Q8IVF4 (DYH10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein heavy chain 10, axonemal

Alternative name(s):
Axonemal beta dynein heavy chain 10
Ciliary dynein heavy chain 10

Gene names

Name:	DNAH10
Synonyms:	KIAA2017

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4471 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity. Probable inner arm dynein heavy chain.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme Potential.
Tissue specificity	Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.
Domain	Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.
Sequence similarities	Belongs to the dynein heavy chain family. Contains 5 TPR repeats.
Sequence caution	The sequence BAC04579.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC86296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat TPR repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell dynein complex Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IVF4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q8IVF4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1095: HLAKNL → VLNRCV
     1096-4471: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4471	4471	Dynein heavy chain 10, axonemal		PRO_0000318938
Regions
	Repeat	1221 – 1254	34	TPR 1
	Repeat	2736 – 2769	34	TPR 2
	Repeat	2771 – 2797	27	TPR 3
	Repeat	3802 – 3837	36	TPR 4
	Repeat	4074 – 4108	35	TPR 5
	Nucleotide binding	1832 – 1839	8	ATP Potential
	Nucleotide binding	2113 – 2120	8	ATP Potential
	Nucleotide binding	2455 – 2462	8	ATP Potential
	Nucleotide binding	2803 – 2810	8	ATP Potential
	Region	1 – 1793	1793	Stem By similarity
	Region	1794 – 2015	222	AAA 1 By similarity
	Region	2075 – 2294	220	AAA 2 By similarity
	Region	2417 – 2665	249	AAA 3 By similarity
	Region	2765 – 3014	250	AAA 4 By similarity
	Region	3029 – 3313	285	Stalk By similarity
	Region	3399 – 3629	231	AAA 5 By similarity
	Region	3845 – 4062	218	AAA 6 By similarity
	Coiled coil	203 – 223	21	Potential
	Coiled coil	602 – 622	21	Potential
	Coiled coil	1071 – 1106	36	Potential
	Coiled coil	1217 – 1245	29	Potential
	Coiled coil	2747 – 2770	24	Potential
	Coiled coil	3045 – 3131	87	Potential
	Coiled coil	3257 – 3327	71	Potential
	Coiled coil	3567 – 3638	72	Potential
	Coiled coil	4235 – 4260	26	Potential
	Motif	1832 – 1839	8	GPAGTGKT motif
	Motif	1882 – 1888	7	CFDEFNR motif
	Compositional bias	18 – 25	8	Poly-Glu
	Compositional bias	949 – 952	4	Poly-Glu
Amino acid modifications
	Glycosylation	1074	1	N-linked (GlcNAc...) Ref.5
Natural variations
	Alternative sequence	1090 – 1095	6	HLAKNL → VLNRCV in isoform 2.		VSP_033518
	Alternative sequence	1096 – 4471	3376	Missing in isoform 2.		VSP_033519
	Natural variant	167	1	S → P. Corresponds to variant rs11057353 [ dbSNP | Ensembl ].		VAR_060135
	Natural variant	480	1	I → V. Ref.2 Corresponds to variant rs10846559 [ dbSNP | Ensembl ].		VAR_038916
	Natural variant	1724	1	T → M. Corresponds to variant rs34934281 [ dbSNP | Ensembl ].		VAR_060136
	Natural variant	1767	1	D → E. Corresponds to variant rs7969937 [ dbSNP | Ensembl ].		VAR_060137
	Natural variant	1865	1	R → K. Corresponds to variant rs35685787 [ dbSNP | Ensembl ].		VAR_060138
	Natural variant	1986	1	T → M. Corresponds to variant rs33935373 [ dbSNP | Ensembl ].		VAR_062177
	Natural variant	2403	1	R → W. Corresponds to variant rs7977449 [ dbSNP | Ensembl ].		VAR_060139
	Natural variant	2483	1	N → S. Corresponds to variant rs11835416 [ dbSNP | Ensembl ].		VAR_060140
Experimental info
	Sequence conflict	1631	1	L → V in BAC86296. Ref.2
	Sequence conflict	1631	1	L → V in BAC23113. Ref.3
	Sequence conflict	2046	1	F → L in BAC86296. Ref.2
	Sequence conflict	2132 – 2134	3	KLG → NLS in BAC86296. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 4. Checksum: 85D09303637E7D5C	FASTA	4,471	514,841
	10 20 30 40 50 60 MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG QPLNREDEEM 70 80 90 100 110 120 DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV FFLRNTKEAI SEATDMKEAM 130 140 150 160 170 180 EIMPETLEYG IINANVLHFL KNIICQVFLP ALSFNQHRTS TTVGVTSGEV SNSSEHESDL 190 200 210 220 230 240 PPMPGEAVEY HSIQLIRDEF LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA 250 260 270 280 290 300 DPETVDILEQ CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP 310 320 330 340 350 360 IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN ITHGSGFHVV 370 380 390 400 410 420 LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE RVCRVVNLRT LFKENRASAQ 430 440 450 460 470 480 SKTLEARNTL RLWKKAYFDT RAKIEASGRE DRWEFDRKRL FERTDYMATI CQDLSDVLQI 490 500 510 520 530 540 LEEFYNIFGP ELKAVTGDPK RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK 550 560 570 580 590 600 IEVLIDIINK IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR 610 620 630 640 650 660 GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT EEPSTLERGA 670 680 690 700 710 720 VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK FLRYTAGIQR MLDHYHMLIG 730 740 750 760 770 780 TLNDAESVLL KDHSQELLRV FRSGYKRLNW NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA 790 800 810 820 830 840 DDISSRLTLI EAINLFKYPA AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT 850 860 870 880 890 900 KVEGLVVHTN TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL 910 920 930 940 950 960 TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE EEVVIINFYN 970 980 990 1000 1010 1020 DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW KLDKAIVMEK FAAKKPPCVA 1030 1040 1050 1060 1070 1080 YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ LRHLANTVQE NAKSWVISLG KLLNESAKEE 1090 1100 1110 1120 1130 1140 LYNLHEEMEH LAKNLRKIPN TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN 1150 1160 1170 1180 1190 1200 LFPPDAEKEL VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR 1210 1220 1230 1240 1250 1260 FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM YPELLKVQKE 1270 1280 1290 1300 1310 1320 MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG FLRALRKLPR PVRGLSVTYY 1330 1340 1350 1360 1370 1380 LEAKMKAFKD SIPLLLDLKN EALRDRHWKE LMEKTSVFFE MTETFTLENM FAMELHKHTD 1390 1400 1410 1420 1430 1440 VLNEIVTAAI KEVAIEKAVK EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN 1450 1460 1470 1480 1490 1500 TFNLQSISGS RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL 1510 1520 1530 1540 1550 1560 PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC QKSLNDYLDS 1570 1580 1590 1600 1610 1620 KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA SLRFNDGDSG EKLVSAMISA 1630 1640 1650 1660 1670 1680 EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR TNRLITKEAI FRYCEDRSRV DWMLLYQGMV 1690 1700 1710 1720 1730 1740 VLAASQVWWT WEVEDVFHKA QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT 1750 1760 1770 1780 1790 1800 VLIIDVHARD IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG 1810 1820 1830 1840 1850 1860 LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG LLCVVTNCGE 1870 1880 1890 1900 1910 1920 GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ IQTIRNALIH QLTTFQFEGQ 1930 1940 1950 1960 1970 1980 EISLDSRMGI FITMNPGYAG RTELPESVKA LFRPVVVIVP DLQQICEIML FSEGFLEAKT 1990 2000 2010 2020 2030 2040 LAKKMTVLYK LAREQLSKQY HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN 2050 2060 2070 2080 2090 2100 LPKFVFEDVP LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF 2110 2120 2130 2140 2150 2160 ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI ELYGILDPTT 2170 2180 2190 2200 2210 2220 RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN MNSVMDDNRL LTLANGERIR 2230 2240 2250 2260 2270 2280 LQAHCALLFE VGDLQYASPA TVSRCGMVYV DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL 2290 2300 2310 2320 2330 2340 FEKYVPYLMD VIVEGIVDGR QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC 2350 2360 2370 2380 2390 2400 YFLEALYCSL GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD 2410 2420 2430 2440 2450 2460 NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP VIFVGESGTS 2470 2480 2490 2500 2510 2520 KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN VEKRTKDTYG PPMGKRLLVF 2530 2540 2550 2560 2570 2580 MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL YDRGKELNCK SIRDLGFIAA MGKAGGGRNE 2590 2600 2610 2620 2630 2640 VDPRFISLFS VFNVPFPSEE SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV 2650 2660 2670 2680 2690 2700 QDLPPTPSKF HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET 2710 2720 2730 2740 2750 2760 DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ DYEAAKALFQ 2770 2780 2790 2800 2810 2820 EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL LVGVGGSGKQ SLSRLAAFTA 2830 2840 2850 2860 2870 2880 SCEVFEILLS RGYSENSFRE DLKSLYLKLG IENKAMIFLF TDAHVAEEGF LELINNMLTS 2890 2900 2910 2920 2930 2940 GIVPALFSEE EKESILSQIG QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL 2950 2960 2970 2980 2990 3000 RTWCRNFPGM VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV 3010 3020 3030 3040 3050 3060 DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG LDKLKEATIQ 3070 3080 3090 3100 3110 3120 LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK KLAEEKAMEI EEQNKVIAME 3130 3140 3150 3160 3170 3180 KAEAETTLAE VMPILEAAKL ELQKLDKSDV TEIRSFAKPP KQVQTVCECI LIMKGYKELN 3190 3200 3210 3220 3230 3240 WKTAKGVMSD PNFLRSLMEI DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF 3250 3260 3270 3280 3290 3300 VEAVMGYCDV FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI 3310 3320 3330 3340 3350 3360 LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG DCLLCAAFLS 3370 3380 3390 3400 3410 3420 YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT DDVEISRWGS QGLPPDELSV 3430 3440 3450 3460 3470 3480 QNGILTTRAS RFPLCIDPQQ QALNWIKRKE EKNNLRVASF NDPDFLKQLE MSIKYGTPFL 3490 3500 3510 3520 3530 3540 FRDVDEYIDP VIDNVLEKNI KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF 3550 3560 3570 3580 3590 3600 GKAMVINYTV TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL 3610 3620 3630 3640 3650 3660 ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP AARRGAILFF 3670 3680 3690 3700 3710 3720 VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL RNIMDTLTFS IYNHGCTGLF 3730 3740 3750 3760 3770 3780 ERHKLLFSFN MTIKIEQAEG RVPQEELDFF LKGNISLEKS KRKKPCAWLS DQGWEDIILL 3790 3800 3810 3820 3830 3840 SEMFSDNFGQ LPDDVENNQT VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR 3850 3860 3870 3880 3890 3900 VYRAVTDYVT VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG 3910 3920 3930 3940 3950 3960 FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK SLERITKPHP 3970 3980 3990 4000 4010 4020 DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT YFKISHEMLD QCPHPAFKPL 4030 4040 4050 4060 4070 4080 VYVLAFFHAV VQERRKFGKI GWNVYYDFNE SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL 4090 4100 4110 4120 4130 4140 KYLIGEVMYG GRAIDSFDRR ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE 4150 4160 4170 4180 4190 4200 KFVEAIEALP LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI 4210 4220 4230 4240 4250 4260 GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT KSLAELQRAL 4270 4280 4290 4300 4310 4320 AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW MVYFLRRFSQ YMLWVTESEP 4330 4340 4350 4360 4370 4380 SVMWLSGLHI PESYLTALVQ ATCRKNGWPL DRSTLFTQVT KFQDADEVNE RAGQGCFVSG 4390 4400 4410 4420 4430 4440 LYLEGADWDI EKGCLIKSKP KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM 4450 4460 4470 GVGLVFEADL FTTRHISHWV LQGVCLTLNS D
	Isoform 2 [UniParc]. Checksum: 189918445315B686	FASTA	1,095	127,259
	10 20 30 40 50 60 MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG QPLNREDEEM 70 80 90 100 110 120 DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV FFLRNTKEAI SEATDMKEAM 130 140 150 160 170 180 EIMPETLEYG IINANVLHFL KNIICQVFLP ALSFNQHRTS TTVGVTSGEV SNSSEHESDL 190 200 210 220 230 240 PPMPGEAVEY HSIQLIRDEF LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA 250 260 270 280 290 300 DPETVDILEQ CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP 310 320 330 340 350 360 IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN ITHGSGFHVV 370 380 390 400 410 420 LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE RVCRVVNLRT LFKENRASAQ 430 440 450 460 470 480 SKTLEARNTL RLWKKAYFDT RAKIEASGRE DRWEFDRKRL FERTDYMATI CQDLSDVLQI 490 500 510 520 530 540 LEEFYNIFGP ELKAVTGDPK RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK 550 560 570 580 590 600 IEVLIDIINK IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR 610 620 630 640 650 660 GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT EEPSTLERGA 670 680 690 700 710 720 VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK FLRYTAGIQR MLDHYHMLIG 730 740 750 760 770 780 TLNDAESVLL KDHSQELLRV FRSGYKRLNW NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA 790 800 810 820 830 840 DDISSRLTLI EAINLFKYPA AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT 850 860 870 880 890 900 KVEGLVVHTN TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL 910 920 930 940 950 960 TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE EEVVIINFYN 970 980 990 1000 1010 1020 DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW KLDKAIVMEK FAAKKPPCVA 1030 1040 1050 1060 1070 1080 YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ LRHLANTVQE NAKSWVISLG KLLNESAKEE 1090 LYNLHEEMEV LNRCV

References

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[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-4471 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1487-2134 AND 2926-3760 (ISOFORM 1), VARIANT VAL-480. Tissue: Brain and Testis.
[3]	"The nucleotide sequence of a long cDNA clone isolated from human." Nagase T., Kikuno R., Ohara O. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1421-4471 (ISOFORM 1). Tissue: Brain.
[4]	"Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes." Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Zeigler A., Bouvagnet P. Eur. J. Hum. Genet. 8:923-932(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1836-1936 (ISOFORM 1). Tissue: Nasal polyp.
[5]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC079315 Genomic DNA. No translation available. AC117503 Genomic DNA. No translation available. AK095581 mRNA. Translation: BAC04579.1. Different initiation. AK125475 mRNA. Translation: BAC86173.1. AK125796 mRNA. Translation: BAC86296.1. Different initiation. AB095937 mRNA. Translation: BAC23113.2. AJ132089 mRNA. Translation: CAA10562.1.
IPI	IPI00401809. IPI00784869.
RefSeq	NP_997320.2. NM_207437.3.
UniGene	Hs.622654.
3D structure databases
ProteinModelPortal	Q8IVF4.
SMR	Q8IVF4. Positions 3124-3261, 3894-4102.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000386770.
PTM databases
PhosphoSite	Q8IVF4.
Polymorphism databases
DMDM	296439473.
Proteomic databases
PaxDb	Q8IVF4.
PRIDE	Q8IVF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000409039; ENSP00000386770; ENSG00000197653.
GeneID	196385.
KEGG	hsa:196385.
UCSC	uc001uft.4. human. uc010taw.1. human.
Organism-specific databases
CTD	196385.
GeneCards	GC12P124247.
H-InvDB	HIX0022875.
HGNC	HGNC:2941. DNAH10.
HPA	HPA039066.
MIM	605884. gene.
neXtProt	NX_Q8IVF4.
PharmGKB	PA27395.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5245.
HOGENOM	HOG000237308.
HOVERGEN	HBG107827.
InParanoid	Q8IVF4.
OMA	KEEWSQT.
OrthoDB	EOG4FFD0W.
Gene expression databases
ArrayExpress	Q8IVF4.
Bgee	Q8IVF4.
CleanEx	HS_DNAH10.
Genevestigator	Q8IVF4.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR011704. ATPase_dyneun-rel_AAA. IPR026983. DHC_fam. IPR024743. Dynein_HC_stalk. IPR024317. Dynein_heavy_chain_D4_dom. IPR004273. Dynein_heavy_dom. IPR013594. Dynein_heavy_dom-1. IPR013602. Dynein_heavy_dom-2. [Graphical view]
PANTHER	PTHR10676. PTHR10676. 1 hit.
Pfam	PF07728. AAA_5. 1 hit. PF12780. AAA_8. 1 hit. PF08385. DHC_N1. 2 hits. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. PF12777. MT. 1 hit. [Graphical view]
SMART	SM00382. AAA. 3 hits. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DNAH10. human.
GenomeRNAi	196385.
NextBio	89451.
SOURCE	Search...

Entry information

Entry name

DYH10_HUMAN

Accession

Primary (citable) accession number: Q8IVF4
Secondary accession number(s): C9JMF5 , O95495, Q6ZUC9, Q6ZUP6, Q8N761

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 82 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.