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Q8IVF4

- DYH10_HUMAN

UniProt

Q8IVF4 - DYH10_HUMAN

Protein

Dynein heavy chain 10, axonemal

Gene

DNAH10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity. Probable inner arm dynein heavy chain.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1832 – 18398ATPSequence Analysis
    Nucleotide bindingi2113 – 21208ATPSequence Analysis
    Nucleotide bindingi2455 – 24628ATPSequence Analysis
    Nucleotide bindingi2803 – 28108ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. microtubule motor activity Source: InterPro

    GO - Biological processi

    1. microtubule-based movement Source: InterPro

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynein heavy chain 10, axonemal
    Alternative name(s):
    Axonemal beta dynein heavy chain 10
    Ciliary dynein heavy chain 10
    Gene namesi
    Name:DNAH10
    Synonyms:KIAA2017
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:2941. DNAH10.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-KW
    3. dynein complex Source: UniProtKB-KW
    4. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 44714471Dynein heavy chain 10, axonemalPRO_0000318938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi1074 – 10741N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8IVF4.
    PaxDbiQ8IVF4.
    PRIDEiQ8IVF4.

    PTM databases

    PhosphoSiteiQ8IVF4.

    Expressioni

    Tissue specificityi

    Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.

    Gene expression databases

    ArrayExpressiQ8IVF4.
    BgeeiQ8IVF4.
    CleanExiHS_DNAH10.
    GenevestigatoriQ8IVF4.

    Organism-specific databases

    HPAiHPA039065.
    HPA039066.

    Interactioni

    Subunit structurei

    Consists of at least two heavy chains and a number of intermediate and light chains.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000386770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IVF4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1221 – 125434TPR 1Add
    BLAST
    Repeati2736 – 276934TPR 2Add
    BLAST
    Repeati2771 – 279727TPR 3Add
    BLAST
    Repeati3802 – 383736TPR 4Add
    BLAST
    Repeati4074 – 410835TPR 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 17931793StemBy similarityAdd
    BLAST
    Regioni1794 – 2015222AAA 1By similarityAdd
    BLAST
    Regioni2075 – 2294220AAA 2By similarityAdd
    BLAST
    Regioni2417 – 2665249AAA 3By similarityAdd
    BLAST
    Regioni2765 – 3014250AAA 4By similarityAdd
    BLAST
    Regioni3029 – 3313285StalkBy similarityAdd
    BLAST
    Regioni3399 – 3629231AAA 5By similarityAdd
    BLAST
    Regioni3845 – 4062218AAA 6By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili203 – 22321Sequence AnalysisAdd
    BLAST
    Coiled coili602 – 62221Sequence AnalysisAdd
    BLAST
    Coiled coili1071 – 110636Sequence AnalysisAdd
    BLAST
    Coiled coili1217 – 124529Sequence AnalysisAdd
    BLAST
    Coiled coili2747 – 277024Sequence AnalysisAdd
    BLAST
    Coiled coili3045 – 313187Sequence AnalysisAdd
    BLAST
    Coiled coili3257 – 332771Sequence AnalysisAdd
    BLAST
    Coiled coili3567 – 363872Sequence AnalysisAdd
    BLAST
    Coiled coili4235 – 426026Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1832 – 18398GPAGTGKT motif
    Motifi1882 – 18887CFDEFNR motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 258Poly-Glu
    Compositional biasi949 – 9524Poly-Glu

    Domaini

    Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.By similarity

    Sequence similaritiesi

    Belongs to the dynein heavy chain family.Curated
    Contains 5 TPR repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG5245.
    HOGENOMiHOG000237308.
    HOVERGENiHBG107827.
    InParanoidiQ8IVF4.
    OMAiKEEWSQT.
    OrthoDBiEOG7RRF64.
    PhylomeDBiQ8IVF4.
    TreeFamiTF316836.

    Family and domain databases

    Gene3Di3.40.50.300. 4 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011704. ATPase_dyneun-rel_AAA.
    IPR026983. DHC_fam.
    IPR024743. Dynein_HC_stalk.
    IPR024317. Dynein_heavy_chain_D4_dom.
    IPR004273. Dynein_heavy_dom.
    IPR013594. Dynein_heavy_dom-1.
    IPR013602. Dynein_heavy_dom-2.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10676. PTHR10676. 1 hit.
    PfamiPF07728. AAA_5. 1 hit.
    PF12780. AAA_8. 1 hit.
    PF08385. DHC_N1. 2 hits.
    PF08393. DHC_N2. 1 hit.
    PF03028. Dynein_heavy. 1 hit.
    PF12777. MT. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 3 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 5 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IVF4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG     50
    QPLNREDEEM DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV 100
    FFLRNTKEAI SEATDMKEAM EIMPETLEYG IINANVLHFL KNIICQVFLP 150
    ALSFNQHRTS TTVGVTSGEV SNSSEHESDL PPMPGEAVEY HSIQLIRDEF 200
    LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA DPETVDILEQ 250
    CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP 300
    IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN 350
    ITHGSGFHVV LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE 400
    RVCRVVNLRT LFKENRASAQ SKTLEARNTL RLWKKAYFDT RAKIEASGRE 450
    DRWEFDRKRL FERTDYMATI CQDLSDVLQI LEEFYNIFGP ELKAVTGDPK 500
    RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK IEVLIDIINK 550
    IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR 600
    GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT 650
    EEPSTLERGA VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK 700
    FLRYTAGIQR MLDHYHMLIG TLNDAESVLL KDHSQELLRV FRSGYKRLNW 750
    NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA DDISSRLTLI EAINLFKYPA 800
    AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT KVEGLVVHTN 850
    TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL 900
    TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE 950
    EEVVIINFYN DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW 1000
    KLDKAIVMEK FAAKKPPCVA YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ 1050
    LRHLANTVQE NAKSWVISLG KLLNESAKEE LYNLHEEMEH LAKNLRKIPN 1100
    TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN LFPPDAEKEL 1150
    VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR 1200
    FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM 1250
    YPELLKVQKE MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG 1300
    FLRALRKLPR PVRGLSVTYY LEAKMKAFKD SIPLLLDLKN EALRDRHWKE 1350
    LMEKTSVFFE MTETFTLENM FAMELHKHTD VLNEIVTAAI KEVAIEKAVK 1400
    EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN TFNLQSISGS 1450
    RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL 1500
    PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC 1550
    QKSLNDYLDS KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA 1600
    SLRFNDGDSG EKLVSAMISA EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR 1650
    TNRLITKEAI FRYCEDRSRV DWMLLYQGMV VLAASQVWWT WEVEDVFHKA 1700
    QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT VLIIDVHARD 1750
    IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG 1800
    LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG 1850
    LLCVVTNCGE GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ 1900
    IQTIRNALIH QLTTFQFEGQ EISLDSRMGI FITMNPGYAG RTELPESVKA 1950
    LFRPVVVIVP DLQQICEIML FSEGFLEAKT LAKKMTVLYK LAREQLSKQY 2000
    HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN LPKFVFEDVP 2050
    LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF 2100
    ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI 2150
    ELYGILDPTT RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN 2200
    MNSVMDDNRL LTLANGERIR LQAHCALLFE VGDLQYASPA TVSRCGMVYV 2250
    DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL FEKYVPYLMD VIVEGIVDGR 2300
    QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC YFLEALYCSL 2350
    GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD 2400
    NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP 2450
    VIFVGESGTS KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN 2500
    VEKRTKDTYG PPMGKRLLVF MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL 2550
    YDRGKELNCK SIRDLGFIAA MGKAGGGRNE VDPRFISLFS VFNVPFPSEE 2600
    SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV QDLPPTPSKF 2650
    HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET 2700
    DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ 2750
    DYEAAKALFQ EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL 2800
    LVGVGGSGKQ SLSRLAAFTA SCEVFEILLS RGYSENSFRE DLKSLYLKLG 2850
    IENKAMIFLF TDAHVAEEGF LELINNMLTS GIVPALFSEE EKESILSQIG 2900
    QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL RTWCRNFPGM 2950
    VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV 3000
    DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG 3050
    LDKLKEATIQ LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK 3100
    KLAEEKAMEI EEQNKVIAME KAEAETTLAE VMPILEAAKL ELQKLDKSDV 3150
    TEIRSFAKPP KQVQTVCECI LIMKGYKELN WKTAKGVMSD PNFLRSLMEI 3200
    DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF VEAVMGYCDV 3250
    FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI 3300
    LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG 3350
    DCLLCAAFLS YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT 3400
    DDVEISRWGS QGLPPDELSV QNGILTTRAS RFPLCIDPQQ QALNWIKRKE 3450
    EKNNLRVASF NDPDFLKQLE MSIKYGTPFL FRDVDEYIDP VIDNVLEKNI 3500
    KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF GKAMVINYTV 3550
    TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL 3600
    ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP 3650
    AARRGAILFF VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL 3700
    RNIMDTLTFS IYNHGCTGLF ERHKLLFSFN MTIKIEQAEG RVPQEELDFF 3750
    LKGNISLEKS KRKKPCAWLS DQGWEDIILL SEMFSDNFGQ LPDDVENNQT 3800
    VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR VYRAVTDYVT 3850
    VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG 3900
    FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK 3950
    SLERITKPHP DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT 4000
    YFKISHEMLD QCPHPAFKPL VYVLAFFHAV VQERRKFGKI GWNVYYDFNE 4050
    SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL KYLIGEVMYG GRAIDSFDRR 4100
    ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE KFVEAIEALP 4150
    LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI 4200
    GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT 4250
    KSLAELQRAL AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW 4300
    MVYFLRRFSQ YMLWVTESEP SVMWLSGLHI PESYLTALVQ ATCRKNGWPL 4350
    DRSTLFTQVT KFQDADEVNE RAGQGCFVSG LYLEGADWDI EKGCLIKSKP 4400
    KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM GVGLVFEADL 4450
    FTTRHISHWV LQGVCLTLNS D 4471

    Note: No experimental confirmation available.

    Length:4,471
    Mass (Da):514,841
    Last modified:May 18, 2010 - v4
    Checksum:i85D09303637E7D5C
    GO
    Isoform 2 (identifier: Q8IVF4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1090-1095: HLAKNL → VLNRCV
         1096-4471: Missing.

    Show »
    Length:1,095
    Mass (Da):127,259
    Checksum:i189918445315B686
    GO

    Sequence cautioni

    The sequence BAC04579.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC86296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1631 – 16311L → V in BAC86296. (PubMed:14702039)Curated
    Sequence conflicti1631 – 16311L → V in BAC23113. 1 PublicationCurated
    Sequence conflicti2046 – 20461F → L in BAC86296. (PubMed:14702039)Curated
    Sequence conflicti2132 – 21343KLG → NLS in BAC86296. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti167 – 1671S → P.
    Corresponds to variant rs11057353 [ dbSNP | Ensembl ].
    VAR_060135
    Natural varianti480 – 4801I → V.1 Publication
    Corresponds to variant rs10846559 [ dbSNP | Ensembl ].
    VAR_038916
    Natural varianti1724 – 17241T → M.
    Corresponds to variant rs34934281 [ dbSNP | Ensembl ].
    VAR_060136
    Natural varianti1767 – 17671D → E.
    Corresponds to variant rs7969937 [ dbSNP | Ensembl ].
    VAR_060137
    Natural varianti1865 – 18651R → K.
    Corresponds to variant rs35685787 [ dbSNP | Ensembl ].
    VAR_060138
    Natural varianti1986 – 19861T → M.
    Corresponds to variant rs33935373 [ dbSNP | Ensembl ].
    VAR_062177
    Natural varianti2403 – 24031R → W.
    Corresponds to variant rs7977449 [ dbSNP | Ensembl ].
    VAR_060139
    Natural varianti2483 – 24831N → S.
    Corresponds to variant rs11835416 [ dbSNP | Ensembl ].
    VAR_060140

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1090 – 10956HLAKNL → VLNRCV in isoform 2. 1 PublicationVSP_033518
    Alternative sequencei1096 – 44713376Missing in isoform 2. 1 PublicationVSP_033519Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079315 Genomic DNA. No translation available.
    AC117503 Genomic DNA. No translation available.
    AK095581 mRNA. Translation: BAC04579.1. Different initiation.
    AK125475 mRNA. Translation: BAC86173.1.
    AK125796 mRNA. Translation: BAC86296.1. Different initiation.
    AB095937 mRNA. Translation: BAC23113.2.
    AJ132089 mRNA. Translation: CAA10562.1.
    CCDSiCCDS9255.2. [Q8IVF4-1]
    RefSeqiNP_997320.2. NM_207437.3. [Q8IVF4-1]
    UniGeneiHs.622654.

    Genome annotation databases

    EnsembliENST00000409039; ENSP00000386770; ENSG00000197653. [Q8IVF4-1]
    GeneIDi196385.
    KEGGihsa:196385.
    UCSCiuc001uft.4. human. [Q8IVF4-1]
    uc010taw.1. human. [Q8IVF4-2]

    Polymorphism databases

    DMDMi296439473.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079315 Genomic DNA. No translation available.
    AC117503 Genomic DNA. No translation available.
    AK095581 mRNA. Translation: BAC04579.1 . Different initiation.
    AK125475 mRNA. Translation: BAC86173.1 .
    AK125796 mRNA. Translation: BAC86296.1 . Different initiation.
    AB095937 mRNA. Translation: BAC23113.2 .
    AJ132089 mRNA. Translation: CAA10562.1 .
    CCDSi CCDS9255.2. [Q8IVF4-1 ]
    RefSeqi NP_997320.2. NM_207437.3. [Q8IVF4-1 ]
    UniGenei Hs.622654.

    3D structure databases

    ProteinModelPortali Q8IVF4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000386770.

    PTM databases

    PhosphoSitei Q8IVF4.

    Polymorphism databases

    DMDMi 296439473.

    Proteomic databases

    MaxQBi Q8IVF4.
    PaxDbi Q8IVF4.
    PRIDEi Q8IVF4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409039 ; ENSP00000386770 ; ENSG00000197653 . [Q8IVF4-1 ]
    GeneIDi 196385.
    KEGGi hsa:196385.
    UCSCi uc001uft.4. human. [Q8IVF4-1 ]
    uc010taw.1. human. [Q8IVF4-2 ]

    Organism-specific databases

    CTDi 196385.
    GeneCardsi GC12P124247.
    H-InvDB HIX0022875.
    HGNCi HGNC:2941. DNAH10.
    HPAi HPA039065.
    HPA039066.
    MIMi 605884. gene.
    neXtProti NX_Q8IVF4.
    PharmGKBi PA27395.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5245.
    HOGENOMi HOG000237308.
    HOVERGENi HBG107827.
    InParanoidi Q8IVF4.
    OMAi KEEWSQT.
    OrthoDBi EOG7RRF64.
    PhylomeDBi Q8IVF4.
    TreeFami TF316836.

    Miscellaneous databases

    ChiTaRSi DNAH10. human.
    GenomeRNAii 196385.
    NextBioi 89451.
    PROi Q8IVF4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IVF4.
    Bgeei Q8IVF4.
    CleanExi HS_DNAH10.
    Genevestigatori Q8IVF4.

    Family and domain databases

    Gene3Di 3.40.50.300. 4 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011704. ATPase_dyneun-rel_AAA.
    IPR026983. DHC_fam.
    IPR024743. Dynein_HC_stalk.
    IPR024317. Dynein_heavy_chain_D4_dom.
    IPR004273. Dynein_heavy_dom.
    IPR013594. Dynein_heavy_dom-1.
    IPR013602. Dynein_heavy_dom-2.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10676. PTHR10676. 1 hit.
    Pfami PF07728. AAA_5. 1 hit.
    PF12780. AAA_8. 1 hit.
    PF08385. DHC_N1. 2 hits.
    PF08393. DHC_N2. 1 hit.
    PF03028. Dynein_heavy. 1 hit.
    PF12777. MT. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 3 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 5 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-4471 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1487-2134 AND 2926-3760 (ISOFORM 1), VARIANT VAL-480.
      Tissue: Brain and Testis.
    3. "The nucleotide sequence of a long cDNA clone isolated from human."
      Nagase T., Kikuno R., Ohara O.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1421-4471 (ISOFORM 1).
      Tissue: Brain.
    4. "Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes."
      Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Zeigler A., Bouvagnet P.
      Eur. J. Hum. Genet. 8:923-932(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1836-1936 (ISOFORM 1).
      Tissue: Nasal polyp.
    5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074.
      Tissue: Liver.

    Entry informationi

    Entry nameiDYH10_HUMAN
    AccessioniPrimary (citable) accession number: Q8IVF4
    Secondary accession number(s): C9JMF5
    , O95495, Q6ZUC9, Q6ZUP6, Q8N761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 96 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3