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Q8IVF4

- DYH10_HUMAN

UniProt

Q8IVF4 - DYH10_HUMAN

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Protein

Dynein heavy chain 10, axonemal

Gene

DNAH10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1832 – 18398ATPSequence Analysis
Nucleotide bindingi2113 – 21208ATPSequence Analysis
Nucleotide bindingi2455 – 24628ATPSequence Analysis
Nucleotide bindingi2803 – 28108ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: InterPro

GO - Biological processi

  1. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 10, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 10
Ciliary dynein heavy chain 10
Gene namesi
Name:DNAH10
Synonyms:KIAA2017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2941. DNAH10.

Subcellular locationi

GO - Cellular componenti

  1. cilium Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. dynein complex Source: UniProtKB-KW
  4. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 44714471Dynein heavy chain 10, axonemalPRO_0000318938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1074 – 10741N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IVF4.
PaxDbiQ8IVF4.
PRIDEiQ8IVF4.

PTM databases

PhosphoSiteiQ8IVF4.

Expressioni

Tissue specificityi

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.

Gene expression databases

BgeeiQ8IVF4.
CleanExiHS_DNAH10.
ExpressionAtlasiQ8IVF4. baseline and differential.
GenevestigatoriQ8IVF4.

Organism-specific databases

HPAiHPA039065.
HPA039066.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

STRINGi9606.ENSP00000386770.

Structurei

3D structure databases

ProteinModelPortaliQ8IVF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1221 – 125434TPR 1Add
BLAST
Repeati2736 – 276934TPR 2Add
BLAST
Repeati2771 – 279727TPR 3Add
BLAST
Repeati3802 – 383736TPR 4Add
BLAST
Repeati4074 – 410835TPR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 17931793StemBy similarityAdd
BLAST
Regioni1794 – 2015222AAA 1By similarityAdd
BLAST
Regioni2075 – 2294220AAA 2By similarityAdd
BLAST
Regioni2417 – 2665249AAA 3By similarityAdd
BLAST
Regioni2765 – 3014250AAA 4By similarityAdd
BLAST
Regioni3029 – 3313285StalkBy similarityAdd
BLAST
Regioni3399 – 3629231AAA 5By similarityAdd
BLAST
Regioni3845 – 4062218AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili203 – 22321Sequence AnalysisAdd
BLAST
Coiled coili602 – 62221Sequence AnalysisAdd
BLAST
Coiled coili1071 – 110636Sequence AnalysisAdd
BLAST
Coiled coili1217 – 124529Sequence AnalysisAdd
BLAST
Coiled coili2747 – 277024Sequence AnalysisAdd
BLAST
Coiled coili3045 – 313187Sequence AnalysisAdd
BLAST
Coiled coili3257 – 332771Sequence AnalysisAdd
BLAST
Coiled coili3567 – 363872Sequence AnalysisAdd
BLAST
Coiled coili4235 – 426026Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1832 – 18398GPAGTGKT motif
Motifi1882 – 18887CFDEFNR motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 258Poly-Glu
Compositional biasi949 – 9524Poly-Glu

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated
Contains 5 TPR repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5245.
GeneTreeiENSGT00760000118964.
HOGENOMiHOG000237308.
HOVERGENiHBG107827.
InParanoidiQ8IVF4.
OMAiKEEWSQT.
OrthoDBiEOG7RRF64.
PhylomeDBiQ8IVF4.
TreeFamiTF316836.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IVF4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG
60 70 80 90 100
QPLNREDEEM DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV
110 120 130 140 150
FFLRNTKEAI SEATDMKEAM EIMPETLEYG IINANVLHFL KNIICQVFLP
160 170 180 190 200
ALSFNQHRTS TTVGVTSGEV SNSSEHESDL PPMPGEAVEY HSIQLIRDEF
210 220 230 240 250
LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA DPETVDILEQ
260 270 280 290 300
CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP
310 320 330 340 350
IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN
360 370 380 390 400
ITHGSGFHVV LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE
410 420 430 440 450
RVCRVVNLRT LFKENRASAQ SKTLEARNTL RLWKKAYFDT RAKIEASGRE
460 470 480 490 500
DRWEFDRKRL FERTDYMATI CQDLSDVLQI LEEFYNIFGP ELKAVTGDPK
510 520 530 540 550
RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK IEVLIDIINK
560 570 580 590 600
IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR
610 620 630 640 650
GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT
660 670 680 690 700
EEPSTLERGA VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK
710 720 730 740 750
FLRYTAGIQR MLDHYHMLIG TLNDAESVLL KDHSQELLRV FRSGYKRLNW
760 770 780 790 800
NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA DDISSRLTLI EAINLFKYPA
810 820 830 840 850
AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT KVEGLVVHTN
860 870 880 890 900
TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL
910 920 930 940 950
TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE
960 970 980 990 1000
EEVVIINFYN DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW
1010 1020 1030 1040 1050
KLDKAIVMEK FAAKKPPCVA YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ
1060 1070 1080 1090 1100
LRHLANTVQE NAKSWVISLG KLLNESAKEE LYNLHEEMEH LAKNLRKIPN
1110 1120 1130 1140 1150
TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN LFPPDAEKEL
1160 1170 1180 1190 1200
VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR
1210 1220 1230 1240 1250
FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM
1260 1270 1280 1290 1300
YPELLKVQKE MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG
1310 1320 1330 1340 1350
FLRALRKLPR PVRGLSVTYY LEAKMKAFKD SIPLLLDLKN EALRDRHWKE
1360 1370 1380 1390 1400
LMEKTSVFFE MTETFTLENM FAMELHKHTD VLNEIVTAAI KEVAIEKAVK
1410 1420 1430 1440 1450
EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN TFNLQSISGS
1460 1470 1480 1490 1500
RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL
1510 1520 1530 1540 1550
PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC
1560 1570 1580 1590 1600
QKSLNDYLDS KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA
1610 1620 1630 1640 1650
SLRFNDGDSG EKLVSAMISA EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR
1660 1670 1680 1690 1700
TNRLITKEAI FRYCEDRSRV DWMLLYQGMV VLAASQVWWT WEVEDVFHKA
1710 1720 1730 1740 1750
QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT VLIIDVHARD
1760 1770 1780 1790 1800
IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG
1810 1820 1830 1840 1850
LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG
1860 1870 1880 1890 1900
LLCVVTNCGE GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ
1910 1920 1930 1940 1950
IQTIRNALIH QLTTFQFEGQ EISLDSRMGI FITMNPGYAG RTELPESVKA
1960 1970 1980 1990 2000
LFRPVVVIVP DLQQICEIML FSEGFLEAKT LAKKMTVLYK LAREQLSKQY
2010 2020 2030 2040 2050
HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN LPKFVFEDVP
2060 2070 2080 2090 2100
LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF
2110 2120 2130 2140 2150
ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI
2160 2170 2180 2190 2200
ELYGILDPTT RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN
2210 2220 2230 2240 2250
MNSVMDDNRL LTLANGERIR LQAHCALLFE VGDLQYASPA TVSRCGMVYV
2260 2270 2280 2290 2300
DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL FEKYVPYLMD VIVEGIVDGR
2310 2320 2330 2340 2350
QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC YFLEALYCSL
2360 2370 2380 2390 2400
GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD
2410 2420 2430 2440 2450
NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP
2460 2470 2480 2490 2500
VIFVGESGTS KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN
2510 2520 2530 2540 2550
VEKRTKDTYG PPMGKRLLVF MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL
2560 2570 2580 2590 2600
YDRGKELNCK SIRDLGFIAA MGKAGGGRNE VDPRFISLFS VFNVPFPSEE
2610 2620 2630 2640 2650
SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV QDLPPTPSKF
2660 2670 2680 2690 2700
HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET
2710 2720 2730 2740 2750
DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ
2760 2770 2780 2790 2800
DYEAAKALFQ EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL
2810 2820 2830 2840 2850
LVGVGGSGKQ SLSRLAAFTA SCEVFEILLS RGYSENSFRE DLKSLYLKLG
2860 2870 2880 2890 2900
IENKAMIFLF TDAHVAEEGF LELINNMLTS GIVPALFSEE EKESILSQIG
2910 2920 2930 2940 2950
QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL RTWCRNFPGM
2960 2970 2980 2990 3000
VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV
3010 3020 3030 3040 3050
DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG
3060 3070 3080 3090 3100
LDKLKEATIQ LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK
3110 3120 3130 3140 3150
KLAEEKAMEI EEQNKVIAME KAEAETTLAE VMPILEAAKL ELQKLDKSDV
3160 3170 3180 3190 3200
TEIRSFAKPP KQVQTVCECI LIMKGYKELN WKTAKGVMSD PNFLRSLMEI
3210 3220 3230 3240 3250
DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF VEAVMGYCDV
3260 3270 3280 3290 3300
FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI
3310 3320 3330 3340 3350
LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG
3360 3370 3380 3390 3400
DCLLCAAFLS YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT
3410 3420 3430 3440 3450
DDVEISRWGS QGLPPDELSV QNGILTTRAS RFPLCIDPQQ QALNWIKRKE
3460 3470 3480 3490 3500
EKNNLRVASF NDPDFLKQLE MSIKYGTPFL FRDVDEYIDP VIDNVLEKNI
3510 3520 3530 3540 3550
KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF GKAMVINYTV
3560 3570 3580 3590 3600
TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL
3610 3620 3630 3640 3650
ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP
3660 3670 3680 3690 3700
AARRGAILFF VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL
3710 3720 3730 3740 3750
RNIMDTLTFS IYNHGCTGLF ERHKLLFSFN MTIKIEQAEG RVPQEELDFF
3760 3770 3780 3790 3800
LKGNISLEKS KRKKPCAWLS DQGWEDIILL SEMFSDNFGQ LPDDVENNQT
3810 3820 3830 3840 3850
VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR VYRAVTDYVT
3860 3870 3880 3890 3900
VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG
3910 3920 3930 3940 3950
FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK
3960 3970 3980 3990 4000
SLERITKPHP DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT
4010 4020 4030 4040 4050
YFKISHEMLD QCPHPAFKPL VYVLAFFHAV VQERRKFGKI GWNVYYDFNE
4060 4070 4080 4090 4100
SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL KYLIGEVMYG GRAIDSFDRR
4110 4120 4130 4140 4150
ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE KFVEAIEALP
4160 4170 4180 4190 4200
LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI
4210 4220 4230 4240 4250
GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT
4260 4270 4280 4290 4300
KSLAELQRAL AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW
4310 4320 4330 4340 4350
MVYFLRRFSQ YMLWVTESEP SVMWLSGLHI PESYLTALVQ ATCRKNGWPL
4360 4370 4380 4390 4400
DRSTLFTQVT KFQDADEVNE RAGQGCFVSG LYLEGADWDI EKGCLIKSKP
4410 4420 4430 4440 4450
KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM GVGLVFEADL
4460 4470
FTTRHISHWV LQGVCLTLNS D

Note: No experimental confirmation available.

Length:4,471
Mass (Da):514,841
Last modified:May 18, 2010 - v4
Checksum:i85D09303637E7D5C
GO
Isoform 2 (identifier: Q8IVF4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1095: HLAKNL → VLNRCV
     1096-4471: Missing.

Show »
Length:1,095
Mass (Da):127,259
Checksum:i189918445315B686
GO

Sequence cautioni

The sequence BAC04579.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1631 – 16311L → V in BAC86296. (PubMed:14702039)Curated
Sequence conflicti1631 – 16311L → V in BAC23113. 1 PublicationCurated
Sequence conflicti2046 – 20461F → L in BAC86296. (PubMed:14702039)Curated
Sequence conflicti2132 – 21343KLG → NLS in BAC86296. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671S → P.
Corresponds to variant rs11057353 [ dbSNP | Ensembl ].
VAR_060135
Natural varianti480 – 4801I → V.1 Publication
Corresponds to variant rs10846559 [ dbSNP | Ensembl ].
VAR_038916
Natural varianti1724 – 17241T → M.
Corresponds to variant rs34934281 [ dbSNP | Ensembl ].
VAR_060136
Natural varianti1767 – 17671D → E.
Corresponds to variant rs7969937 [ dbSNP | Ensembl ].
VAR_060137
Natural varianti1865 – 18651R → K.
Corresponds to variant rs35685787 [ dbSNP | Ensembl ].
VAR_060138
Natural varianti1986 – 19861T → M.
Corresponds to variant rs33935373 [ dbSNP | Ensembl ].
VAR_062177
Natural varianti2403 – 24031R → W.
Corresponds to variant rs7977449 [ dbSNP | Ensembl ].
VAR_060139
Natural varianti2483 – 24831N → S.
Corresponds to variant rs11835416 [ dbSNP | Ensembl ].
VAR_060140

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1090 – 10956HLAKNL → VLNRCV in isoform 2. 1 PublicationVSP_033518
Alternative sequencei1096 – 44713376Missing in isoform 2. 1 PublicationVSP_033519Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079315 Genomic DNA. No translation available.
AC117503 Genomic DNA. No translation available.
AK095581 mRNA. Translation: BAC04579.1. Different initiation.
AK125475 mRNA. Translation: BAC86173.1.
AK125796 mRNA. Translation: BAC86296.1. Different initiation.
AB095937 mRNA. Translation: BAC23113.2.
AJ132089 mRNA. Translation: CAA10562.1.
CCDSiCCDS9255.2. [Q8IVF4-1]
RefSeqiNP_997320.2. NM_207437.3. [Q8IVF4-1]
UniGeneiHs.622654.

Genome annotation databases

EnsembliENST00000409039; ENSP00000386770; ENSG00000197653. [Q8IVF4-1]
GeneIDi196385.
KEGGihsa:196385.
UCSCiuc001uft.4. human. [Q8IVF4-1]
uc010taw.1. human. [Q8IVF4-2]

Polymorphism databases

DMDMi296439473.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079315 Genomic DNA. No translation available.
AC117503 Genomic DNA. No translation available.
AK095581 mRNA. Translation: BAC04579.1 . Different initiation.
AK125475 mRNA. Translation: BAC86173.1 .
AK125796 mRNA. Translation: BAC86296.1 . Different initiation.
AB095937 mRNA. Translation: BAC23113.2 .
AJ132089 mRNA. Translation: CAA10562.1 .
CCDSi CCDS9255.2. [Q8IVF4-1 ]
RefSeqi NP_997320.2. NM_207437.3. [Q8IVF4-1 ]
UniGenei Hs.622654.

3D structure databases

ProteinModelPortali Q8IVF4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386770.

PTM databases

PhosphoSitei Q8IVF4.

Polymorphism databases

DMDMi 296439473.

Proteomic databases

MaxQBi Q8IVF4.
PaxDbi Q8IVF4.
PRIDEi Q8IVF4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409039 ; ENSP00000386770 ; ENSG00000197653 . [Q8IVF4-1 ]
GeneIDi 196385.
KEGGi hsa:196385.
UCSCi uc001uft.4. human. [Q8IVF4-1 ]
uc010taw.1. human. [Q8IVF4-2 ]

Organism-specific databases

CTDi 196385.
GeneCardsi GC12P124247.
H-InvDB HIX0022875.
HGNCi HGNC:2941. DNAH10.
HPAi HPA039065.
HPA039066.
MIMi 605884. gene.
neXtProti NX_Q8IVF4.
PharmGKBi PA27395.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5245.
GeneTreei ENSGT00760000118964.
HOGENOMi HOG000237308.
HOVERGENi HBG107827.
InParanoidi Q8IVF4.
OMAi KEEWSQT.
OrthoDBi EOG7RRF64.
PhylomeDBi Q8IVF4.
TreeFami TF316836.

Miscellaneous databases

ChiTaRSi DNAH10. human.
GenomeRNAii 196385.
NextBioi 89451.
PROi Q8IVF4.
SOURCEi Search...

Gene expression databases

Bgeei Q8IVF4.
CleanExi HS_DNAH10.
ExpressionAtlasi Q8IVF4. baseline and differential.
Genevestigatori Q8IVF4.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10676. PTHR10676. 1 hit.
Pfami PF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 3 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-4471 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1487-2134 AND 2926-3760 (ISOFORM 1), VARIANT VAL-480.
    Tissue: Brain and Testis.
  3. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1421-4471 (ISOFORM 1).
    Tissue: Brain.
  4. "Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes."
    Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Zeigler A., Bouvagnet P.
    Eur. J. Hum. Genet. 8:923-932(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1836-1936 (ISOFORM 1).
    Tissue: Nasal polyp.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074.
    Tissue: Liver.

Entry informationi

Entry nameiDYH10_HUMAN
AccessioniPrimary (citable) accession number: Q8IVF4
Secondary accession number(s): C9JMF5
, O95495, Q6ZUC9, Q6ZUP6, Q8N761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 97 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3