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Protein

NUT family member 2A

Gene

NUTM2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NUT family member 2A
Gene namesi
Name:NUTM2A
Synonyms:FAM22A, KIAA2020
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000184923.12.
HGNCiHGNC:23438. NUTM2A.

Pathology & Biotechi

Organism-specific databases

DisGeNETi728118.
MalaCardsiNUTM2A.
OpenTargetsiENSG00000184923.
PharmGKBiPA134875735.

Polymorphism and mutation databases

BioMutaiNUTM2A.
DMDMi269849751.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002660321 – 878NUT family member 2AAdd BLAST878

Proteomic databases

PaxDbiQ8IVF1.
PeptideAtlasiQ8IVF1.
PRIDEiQ8IVF1.

PTM databases

iPTMnetiQ8IVF1.
PhosphoSitePlusiQ8IVF1.

Expressioni

Gene expression databases

BgeeiENSG00000184923.
CleanExiHS_FAM22A.
HS_FAM22D.
GenevisibleiQ8IVF1. HS.

Organism-specific databases

HPAiHPA064635.

Interactioni

Protein-protein interaction databases

IntActiQ8IVF1. 1 interactor.
STRINGi9606.ENSP00000371126.

Structurei

3D structure databases

ProteinModelPortaliQ8IVF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 285Poly-Pro8
Compositional biasi425 – 514Pro-richAdd BLAST90

Sequence similaritiesi

Belongs to the NUT family.Curated

Phylogenomic databases

eggNOGiENOG410J94Q. Eukaryota.
ENOG4111C0H. LUCA.
GeneTreeiENSGT00410000025793.
HOGENOMiHOG000112470.
HOVERGENiHBG107898.
InParanoidiQ8IVF1.
OMAiSSQPQKR.
OrthoDBiEOG091G034P.
PhylomeDBiQ8IVF1.
TreeFamiTF337728.

Family and domain databases

InterProiView protein in InterPro
IPR024310. NUT.
IPR024309. NUT_N.
PANTHERiPTHR22879. PTHR22879. 1 hit.
PfamiView protein in Pfam
PF12881. NUT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAKALH
60 70 80 90 100
RMSPTPNSCP LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG
110 120 130 140 150
LTLGFSHCGN CQTAVVSAQP EGMASNGAYP ALGPGVTANP GTSLSVFTAL
160 170 180 190 200
PFTTPAPGPA HGPLLVTAGA PPGGPLVLST LPSTPLVTEQ DGCGPSGAGA
210 220 230 240 250
SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG VVCPPPLLLA
260 270 280 290 300
AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP
310 320 330 340 350
WPQGAHGEGS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS
360 370 380 390 400
PDTEALSCFL IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE
410 420 430 440 450
MAEKFLEFEA EEEMQIQKSQ WMKGPQCLPP PATPRLEPRG PPAPEVVKQP
460 470 480 490 500
VYLPSKAGPK APTACLPPPR PQRPVTKARR PPPRPHRRAE TKARLPPPRP
510 520 530 540 550
QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK QREEGEVKQP
560 570 580 590 600
QEEDWTPPDP GLLSYTDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF
610 620 630 640 650
LALSQELEQE EGLTLAQLVE KRLLPLKEKQ HARAAPSRGT ARLDSSSSKF
660 670 680 690 700
AAGQGAERDV PVPQQGVGME TCPPQTTARD SQGRGRAHTG MARSKDSVVL
710 720 730 740 750
LGCQDSPGLR AARPTSPPQD HRPTCPGVGT KDALDLPGGS PVRESHGLAQ
760 770 780 790 800
GSSEEEELPS LAFLLGSQHK LLPWWLPQSP VPASGLLSPE KWGPQGTHQF
810 820 830 840 850
PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPHPGPGL RVSGEQSLTW
860 870
GLGGPSQSQK RKGDPLVSRK EKKQRCSQ
Length:878
Mass (Da):93,890
Last modified:November 24, 2009 - v4
Checksum:iB65B88FE85A912A1
GO
Isoform 2 (identifier: Q8IVF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-629: LVEKRLLPLKEK → GAPSDAPGTDRC
     630-878: Missing.

Show »
Length:629
Mass (Da):67,315
Checksum:i99F74628C11E4481
GO

Sequence cautioni

The sequence BAC23116 differs from that shown. Reason: Frameshift at position 83.Curated
The sequence CAH72466 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47K → E in BAC23116 (Ref. 1) Curated1
Sequence conflicti160A → T in BAC23116 (Ref. 1) Curated1
Sequence conflicti546E → K in BAC23116 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034018618 – 629LVEKR…PLKEK → GAPSDAPGTDRC in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_034020630 – 878Missing in isoform 2. 1 PublicationAdd BLAST249

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095940 mRNA. Translation: BAC23116.1. Frameshift.
AL157893 Genomic DNA. Translation: CAH72466.1. Sequence problems.
CCDSiCCDS44452.1. [Q8IVF1-1]
RefSeqiNP_001009610.1. NM_001009610.1.
NP_001092808.1. NM_001099338.1. [Q8IVF1-1]
XP_011538424.1. XM_011540122.2. [Q8IVF1-1]
XP_016872096.1. XM_017016607.1. [Q8IVF1-2]
UniGeneiHs.701044.
Hs.710565.

Genome annotation databases

EnsembliENST00000381689; ENSP00000371107; ENSG00000184923. [Q8IVF1-2]
ENST00000381707; ENSP00000371126; ENSG00000184923. [Q8IVF1-1]
GeneIDi728118.
728130.
KEGGihsa:728118.
hsa:728130.
UCSCiuc001kek.4. human. [Q8IVF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNTM2A_HUMAN
AccessioniPrimary (citable) accession number: Q8IVF1
Secondary accession number(s): A6NMX5, C9JDI1, Q5VZW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 95 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families