q8IVF4; baseline and differential.
DR   GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR   GO; GO:0005930; C:axoneme; IEA:UniProt.
DR   GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR   PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 2.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   Genevisible; Q8IVF4; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil;
KW   Cytoplasm; Cytoskeleton; Disease variant; Dynein; Glycoprotein;
KW   Microtubule; Motor protein; Nucleotide-binding; Reference proteome; Repeat;
KW   TPR repeat.
FT   CHAIN           1..4471
FT                   /note="Dynein axonemal heavy chain 10"
FT                   /id="PRO_0000318938"
FT   REPEAT          1221..1254
FT                   /note="TPR 1"
FT   REPEAT          2736..2769
FT                   /note="TPR 2"
FT   REPEAT          2771..2797
FT                   /note="TPR 3"
FT   REPEAT          3802..3837
FT                   /note="TPR 4"
FT   REPEAT          4074..4108
FT                   /note="TPR 5"
FT   REGION          1..1793
FT                   /note="Stem"
FT                   /evidence="ECO:0000250"
FT   REGION          46..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1794..2015
FT                   /note="AAA 1"
FT                   /evidence="ECO:0000250"
FT   REGION          2075..2294
FT                   /note="AAA 2"
FT                   /evidence="ECO:0000250"
FT   REGION          2417..2665
FT                   /note="AAA 3"
FT                   /evidence="ECO:0000250"
FT   REGION          2765..3014
FT                   /note="AAA 4"
FT                   /evidence="ECO:0000250"
FT   REGION          3029..3313
FT                   /note="Stalk"
FT                   /evidence="ECO:0000250"
FT   REGION          3399..3629
FT                   /note="AAA 5"
FT                   /evidence="ECO:0000250"
FT   REGION          3845..4062
FT                   /note="AAA 6"
FT                   /evidence="ECO:0000250"
FT   COILED          203..223
FT                   /evidence="ECO:0000255"
FT   COILED          602..622
FT                   /evidence="ECO:0000255"
FT   COILED          1071..1106
FT                   /evidence="ECO:0000255"
FT   COILED          1217..1245
FT                   /evidence="ECO:0000255"
FT   COILED          2747..2770
FT                   /evidence="ECO:0000255"
FT   COILED          3045..3131
FT                   /evidence="ECO:0000255"
FT   COILED          3257..3327
FT                   /evidence="ECO:0000255"
FT   COILED          3567..3638
FT                   /evidence="ECO:0000255"
FT   COILED          4235..4260
FT                   /evidence="ECO:0000255"
FT   MOTIF           1832..1839
FT                   /note="GPAGTGKT motif"
FT   MOTIF           1882..1888
FT                   /note="CFDEFNR motif"
FT   COMPBIAS        51..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1832..1839
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         2113..2120
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         2455..2462
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         2803..2810
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1074
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
FT   VAR_SEQ         1090..1095
FT                   /note="HLAKNL -> VLNRCV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_033518"
FT   VAR_SEQ         1096..4471
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_033519"
FT   VARIANT         167
FT                   /note="S -> P (in dbSNP:rs11057353)"
FT                   /id="VAR_060135"
FT   VARIANT         480
FT                   /note="I -> V (in dbSNP:rs10846559)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_038916"
FT   VARIANT         1724
FT                   /note="T -> M (in dbSNP:rs34934281)"
FT                   /id="VAR_060136"
FT   VARIANT         1767
FT                   /note="D -> E (in dbSNP:rs7969937)"
FT                   /id="VAR_060137"
FT   VARIANT         1865
FT                   /note="R -> K (in dbSNP:rs35685787)"
FT                   /id="VAR_060138"
FT   VARIANT         1888
FT                   /note="R -> Q (in SPGF56; uncertain significance;
FT                   dbSNP:rs369904884)"
FT                   /evidence="ECO:0000269|PubMed:34237282"
FT                   /id="VAR_086228"
FT   VARIANT         1986
FT                   /note="T -> M (in dbSNP:rs33935373)"
FT                   /id="VAR_062177"
FT   VARIANT         2403
FT                   /note="R -> W (in dbSNP:rs7977449)"
FT                   /id="VAR_060139"
FT   VARIANT         2483
FT                   /note="N -> S (in dbSNP:rs11835416)"
FT                   /id="VAR_060140"
FT   VARIANT         2534
FT                   /note="T -> M (in SPGF56; uncertain significance;
FT                   dbSNP:rs764317091)"
FT                   /evidence="ECO:0000269|PubMed:34237282"
FT                   /id="VAR_086229"
FT   VARIANT         3963
FT                   /note="R -> C (in SPGF56; uncertain significance;
FT                   dbSNP:rs755346965)"
FT                   /evidence="ECO:0000269|PubMed:34237282"
FT                   /id="VAR_086230"
FT   VARIANT         4280
FT                   /note="G -> R (in SPGF56; dbSNP:rs759073156)"
FT                   /evidence="ECO:0000269|PubMed:34237282"
FT                   /id="VAR_086231"
FT   CONFLICT        1631
FT                   /note="L -> V (in Ref. 2; BAC86296 and 3; BAC23113)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2046
FT                   /note="F -> L (in Ref. 2; BAC86296)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2132..2134
FT                   /note="KLG -> NLS (in Ref. 2; BAC86296)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   4471 AA;  514841 MW;  85D09303637E7D5C CRC64;
     MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG QPLNREDEEM
     DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV FFLRNTKEAI SEATDMKEAM
     EIMPETLEYG IINANVLHFL KNIICQVFLP ALSFNQHRTS TTVGVTSGEV SNSSEHESDL
     PPMPGEAVEY HSIQLIRDEF LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA
     DPETVDILEQ CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP
     IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN ITHGSGFHVV
     LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE RVCRVVNLRT LFKENRASAQ
     SKTLEARNTL RLWKKAYFDT RAKIEASGRE DRWEFDRKRL FERTDYMATI CQDLSDVLQI
     LEEFYNIFGP ELKAVTGDPK RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK
     IEVLIDIINK IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR
     GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT EEPSTLERGA
     VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK FLRYTAGIQR MLDHYHMLIG
     TLNDAESVLL KDHSQELLRV FRSGYKRLNW NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA
     DDISSRLTLI EAINLFKYPA AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT
     KVEGLVVHTN TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL
     TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE EEVVIINFYN
     DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW KLDKAIVMEK FAAKKPPCVA
     YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ LRHLANTVQE NAKSWVISLG KLLNESAKEE
     LYNLHEEMEH LAKNLRKIPN TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN
     LFPPDAEKEL VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR
     FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM YPELLKVQKE
     MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG FLRALRKLPR PVRGLSVTYY
     LEAKMKAFKD SIPLLLDLKN EALRDRHWKE LMEKTSVFFE MTETFTLENM FAMELHKHTD
     VLNEIVTAAI KEVAIEKAVK EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN
     TFNLQSISGS RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL
     PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC QKSLNDYLDS
     KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA SLRFNDGDSG EKLVSAMISA
     EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR TNRLITKEAI FRYCEDRSRV DWMLLYQGMV
     VLAASQVWWT WEVEDVFHKA QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT
     VLIIDVHARD IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG
     LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG LLCVVTNCGE
     GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ IQTIRNALIH QLTTFQFEGQ
     EISLDSRMGI FITMNPGYAG RTELPESVKA LFRPVVVIVP DLQQICEIML FSEGFLEAKT
     LAKKMTVLYK LAREQLSKQY HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN
     LPKFVFEDVP LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF
     ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI ELYGILDPTT
     RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN MNSVMDDNRL LTLANGERIR
     LQAHCALLFE VGDLQYASPA TVSRCGMVYV DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL
     FEKYVPYLMD VIVEGIVDGR QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC
     YFLEALYCSL GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD
     NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP VIFVGESGTS
     KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN VEKRTKDTYG PPMGKRLLVF
     MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL YDRGKELNCK SIRDLGFIAA MGKAGGGRNE
     VDPRFISLFS VFNVPFPSEE SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV
     QDLPPTPSKF HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET
     DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ DYEAAKALFQ
     EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL LVGVGGSGKQ SLSRLAAFTA
     SCEVFEILLS RGYSENSFRE DLKSLYLKLG IENKAMIFLF TDAHVAEEGF LELINNMLTS
     GIVPALFSEE EKESILSQIG QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL
     RTWCRNFPGM VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV
     DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG LDKLKEATIQ
     LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK KLAEEKAMEI EEQNKVIAME
     KAEAETTLAE VMPILEAAKL ELQKLDKSDV TEIRSFAKPP KQVQTVCECI LIMKGYKELN
     WKTAKGVMSD PNFLRSLMEI DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF
     VEAVMGYCDV FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI
     LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG DCLLCAAFLS
     YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT DDVEISRWGS QGLPPDELSV
     QNGILTTRAS RFPLCIDPQQ QALNWIKRKE EKNNLRVASF NDPDFLKQLE MSIKYGTPFL
     FRDVDEYIDP VIDNVLEKNI KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF
     GKAMVINYTV TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL
     ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP AARRGAILFF
     VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL RNIMDTLTFS IYNHGCTGLF
     ERHKLLFSFN MTIKIEQAEG RVPQEELDFF LKGNISLEKS KRKKPCAWLS DQGWEDIILL
     SEMFSDNFGQ LPDDVENNQT VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR
     VYRAVTDYVT VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG
     FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK SLERITKPHP
     DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT YFKISHEMLD QCPHPAFKPL
     VYVLAFFHAV VQERRKFGKI GWNVYYDFNE SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL
     KYLIGEVMYG GRAIDSFDRR ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE
     KFVEAIEALP LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI
     GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT KSLAELQRAL
     AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW MVYFLRRFSQ YMLWVTESEP
     SVMWLSGLHI PESYLTALVQ ATCRKNGWPL DRSTLFTQVT KFQDADEVNE RAGQGCFVSG
     LYLEGADWDI EKGCLIKSKP KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM
     GVGLVFEADL FTTRHISHWV LQGVCLTLNS D
//