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Protein

Protein AHNAK2

Gene

AHNAK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31628-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AHNAK2
Gene namesi
Name:AHNAK2
Synonyms:C14orf78, KIAA2019
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20125. AHNAK2.

Subcellular locationi

GO - Cellular componenti

  • costamere Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytoplasmic vesicle membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: HPA
  • sarcolemma Source: UniProtKB
  • T-tubule Source: UniProtKB
  • Z disc Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185567.
PharmGKBiPA162376085.

Polymorphism and mutation databases

BioMutaiAHNAK2.
DMDMi172045740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199621 – 5795Protein AHNAK2Add BLAST5795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei280PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei842PhosphoserineCombined sources1
Modified residuei1007PhosphoserineCombined sources1
Modified residuei1112PhosphoserineCombined sources1
Modified residuei1337PhosphoserineCombined sources1
Modified residuei1418PhosphoserineCombined sources1
Modified residuei1502PhosphoserineCombined sources1
Modified residuei1510N6-acetyllysineCombined sources1
Modified residuei1667PhosphoserineCombined sources1
Modified residuei1832PhosphoserineCombined sources1
Modified residuei1840N6-acetyllysineCombined sources1
Modified residuei2162PhosphoserineCombined sources1
Modified residuei2243PhosphoserineCombined sources1
Modified residuei2408PhosphoserineCombined sources1
Modified residuei2492PhosphoserineCombined sources1
Modified residuei2500N6-acetyllysineCombined sources1
Modified residuei2738PhosphoserineCombined sources1
Modified residuei2822PhosphoserineCombined sources1
Modified residuei2987PhosphoserineCombined sources1
Modified residuei3068PhosphoserineCombined sources1
Modified residuei3152PhosphoserineCombined sources1
Modified residuei3233PhosphoserineCombined sources1
Modified residuei3408PhosphoserineCombined sources1
Modified residuei3812PhosphoserineCombined sources1
Modified residuei3977PhosphoserineCombined sources1
Modified residuei4142PhosphoserineCombined sources1
Modified residuei4307PhosphoserineCombined sources1
Modified residuei4388PhosphoserineCombined sources1
Modified residuei4472PhosphoserineCombined sources1
Modified residuei4477PhosphoserineCombined sources1
Modified residuei4894PhosphoserineCombined sources1
Modified residuei4897PhosphoserineCombined sources1
Modified residuei5707PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IVF2.
MaxQBiQ8IVF2.
PaxDbiQ8IVF2.
PeptideAtlasiQ8IVF2.
PRIDEiQ8IVF2.

PTM databases

iPTMnetiQ8IVF2.
PhosphoSitePlusiQ8IVF2.
SwissPalmiQ8IVF2.

Expressioni

Gene expression databases

BgeeiENSG00000185567.
GenevisibleiQ8IVF2. HS.

Organism-specific databases

HPAiHPA000878.
HPA002940.
HPA004145.
HPA020111.

Interactioni

Subunit structurei

Homodimer (via PDZ domain) (PubMed:24675079). Interacts with DYSF; the interaction is direct and Ca2+-independent (PubMed:17185750).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPL1Q9H0R83EBI-10217765,EBI-746969
GABARAPL2P605203EBI-10217765,EBI-720116

Protein-protein interaction databases

BioGridi125226. 23 interactors.
IntActiQ8IVF2. 7 interactors.
STRINGi9606.ENSP00000353114.

Structurei

Secondary structure

15795
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi111 – 116Combined sources6
Beta strandi125 – 130Combined sources6
Beta strandi136 – 141Combined sources6
Helixi146 – 149Combined sources4
Beta strandi158 – 165Combined sources8
Helixi171 – 181Combined sources11
Beta strandi184 – 193Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CN0X-ray1.75A/B108-203[»]
ProteinModelPortaliQ8IVF2.
SMRiQ8IVF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 193PDZPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGCZ. Eukaryota.
ENOG41116CJ. LUCA.
GeneTreeiENSGT00530000063716.
InParanoidiQ8IVF2.
OMAiGVGIKAH.
OrthoDBiEOG091G01FG.
PhylomeDBiQ8IVF2.
TreeFamiTF350595.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCDCFHMVLP TWPGTPGSVS GRQLQPGEPG AETEDDHSVT EGPADEGIRP
60 70 80 90 100
RPQGSSPVYE YTTEAADFGL QEDAPGRQGS AGRRRSWWKR DSGDSRTFFR
110 120 130 140 150
MSRPEAVQEA TEVTLKTEVE AGASGYSVTG GGDQGIFVKQ VLKDSSAAKL
160 170 180 190 200
FNLREGDQLL STTVFFENIK YEDALKILQY SEPYKVQFKI RRQLPAPQDE
210 220 230 240 250
EWASSDAQHG PQGKEKEDTD VADGCRETPT KTLEGDGDQE RLISKPRVGR
260 270 280 290 300
GRQSQRERLS WPKFQSIKSK RGPGPQRSHS SSEAYEPRDA HDVSPTSTDT
310 320 330 340 350
EAQLTVERQE QKAGPGSQRR RKFLNLRFRT GSGQGPSSTG QPGRGFQSGV
360 370 380 390 400
GRAGVLEELG PWGDSLEETG AATGSRREER AEQDREVMPA QSMPLPTELG
410 420 430 440 450
DPRLCEGTPQ EGGLRAARLH GKTLEGQAQE TAVAQRKPRA QPTPGMSREG
460 470 480 490 500
EGEGLQSLEI GIARLSLRDT TEGGTQIGPP EIRVRVHDLK TPKFAFSTEK
510 520 530 540 550
EPERERRLST PQRGKRQDAS SKAGTGLKGE EVEGAGWMPG REPTTHAEAQ
560 570 580 590 600
GDEGDGEEGL QRTRITEEQD KGREDTEGQI RMPKFKIPSL GWSPSKHTKT
610 620 630 640 650
GREKATEDTE QGREGEATAT ADRREQRRTE EGLKDKEDSD SMTNTTKIQL
660 670 680 690 700
IHDEKRLKKE QILTEKEVAT KDSKFKMPKF KMPLFGASAP GKSMEASVDV
710 720 730 740 750
SAPKVEADVS LLSMQGDLKT TDLSVQTPSA DLEVQDGQVD VKLPEGPLPE
760 770 780 790 800
GASLKGHLPK VQRPSLKMPK VDLKGPKLDL KGPKAEVTAP DVKMSLSSME
810 820 830 840 850
VDVQAPRAKL DGARLEGDLS LADKEVTAKD SKFKMPKFKM PSFGVSAPGK
860 870 880 890 900
SMEDSVDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAGQVDVK
910 920 930 940 950
LPEGPVPEGA GPKVHLPKVE MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA
960 970 980 990 1000
EVTAPDGEVS LPSMEVDVQA QKAKLDGAWL EGDLSLADKD VTAKDSKFKM
1010 1020 1030 1040 1050
PKFKMPSFGV SAPGKSIKAL VDVSAPKVEA DLSLPSMQGD LKTTDLSIQP
1060 1070 1080 1090 1100
ASTDLKVQAD QVDVKLPEGH LPEGAGLKGH LPKVEMPSFK MPKVALKGPQ
1110 1120 1130 1140 1150
VDVKGPKLDL KSPKAEVTAP DVEVSLPSVE VDVEAPGAKL DSARLEGELS
1160 1170 1180 1190 1200
LADKDVTAKD SRFKMPKFKM PSFGASAPGK SIEASVDVSA PKVEADVSLP
1210 1220 1230 1240 1250
SMQGDLKTTD LSIQPPSADL EVHAGQVDVK LLEGHVPEGA GFKGHLPKVQ
1260 1270 1280 1290 1300
MPSLKMPKVD LKGPQVEVRG PKLDLKGHKA EVTAHEVAVS LPSVEVDMQA
1310 1320 1330 1340 1350
PGAKLDGAQL DGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS
1360 1370 1380 1390 1400
VDLSAPKVEA DMSLPSMQGD LKTTDLSIQP PSTDLELQAG QLDVKLPEGP
1410 1420 1430 1440 1450
VPEGAGLKGH LPKLQMPSFK VPKVDLKGPE IDIKGPKLDL KDPKVEVTAP
1460 1470 1480 1490 1500
DVEVSLPSVE VDVEAPGAKL DGGRLEEDMS LADKDLTTKD SKFKMPKFKM
1510 1520 1530 1540 1550
PSFGVSAPGK SIEASVDVSA PKVEADVSLP SMQGDLKATD LSIQPPSADL
1560 1570 1580 1590 1600
EVQAGQVDVK LPEGPVSEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG
1610 1620 1630 1640 1650
PKLDLKGPKV EVTAPDVKMS LSSMEVDVQA PRAKLDGAQL EGDLSLADKA
1660 1670 1680 1690 1700
VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS VDVSEPKVEA DVSLPSMQGD
1710 1720 1730 1740 1750
LKTTDLSIQS PSADLEVQAG QVNVKLPEGP LPEGAGFKGH LPKVQMPSLK
1760 1770 1780 1790 1800
MPKVALKGPQ MDVKGPKLDL KGPKAEVMAP DVEVSLPSVE VDVEAPGAKL
1810 1820 1830 1840 1850
DSVRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSA
1860 1870 1880 1890 1900
PKVEAEVSLP SMQGDLKTTD LCIPLPSADL VVQAGQVDMK LPEGQVPEGA
1910 1920 1930 1940 1950
GLKGHLPKVD MPSFKMPKVD LKGPQTDVKG AKLDLKGPKA EVTAPDVEVS
1960 1970 1980 1990 2000
LPSMEVDVQA QKAKLDGARL EGDLSLADKD MTAKDSKFKM PKFKMPSFGV
2010 2020 2030 2040 2050
SAPGRSIEAS VDVPAPKVEA DVSLPSMQGD LKTTDLSIQP PSADLKVQTG
2060 2070 2080 2090 2100
QVDVKLPEGH VPEGAGLKGH LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL
2110 2120 2130 2140 2150
KDPKVEMRVP DVEVSLPSME VDVQAPRAKL DSAHLQGDLT LANKDLTTKD
2160 2170 2180 2190 2200
SKFKMPKFKM PSFGVSAPGK SIEASVDVSP PKVEADMSLP SMQGDLKTTD
2210 2220 2230 2240 2250
LSIQPLSADV KVQAGQVDVK LLEGPVPEEV GLKGHLPKLQ MPSFKVPKVD
2260 2270 2280 2290 2300
LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS LPSVEVDVKA PGAKLDGARL
2310 2320 2330 2340 2350
EGDMSLADKD VTAKDSKFKM PKFKMLSFGV SALGKSIEAS ADVSALKVEA
2360 2370 2380 2390 2400
DVSLPSMQGD LKTTDLSVQP PSADLEVQAG QVDVKLPEGP VPEGAGLKGH
2410 2420 2430 2440 2450
LPKLQMPSFK MPKVDLKGPQ IDVKGPKLDL KGPKTDVMAP DVEVSQPSVE
2460 2470 2480 2490 2500
VDVEAPGAKL DGAWLEGDLS VADKDVTTKD SRFKIPKFKM PSFGVSAPGK
2510 2520 2530 2540 2550
SIEASVDVSA PKVEADGSLS SMQGDLKATD LSIQPPSADL EVQAGQVDVK
2560 2570 2580 2590 2600
LPEGPVPEGA GLKGHLPKVQ MPSFKMPEMD LKGPQLDVKG PKLDLKGPKA
2610 2620 2630 2640 2650
EVTAPDVEMS LSSMEVDVQA PRAKLDGARL EGDLSLADKG VTAKDSKFKM
2660 2670 2680 2690 2700
PKFKMPSFRV SAPGESIEAL VDVSELKVEA DMSLPSMQGD LKTTDISIQP
2710 2720 2730 2740 2750
PSAQLEVQAG QVDVKLPEGH VPEGAGLKGH LPKLQMPSFK MPEVDLKGPQ
2760 2770 2780 2790 2800
IDVKGPNVDL KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS
2810 2820 2830 2840 2850
LADKGMTAKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSE LKVEADGSFP
2860 2870 2880 2890 2900
SMQGDLKTTD IRIQPPSAQL EVQAGQVDVK LPEGHVPEGA GLKGHLPKVQ
2910 2920 2930 2940 2950
MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDVEVS LPSVEVDVEA
2960 2970 2980 2990 3000
PRAKLDGARL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIEVS
3010 3020 3030 3040 3050
VDVSAPKVEA EVSLPSMQGD LKTTDISIEP PSAQLEVQAG QVDLKLPEGH
3060 3070 3080 3090 3100
VPEGAGLKGH LPKLQMPSFK MPKVDRKGPQ IDVKGPKLDL KGPKTDVTAP
3110 3120 3130 3140 3150
DVEVSQPGME VDVEAPGAKL DGARLEGDLS LADKDVTAKD SKFKMPKFKM
3160 3170 3180 3190 3200
PSFGVSAPGK SIEVLVDVSA PKVEADLSLP SMQGDLKNTD ISIEPPSAQL
3210 3220 3230 3240 3250
EVQAGQVDVK LPEGHVLEGA GLKGHLPKLQ MPSFKMPKVD RKGPQIDIKG
3260 3270 3280 3290 3300
PKLDLKGPKM DVTAPDVEVS QPSMEVDVEA PGAKLDGARL EGDLSLADKD
3310 3320 3330 3340 3350
VTAKDSKFKM PKFKMPSYRA SAPGKSIQAS VDVSAPKAEA DVSLPSMQGD
3360 3370 3380 3390 3400
LKTTDLSIQL PSVDLEVQAG QVDVKLPEGH VPEGAGLKGH LPKVEMPSFK
3410 3420 3430 3440 3450
MPKVDLKSPQ VDIKGPKLDL KVPKAEVTVP DVEVSLPSVE VDVQAPRAKL
3460 3470 3480 3490 3500
DGARLEGDLS LAEKDVTAKD SKFKMPKFKM PSFGVSAPGR SIEASLDVSA
3510 3520 3530 3540 3550
PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAVQVDVE LLEGPVPEGA
3560 3570 3580 3590 3600
GLKGHLPKVE MPSLKTPKVD LKGPQIDVKG PKLDLKGPKA EVRVPDVEVS
3610 3620 3630 3640 3650
LPSVEVDVQA PKAKLDAGRL EGDLSLADKD VTAKDSKFKM PKFKMPSFRV
3660 3670 3680 3690 3700
SAPGKSMEAS VDVSAPKVEA DVSLPSMQGD LKTTDLSIQP PSADLKVQAG
3710 3720 3730 3740 3750
QMDVKLPEGQ VPEGAGLKEH LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL
3760 3770 3780 3790 3800
KVSKAEVTAP DVEVSLPSVE VDVQAPRAKL DSAQLEGDLS LADKDVTAKD
3810 3820 3830 3840 3850
SKFKMPKFKM PSFGVSAPGK SIEASVHVSA PKVEADVSLP SMQGDLKTTD
3860 3870 3880 3890 3900
LSIQPHSADL TVQARQVDMK LLEGHVPEEA GLKGHLPKVQ MPSFKMPKVD
3910 3920 3930 3940 3950
LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS LPSVEVDVEA PGAKLDGARL
3960 3970 3980 3990 4000
EGDLSLADKD MTAKDSKFKM PKFKMPSFGV SAPGKSMEAS VDVTAPKVEA
4010 4020 4030 4040 4050
DVSLPSMQGD LKATDLSVQP PSADLEVQAG QVDVKLPEGP VPEGASLKGH
4060 4070 4080 4090 4100
LPKVQMPSFK MPKVDLKGPQ IDVKGPKLDL KGPKAEVTAP DVKMSLSSME
4110 4120 4130 4140 4150
VDVQAPRAKL DGVQLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK
4160 4170 4180 4190 4200
SMEASVDVSE LKAKADVSLP SMQGDLKTTD LSIQSPSADL EVQAGQVDVK
4210 4220 4230 4240 4250
LPEGPLPKGA GLKGHLPKVQ MPCLKMPKVA LKGPQVDVKG PKLDLKGPKA
4260 4270 4280 4290 4300
DVMTPVVEVS LPSMEVDVEA PGAKLDSVRL EGDLSLADKD MTAKDSKFKM
4310 4320 4330 4340 4350
PKFKMPSFGV SAPGKSIEAS LDVSALKVEA DVSLPSMQGD LKTTHLSIQP
4360 4370 4380 4390 4400
PSADLEVQAG QEDVKLPEGP VHEGAGLKGH LPKLQMPSFK VPKVDLKGPQ
4410 4420 4430 4440 4450
IDVNVPKLDL KGPKVEVTSP NLDVSLPSME VDIQAPGAKL DSTRLEGDLS
4460 4470 4480 4490 4500
LADKDVTAKD SKFKMPKFKM PSFGMLSPGK SIEVSVDVSA PKMEADMSIP
4510 4520 4530 4540 4550
SMQGDLKTTD LRIQAPSADL EVQAGQVDLK LPEGHMPEVA GLKGHLPKVE
4560 4570 4580 4590 4600
MPSFKMPKVD LKGPQVDVKG PKLDLKGPKA EVMAPDVEVS LPSVETDVQA
4610 4620 4630 4640 4650
PGSMLDGARL EGDLSLAHED VAGKDSKFQG PKLSTSGFEW SSKKVSMSSS
4660 4670 4680 4690 4700
EIEGNVTFHE KTSTFPIVES VVHEGDLHDP SRDGNLGLAV GEVGMDSKFK
4710 4720 4730 4740 4750
KLHFKVPKVS FSSTKTPKDS LVPGAKSSIG LSTIPLSSSE CSSFELQQVS
4760 4770 4780 4790 4800
ACSEPSMQMP KVGFAGFPSS RLDLTGPHFE SSILSPCEDV TLTKYQVTVP
4810 4820 4830 4840 4850
RAALAPELAL EIPSGSQADI PLPKTECSTD LQPPEGVPTS QAESHSGPLN
4860 4870 4880 4890 4900
SMIPVSLGQV SFPKFYKPKF VFSVPQMAVP EGDLHAAVGA PVMSPLSPGE
4910 4920 4930 4940 4950
RVQCPLPSTQ LPSPGTCVSQ GPEELVASLQ TSVVAPGEAP SEDADHEGKG
4960 4970 4980 4990 5000
SPLKMPKIKL PSFRWSPKKE TGPKVDPECS VEDSKLSLVL DKDEVAPQSA
5010 5020 5030 5040 5050
IHMDLPPERD GEKGRSTKPG FAMPKLALPK MKASKSGVSL PQRDVDPSLS
5060 5070 5080 5090 5100
SATAGGSFQD TEKASSDGGR GGLGATASAT GSEGVNLHRP QVHIPSLGFA
5110 5120 5130 5140 5150
KPDLRSSKAK VEVSQPEADL PLPKHDLSTE GDSRGCGLGD VPVSQPCGEG
5160 5170 5180 5190 5200
IAPTPEDPLQ PSCRKPDAEV LTVESPEEEA MTKYSQESWF KMPKFRMPSL
5210 5220 5230 5240 5250
RRSFRDRGGA GKLEVAQTQA PAATGGEAAA KVKEFLVSGS NVEAAMSLQL
5260 5270 5280 5290 5300
PEADAEVTAS ESKSSTDILR CDLDSTGLKL HLSTAGMTGD ELSTSEVRIH
5310 5320 5330 5340 5350
PSKGPLPFQM PGMRLPETQV LPGEIDETPL SKPGHDLASM EDKTEKWSSQ
5360 5370 5380 5390 5400
PEGPLKLKAS STDMPSQISV VNVDQLWEDS VLTVKFPKLM VPRFSFPAPS
5410 5420 5430 5440 5450
SEDDVFIPTV REVQCPEANI DTALCKESPG LWGASILKAG AGVPGEQPVD
5460 5470 5480 5490 5500
LNLPLEAPPI SKVRVHIQGA QVESQEVTIH SIVTPEFVDL SVPRTFSTQI
5510 5520 5530 5540 5550
VRESEIPTSE IQTPSYGFSL LKVKIPEPHT QARVYTTMTQ HSRTQEGTEE
5560 5570 5580 5590 5600
APIQATPGVD SISGDLQPDT GEPFEMISSS VNVLGQQTLT FEVPSGHQLA
5610 5620 5630 5640 5650
DSCSDEEPAE ILEFPPDDSQ EATTPLADEG RAPKDKPESK KSGLLWFWLP
5660 5670 5680 5690 5700
NIGFSSSVDE TGVDSKNDVQ RSAPIQTQPE ARPEAELPKK QEKAGWFRFP
5710 5720 5730 5740 5750
KLGFSSSPTK KSKSTEDGAE LEEQKLQEET ITFFDARESF SPEEKEEGEL
5760 5770 5780 5790
IGPVGTGLDS RVMVTSAART ELILPEQDRK ADDESKGSGL GPNEG
Length:5,795
Mass (Da):616,629
Last modified:February 26, 2008 - v2
Checksum:iBEC73677308C1FAB
GO
Isoform 2 (identifier: Q8IVF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5002: Missing.

Note: No experimental confirmation available.
Show »
Length:793
Mass (Da):85,128
Checksum:iE2543EB1BE640F9A
GO
Isoform 3 (identifier: Q8IVF2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:5,695
Mass (Da):605,648
Checksum:i3EC13F00BECDE25A
GO

Sequence cautioni

The sequence AAH49216 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH90889 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC23115 differs from that shown. Reason: Frameshift at position 3008.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3195P → L in BAC23115 (Ref. 4) Curated1
Sequence conflicti3198A → V in BAC23115 (Ref. 4) Curated1
Sequence conflicti4740E → G in CAD98019 (PubMed:17974005).Curated1
Sequence conflicti5269L → P in CAD98019 (PubMed:17974005).Curated1
Sequence conflicti5560D → G in CAD97904 (PubMed:17974005).Curated1
Sequence conflicti5577I → V in CAD97904 (PubMed:17974005).Curated1
Sequence conflicti5590T → A in CAD97981 (PubMed:17974005).Curated1
Sequence conflicti5601D → G in CAD98034 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050635525T → A.Corresponds to variant rs2278607dbSNPEnsembl.1
Natural variantiVAR_0390691266V → M.Corresponds to variant rs11850930dbSNPEnsembl.1
Natural variantiVAR_0615481298M → I.Corresponds to variant rs2819440dbSNPEnsembl.1
Natural variantiVAR_0390701470L → V.Corresponds to variant rs12890949dbSNPEnsembl.1
Natural variantiVAR_0595601856E → D.Corresponds to variant rs2819435dbSNPEnsembl.1
Natural variantiVAR_0506362107M → V.Corresponds to variant rs11846918dbSNPEnsembl.1
Natural variantiVAR_0390712115S → R.Corresponds to variant rs2582514dbSNPEnsembl.1
Natural variantiVAR_0595612146L → V.Corresponds to variant rs12890949dbSNPEnsembl.1
Natural variantiVAR_0506372410K → R.Corresponds to variant rs11845746dbSNPEnsembl.1
Natural variantiVAR_0390722429D → E.Corresponds to variant rs11160826dbSNPEnsembl.1
Natural variantiVAR_0390732430L → V.Corresponds to variant rs2819426dbSNPEnsembl.1
Natural variantiVAR_0595622503E → A.Corresponds to variant rs2819429dbSNPEnsembl.1
Natural variantiVAR_0390742616V → A.Corresponds to variant rs4264326dbSNPEnsembl.1
Natural variantiVAR_0595632862R → S.Corresponds to variant rs2582514dbSNPEnsembl.1
Natural variantiVAR_0595643176D → E.Corresponds to variant rs11160826dbSNPEnsembl.1
Natural variantiVAR_0595653177L → V.Corresponds to variant rs2819426dbSNPEnsembl.1
Natural variantiVAR_0595663336P → L.Corresponds to variant rs10438247dbSNPEnsembl.1
Natural variantiVAR_0595673363V → A.Corresponds to variant rs4264326dbSNPEnsembl.1
Natural variantiVAR_0615493654G → E.Corresponds to variant rs28380382dbSNPEnsembl.1
Natural variantiVAR_0595683793D → N.Corresponds to variant rs11160825dbSNPEnsembl.1
Natural variantiVAR_0506383796V → L.Corresponds to variant rs12890949dbSNPEnsembl.1
Natural variantiVAR_0595693869M → V.Corresponds to variant rs10438246dbSNPEnsembl.1
Natural variantiVAR_0595703902K → N.Corresponds to variant rs2819423dbSNPEnsembl.1
Natural variantiVAR_0506393961M → V.Corresponds to variant rs10141053dbSNPEnsembl.1
Natural variantiVAR_0506404071I → M.Corresponds to variant rs2582511dbSNPEnsembl.1
Natural variantiVAR_0595714085A → V.Corresponds to variant rs2013462dbSNPEnsembl.1
Natural variantiVAR_0506414138F → L.Corresponds to variant rs2582505dbSNPEnsembl.1
Natural variantiVAR_0595724198D → N.Corresponds to variant rs11848082dbSNPEnsembl.1
Natural variantiVAR_0506424232K → N.Corresponds to variant rs2819423dbSNPEnsembl.1
Natural variantiVAR_0506434278V → A.Corresponds to variant rs2819422dbSNPEnsembl.1
Natural variantiVAR_0595734326L → P.Corresponds to variant rs2819421dbSNPEnsembl.1
Natural variantiVAR_0595744478P → L.Corresponds to variant rs2582513dbSNPEnsembl.1
Natural variantiVAR_0506444536M → L.Corresponds to variant rs9672139dbSNPEnsembl.1
Natural variantiVAR_0506454664T → A.1 PublicationCorresponds to variant rs4465542dbSNPEnsembl.1
Natural variantiVAR_0390755028L → M.Corresponds to variant rs9672139dbSNPEnsembl.1
Natural variantiVAR_0506465072G → R.Corresponds to variant rs2819420dbSNPEnsembl.1
Natural variantiVAR_0615505139G → E.Corresponds to variant rs61421370dbSNPEnsembl.1
Natural variantiVAR_0506475184Y → D.1 PublicationCorresponds to variant rs2819419dbSNPEnsembl.1
Natural variantiVAR_0506485397P → A.2 PublicationsCorresponds to variant rs3742935dbSNPEnsembl.1
Natural variantiVAR_0390765564G → R.Corresponds to variant rs2819420dbSNPEnsembl.1
Natural variantiVAR_0506495732T → M.Corresponds to variant rs748358dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0315501 – 5002Missing in isoform 2. 1 PublicationAdd BLAST5002
Alternative sequenceiVSP_0315511 – 100Missing in isoform 3. 2 PublicationsAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512802 Genomic DNA. No translation available.
AI915159 mRNA. No translation available.
BC011859 mRNA. Translation: AAH11859.2.
BC033372 mRNA. Translation: AAH33372.1.
BC049216 mRNA. Translation: AAH49216.1. Different initiation.
BC090889 mRNA. Translation: AAH90889.1. Different initiation.
AK094143 mRNA. No translation available.
AB095939 mRNA. Translation: BAC23115.1. Frameshift.
AL834367 mRNA. Translation: CAD39030.1.
BX537923 mRNA. Translation: CAD97904.1.
BX538040 mRNA. Translation: CAD97981.1.
BX538106 mRNA. Translation: CAD98019.1.
BX538133 mRNA. Translation: CAD98034.1.
CCDSiCCDS45177.1. [Q8IVF2-1]
RefSeqiNP_612429.2. NM_138420.2. [Q8IVF2-1]
XP_005267356.1. XM_005267299.1. [Q8IVF2-3]
UniGeneiHs.441783.

Genome annotation databases

EnsembliENST00000333244; ENSP00000353114; ENSG00000185567. [Q8IVF2-1]
ENST00000557457; ENSP00000450998; ENSG00000185567. [Q8IVF2-2]
GeneIDi113146.
KEGGihsa:113146.
UCSCiuc010axc.2. human. [Q8IVF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512802 Genomic DNA. No translation available.
AI915159 mRNA. No translation available.
BC011859 mRNA. Translation: AAH11859.2.
BC033372 mRNA. Translation: AAH33372.1.
BC049216 mRNA. Translation: AAH49216.1. Different initiation.
BC090889 mRNA. Translation: AAH90889.1. Different initiation.
AK094143 mRNA. No translation available.
AB095939 mRNA. Translation: BAC23115.1. Frameshift.
AL834367 mRNA. Translation: CAD39030.1.
BX537923 mRNA. Translation: CAD97904.1.
BX538040 mRNA. Translation: CAD97981.1.
BX538106 mRNA. Translation: CAD98019.1.
BX538133 mRNA. Translation: CAD98034.1.
CCDSiCCDS45177.1. [Q8IVF2-1]
RefSeqiNP_612429.2. NM_138420.2. [Q8IVF2-1]
XP_005267356.1. XM_005267299.1. [Q8IVF2-3]
UniGeneiHs.441783.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CN0X-ray1.75A/B108-203[»]
ProteinModelPortaliQ8IVF2.
SMRiQ8IVF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125226. 23 interactors.
IntActiQ8IVF2. 7 interactors.
STRINGi9606.ENSP00000353114.

PTM databases

iPTMnetiQ8IVF2.
PhosphoSitePlusiQ8IVF2.
SwissPalmiQ8IVF2.

Polymorphism and mutation databases

BioMutaiAHNAK2.
DMDMi172045740.

Proteomic databases

EPDiQ8IVF2.
MaxQBiQ8IVF2.
PaxDbiQ8IVF2.
PeptideAtlasiQ8IVF2.
PRIDEiQ8IVF2.

Protocols and materials databases

DNASUi113146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333244; ENSP00000353114; ENSG00000185567. [Q8IVF2-1]
ENST00000557457; ENSP00000450998; ENSG00000185567. [Q8IVF2-2]
GeneIDi113146.
KEGGihsa:113146.
UCSCiuc010axc.2. human. [Q8IVF2-1]

Organism-specific databases

CTDi113146.
GeneCardsiAHNAK2.
H-InvDBHIX0012023.
HGNCiHGNC:20125. AHNAK2.
HPAiHPA000878.
HPA002940.
HPA004145.
HPA020111.
MIMi608570. gene.
neXtProtiNX_Q8IVF2.
OpenTargetsiENSG00000185567.
PharmGKBiPA162376085.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGCZ. Eukaryota.
ENOG41116CJ. LUCA.
GeneTreeiENSGT00530000063716.
InParanoidiQ8IVF2.
OMAiGVGIKAH.
OrthoDBiEOG091G01FG.
PhylomeDBiQ8IVF2.
TreeFamiTF350595.

Enzyme and pathway databases

BioCyciZFISH:G66-31628-MONOMER.

Miscellaneous databases

ChiTaRSiAHNAK2. human.
GenomeRNAii113146.
PROiQ8IVF2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185567.
GenevisibleiQ8IVF2. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAHNK2_HUMAN
AccessioniPrimary (citable) accession number: Q8IVF2
Secondary accession number(s): Q5BKX7
, Q7Z343, Q7Z358, Q7Z394, Q7Z3G0, Q86WQ6, Q8IYY1, Q8N3G4, Q96EX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.