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Q8IVF4

- DYH10_HUMAN

UniProt

Q8IVF4 - DYH10_HUMAN

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Protein

Dynein heavy chain 10, axonemal

Gene
DNAH10, KIAA2017
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity. Probable inner arm dynein heavy chain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1832 – 18398ATP Reviewed prediction
Nucleotide bindingi2113 – 21208ATP Reviewed prediction
Nucleotide bindingi2455 – 24628ATP Reviewed prediction
Nucleotide bindingi2803 – 28108ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: InterPro

GO - Biological processi

  1. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 10, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 10
Ciliary dynein heavy chain 10
Gene namesi
Name:DNAH10
Synonyms:KIAA2017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2941. DNAH10.

Subcellular locationi

Cytoplasmcytoskeletoncilium axoneme Reviewed prediction

GO - Cellular componenti

  1. cilium Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. dynein complex Source: UniProtKB-KW
  4. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 44714471Dynein heavy chain 10, axonemalPRO_0000318938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1074 – 10741N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IVF4.
PaxDbiQ8IVF4.
PRIDEiQ8IVF4.

PTM databases

PhosphoSiteiQ8IVF4.

Expressioni

Tissue specificityi

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.

Gene expression databases

ArrayExpressiQ8IVF4.
BgeeiQ8IVF4.
CleanExiHS_DNAH10.
GenevestigatoriQ8IVF4.

Organism-specific databases

HPAiHPA039065.
HPA039066.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

STRINGi9606.ENSP00000386770.

Structurei

3D structure databases

ProteinModelPortaliQ8IVF4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1221 – 125434TPR 1Add
BLAST
Repeati2736 – 276934TPR 2Add
BLAST
Repeati2771 – 279727TPR 3Add
BLAST
Repeati3802 – 383736TPR 4Add
BLAST
Repeati4074 – 410835TPR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 17931793Stem By similarityAdd
BLAST
Regioni1794 – 2015222AAA 1 By similarityAdd
BLAST
Regioni2075 – 2294220AAA 2 By similarityAdd
BLAST
Regioni2417 – 2665249AAA 3 By similarityAdd
BLAST
Regioni2765 – 3014250AAA 4 By similarityAdd
BLAST
Regioni3029 – 3313285Stalk By similarityAdd
BLAST
Regioni3399 – 3629231AAA 5 By similarityAdd
BLAST
Regioni3845 – 4062218AAA 6 By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili203 – 22321 Reviewed predictionAdd
BLAST
Coiled coili602 – 62221 Reviewed predictionAdd
BLAST
Coiled coili1071 – 110636 Reviewed predictionAdd
BLAST
Coiled coili1217 – 124529 Reviewed predictionAdd
BLAST
Coiled coili2747 – 277024 Reviewed predictionAdd
BLAST
Coiled coili3045 – 313187 Reviewed predictionAdd
BLAST
Coiled coili3257 – 332771 Reviewed predictionAdd
BLAST
Coiled coili3567 – 363872 Reviewed predictionAdd
BLAST
Coiled coili4235 – 426026 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1832 – 18398GPAGTGKT motif
Motifi1882 – 18887CFDEFNR motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 258Poly-Glu
Compositional biasi949 – 9524Poly-Glu

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.

Sequence similaritiesi

Contains 5 TPR repeats.

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5245.
HOGENOMiHOG000237308.
HOVERGENiHBG107827.
InParanoidiQ8IVF4.
OMAiKEEWSQT.
OrthoDBiEOG7RRF64.
PhylomeDBiQ8IVF4.
TreeFamiTF316836.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVF4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG     50
QPLNREDEEM DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV 100
FFLRNTKEAI SEATDMKEAM EIMPETLEYG IINANVLHFL KNIICQVFLP 150
ALSFNQHRTS TTVGVTSGEV SNSSEHESDL PPMPGEAVEY HSIQLIRDEF 200
LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA DPETVDILEQ 250
CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP 300
IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN 350
ITHGSGFHVV LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE 400
RVCRVVNLRT LFKENRASAQ SKTLEARNTL RLWKKAYFDT RAKIEASGRE 450
DRWEFDRKRL FERTDYMATI CQDLSDVLQI LEEFYNIFGP ELKAVTGDPK 500
RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK IEVLIDIINK 550
IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR 600
GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT 650
EEPSTLERGA VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK 700
FLRYTAGIQR MLDHYHMLIG TLNDAESVLL KDHSQELLRV FRSGYKRLNW 750
NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA DDISSRLTLI EAINLFKYPA 800
AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT KVEGLVVHTN 850
TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL 900
TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE 950
EEVVIINFYN DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW 1000
KLDKAIVMEK FAAKKPPCVA YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ 1050
LRHLANTVQE NAKSWVISLG KLLNESAKEE LYNLHEEMEH LAKNLRKIPN 1100
TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN LFPPDAEKEL 1150
VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR 1200
FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM 1250
YPELLKVQKE MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG 1300
FLRALRKLPR PVRGLSVTYY LEAKMKAFKD SIPLLLDLKN EALRDRHWKE 1350
LMEKTSVFFE MTETFTLENM FAMELHKHTD VLNEIVTAAI KEVAIEKAVK 1400
EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN TFNLQSISGS 1450
RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL 1500
PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC 1550
QKSLNDYLDS KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA 1600
SLRFNDGDSG EKLVSAMISA EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR 1650
TNRLITKEAI FRYCEDRSRV DWMLLYQGMV VLAASQVWWT WEVEDVFHKA 1700
QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT VLIIDVHARD 1750
IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG 1800
LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG 1850
LLCVVTNCGE GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ 1900
IQTIRNALIH QLTTFQFEGQ EISLDSRMGI FITMNPGYAG RTELPESVKA 1950
LFRPVVVIVP DLQQICEIML FSEGFLEAKT LAKKMTVLYK LAREQLSKQY 2000
HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN LPKFVFEDVP 2050
LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF 2100
ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI 2150
ELYGILDPTT RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN 2200
MNSVMDDNRL LTLANGERIR LQAHCALLFE VGDLQYASPA TVSRCGMVYV 2250
DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL FEKYVPYLMD VIVEGIVDGR 2300
QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC YFLEALYCSL 2350
GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD 2400
NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP 2450
VIFVGESGTS KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN 2500
VEKRTKDTYG PPMGKRLLVF MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL 2550
YDRGKELNCK SIRDLGFIAA MGKAGGGRNE VDPRFISLFS VFNVPFPSEE 2600
SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV QDLPPTPSKF 2650
HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET 2700
DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ 2750
DYEAAKALFQ EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL 2800
LVGVGGSGKQ SLSRLAAFTA SCEVFEILLS RGYSENSFRE DLKSLYLKLG 2850
IENKAMIFLF TDAHVAEEGF LELINNMLTS GIVPALFSEE EKESILSQIG 2900
QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL RTWCRNFPGM 2950
VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV 3000
DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG 3050
LDKLKEATIQ LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK 3100
KLAEEKAMEI EEQNKVIAME KAEAETTLAE VMPILEAAKL ELQKLDKSDV 3150
TEIRSFAKPP KQVQTVCECI LIMKGYKELN WKTAKGVMSD PNFLRSLMEI 3200
DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF VEAVMGYCDV 3250
FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI 3300
LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG 3350
DCLLCAAFLS YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT 3400
DDVEISRWGS QGLPPDELSV QNGILTTRAS RFPLCIDPQQ QALNWIKRKE 3450
EKNNLRVASF NDPDFLKQLE MSIKYGTPFL FRDVDEYIDP VIDNVLEKNI 3500
KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF GKAMVINYTV 3550
TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL 3600
ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP 3650
AARRGAILFF VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL 3700
RNIMDTLTFS IYNHGCTGLF ERHKLLFSFN MTIKIEQAEG RVPQEELDFF 3750
LKGNISLEKS KRKKPCAWLS DQGWEDIILL SEMFSDNFGQ LPDDVENNQT 3800
VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR VYRAVTDYVT 3850
VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG 3900
FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK 3950
SLERITKPHP DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT 4000
YFKISHEMLD QCPHPAFKPL VYVLAFFHAV VQERRKFGKI GWNVYYDFNE 4050
SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL KYLIGEVMYG GRAIDSFDRR 4100
ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE KFVEAIEALP 4150
LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI 4200
GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT 4250
KSLAELQRAL AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW 4300
MVYFLRRFSQ YMLWVTESEP SVMWLSGLHI PESYLTALVQ ATCRKNGWPL 4350
DRSTLFTQVT KFQDADEVNE RAGQGCFVSG LYLEGADWDI EKGCLIKSKP 4400
KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM GVGLVFEADL 4450
FTTRHISHWV LQGVCLTLNS D 4471

Note: No experimental confirmation available.

Length:4,471
Mass (Da):514,841
Last modified:May 18, 2010 - v4
Checksum:i85D09303637E7D5C
GO
Isoform 2 (identifier: Q8IVF4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1095: HLAKNL → VLNRCV
     1096-4471: Missing.

Show »
Length:1,095
Mass (Da):127,259
Checksum:i189918445315B686
GO

Sequence cautioni

The sequence BAC04579.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC86296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671S → P.
Corresponds to variant rs11057353 [ dbSNP | Ensembl ].
VAR_060135
Natural varianti480 – 4801I → V.1 Publication
Corresponds to variant rs10846559 [ dbSNP | Ensembl ].
VAR_038916
Natural varianti1724 – 17241T → M.
Corresponds to variant rs34934281 [ dbSNP | Ensembl ].
VAR_060136
Natural varianti1767 – 17671D → E.
Corresponds to variant rs7969937 [ dbSNP | Ensembl ].
VAR_060137
Natural varianti1865 – 18651R → K.
Corresponds to variant rs35685787 [ dbSNP | Ensembl ].
VAR_060138
Natural varianti1986 – 19861T → M.
Corresponds to variant rs33935373 [ dbSNP | Ensembl ].
VAR_062177
Natural varianti2403 – 24031R → W.
Corresponds to variant rs7977449 [ dbSNP | Ensembl ].
VAR_060139
Natural varianti2483 – 24831N → S.
Corresponds to variant rs11835416 [ dbSNP | Ensembl ].
VAR_060140

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1090 – 10956HLAKNL → VLNRCV in isoform 2. VSP_033518
Alternative sequencei1096 – 44713376Missing in isoform 2. VSP_033519Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1631 – 16311L → V in BAC86296. 1 Publication
Sequence conflicti1631 – 16311L → V in BAC23113. 1 Publication
Sequence conflicti2046 – 20461F → L in BAC86296. 1 Publication
Sequence conflicti2132 – 21343KLG → NLS in BAC86296. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079315 Genomic DNA. No translation available.
AC117503 Genomic DNA. No translation available.
AK095581 mRNA. Translation: BAC04579.1. Different initiation.
AK125475 mRNA. Translation: BAC86173.1.
AK125796 mRNA. Translation: BAC86296.1. Different initiation.
AB095937 mRNA. Translation: BAC23113.2.
AJ132089 mRNA. Translation: CAA10562.1.
CCDSiCCDS9255.2. [Q8IVF4-1]
RefSeqiNP_997320.2. NM_207437.3. [Q8IVF4-1]
UniGeneiHs.622654.

Genome annotation databases

EnsembliENST00000409039; ENSP00000386770; ENSG00000197653. [Q8IVF4-1]
GeneIDi196385.
KEGGihsa:196385.
UCSCiuc001uft.4. human. [Q8IVF4-1]
uc010taw.1. human. [Q8IVF4-2]

Polymorphism databases

DMDMi296439473.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079315 Genomic DNA. No translation available.
AC117503 Genomic DNA. No translation available.
AK095581 mRNA. Translation: BAC04579.1 . Different initiation.
AK125475 mRNA. Translation: BAC86173.1 .
AK125796 mRNA. Translation: BAC86296.1 . Different initiation.
AB095937 mRNA. Translation: BAC23113.2 .
AJ132089 mRNA. Translation: CAA10562.1 .
CCDSi CCDS9255.2. [Q8IVF4-1 ]
RefSeqi NP_997320.2. NM_207437.3. [Q8IVF4-1 ]
UniGenei Hs.622654.

3D structure databases

ProteinModelPortali Q8IVF4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386770.

PTM databases

PhosphoSitei Q8IVF4.

Polymorphism databases

DMDMi 296439473.

Proteomic databases

MaxQBi Q8IVF4.
PaxDbi Q8IVF4.
PRIDEi Q8IVF4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409039 ; ENSP00000386770 ; ENSG00000197653 . [Q8IVF4-1 ]
GeneIDi 196385.
KEGGi hsa:196385.
UCSCi uc001uft.4. human. [Q8IVF4-1 ]
uc010taw.1. human. [Q8IVF4-2 ]

Organism-specific databases

CTDi 196385.
GeneCardsi GC12P124247.
H-InvDB HIX0022875.
HGNCi HGNC:2941. DNAH10.
HPAi HPA039065.
HPA039066.
MIMi 605884. gene.
neXtProti NX_Q8IVF4.
PharmGKBi PA27395.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5245.
HOGENOMi HOG000237308.
HOVERGENi HBG107827.
InParanoidi Q8IVF4.
OMAi KEEWSQT.
OrthoDBi EOG7RRF64.
PhylomeDBi Q8IVF4.
TreeFami TF316836.

Miscellaneous databases

ChiTaRSi DNAH10. human.
GenomeRNAii 196385.
NextBioi 89451.
PROi Q8IVF4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IVF4.
Bgeei Q8IVF4.
CleanExi HS_DNAH10.
Genevestigatori Q8IVF4.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10676. PTHR10676. 1 hit.
Pfami PF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 3 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-4471 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1487-2134 AND 2926-3760 (ISOFORM 1), VARIANT VAL-480.
    Tissue: Brain and Testis.
  3. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1421-4471 (ISOFORM 1).
    Tissue: Brain.
  4. "Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes."
    Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Zeigler A., Bouvagnet P.
    Eur. J. Hum. Genet. 8:923-932(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1836-1936 (ISOFORM 1).
    Tissue: Nasal polyp.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074.
    Tissue: Liver.

Entry informationi

Entry nameiDYH10_HUMAN
AccessioniPrimary (citable) accession number: Q8IVF4
Secondary accession number(s): C9JMF5
, O95495, Q6ZUC9, Q6ZUP6, Q8N761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 95 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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