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Q8IVF4 (DYH10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynein heavy chain 10, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 10
Ciliary dynein heavy chain 10
Gene names
Name:DNAH10
Synonyms:KIAA2017
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4471 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity. Probable inner arm dynein heavy chain.

Subunit structure

Consists of at least two heavy chains and a number of intermediate and light chains.

Subcellular location

Cytoplasmcytoskeletoncilium axoneme Potential.

Tissue specificity

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.

Domain

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.

Sequence similarities

Belongs to the dynein heavy chain family.

Contains 5 TPR repeats.

Sequence caution

The sequence BAC04579.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC86296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IVF4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q8IVF4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1095: HLAKNL → VLNRCV
     1096-4471: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 44714471Dynein heavy chain 10, axonemal
PRO_0000318938

Regions

Repeat1221 – 125434TPR 1
Repeat2736 – 276934TPR 2
Repeat2771 – 279727TPR 3
Repeat3802 – 383736TPR 4
Repeat4074 – 410835TPR 5
Nucleotide binding1832 – 18398ATP Potential
Nucleotide binding2113 – 21208ATP Potential
Nucleotide binding2455 – 24628ATP Potential
Nucleotide binding2803 – 28108ATP Potential
Region1 – 17931793Stem By similarity
Region1794 – 2015222AAA 1 By similarity
Region2075 – 2294220AAA 2 By similarity
Region2417 – 2665249AAA 3 By similarity
Region2765 – 3014250AAA 4 By similarity
Region3029 – 3313285Stalk By similarity
Region3399 – 3629231AAA 5 By similarity
Region3845 – 4062218AAA 6 By similarity
Coiled coil203 – 22321 Potential
Coiled coil602 – 62221 Potential
Coiled coil1071 – 110636 Potential
Coiled coil1217 – 124529 Potential
Coiled coil2747 – 277024 Potential
Coiled coil3045 – 313187 Potential
Coiled coil3257 – 332771 Potential
Coiled coil3567 – 363872 Potential
Coiled coil4235 – 426026 Potential
Motif1832 – 18398GPAGTGKT motif
Motif1882 – 18887CFDEFNR motif
Compositional bias18 – 258Poly-Glu
Compositional bias949 – 9524Poly-Glu

Amino acid modifications

Glycosylation10741N-linked (GlcNAc...) Ref.5

Natural variations

Alternative sequence1090 – 10956HLAKNL → VLNRCV in isoform 2.
VSP_033518
Alternative sequence1096 – 44713376Missing in isoform 2.
VSP_033519
Natural variant1671S → P.
Corresponds to variant rs11057353 [ dbSNP | Ensembl ].
VAR_060135
Natural variant4801I → V. Ref.2
Corresponds to variant rs10846559 [ dbSNP | Ensembl ].
VAR_038916
Natural variant17241T → M.
Corresponds to variant rs34934281 [ dbSNP | Ensembl ].
VAR_060136
Natural variant17671D → E.
Corresponds to variant rs7969937 [ dbSNP | Ensembl ].
VAR_060137
Natural variant18651R → K.
Corresponds to variant rs35685787 [ dbSNP | Ensembl ].
VAR_060138
Natural variant19861T → M.
Corresponds to variant rs33935373 [ dbSNP | Ensembl ].
VAR_062177
Natural variant24031R → W.
Corresponds to variant rs7977449 [ dbSNP | Ensembl ].
VAR_060139
Natural variant24831N → S.
Corresponds to variant rs11835416 [ dbSNP | Ensembl ].
VAR_060140

Experimental info

Sequence conflict16311L → V in BAC86296. Ref.2
Sequence conflict16311L → V in BAC23113. Ref.3
Sequence conflict20461F → L in BAC86296. Ref.2
Sequence conflict2132 – 21343KLG → NLS in BAC86296. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: 85D09303637E7D5C

FASTA4,471514,841
        10         20         30         40         50         60 
MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG QPLNREDEEM 

        70         80         90        100        110        120 
DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV FFLRNTKEAI SEATDMKEAM 

       130        140        150        160        170        180 
EIMPETLEYG IINANVLHFL KNIICQVFLP ALSFNQHRTS TTVGVTSGEV SNSSEHESDL 

       190        200        210        220        230        240 
PPMPGEAVEY HSIQLIRDEF LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA 

       250        260        270        280        290        300 
DPETVDILEQ CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP 

       310        320        330        340        350        360 
IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN ITHGSGFHVV 

       370        380        390        400        410        420 
LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE RVCRVVNLRT LFKENRASAQ 

       430        440        450        460        470        480 
SKTLEARNTL RLWKKAYFDT RAKIEASGRE DRWEFDRKRL FERTDYMATI CQDLSDVLQI 

       490        500        510        520        530        540 
LEEFYNIFGP ELKAVTGDPK RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK 

       550        560        570        580        590        600 
IEVLIDIINK IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR 

       610        620        630        640        650        660 
GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT EEPSTLERGA 

       670        680        690        700        710        720 
VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK FLRYTAGIQR MLDHYHMLIG 

       730        740        750        760        770        780 
TLNDAESVLL KDHSQELLRV FRSGYKRLNW NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA 

       790        800        810        820        830        840 
DDISSRLTLI EAINLFKYPA AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT 

       850        860        870        880        890        900 
KVEGLVVHTN TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL 

       910        920        930        940        950        960 
TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE EEVVIINFYN 

       970        980        990       1000       1010       1020 
DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW KLDKAIVMEK FAAKKPPCVA 

      1030       1040       1050       1060       1070       1080 
YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ LRHLANTVQE NAKSWVISLG KLLNESAKEE 

      1090       1100       1110       1120       1130       1140 
LYNLHEEMEH LAKNLRKIPN TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN 

      1150       1160       1170       1180       1190       1200 
LFPPDAEKEL VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR 

      1210       1220       1230       1240       1250       1260 
FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM YPELLKVQKE 

      1270       1280       1290       1300       1310       1320 
MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG FLRALRKLPR PVRGLSVTYY 

      1330       1340       1350       1360       1370       1380 
LEAKMKAFKD SIPLLLDLKN EALRDRHWKE LMEKTSVFFE MTETFTLENM FAMELHKHTD 

      1390       1400       1410       1420       1430       1440 
VLNEIVTAAI KEVAIEKAVK EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN 

      1450       1460       1470       1480       1490       1500 
TFNLQSISGS RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL 

      1510       1520       1530       1540       1550       1560 
PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC QKSLNDYLDS 

      1570       1580       1590       1600       1610       1620 
KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA SLRFNDGDSG EKLVSAMISA 

      1630       1640       1650       1660       1670       1680 
EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR TNRLITKEAI FRYCEDRSRV DWMLLYQGMV 

      1690       1700       1710       1720       1730       1740 
VLAASQVWWT WEVEDVFHKA QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT 

      1750       1760       1770       1780       1790       1800 
VLIIDVHARD IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG 

      1810       1820       1830       1840       1850       1860 
LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG LLCVVTNCGE 

      1870       1880       1890       1900       1910       1920 
GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ IQTIRNALIH QLTTFQFEGQ 

      1930       1940       1950       1960       1970       1980 
EISLDSRMGI FITMNPGYAG RTELPESVKA LFRPVVVIVP DLQQICEIML FSEGFLEAKT 

      1990       2000       2010       2020       2030       2040 
LAKKMTVLYK LAREQLSKQY HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN 

      2050       2060       2070       2080       2090       2100 
LPKFVFEDVP LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF 

      2110       2120       2130       2140       2150       2160 
ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI ELYGILDPTT 

      2170       2180       2190       2200       2210       2220 
RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN MNSVMDDNRL LTLANGERIR 

      2230       2240       2250       2260       2270       2280 
LQAHCALLFE VGDLQYASPA TVSRCGMVYV DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL 

      2290       2300       2310       2320       2330       2340 
FEKYVPYLMD VIVEGIVDGR QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC 

      2350       2360       2370       2380       2390       2400 
YFLEALYCSL GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD 

      2410       2420       2430       2440       2450       2460 
NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP VIFVGESGTS 

      2470       2480       2490       2500       2510       2520 
KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN VEKRTKDTYG PPMGKRLLVF 

      2530       2540       2550       2560       2570       2580 
MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL YDRGKELNCK SIRDLGFIAA MGKAGGGRNE 

      2590       2600       2610       2620       2630       2640 
VDPRFISLFS VFNVPFPSEE SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV 

      2650       2660       2670       2680       2690       2700 
QDLPPTPSKF HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET 

      2710       2720       2730       2740       2750       2760 
DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ DYEAAKALFQ 

      2770       2780       2790       2800       2810       2820 
EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL LVGVGGSGKQ SLSRLAAFTA 

      2830       2840       2850       2860       2870       2880 
SCEVFEILLS RGYSENSFRE DLKSLYLKLG IENKAMIFLF TDAHVAEEGF LELINNMLTS 

      2890       2900       2910       2920       2930       2940 
GIVPALFSEE EKESILSQIG QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL 

      2950       2960       2970       2980       2990       3000 
RTWCRNFPGM VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV 

      3010       3020       3030       3040       3050       3060 
DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG LDKLKEATIQ 

      3070       3080       3090       3100       3110       3120 
LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK KLAEEKAMEI EEQNKVIAME 

      3130       3140       3150       3160       3170       3180 
KAEAETTLAE VMPILEAAKL ELQKLDKSDV TEIRSFAKPP KQVQTVCECI LIMKGYKELN 

      3190       3200       3210       3220       3230       3240 
WKTAKGVMSD PNFLRSLMEI DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF 

      3250       3260       3270       3280       3290       3300 
VEAVMGYCDV FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI 

      3310       3320       3330       3340       3350       3360 
LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG DCLLCAAFLS 

      3370       3380       3390       3400       3410       3420 
YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT DDVEISRWGS QGLPPDELSV 

      3430       3440       3450       3460       3470       3480 
QNGILTTRAS RFPLCIDPQQ QALNWIKRKE EKNNLRVASF NDPDFLKQLE MSIKYGTPFL 

      3490       3500       3510       3520       3530       3540 
FRDVDEYIDP VIDNVLEKNI KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF 

      3550       3560       3570       3580       3590       3600 
GKAMVINYTV TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL 

      3610       3620       3630       3640       3650       3660 
ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP AARRGAILFF 

      3670       3680       3690       3700       3710       3720 
VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL RNIMDTLTFS IYNHGCTGLF 

      3730       3740       3750       3760       3770       3780 
ERHKLLFSFN MTIKIEQAEG RVPQEELDFF LKGNISLEKS KRKKPCAWLS DQGWEDIILL 

      3790       3800       3810       3820       3830       3840 
SEMFSDNFGQ LPDDVENNQT VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR 

      3850       3860       3870       3880       3890       3900 
VYRAVTDYVT VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG 

      3910       3920       3930       3940       3950       3960 
FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK SLERITKPHP 

      3970       3980       3990       4000       4010       4020 
DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT YFKISHEMLD QCPHPAFKPL 

      4030       4040       4050       4060       4070       4080 
VYVLAFFHAV VQERRKFGKI GWNVYYDFNE SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL 

      4090       4100       4110       4120       4130       4140 
KYLIGEVMYG GRAIDSFDRR ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE 

      4150       4160       4170       4180       4190       4200 
KFVEAIEALP LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI 

      4210       4220       4230       4240       4250       4260 
GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT KSLAELQRAL 

      4270       4280       4290       4300       4310       4320 
AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW MVYFLRRFSQ YMLWVTESEP 

      4330       4340       4350       4360       4370       4380 
SVMWLSGLHI PESYLTALVQ ATCRKNGWPL DRSTLFTQVT KFQDADEVNE RAGQGCFVSG 

      4390       4400       4410       4420       4430       4440 
LYLEGADWDI EKGCLIKSKP KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM 

      4450       4460       4470 
GVGLVFEADL FTTRHISHWV LQGVCLTLNS D 

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Isoform 2 [UniParc].

Checksum: 189918445315B686
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FASTA1,095127,259

References

« Hide 'large scale' references
[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-4471 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1487-2134 AND 2926-3760 (ISOFORM 1), VARIANT VAL-480.
Tissue: Brain and Testis.
[3]"The nucleotide sequence of a long cDNA clone isolated from human."
Nagase T., Kikuno R., Ohara O.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1421-4471 (ISOFORM 1).
Tissue: Brain.
[4]"Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes."
Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Zeigler A., Bouvagnet P.
Eur. J. Hum. Genet. 8:923-932(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1836-1936 (ISOFORM 1).
Tissue: Nasal polyp.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC079315 Genomic DNA. No translation available.
AC117503 Genomic DNA. No translation available.
AK095581 mRNA. Translation: BAC04579.1. Different initiation.
AK125475 mRNA. Translation: BAC86173.1.
AK125796 mRNA. Translation: BAC86296.1. Different initiation.
AB095937 mRNA. Translation: BAC23113.2.
AJ132089 mRNA. Translation: CAA10562.1.
CCDSCCDS9255.2. [Q8IVF4-1]
RefSeqNP_997320.2. NM_207437.3. [Q8IVF4-1]
UniGeneHs.622654.

3D structure databases

ProteinModelPortalQ8IVF4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000386770.

PTM databases

PhosphoSiteQ8IVF4.

Polymorphism databases

DMDM296439473.

Proteomic databases

MaxQBQ8IVF4.
PaxDbQ8IVF4.
PRIDEQ8IVF4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000409039; ENSP00000386770; ENSG00000197653. [Q8IVF4-1]
GeneID196385.
KEGGhsa:196385.
UCSCuc001uft.4. human. [Q8IVF4-1]
uc010taw.1. human. [Q8IVF4-2]

Organism-specific databases

CTD196385.
GeneCardsGC12P124247.
H-InvDBHIX0022875.
HGNCHGNC:2941. DNAH10.
HPAHPA039065.
HPA039066.
MIM605884. gene.
neXtProtNX_Q8IVF4.
PharmGKBPA27395.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5245.
HOGENOMHOG000237308.
HOVERGENHBG107827.
InParanoidQ8IVF4.
OMAKEEWSQT.
OrthoDBEOG7RRF64.
PhylomeDBQ8IVF4.
TreeFamTF316836.

Gene expression databases

ArrayExpressQ8IVF4.
BgeeQ8IVF4.
CleanExHS_DNAH10.
GenevestigatorQ8IVF4.

Family and domain databases

Gene3D3.40.50.300. 4 hits.
InterProIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10676. PTHR10676. 1 hit.
PfamPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 2 hits.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 5 hits.
ProtoNetSearch...

Other

ChiTaRSDNAH10. human.
GenomeRNAi196385.
NextBio89451.
PROQ8IVF4.
SOURCESearch...

Entry information

Entry nameDYH10_HUMAN
AccessionPrimary (citable) accession number: Q8IVF4
Secondary accession number(s): C9JMF5 expand/collapse secondary AC list , O95495, Q6ZUC9, Q6ZUP6, Q8N761
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 94 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM